Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson's disease
Abstract
Gut microbial metabolites, SCFAs, were related with the occurrence and development of Parkinson's disease (PD). But the effects of different short-chain fatty acids (SCFAs) on PD and involving mechanisms are still undefined. In this study we evaluate the effects of three dominant SCFAs (acetate, propionate and butyrate) on motor damage, dopaminergic neuronal degeneration and underlying neuroinflammation related mechanisms in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD mice. High (2.0 g/kg) or low doses (0.2 g/kg) of sodium acetate (NaA), sodium propionate (NaP) or sodium butyrate (NaB) were gavaged into PD mice for 6 weeks. High doses of NaA reduced the turning time of PD mice. NaB significantly reduced the turning and total time in pole test, and increased the average velocity in open field test when compared with PD mice, indicating the most effective alleviation of PD-induced motor disorder. Low and high doses of NaB significantly increased the content of tyrosine hydroxylase (TH) by 12.3% and 20.2%, while reduced α-synuclein activation by 159.4% and 132.7% in the substantia nigra pars compacta (SNpc), compared with PD groups. Butyrate reached into the midbrain SNpc and suppressed microglia over-activation. It inhibited the levels of pro-inflammatory factors (IL-6, IL-1β and TNF-α) (P < 0.01) and iNOS. Besides, butyrate inhibited the activation of NF-κB and MAPK signaling pathways in the SNpc region. Consequently, sodium butyrate could inhibit neuroinflammation and alleviate neurological damage of PD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sodium butyrate has neuroprotective effects in MPTP-induced PD mice by attenuating microglial reactivity via inhibition of TLR4/MyD88/NF-κB and MAPK signaling pathway.
“Additionally, studies have demonstrated the neuroprotective effects of sodium butyrate in MPTP-induced PD mice by attenuating microglial reactivity via the inhibition of TLR4/MyD88/NF-κB and MAPK signaling pathway.319–321”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [319]
NaB can improve motor symptoms, neuronal loss, and neuroinflammation in MPTP-induced PD mice.
“NaB can improve motor symptoms, neuronal loss, and neuroinflammation in MPTP-induced PD mice [23,24,25].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [23]
Cites
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357 · see citing works
Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M.-Y. (2012) · Science · doi:10.1126/science.1227157 · Cited by 2,563 · see citing works
Braak, H., R�b, U., Gai, W. P., & Del Tredici, K. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0808-2 · Cited by 1,683 · see citing works
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329 · see citing works
Unger, M. M., Spiegel, J., Dillmann, K.-U., Grundmann, D., Philippeit, H., Bürmann, J., Faßbender, K., Schwiertz, A., & Schäfer, K.-H. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.08.019 · Cited by 1,159 · see citing works
Butyrate: A Double-Edged Sword for Health?
Liu, H., Wang, J., He, T., Becker, S. R., Zhang, G., Li, D., & Ma, X. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx009 · Cited by 1,158 · see citing works
Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases
Sun, M., Wu, W. H., Liu, Z., & Cong, Y. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1242-9 · Cited by 1,073 · see citing works
Microglial Activation and Chronic Neurodegeneration
Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works
Fox, S. H., Katzenschlager, R., Lim, S., Barton, B. R., de Bie, R. M. A., Seppi, K., Coelho, M. M., & Sampaio, C. (2018) · Movement Disorders · doi:10.1002/mds.27372 · Cited by 1,009 · see citing works
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Irwin, D. J., Lee, V. M. ‐., & Trojanowski, J. Q. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3549 · Cited by 875 · see citing works
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Maini Rekdal, V., Bess, E. N., Bisanz, J. E., Turnbaugh, P. J., & Balskus, E. P. (2019) · Science · doi:10.1126/science.aau6323 · Cited by 753 · see citing works
Sun, M.-F., Zhu, Y.-L., Zhou, Z.-L., Jia, X.-B., Xu, Y.-D., Yang, Q., Cui, C., & Shen, Y.-Q. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.005 · Cited by 736 · see citing works
Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism
