Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice
Open accessAbstract
ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis , Lactobacillus casei , Bifidobacterium bifidum , and Lactobacillus acidophilus . This study aims to investigate the effects of ProBiotic-4 on the microbiota–gut–brain axis and cognitive deficits , and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBiotic-4 significantly improved the memory deficits , cerebral neuronal and synaptic injuries , glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice. ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood–brain barrier, decreased interleukin-6 and tumor necrosis factor- α at both mRNA and protein levels, reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor- κ B (NF- κ B) nuclear translocation in the brain. In addition, not only did ProBiotic-4 significantly decreased the levels of γ -H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I), it also abrogated RIG-I multimerization in the brain. These findings suggest that targeting gut microbiota with probiotics may have a therapeutic potential for the deficits of the microbiota–gut–brain axis and cognitive function in aging, and that its mechanism is associated with inhibition of both TLR4-and RIG-I-mediated NF- κ B signaling pathway and inflammatory responses.
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Probiotic-4 attenuates aging-related disruptions in the integrity of the blood-brain barrier and the intestinal barrier, in plasma and brain LPS levels, and in IL-6, TNF-α, TLR4, and NF-κB translocation in the brains of aged mice.
“Probiotic-4 (which contains Lactobacillus, Bifidobacterium, Typhimurium, and Eosinophilus) has been shown to attenuate aging-related disruptions in the integrity of the blood–brain barrier and the intestinal barrier; in plasma and brain LPS levels; and in IL-6, TNF-α, TLR4, and NF-κB translocation in the brains of aged mice (104).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [104]
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“It is well known that communication between the gut microbiota and the CNS occurs primarily through microbial-derived intermediates, most commonly SCFAs, secondary bile acids (2BAs), and tryptophan metabolites, which are also commonly detected as “signals” [84].”
BackgroundJiang, Z., Li, M., McClements, D. J., Liu, X., & Liu, F. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.107438 · Cited by 95 · see citing works
The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging
Untersmayr, E., Brandt, A., Koidl, L., & Bergheim, I. (2022) · Nutrients · doi:10.3390/nu14050949 · Cited by 99 · see citing works
“, Akkermansia muciniphila, in mice with cognitive deficits has been found to protect the intestinal barrier and improve cognitive functions [164,173].”
BackgroundResultThe 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience
Wrona, M. V., Ghosh, R. B., Coll, K., Chun, C., & Yousefzadeh, M. J. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1490302 · Cited by 102 · see citing works
“Lastly, age-related changes in genes related to leukocyte activation reduce the ability to recognize new pathogens, impacting responses to vaccination and increasing infection risks in the old (Yang et al., 2020a).”
BackgroundThe gut microbiome and Alzheimer’s disease: Complex and bidirectional interactions
Tarawneh, R. M., & Penhos, E. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104814 · Cited by 88 · see citing works
Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease
Wu, L., Xian, X., Xu, G., Tan, Z., Dong, F., Zhang, M., & Zhang, F. (2022) · Mediators of Inflammation · doi:10.1155/2022/7924199 · Cited by 85 · see citing works
“ProBiotic-4 9-month-old senescence-accelerated mouse prone 8 (SAMP8) mice 2 × 109 CFU once daily for 12 weeks (a) Reducing IL-6 and TNF-α levels, plasma, and brain LPS concentrations, TLR4 expression and NF-kB nuclear translocation in the brain, resulting in improved cognitive dysfunction in aged mice [153]”
BackgroundMethodEarly life adversity as a risk factor for cognitive impairment and Alzheimer’s disease
Huang, Z., Jordan, J. D., & Zhang, Q. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00355-z · Cited by 92 · see citing works
Psychobiotics, gut microbiota and fermented foods can help preserving mental health
Casertano, M., Fogliano, V., & Ercolini, D. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110892 · Cited by 89 · see citing works
The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline
Shah, Z., & Alsegiani, A. S. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335837 · Cited by 83 · see citing works
“In addition, a probiotic mixture has also shown an improvement in aged mice memory and reduction in glial activation, and modified microbiota composition in the feces and the brain (Ho et al., 2019; Yang et al., 2020).”
