Cited by 240Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research StudiesAlzheimer's disease research and treatments

Systemic inflammatory cells fight off neurodegenerative disease

Schwartz, Michal, Shechter, Ravid·2010·Nature Reviews Neurology

Abstract

Treatment of Alzheimer disease or amyotrophic lateral sclerosis with anti-inflammatory drugs (to prevent disease or slow its progression) has yielded mixed results, despite evidence indicating that local cytotoxic inflammation occurs in these conditions. Here, through consideration of the importance of immune cell origin (resident versus blood-derived immune cells) and activity (pro-inflammatory versus anti-inflammatory activity) under neurodegenerative conditions, we propose a model that reconciles these seemingly inconsistent data. We suggest that systemic immune cells (CD4(+) T cells and peripheral blood-derived monocytes) must be recruited to the CNS to modify potentially destructive local inflammation, and that the failure of systemic anti-inflammatory drug therapies to arrest neurodegenerative disease progression might result from drug-induced suppression of such recruitment. Thus, we propose that an appreciation of the distinctive temporal and spatial contributions of resident and systemic leukocytes to disease progression is essential for the development of effective therapeutic regimens.

Integrity signals

Registry

Crossref · 10.1038/nrneurol.2010.71

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45 of 45 references verified0 citation errors · 0 not checkable

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  • Maintenance of certain brain functions is dependent on T cell actions in the CNS.

    “maintenance of certain brain functions is dependent on T cell actions in the CNS (31, 32)”
  • T cells are present and functional in the brain where they modulate higher functions, such as cognition.

    “previous findings that T cells are present and functional in the brain (32) where they modulate higher functions, such as cognition.”

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Authors
Schwartz, M., & Shechter, R.
Affiliations
Weizmann Institute of Science (IL)
Corresponding author
Schwartz, Michal
Venue
Nature Reviews Neurology
Published
2010-06-08
Volume
6
Issue
7
Pages
405-410
ISSN
  • 1759-4758 (ISSN-L)
  • 1759-4766
OpenAlex
W2081117923
Cited by
240
References
45
Citations by year
2026: 6 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 10 · 2020: 18 · 2019: 9 · 2018: 5 · 2017: 17 · 2016: 19 · 2015: 15 · 2014: 33 · 2013: 21 · 2012: 34
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
neurodegenerative diseases, systemic inflammation, microglia, amyotrophic lateral sclerosis, Alzheimer's disease, anti-inflammatory agents, CD4+ T cells, monocytes, immune cell recruitment, disease progression
MeSH terms
Anti-Inflammatory Agents, Non-Steroidal, Humans, Immune System Diseases, Inflammation, Leukocytes, Macrophages, Microglia, Neurodegenerative Diseases, Adaptive Immunity

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