Duscha, A., Gisevius, B., Hirschberg, S., Yissachar, N., Stangl, G. I., Dawin, E., Bader, V., Haase, S., Kaisler, J., David, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.035 · Cited by 639 · see citing works
Norden, D. M., Trojanowski, P. J., Villanueva, E., Navarro, E., & Godbout, J. P. (2015) · Glia · doi:10.1002/glia.22930 · Cited by 596 · see citing works
Wang, M., Wichienchot, S., He, X., Fu, X., Huang, Q., & Zhang, B. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.005 · Cited by 519 · see citing works
Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-Synuclein
Fleming, S. M., Salcedo, J. D., Fernagut, P., Rockenstein, E. M., Masliah, E., Levine, M. S., & Chesselet, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3080-04.2004 · Cited by 477 · see citing works
Ghosh, A., Roy, A., Liu, X., Kordower, J. H., Mufson, E. J., Hartley, D. M., Ghosh, S., Mosley, R. L., Gendelman, H. E., & Pahan, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704908104 · Cited by 438 · see citing works
Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice
Yang, X., Yu, D., Xue, L., Li, H., & Du, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.07.001 · Cited by 407 · see citing works
Self-citationLi, W., Wu, X., Hu, X., Wang, T., Liang, S., Duan, Y., Jin, F., & Qin, B. (2017) · Science China Life Sciences · doi:10.1007/s11427-016-9001-4 · Cited by 406 · see citing works
Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai
Zhang, Z., Román, G. C., Hong, Z., Wu, C.-B., Qu, Q.-M., Huang, J.-B., Zhou, B., Geng, Z.-P., Wu, J.-X., Wen, H.-B., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17909-4 · Cited by 398 · see citing works
Gut microbial molecules in behavioural and neurodegenerative conditions
Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00381-0 · Cited by 379 · see citing works
Prospective study of dietary pattern and risk of Parkinson disease
Gao, X., Chen, H., Fung, T. T., Logroscino, G., Schwarzschild, M. A., Hu, F. B., & Ascherio, A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1486 · Cited by 340 · see citing works
Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson’s Disease
Caputi, V., & Giron, M. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061689 · Cited by 338 · see citing works
Johnson, M., & Bobrovskaya, L. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.12.002 · Cited by 335 · see citing works
Microbiota composition and metabolism are associated with gut function in Parkinson's disease
Cirstea, M. S., Yu, A. C., Golz, E., Sundvick, K., Kliger, D., Radisavljevic, N., Foulger, L. H., Mackenzie, M., Huan, T., Finlay, B. B., et al. (2020) · Movement Disorders · doi:10.1002/mds.28052 · Cited by 326 · see citing works
Cersosimo, M. G., Raina, G. B., Pecci, C., Pellene, A., Calandra, C. R., Gutiérrez, C., Micheli, F. E., & Benarroch, E. E. (2013) · Journal of Neurology · doi:10.1007/s00415-012-6801-2 · Cited by 314 · see citing works
Altered brain-gut axis in autism: comorbidity or causative mechanisms
Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · see citing works
Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai
ZHANG, Z., Román, G. C., Hong, Z., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)70801-1 · Cited by 302 · see citing works
Nonpharmacological treatments for patients with Parkinson's disease
Bloem, B. R., de Vries, N. M., & Ebersbach, G. (2015) · Movement Disorders · doi:10.1002/mds.26363 · Cited by 273 · see citing works
Levodopa in the treatment of Parkinson’s disease: an old drug still going strong
Antonini, A. (2010) · Clinical Interventions in Aging · doi:10.2147/cia.s6456 · Cited by 251 · see citing works
p53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain
Mogi, M., Kondo, T., Mizuno, Y., & Nagatsu, T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.12.003 · Cited by 242 · see citing works
Elamin, E. E., Masclee, A., Jan, D., Pieters, H., & Jonkers, D. M. A. E. (2013) · Journal of Nutrition · doi:10.3945/jn.113.179549 · Cited by 237 · see citing works
Gut microbiota: Implications in Parkinson's disease
Parashar, A., & Malairaman, U. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.02.002 · Cited by 231 · see citing works
α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia
Klegeris, A., Pelech, S., Giasson, B. I., Maguire, J., Zhang, H., McGeer, E. G., & McGeer, P. L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.013 · Cited by 227 · see citing works
Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease
Surmeier, D. J., Guzmán, J. N., & Sánchez-Padilla, J. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.003 · Cited by 221 · see citing works
Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms
Felice, V. D., Quigley, E. M., Sullivan, A. M., O'Keeffe, G. W., & O'Mahony, S. M. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.03.012 · Cited by 205 · see citing works
Yamawaki, Y., Yoshioka, N., Nozaki, K., Ito, H., Oda, K., Harada, K., Shirawachi, S., Asano, S., Aizawa, H., Yamawaki, S., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2017.12.004 · Cited by 204 · see citing works
St. Laurent, R., O’Brien, L. M., & Ahmad, S. T. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.037 · Cited by 199 · see citing works
Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE
Ziehn, M. O., Avedisian, A., Tiwari-Woodruff, S., & Voskuhl, R. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.6 · Cited by 190 · see citing works
Paiva, I., Pinho, R., Pavlou, M. A., Hennion, M., Wales, P., Schütz, A.-L., Rajput, A., Szegő, É. M., Kerimoglu, C., Gerhardt, E., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx114 · Cited by 185 · see citing works
Parkinson disease and the gut: new insights into pathogenesis and clinical relevance
Travagli, R. A., Browning, K. N., & Camilleri, M. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0339-z · Cited by 181 · see citing works
Levodopa therapy for Parkinson disease
LeWitt, P. A., & Fahn, S. (2016) · Neurology · doi:10.1212/wnl.0000000000002509 · Cited by 179 · see citing works
Shultz, S. R., MacFabe, D. F., Martin, S. P., Jackson, J., Taylor, R., Boon, F. H., Ossenkopp, K., & Cain, D. P. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.023 · Cited by 156 · see citing works
Oxidative Stress and Parkinson's Diseasea
Owen, A., Schapira, A. H. V., Jenner, P. G., & MARSDEN, C. D. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb39064.x · Cited by 154 · see citing works
Sharma, S., Taliyan, R., & Singh, S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.052 · Cited by 142 · see citing works
Plasma Short‐Chain Fatty Acids in Patients With Parkinson's Disease
Shin, C., Lim, Y., Lim, H., & Ahn, T. (2020) · Movement Disorders · doi:10.1002/mds.28016 · Cited by 116 · see citing works
Paknahad, Z., Sheklabadi, E., Derakhshan, Y., Bagherniya, M., & Chitsaz, A. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102366 · Cited by 113 · see citing works
Novel formulations and modes of delivery of levodopa
Poewe, W. H., & Antonini, A. (2014) · Movement Disorders · doi:10.1002/mds.26078 · Cited by 108 · see citing works
French, S. A., Harnack, L., Toomey, T. L., & Hannan, P. J. (2007) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-4-52 · Cited by 68 · see citing works
Fan, H., Wu, P., Zhang, L., Hu, Z., Wang, W., Guan, X., Luo, H., Ni, M., Yang, J., Li, M., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6022 · Cited by 66 · see citing works
Neurodegenerative signaling factors and mechanisms in Parkinson's pathology
Goswami, P., Joshi, N., & Singh, S. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.06.008 · Cited by 50 · see citing works
Diet and medical foods in Parkinson’s disease
Lange, K. W., NAKAMURA, Y., Chen, N., Guo, J., Kanaya, S., Lange, K. M., & Li, S. (2019) · Food Science and Human Wellness · doi:10.1016/j.fshw.2019.03.006 · Cited by 42 · see citing works
Bavafa-Valenlia, K., Morshedi, M., Saghafi‐Asl, M., Shahabi, P., & Abbasi, M. M. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.069 · Cited by 40 · see citing works
Olfactory dysfunction in Parkinson's disease: Positive effect of cigarette smoking
Sharer, J. D., Leon‐Sarmiento, F. E., Morley, J. F., Weintraub, D. A., & Doty, R. L. (2014) · Movement Disorders · doi:10.1002/mds.26126 · Cited by 36 · see citing works
Chen, J. J., & Wilkinson, J. R. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270011406279 · Cited by 34 · see citing works
von Twickel, A., Kowatschew, D., Saltürk, M., Schauer, M., Robertson, B., Korsching, S. I., Walkowiak, W., Grillner, S. E., & Pérez‐Fernández, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.01.004 · Cited by 33 · see citing works
PBPK/PD assessment for Parkinson’s disease risk posed by airborne pesticide paraquat exposure
Cheng, Y., Chou, W., Yang, Y., Huang, C., How, C. M., Chen, S., Chen, W., Hsieh, N., Lin, Y., You, S., et al. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-0875-4 · Cited by 27 · see citing works