BackgroundXiao-hang, Q., Si-yue, C., & Tang, H. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.031 · Cited by 86 · see citing works
Holmes, A., Finger, C. E., Morales‐Scheihing, D., Lee, J., & McCullough, L. D. (2020) · Translational research · doi:10.1016/j.trsl.2020.07.012 · Cited by 87 · see citing works
The Gut Microbiome as a Regulator of the Neuroimmune Landscape
Yu, L. W., Agirman, G., & Hsiao, E. Y. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-014237 · Cited by 75 · see citing works
Pan, L., Yu, H., Fu, J., Hu, J., Xu, H. X., Zhang, Z., Bu, M.-M., Yang, X., Zhang, H., Lu, J., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.010 · Cited by 81 · see citing works
Self-citationFaraji, N., Payami, B., Ebadpour, N., & Gorji, A. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105990 · Cited by 86 · see citing works
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Self-citationChronic periodontitis induces microbiota-gut-brain axis disorders and cognitive impairment in mice
Li, X., Zou, X., Yang, X., Peng, F., Yu, D., & Du, J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113176 · Cited by 79 · see citing works
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Alterations in the gut microbiota and metabolite profiles in the context of neuropathic pain
Chen, P., Wang, C., Ren, Y.-N., Ye, Z., Jiang, C. Q., & Wu, Z. (2021) · Molecular Brain · doi:10.1186/s13041-021-00765-y · Cited by 76 · see citing works
Li, S., Yang, S., Zhou, Y., Disoma, C., Dong, Z., Du, A., Zhang, Y., Chen, Y., Huang, W., Chen, J., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.712081 · Cited by 77 · see citing works
“While there are reports about changes in microbial community during the disease presence (Zuo et al., 2020a,b; Chen et al., 2021; Yeoh et al., 2021), a consensus about the clinical relevance of these findings is still difficult to achieve.”
BackgroundSelenium at the Neural Barriers: AReview
Solovyev, N. D., Drobyshev, E. J., Blume, B., & Michalke, B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.630016 · Cited by 74 · see citing works
“The effect of the gut microbiota on the host’s health is related to the production of biologically active compounds per se, competing with the host for essential nutrients, and affecting the host’s immune system (de Vos and de Vos, 2012; Caracciolo et al., 2014; O’Mahony et al., 2015; Yang et al., 2020) and epigenome…”
BackgroundPentón-Rol, G., Marín-Prida, J., & McCarty, M. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210408123807 · Cited by 73 · see citing works
“Formulations with Lactobacillus species, which have been extensively studied for promotion of healthy dietary supplementations, and received the GRAS (generally regarded as safe) certification, have also shown promising beneficial actions in several models of AD, such as 3xTgAD [165], APP/PS1 [166] and aged SAMP8 mice…”
Lee, C., Liao, Y.-C., Lee, M., Lin, K., Hsu, H., Chiou, S., Young, S.-L., Lin, J., Huang, C., & Watanabe, K. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.708096 · Cited by 76 · see citing works
Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator
Salazar, J., Durán, P., Díaz, M. P., Chacín, M., Santeliz, R., Mengual, E., Gutiérrez, E., León, X., Díaz, A., Bernal, M., et al. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20105845 · Cited by 71 · see citing works
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Xiao, Y., Feng, Y., Zhao, J., Chen, W., & Lu, W. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.005 · Cited by 75 · see citing works
Lei, W., Cheng, Y., Liu, X., Gao, J., Zhu, Z., Ding, W., Xu, X., Li, Y., Ling, Z., Jiang, R., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582119 · Cited by 68 · see citing works
Billeci, L., Callara, A. L., Guiducci, L., Prosperi, M., Morales, M. A., Calderoni, S., Muratori, F., & Santocchi, E. (2023) · Autism · doi:10.1177/13623613221082710 · Cited by 69 · see citing works
“Therefore, we can hypothesize a central neuroprotective effect of the probiotics through this pathway, as suggested by animal models (Yang et al., 2020).”
BackgroundLiang, Y., Liu, C., Cheng, M., Geng, L., Li, J., Du, W., Song, M., Chen, N., Yeleen, T. A. N., Li, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14057 · Cited by 70 · see citing works
“108 111 Kauretal.usedaprobioticpreparationcalledVSL#3totreat6-month-old APP NL-G-F mice for 8 weeks.”
Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67 · see citing works
Qiao, L., Chen, Y., Song, X., Dou, X., & Xu, C. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s374024 · Cited by 66 · see citing works
“Accumulating evidence suggested that AD histological and behavioral manifestations are correlated with gut microbiota dysbiosis.(7) In addition, evidence shows that gut barrier”
BackgroundInfluentialLiu, Q. F., Xie, T., Xi, Y., Li, L., Mo, F., Liu, X., Liu, Z., Gao, J., & Yuan, T. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04687 · Cited by 65 · see citing works
Role of Probiotics, Prebiotics, and Synbiotics in the Elderly: Insights Into Their Applications
Ale, E. C., & Binetti, A. G. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.631254 · Cited by 64 · see citing works
Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease
Sun, P., Su, L., Zhu, H., Li, X., Guo, Y., Du, X., Zhang, L., & Qin, C. (2021) · Microorganisms · doi:10.3390/microorganisms9112281 · Cited by 66 · see citing works
“It functions to significantly inhibit Proteobacteria (phylum), Pseudomonas (genus) and the Lachnospiraceae_NK4A136_group (genus); meanwhile, it significantly reduces the ratio of Firmicutes to Bacteroidetes and improves the cognitive function of aged SAMP8 mice through the inhibition of the NF-κB signaling pathway and…”
BackgroundMechanisms underlying delirium in patients with critical illness
Fan, Y.-Y., Luo, R.-Y., Wang, M., Yuan, C.-Y., Sun, Y., & Jing, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1446523 · Cited by 69 · see citing works
Wang, Y., Tan, Q., Pan, M., Yu, J., Wu, S., Tu, W., Li, M., & Jiang, S. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112030 · Cited by 63 · see citing works
Wang, L., Sui, L., Fan, H., Han, M., Xie, J., Du, J., & Peng, F. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.986837 · Cited by 61 · see citing works
“Real-time-polymerase chain reaction was conducted according to previous research and data was processed by 2−ΔΔCT method (Yang et al., 2020).”
MethodInfluentialSelf-citationLiu, X., Su, S., Yao, J., Zhang, X., Wu, Z., Jia, L., Liu, L., Hou, R., Farag, M. A., & Liu, L. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103831 · Cited by 64 · see citing works
Biofilm-based delivery approaches and specific enrichment strategies of probiotics in the human gut
Gao, J., Sadiq, F. A., Zheng, Y., Zhao, J., He, G., & Sang, Y. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2126274 · Cited by 60 · see citing works
Zhang, W., Guo, Y., Cheng, Y., Yao, W., & Qian, H. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.160 · Cited by 60 · see citing works
Krishaa, L., Ng, T. K. S., Wee, H. N., & Ching, J. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111787 · Cited by 60 · see citing works
Liu, S., Gao, J., Liu, K., & Zhang, H. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111560 · Cited by 58 · see citing works
Wang, Y., Du, W., Hu, X., Yu, X., Guo, C., Jin, X., & Wang, W. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.009 · Cited by 56 · see citing works
“In addition, treatment of aged senescence-accelerated mice P8 (SAMP8) mice with ProBiotic-4, a probiotic preparation composed of Bifido-bacterium lactis , Lactobacillus casei , B. bifidum , and Lactobacillus acidophilus , significantly decreased Firmicutes / Bacteroidetes (F:B) ratio, Proteobacteria, Pseudomonas (genus),…”
BackgroundLu, L., Li, F., Gao, Y., Kang, S., Li, J., & Guo, J. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00873-0 · Cited by 59 · see citing works
“Interestingly, Xueqin and colleagues [199] demonstrated that the probiotic combination ProBiotic-4 alleviates cognitive deficits in geriatric Senescence Accelerated Mouse-Prone 8 (SAMP8) mice by modulating the microbiota-gut-brain axis, suggesting that studying the gut microbiota may be beneficial…”
BackgroundAyed, L., M’hir, S., Nuzzolese, D., Cagno, R. D., & Filannino, P. (2024) · Foods · doi:10.3390/foods13101538 · Cited by 55 · see citing works
The Roles of the Gut Microbiota and Chronic Low-Grade Inflammation in Older Adults With Frailty
Xu, Y., Liu, X., Liu, X., Chen, D., Wang, M., Jiang, X., & Xiong, Z. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.675414 · Cited by 57 · see citing works
“Moreover, probiotics supplementation may delay the onset of aging-related cognitive deficits (Yang et al., 2020).”
BackgroundAlterations in gut microbiota are related to metabolite profiles in spinal cord injury
Jiang, J.-H., Ning, B., Kang, J.-N., Sun, Z.-F., Li, X., Zhang, X., Jin, Z., Zhang, C., Zhang, Y., Wang, H., et al. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355769 · Cited by 54 · see citing works
“In previous studies, an increased F/B ratio has been associated with several neurological disorders, such as neuropathic pain, cognitive impairment, and stroke (Park et al., 2020; Yang et al., 2020).”
