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Cited by 79Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Migration of blood cells to β-amyloid plaques in Alzheimer's disease

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Hohsfield, Lindsay A., Humpel, Christian·2015·Experimental Gerontology
DOI 10.1016/j.exger.2015.03.002PMC PMC4526125
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that leads to the progressive deterioration of cognitive and memory functions. The deposition of extracellular beta-amyloid (Aβ) senile plaques and intracellular tau neurofibrillary tangles are considered the cardinal pathological hallmarks of AD, however, accumulating evidence indicates that immune cells may also play an important role in disease pathogenesis. Among these immune cells, blood-derived cells and their infiltration into the CNS towards Aβ plaques have been implicated in therapeutic strategies against AD. Here, we review the current literature on blood cell migration into the AD brain and the important players involved in this selective migration towards Aβ plaques.

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  • The primary mechanism of action of 10D5 mAb is based on its direct binding to deposited Aβ and stimulating Fc receptor-mediated Aβ plaque removal by activated microglia and possibly blood derived macrophages.

    “The primary mechanism of action of 10D5 mAb is based on its direct binding to deposited Aβ and stimulating Fc receptor-mediated Aβ plaque removal by activated microglia and possibly blood derived macrophages [9, 34].”

    From APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice (2017) · cites this paper as [34]

    Section 3.5 (page unavailable) reports that blood-derived monocytes or macrophages can reach Aβ plaques and eliminate deposits by phagocytosis. It does not identify 10D5 mAb, describe its binding to deposited Aβ, or establish Fc receptor-mediated removal as its primary mechanism. (LLM, conf=0.82)

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Sorted by citations

Authors
Hohsfield, L. A., & Humpel, C.
Affiliations
Innsbruck Medical University (AT)
Corresponding author
Humpel, Christian
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2015-05
Volume
65
Pages
8-15
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/j.exger.2015.03.002
PMC
PMC4526125
OpenAlex
W1989038107
Cited by
79
References
21
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 11 · 2020: 5 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 8 · 2015: 3 · 2013: 1
FWCI
1.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Experimental Gerontology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
Alzheimer's disease, amyloid plaques, leukocyte infiltration, blood-brain barrier, neuroinflammation, immune cells, neurofibrillary tangles, pathogenesis
MeSH terms
Alzheimer Disease, Blood Cells, Brain, Cell Movement, Humans, Amyloid beta-Protein Precursor, Neurofibrillary Tangles, Plaque, Amyloid

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