Huang, W., Xu, Y., Zhang, Y., Zhang, P., Zhang, Q., Zhang, Z., & Xu, F. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14774 · Cited by 26 · see citing works
Kim, S. J., Ryu, M. J., Han, J., Jang, Y., Kim, J., Lee, M. J., Ryu, I., Ju, X., Oh, E., Chung, W., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.017 · Cited by 23 · see citing works
Tan, X., Zhang, L., Zhu, H., Qin, J., Tian, M., Dong, C., Li, H., & Jin, G. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.04.019 · Cited by 21 · see citing works
Peng, Z., Luchtman, D. W., Wang, X., Zhang, Y., & Song, C. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.01.024 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies
Zhang, X., Tang, B., & Guo, J. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00392-8 · Cited by 205 · see citing works
Self-citationGut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease
Zhu, M., Liu, X., Ye, Y., Yan, X., Cheng, Y., Zhao, L., Chen, F., & Ling, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.937555 · Cited by 177 · see citing works
Self-citationKalyanaraman, B., Cheng, G., & Hardy, M. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103092 · Cited by 174 · see citing works
Cao, Q., Shen, M., Li, R., Liu, Y., Zeng, Z., Zhou, J., Niu, D., Zhang, Q., Wang, R., Yao, J., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03454-y · Cited by 129 · see citing works
Neurodegenerative disorders and gut-brain interactions
Singh, A., Dawson, T. M., & Kulkarni, S. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143775 · Cited by 102 · see citing works
Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?
Lei, W., Cheng, Y., Gao, J., Liu, X., Shao, L., Kong, Q., Zheng, N., Ling, Z., & Hu, W. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1224155 · Cited by 101 · see citing works
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
Abdel-Haq, R., Schlachetzki, J. C., Boktor, J. C., Cantu-Jungles, T. M., Thron, T., Zhang, M., Bostick, J. W., Khazaei, T., Chilakala, S., Morais, L. H., et al. (2022) · eLife · doi:10.7554/elife.81453 · Cited by 82 · see citing works
Self-citationGuo, T.-T., Zhang, Z., Sun, Y., Zhu, R.-Y., Wang, F.-X., Ma, L.-J., Jiang, L., & Liu, H.-D. (2023) · Nutrients · doi:10.3390/nu15040930 · Cited by 82 · see citing works
Duan, W.-X., Wang, F., Liu, J., & Liu, C. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01123-9 · Cited by 78 · see citing works
Self-citationBile acid receptors and signaling crosstalk in the liver, gut and brain
Ferrell, J. M., & Chiang, J. Y. L. (2021) · Liver Research · doi:10.1016/j.livres.2021.07.002 · Cited by 69 · see citing works
Yadav, S., Dwivedi, A., Tripathi, A., & Tripathi, A. K. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.07.007 · Cited by 63 · see citing works
Zhao, Q., Chen, J., Wu, M., Yin, X., Jiang, Q., Gao, H., & Zheng, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110638 · Cited by 49 · see citing works
Zhang, Y., Xu, S., Qian, Y., Mo, C., Ai, P., Yang, X., & Xiao, Q. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1099018 · Cited by 49 · see citing works
Cavaliere, G., Catapano, A., Trinchese, G., Cimmino, F., Penna, E., Pizzella, A., Cristiano, C., Lama, A., Crispino, M., & Mollica, M. P. (2022) · Antioxidants · doi:10.3390/antiox12010004 · Cited by 52 · see citing works
Novel Pharmacotherapies in Parkinson’s Disease
Tizabi, Y., Getachew, B., & Aschner, M. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00375-5 · Cited by 43 · see citing works
Qiao, C.-M., Quan, W., Zhou, Y., Niu, G.-Y., Hong, H., Wu, J., Zhao, L.-P., Li, T., Cui, C., Zhao, W.-J., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03392-x · Cited by 45 · see citing works
Self-citationConvergent pathways of the gut microbiota–brain axis and neurodegenerative disorders
Gubert, C., Gasparotto, J., & Morais, L. H. (2022) · Gastroenterology report · doi:10.1093/gastro/goac017 · Cited by 40 · see citing works
Xu, R.-C., Miao, W.-T., Xu, J., Xu, W. V., Liu, M.-R., Ding, S., Jian, Y.-X., Lei, Y.-H., Yan, N., & Liu, H.-D. (2022) · Nutrients · doi:10.3390/nu14194163 · Cited by 39 · see citing works
Catumbela, C. S. G., Giridharan, V. V., Barichello, T., & Morales, R. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00369-7 · Cited by 37 · see citing works
Lan, Z., Tang, X., Lu, M., Hu, Z., & Tang, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26377 · Cited by 39 · see citing works
Targeting TREM2 for Parkinson’s Disease: Where to Go?