BackgroundMao, J., Zhan, H., Meng, F., Wang, G., Huang, D. Y., Liao, Z., & Chen, M. (2022) · Phytotherapy Research · doi:10.1002/ptr.7383 · Cited by 51 · see citing works
Effects of gut microbiota on neurodegenerative diseases
Khatoon, S., Kalam, N., Rashid, S., & Bano, G. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1145241 · Cited by 51 · see citing works
Microbiome-based therapeutics towards healthier aging and longevity
Kadyan, S., Park, G., Singh, T. P., Patoine, C., Singar, S., Heise, T., Domeier, C., Ray, C. A., Kumar, M., Behare, P. V., et al. (2025) · Genome Medicine · doi:10.1186/s13073-025-01493-x · Cited by 55 · see citing works
Mechanistic new insights of flavonols on neurodegenerative diseases
Tahir, M. S., Almezgagi, M., Zhang, Y., Bashir, A., Abdullah, H. M., Gamah, M., Wang, X., Zhu, Q., Shen, X., Ma, Q., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111253 · Cited by 51 · see citing works
Zhong, S.-R., Kuang, Q., Zhang, F., Chen, B., & Zhong, Z.-G. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2020-0206 · Cited by 51 · see citing works
“demonstrated that probiotic-4 (Bifidobacterium lactis, Lactobacillus acidophilus, Bifidobacterium bifidum, and Lactobacillus casei) attenuated aging-related disruption of IEB and BBB, reduced LPS in plasma and cerebral, characterized by inhibition of the NF-κB inflammatory signaling pathway [98].”
BackgroundHutchinson, A. N., Bergh, C., Krüger, K., Sűsserová, M., Allen, J., Améen, S., & Tingö, L. (2021) · Microorganisms · doi:10.3390/microorganisms9061344 · Cited by 54 · see citing works
Fan, T., Du, Y., Zhang, M., Zhu, A. R., & Zhang, J. (2022) · Gerontology · doi:10.1159/000522656 · Cited by 49 · see citing works
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO
Tu, R., & Xia, J. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230203140805 · Cited by 47 · see citing works
Li, T., Yang, S., Liu, X., Li, Y., Gu, Z., & Jiang, Z. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.04.014 · Cited by 47 · see citing works
Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions
Shen, W., He, J., Hou, T., Si, J., & Chen, S. (2022) · Aging and Disease · doi:10.14336/ad.2021.1208 · Cited by 45 · see citing works
Lista, S., Munafò, A., Caraci, F., Imbimbo, C., Emanuele, E., Minoretti, P., Pinto-Fraga, J., Merino-País, M., Crespo‐Escobar, P., López‐Ortiz, S., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102659 · Cited by 48 · see citing works
Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics
Xu, H., Pan, L., Yu, H., Han, P., Fu, J., Zhang, Z., Hu, J.-C., Yang, X., Keranmu, A., Zhang, H.-J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.919181 · Cited by 45 · see citing works
Self-citationSoriano, S., Curry, K. D., Wang, Q., Chow, E., Treangen, T. J., & Villapol, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094476 · Cited by 44 · see citing works
Hashim, H. M., & Makpol, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1007166 · Cited by 46 · see citing works
“The involvement of segmented filamentous bacteria (SFB) such as Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria phyla in the gut has been linked to the induction of Th17-mediated autoimmune disorders (Yi et al., 2010; Lee et al., 2011).”
BackgroundResearch progress on perioperative blood-brain barrier damage and its potential mechanism
Qiu, Y., Mo, C., Xu, S., Chen, L., Ye, W., Kang, Y., Chen, G., & Zhu, T. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1174043 · Cited by 44 · see citing works
Yadav, H., Jaldhi, Bhardwaj, R., Anamika, A., Bakshi, A., Gupta, S., & Maurya, S. K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122022 · Cited by 46 · see citing works
Zhou, H., Zhao, J., Liu, C., Zhang, Z., Zhang, Y., & Meng, D. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153937 · Cited by 44 · see citing works
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored
Kapoor, B., Biswas, P., Gulati, M., Rani, P., & Gupta, R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102570 · Cited by 46 · see citing works
The Role of Gut Microbiota—Gut—Brain Axis in Perioperative Neurocognitive Dysfunction
Lu, J. G., Hou, W., Gao, S., Zhang, Y., & Zong, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.879745 · Cited by 43 · see citing works
Sun, W., Zhu, J., Qin, G., Huang, Y., Cheng, S., Chen, Z., Zhang, Y., Shu, Y., Zeng, X., & Guo, R. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125517 · Cited by 43 · see citing works
Qu, L., Li, Y., Liu, F., Fang, Y., He, J., Ma, J., Xu, T., Wang, L., Lei, P., Dong, H., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0823-2 · Cited by 46 · see citing works
“Furthermore, the study revealed a decrease in NF-κB translocation, toll-like receptor 4 (TLR4) expression, as well as a reduction in decreased plasma and brain LPS concentration[113].”
