Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage
Open accessAbstract
Alpha-synuclein (aSyn) is considered a major culprit in Parkinson's disease (PD) pathophysiology. However, the precise molecular function of the protein remains elusive. Recent evidence suggests that aSyn may play a role on transcription regulation, possibly by modulating the acetylation status of histones. Our study aimed at evaluating the impact of wild-type (WT) and mutant A30P aSyn on gene expression, in a dopaminergic neuronal cell model, and decipher potential mechanisms underlying aSyn-mediated transcriptional deregulation. We performed gene expression analysis using RNA-sequencing in Lund Human Mesencephalic (LUHMES) cells expressing endogenous (control) or increased levels of WT or A30P aSyn. Compared to control cells, cells expressing both aSyn variants exhibited robust changes in the expression of several genes, including downregulation of major genes involved in DNA repair. WT aSyn, unlike A30P aSyn, promoted DNA damage and increased levels of phosphorylated p53. In dopaminergic neuronal cells, increased aSyn expression led to reduced levels of acetylated histone 3. Importantly, treatment with sodium butyrate, a histone deacetylase inhibitor (HDACi), rescued WT aSyn-induced DNA damage, possibly via upregulation of genes involved in DNA repair. Overall, our findings provide novel and compelling insight into the mechanisms associated with aSyn neurotoxicity in dopaminergic cells, which could be ameliorated with an HDACi. Future studies will be crucial to further validate these findings and to define novel possible targets for intervention in PD.
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FMT from healthy donors and butyrate administration in animal models of PD improves motor impairment and dopamine deficiency.
“Supporting this hypothesis, growing evidence has shown that FMT from healthy donors (171) as well as butyrate administration in animal models of PD improves motor impairment and dopamine deficiency (172–175).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [173]
The Discussion (p. 12) reports that sodium butyrate reduced DNA damage in dopaminergic cells, and the results (p. 6) report protection in another cell-based PD model. This supports a protective effect of butyrate, but not the attributed improvement in motor impairment or dopamine deficiency in animal models. FMT is attached to a different citation and is not assessed here. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSodium butyrate exerts anti-apoptotic, anti-inflammatory, and neuroprotective effects on mice with Parkinson's disease.
“Notably, NaB exerts anti-apoptotic, anti-inflammatory, and neuroprotective effects on mice with PD [36,37,38]”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [37]
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- Authors
- Paiva, I., Pinho, R., Pavlou, M. A., Hennion, M., Wales, P., Schütz, A.-L., Rajput, A., Szegő, É. M., Kerimoglu, C., Gerhardt, E., Rego, A. C., Fischer, A., Bonn, S., & Outeiro, T. F.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Universidade do Porto (PT)
- Centro de Neurociências e Biologia Celular (PT)
- German Center for Neurodegenerative Diseases (DE)
- Corresponding author
- Outeiro, Tiago F.
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-24
- Volume
- 26
- Issue
- 12
- Pages
- 2231-2246
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2599614419
- Cited by
- 185
- References
- 61
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 27 · 2023: 16 · 2022: 35 · 2021: 29 · 2020: 17 · 2019: 13 · 2018: 10 · 2017: 2
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- DZNE Pub (submittedVersion)
- GRO (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Deutsche Forschungsgemeinschaft (01KU1503B)
- Bundesministerium für Bildung und Forschung (01KU1503B)
- Fundação para a Ciência e a Tecnologia (SFRH/BD/80884/2011)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- alpha-synuclein, Parkinson's disease, sodium butyrate, histone deacetylase inhibitors, dopaminergic neurons, transcriptional dysregulation, DNA damage, DNA repair genes, p53 phosphorylation, histone H3 acetylation, neurotoxicity, LUHMES cells
- MeSH terms
- DNA Damage, Gene Expression Regulation, Humans, Parkinson Disease, Gene Expression, Cell Culture Techniques, Butyric Acid, alpha-Synuclein, Dopaminergic Neurons
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