Li, X., & Zhang, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.795036 · Cited by 36 · see citing works
Self-citationValvaikar, S., Vaidya, B., Sharma, S., Bishnoi, M., Kondepudi, K. K., & Sharma, S. S. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105691 · Cited by 35 · see citing works
Gut microbiota immune cross-talk in amyotrophic lateral sclerosis
Kaul, M., Mukherjee, D., Weiner, H. L., & Cox, L. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00469 · Cited by 35 · see citing works
Mazzocchi, M., Goulding, S. R., Morales-Prieto, N., Foley, T., Collins, L. M., Sullivan, A. M., & O'Keeffe, G. W. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.02.025 · Cited by 32 · see citing works
Zhang, Y., Xu, S., Qian, Y., He, X., Mo, C., Yang, X., & Xiao, Q. (2022) · Brain Research · doi:10.1016/j.brainres.2021.147749 · Cited by 34 · see citing works
The emerging role of microbiota derived SCFAs in neurodegenerative disorders
Wachamo, S., & Gaultier, A. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101012 · Cited by 34 · see citing works
Yang, H., Li, S., & Le, W. (2022) · Aging and Disease · doi:10.14336/ad.2022.01281 · Cited by 31 · see citing works
Zamanian, M. Y., Terefe, E. M., Taheri, N., Kujawska, M., Tork, Y. J., Abdelbasset, W. K., Shoukat, S., Opulencia, M. J. C., Heidari, M., & Alesaeidi, . (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666221005122408 · Cited by 31 · see citing works
Gut microbial production of imidazole propionate drives Parkinson’s pathologies
Park, H., Cheon, J., Kim, H., Kim, J., Kim, J., Shin, J., Kim, H., Ryu, G., Chung, I. Y., Kim, J. H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63473-4 · Cited by 28 · see citing works
Ravi, A., Umapathy, S., & Pan, I. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01609-2 · Cited by 33 · see citing works
Liu, J., Chen, Q., & Su, R. (2024) · Medicine · doi:10.1097/md.0000000000037960 · Cited by 25 · see citing works
Ji, L., Huang, T., Mao, L., Xu, Y., Chen, W., Wang, W., & Wang, L. (2023) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12745 · Cited by 24 · see citing works
Xin, Z., Xin, C., Huo, J., Liu, Q., Dong, H., Li, R., & Liu, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03988-x · Cited by 25 · see citing works
Wiefels, M. D., Furar, E., Eshraghi, R. S., Mittal, J., Memis, I., Moosa, M., Mittal, R., & Eshraghi, A. A. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666221003085508 · Cited by 24 · see citing works
Causal relationship between gut microflora and dementia: a Mendelian randomization study
Fu, J., Qin, Y., Xiao, L., & Dai, X. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1306048 · Cited by 25 · see citing works
Jia, X., Chen, Q., Zhang, Y., & Asakawa, T. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1296713 · Cited by 22 · see citing works
Role of histone deacetylase inhibitors in non-neoplastic diseases
Zhou, C., Zhao, D., Wu, C., Wu, Z., Zhang, W., Chen, S., Zhao, X., & Wu, S.-L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33997 · Cited by 22 · see citing works
Zhang, W., Dong, X., & Huang, R. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106787 · Cited by 21 · see citing works
Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson’s disease model
Sancandi, M., Caro, C. D., Cypaite, N., Marascio, N., Avagliano, C., Marco, C. D., Russo, E., Constanti, A., & Mercer, A. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.986127 · Cited by 20 · see citing works
Duan, W.-X., Xie, W.-Y., Ying, C., Fen, W., Cheng, X.-Y., Mao, C.-J., Liu, J., & Liu, C.-F. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01029-5 · Cited by 21 · see citing works
Self-citationFeng, J., Hu, X., Liu, J., Wang, W., Chen, L., Pang, R., & Zhang, A. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1650807 · Cited by 19 · see citing works
Zhao, R., Mu, B., Wang, D., XinHuang, Ma, Q., & Lu, M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04584-9 · Cited by 19 · see citing works