BackgroundWang, S.-S., Li, X., Liu, P., Li, J., & Liu, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.972982 · Cited by 42 · see citing works
“…of the flora in intestine and brain, reduce the destruction of intestinal barrier and blood-brain barrier, and reduce the level of lipopolysaccharide in plasma and brain, reduce the level of inflammatory factors in the brain and intestine at the level of messenger RNA (Yang et al., 2020).”
BackgroundLactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review
Mutalib, N. A., Mohamad, S. A. S., Jusril, N. A., Hasbullah, N. I., Amin, M. C. I. M., & Ismail, N. H. (2023) · Pharmaceuticals · doi:10.3390/ph16050712 · Cited by 41 · see citing works
“Its mechanism of action is associated with the inhibition of both TLR4- and RIG-I-mediated NFkB signaling pathways as well as inflammatory responses [55].”
BackgroundZhang, S., Lv, S., Li, Y., Wei, D., Zhou, X., Niu, X., Yang, Z., Song, W., Zhang, Z., & Peng, D. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03208-7 · Cited by 41 · see citing works
“One study demonstrated that ProBiotic-4 alleviated the disruption of the intestinal barrier and blood–brain barrier and decreased the levels of TLR4, NF-κB and IL-6 in the brain [16].”
BackgroundImpact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review
Diwan, M. A., Lahimer, M., Bach, V., Gosselet, F., Khorsi‐Cauet, H., & Candela, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076147 · Cited by 40 · see citing works
“In fact, recent research has shown that GM disorders (dysbiosis and/or bacterial translocation) are often associated with a leaky IB and BBB disruption accompanied with inflammation [101,102].”
BackgroundJiang, J. H., Liu, H., Wang, Z., Tian, H., Wang, S., Yang, J., & Ren, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259530 · Cited by 39 · see citing works
“The new research found that: the molecular model of Lactobacillus Enterobacter can effectively inhibit the pathogenic infiltration of peripheral immune cells into the central nervous system [55], thus reducing neuroinflammation [56]; After supplementation with Lactobacillus and Bifidobacterium, the cognitive function…”
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works
Zhang, Z., Deng, S., Chen, C., He, Q., Peng, X., Liang, Q., Zhuang, G., Wang, S., & Tang, D. (2023) · Phytotherapy Research · doi:10.1002/ptr.7827 · Cited by 38 · see citing works
“To explore whether there are intestinal inflammation and neuroinflammation in DCI mice, and the intervention mechanism of pterostilbene, we conducted a series of studies based on the MGBA.”
BackgroundInfluential
- Authors
- Yang, X., Yu, D., Xue, L., Li, H., & Du, J.
- Affiliations
- Sichuan University (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Corresponding author
- Du, Junrong
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 10
- Issue
- 3
- Pages
- 475-487
- ISSN
- 2211-3835 (ISSN-L)
- PMC
- PMC7049608
- OpenAlex
- W2954864461
- Cited by
- 407
- References
- 54
- Citations by year
- 2026: 45 · 2025: 82 · 2024: 91 · 2023: 69 · 2022: 65 · 2021: 41 · 2020: 14
- FWCI
- 23.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81473219, 81973307)
- Sichuan Province Youth Science and Technology Innovation Team (2016TD0001)
- Higher Education Discipline Innovation Project
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- probiotics, microbiota-gut-brain axis, memory impairment, aging, SAMP8 mice, Bifidobacterium animalis subsp. lactis, Lactobacillus casei, Lactobacillus acidophilus, Bifidobacterium bifidum, neuroinflammation, blood-brain barrier, intestinal barrier, lipopolysaccharide, TLR4, NF-κB signaling, RIG-I, oxidative stress, cognitive function
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