Cited by 897Cancer, Hypoxia, and MetabolismCancer Cells and MetastasisMechanisms of cancer metastasis

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

Cardone, Rosa A., Casavola, Valeria, Reshkin, Stephan J.·2005·Nature Reviews Cancer

Abstract

Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?

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Crossref · 10.1038/nrc1713

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Authors
Cardone, R. A., Casavola, V., & Reshkin, S. J.
Affiliations
University of Bari Aldo Moro (IT)
Corresponding author
Reshkin, Stephan J.
Venue
Nature Reviews Cancer
Published
2005-09-20
Volume
5
Issue
10
Pages
786-795
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2060315853
Cited by
897
References
77
Citations by year
2026: 25 · 2025: 23 · 2024: 38 · 2023: 44 · 2022: 33 · 2021: 48 · 2020: 67 · 2019: 44 · 2018: 43 · 2017: 71 · 2016: 62 · 2015: 46 · 2014: 58 · 2013: 63 · 2012: 52
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Funders
  • Ministero dell’Istruzione, dell’Università e della Ricerca
  • Consiglio Nazionale delle Ricerche
  • Centre National de la Recherche Scientifique
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords
tumour metastasis, extracellular pH, invadopodia, tumor invasion, tumor cell migration, tumor microenvironment, tumor progression
MeSH terms
Sodium-Hydrogen Exchanger 1, Animals, Humans, Hydrogen-Ion Concentration, Membrane Proteins, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Signal Transduction, Sodium-Hydrogen Exchangers, Cation Transport Proteins, Mice

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