Missiego-Beltrán, J., Olalla-Álvarez, E. M., González-Brugera, A., & Beltrán-Velasco, A. I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168998 · Cited by 18 · see citing works
Wang, Y., Chen, R., Shi, G., Huang, X., Li, K., Wang, R., Cao, X., Yang, Z., Zhao, N., & Yan, J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01511 · Cited by 18 · see citing works
Wang, B., Pan, M., Yang, L., Xu, J., Ye, C., Li, Y., Gong, Q., Liu, C., Li, L., Qin, J., et al. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01880-x · Cited by 17 · see citing works
Self-citationGuo, M., Gao, H., Wang, Y., & Xiang, Y. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1574512 · Cited by 13 · see citing works
Xu, Y., Wen, L., Tang, Y., Zhao, Z., Xu, M., Wang, T., & Chen, Z. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1194 · Cited by 13 · see citing works
Feng, M., Zou, Z., Shou, P., Peng, W., Liu, M., & Li, X. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1479343 · Cited by 14 · see citing works
Self-citationSodium Butyrate ameliorates pain and mood disorders in a mouse model of Parkinson disease
Avagliano, C., Caro, C. D., Cuozzo, M., Roberti, R., Russo, E., Rana, G. L., & Russo, R. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117903 · Cited by 13 · see citing works
Kong, X., Zhao, J. W., Gao, H., Wang, W., Wang, J., & Tan, X. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103808 · Cited by 12 · see citing works
Sanluca, C., Spagnolo, P., Mancinelli, R., Bartolo, M. I. D., Fava, M., Maccarrone, M., Carotti, S., Gaudio, E., Leuti, A., & Vivacqua, G. (2024) · Metabolites · doi:10.3390/metabo14070352 · Cited by 9 · see citing works
Nohesara, S., Abdolmaleky, H. M., Thiagalingam, S., & Zhou, J. (2023) · Epigenomics · doi:10.2217/epi-2023-0342 · Cited by 17 · see citing works
Shang, M.-Y., Ning, J.-W., Zang, C.-X., Ma, J.-W., Yang, Y., Jiang, Y.-Q., Chen, Q., Dong, Y.-R., Wang, J.-R., Li, F.-F., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.011 · Cited by 9 · see citing works
O'Mahony, A. G., Mazzocchi, M., Morris, A., Morales‐Prieto, N., Guinane, C. M., Wyatt, S. L., Collins, L., Sullivan, A. M., & O’Keeffe, G. W. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110319 · Cited by 9 · see citing works
Cui, Y., Cen, Q., Feng, J., Wei, J., Wang, L., Chang, C., Pang, R., Wang, J., & Zhang, A. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01589-8 · Cited by 9 · see citing works
Therapeutic Potential of Sodium Butyrate in Neurological and Psychiatric Disorders
Rahmani, D., Chodari, L., Kakallahpour, M., & Niknam, Z. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05428-w · Cited by 9 · see citing works
Kovács, A., Langin, L. M., González-Hernández, J. L., & Pearce, D. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-12981-0 · Cited by 10 · see citing works
Du, J., Zhang, P., Tan, Y., Gao, C., Liu, J., Huang, M., Li, H., Shen, X., Huang, P., & Chen, S. (2024) · Movement Disorders · doi:10.1002/mds.29803 · Cited by 8 · see citing works
Jahan, S., Ikram, M. A., Siraj, S., Ullah, S., Zakria, M., & Ahmad, N. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04762-3 · Cited by 8 · see citing works
Zang, Z., Yang, F., Qu, L., Ge, M., Tong, L., Xue, L., Sun, X., & Hai, Y. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1640389 · Cited by 8 · see citing works
Zhu, H., He, H., Yang, M., Zhu, H., Hagiwara, A., Shu, L., Xu, J., Miao, Y., Han, X., & Wang, C. (2025) · iScience · doi:10.1016/j.isci.2025.114044 · Cited by 8 · see citing works
Unveiling Butyrate as a Parkinson’s Disease Therapy
Abreu, A. E., Empadinhas, N., & Cardoso, S. M. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01498-x · Cited by 7 · see citing works
Deciphering the microbial map and its implications in the therapeutics of neurodegenerative disorder
Vashishth, S., Ambasta, R. K., & Kumar, P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102466 · Cited by 7 · see citing works
The role of gut-derived short-chain fatty acids in Parkinson's disease
Saadh, M. J., Mustafa, A. N., Mustafa, M. A., Renuka Jyothi, S., Dabis, H. K., Prasad, G. V. S., Mohammad, I. J., Adnan, A., & Idan, A. H. (2024) · Neurogenetics · doi:10.1007/s10048-024-00779-3 · Cited by 9 · see citing works
Alexoudi, A., Kesidou, L., Gatzonis, S. D., Charalampopoulos, C., & Tsoga, A. (2023) · Cureus · doi:10.7759/cureus.49320 · Cited by 7 · see citing works
Bellitto, D., Bozzo, M., Ravera, S., Bertola, N., Rosamilia, F., Milia, J., Barboro, P., Vargas, G. C., Lisa, D. D., Pastorino, L., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103544 · Cited by 6 · see citing works
Kovács, A., González-Hernández, J. L., & Pearce, D. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-46283-w · Cited by 6 · see citing works
Chen, Y., Wang, D., Liao, Y., Zuo, G., & Lu, X. (2024) · Discover Medicine · doi:10.1007/s44337-024-00135-2 · Cited by 5 · see citing works
Li, X., Hao, X., Chen, C., Zhai, C., Pan, T., Zhou, X., Liu, Y., Wu, D., & Chen, X. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1421270 · Cited by 7 · see citing works
Self-citationAkkermania muciniphila: a rising star in tumor immunology
Wang, L., & Tang, D. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03493-6 · Cited by 5 · see citing works
Parkinson’s disease beyond the brain: implications for treatments
Naeini, S. M., Lopez, M. D., Fraser, P. E., & Tandon, A. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1600782 · Cited by 4 · see citing works
Gut Microbes in Parkinson's Disease
Markidi, A., Elford, J. D., Berkers, C. R., Kraneveld, A. D., & Perez‐Pardo, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00002-3 · Cited by 4 · see citing works
Zhang, H., Fan, C., Li, L., Liu, F., Li, S., Ma, L., Yang, Y., Cooper, D. N., Yang, Y., Hu, R., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01027-7 · Cited by 4 · see citing works
Xin, Z., Xin, C., Huo, J., Liu, Q., Dong, H., Li, X., Liu, Y., & Li, R. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123686 · Cited by 3 · see citing works
Self-citationOnaolapo, A. Y., Ojo, F. O., Olofinnade, A. T., Falade, J., Lawal, I. A., & Onaolapo, O. J. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220903114559 · Cited by 3 · see citing works
Gong, X., Chen, Y., Chen, C., Chen, C., & Zhang, X. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107147 · Cited by 2 · see citing works
Self-citationAn, K., Qu, Y., Li, J., Wang, D., Mao, Z., & Xue, Z. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2558119 · Cited by 2 · see citing works
Roseburia intestinalis Offers Vagus-Dependent Neuroprotection Against Parkinson’s Disease
Li, M., Wu, J., Xiang, J., Yang, Z., Wang, B., Li, P., Zheng, M., Li, Y., Shao, X., & He, L. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05707-0 · Cited by 2 · see citing works
Liu, J., & Su, R. (2026) · PeerJ · doi:10.7717/peerj.20688 · Cited by 2 · see citing works
The neurobiology of fatty acids: Metabolism, signaling, and roles in neurodegenerative diseases
Rojas, R., Pellitero, A., Arslan, B., Pérez‐Samartín, A., & Matute, C. (2026) · Progress in Lipid Research · doi:10.1016/j.plipres.2026.101378 · Cited by 3 · see citing works
Gao, Y., Lu, Y., Zhao, S., Chen, R., Liu, J., Zhang, S., Bai, X., & Zhang, J. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153503 · Cited by 2 · see citing works
Maternal microbiome-derived propionate regulates offspring myelination via histone lactylation
Zhang, Y., Han, B., Wang, X., Li, Y., Zou, Y.-R., Li, S.-H., Li, X., Li, Y.-B., Huang, Y., Sun, D.-Z., et al. (2026) · Brain · doi:10.1093/brain/awag034 · Cited by 2 · see citing works
Self-citationTchung, A., Even, A., & Trudeau, L. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2026.02.003 · Cited by 2 · see citing works
Du, Y., An, Y., Cao, Z., Xu, G., Chu, M., & Lu, Y. (2026) · Food & Function · doi:10.1039/d5fo03902a · Cited by 2 · see citing works
The Role of Gut Microbiota-derived Short Chain Fatty Acids in Amyotrophic Lateral Sclerosis
Saadh, M. J., Dhiaa, S. M., Bansal, P., Dabis, H. K., Katyal, A., Saraswat, V., Ibrahim, A. A., Kadem, R. U., & Ubaid, M. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-024-00292-9 · Cited by 2 · see citing works
Emerging Relationship Between the Gut Microbiota and Neurodegenerative Disorders
Iyer, S., Verma, S., Marathe, S. A., & Tare, M. (2024) · Springer eBooks · doi:10.1007/978-981-97-4288-2_11 · Cited by 2 · see citing works
Wang, Y., Liang, D.-L., Cao, R., Ruhan, A., Zeng, J.-F., Xu, B., Li, J., Zhang, W., Gao, L., Xiao, K., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05386-3 · Cited by 1 · see citing works
Gupta, D. K., & Kumar, R. (2026) · Cureus · doi:10.7759/cureus.103206 · Cited by 1 · see citing works
Devi, S., Debnath, N., Yadav, P., Satyavolu, S., Yadav, A. K., & Tyagi, N. (2026) · Comprehensive physiology · doi:10.1002/cph4.70165 · Cited by 1 · see citing works
Tian, X., Zhang, R., Zhang, H., Liang, Y., Ma, Y., Yang, Z., & Han, F. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2685875 · Cited by 1 · see citing works
Update Review of the Relationship Between Gut Microbiota and Neurodegenerative Diseases
Wang, Y., Jing, G., Fu, Y., Li, Y., & Wu, C. (2024) · Diseases & Research · doi:10.54457/dr.202401007 · Cited by 1 · see citing works
Xin, Z., Xin, C., Huo, J., Liu, Q., Dong, H., Li, R., & Liu, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2061629/v1
Du, J., Huang, P., Zhang, P., Gao, C., Liu, J., Huang, M., Li, H., Shen, X., Tan, Y., & Chen, S. (2024) · Research Square · doi:10.21203/rs.3.rs-5182069/v1
Dairy consumption and the risk of Parkinson's disease
Hasan, R. S., & Forsan, H. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00010-5
Cai, A., Shen, D., Xiong, Q., Zhu, Y., Di, X., Yan, Y., Chen, Z., Yao, Q., Chen, R., Lin, G., et al. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01024-w
Chen, Y., Wei, X., Yi, X., & Jiang, D. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.01.020
Jia, W., Zheng, X., Kuang, J., Zhao, M., & Zhang, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-31402-5.00009-8
Zheng, W., Xu, Q., Ren, M., Wang, Z., Wang, M., Gao, Y., Zhang, J., Zhang, M., & Chen, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116814
Self-citationKhodve, G., Raval, S., & Banerjee, S. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.05.015
- Authors
- Hou, Y., Li, X., Liu, C., Zhang, M., Zhang, X., Ge, S., & Zhao, L.
- Affiliations
- Beijing Advanced Innovation Center for Food Nutrition and Human Health (CN)
- China Agricultural University (CN)
- Beijing Technology and Business University (CN)
- Corresponding author
- Zhao, Liang
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 150
- Pages
- 111376
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W3159598422
- Cited by
- 101
- References
- 63
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 28 · 2023: 15 · 2022: 13 · 2021: 5
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (32072196)
- Beijing Science and Technology Planning Project (Z181100009318005)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- short-chain fatty acids, Parkinson's disease, MPTP-induced neurotoxicity, sodium butyrate, sodium acetate, sodium propionate, neuroprotection, dopaminergic neuron loss, substantia nigra pars compacta, neuroinflammation, microglial activation, alpha-synuclein, tyrosine hydroxylase, NF-κB signaling, MAPK signaling, gut microbiota metabolites, motor impairment
- MeSH terms
- Animals, Disease Models, Animal, Fatty Acids, Volatile, Mice, Inbred C57BL, Parkinson Disease, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neuroprotective Agents, MPTP Poisoning, Mice, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
