Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
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Dissipating excess calories as heat through therapeutic stimulation of brown adipose tissues (BAT) has been proposed as a potential treatment for obesity-linked disorders. Here, we describe the generation of a humanized effector-less bispecific antibody that activates fibroblast growth factor receptor (FGFR) 1/βKlotho complex, a common receptor for FGF21 and FGF19. Using this molecule, we show that antibody-mediated activation of FGFR1/βKlotho complex in mice induces sustained energy expenditure in BAT, browning of white adipose tissue, weight loss, and improvements in obesity-associated metabolic derangements including insulin resistance, hyperglycemia, dyslipidemia and hepatosteatosis. In mice and cynomolgus monkeys, FGFR1/βKlotho activation increased serum high-molecular-weight adiponectin, which appears to contribute over time by enhancing the amplitude of the metabolic benefits. At the same time, insulin sensitization by FGFR1/βKlotho activation occurs even before the onset of weight loss in a manner that is independent of adiponectin. Together, selective activation of FGFR1/βKlotho complex with a long acting therapeutic antibody represents an attractive approach for the treatment of type 2 diabetes and other obesity-linked disorders through enhanced energy expenditure, insulin sensitization and induction of high-molecular-weight adiponectin.
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Both FGF21 and a bispecific activating antibody for the FGFR1-β-klotho receptor complex retain their acute insulin-sensitizing effects in adiponectin knockout mice.
“Moreover, in contrast to previous studies, both FGF21 (11) and a bispecific activating antibody for the FGFR1–β-klotho receptor complex (70) were found to efficiently retain their acute insulin-sensitizing effects in adiponectin knockout mice (Figure 4).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [70]
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Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60460-8 · Cited by 11,952 · see citing works
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Unexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works
Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works
Self-citationEctopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
Shulman, G. I. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1011035 · Cited by 1,126 · see citing works
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038 · see citing works
Fibroblast Growth Factor 21 Corrects Obesity in Mice
Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works
Self-citationActivation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,024 · see citing works
Recruited brown adipose tissue as an antiobesity agent in humans
Yoneshiro, T., Aita, S., Matsushita, M., Kayahara, T., Kameya, T., Kawai, Y., Iwanaga, T., & Saito, M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67803 · Cited by 957 · see citing works
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872 · see citing works
Therapeutic antibodies for autoimmunity and inflammation
Chan, A. C., & Carter, P. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2761 · Cited by 840 · see citing works
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
Yu, Y. J., Zhang, Y., Kenrick, M., Hoyte, K., Luk, W., Lu, Y., Atwal, J., Elliott, J. M., Prabhu, S., Watts, R. J., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002230 · Cited by 794 · see citing works
Self-citationKurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748 · see citing works
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738 · see citing works
Self-citationFon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700 · see citing works
Lin, Z., Tian, H., Lam, K. S. L., Lin, S., Hoo, R. C. L., Konishi, M., Itoh, N., Wang, Y., Bornstein, S. R., Xu, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.005 · Cited by 691 · see citing works
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
Sidossis, L. S., & Kajimura, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78362 · Cited by 689 · see citing works
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
Day, J. W., Ottaway, N., Patterson, J. T., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.209 · Cited by 641 · see citing works
Fu, L., John, L. M., Adams, S. H., Yu, X. X., Tomlinson, E., Renz, M. E., Williams, P. M., Soriano, R. H., Corpuz, R. T., Moffat, B., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1671 · Cited by 580 · see citing works
Self-citationTomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., et al. (2002) · Endocrinology · doi:10.1210/endo.143.5.8850 · Cited by 576 · see citing works
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545 · see citing works
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
Holland, W., Adams, A., Brozinick, J., Bui, H., Miyauchi, Y., Kusminski, C., Bauer, S., Wade, M., Singhal, E., Cheng, C. C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.019 · Cited by 525 · see citing works
FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A., & Mangelsdorf, D. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.012 · Cited by 523 · see citing works
Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426 · see citing works
Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21
Inagaki, T., Lin, V. Y., Goetz, R., Mohammadi, M., Mangelsdorf, D. J., & Kliewer, S. A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.006 · Cited by 409 · see citing works
βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.002 · Cited by 403 · see citing works
Considerations in the Design of Hyperinsulinemic-Euglycemic Clamps in the Conscious Mouse
Ayala, J. E., Bracy, D. P., McGuinness, O. P., & Wasserman, D. H. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0686 · Cited by 399 · see citing works
Self-citationThe fasting polypeptide FGF21 can enter brain from blood
Hsuchou, H., Pan, W., & Kastin, A. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.10.007 · Cited by 280 · see citing works
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
Adams, A. C., Yang, C., Coskun, T., Cheng, C. C., Gimeno, R. E., Luo, Y., & Kharitonenkov, A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2012.08.007 · Cited by 266 · see citing works
Adiponectin, driver or passenger on the road to insulin sensitivity?
Ye, R., & Scherer, P. E. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.04.001 · Cited by 251 · see citing works
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Dong, M., Yang, X., Lim, S., Cao, Z., Honek, J., Lu, H., Zhang, C., Seki, T., Hosaka, K., Wahlberg, E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.003 · Cited by 237 · see citing works
Self-citationFGF21 contributes to neuroendocrine control of female reproduction
Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A., & Mangelsdorf, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3250 · Cited by 230 · see citing works
Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models
French, D., Lin, B. C., Wang, M.-T., Adams, C. W., Shek, T., Hötzel, K., Bolon, B., Ferrando, R., Blackmore, C., Schroeder, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036713 · Cited by 216 · see citing works
White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma
Frontini, A., Vitali, A., Perugini, J., Murano, I., Romiti, C., Ricquier, D., Guerrieri, M., & Cinti, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.005 · Cited by 211 · see citing works
Foltz, I. N., Hu, S., King, C., Wu, X., Yang, C., Wang, W., Weiszmann, J., Stevens, J., Chen, J. S., Nuanmanee, N., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004690 · Cited by 211 · see citing works
Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue
Véniant, M. M., Sivits, G., Helmering, J., Komorowski, R., Lee, J., Fan, W., Moyer, C., & Lloyd, D. J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.019 · Cited by 204 · see citing works
Spiess, C., Merchant, M. A., Huang, A. J. Y., Zheng, Z., Yang, N.-Y., Peng, J., Ellerman, D. A., Shatz-Binder, W., Reilly, D. E., Yansura, D. G., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2621 · Cited by 197 · see citing works
Self-citationWu, A.-L., Coulter, S., Liddle, C., Wong, A., Eastham‐Anderson, J., French, D. M., Peterson, A. S., & Sonoda, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017868 · Cited by 185 · see citing works
Self-citationWu, A.-L., Kolumam, G., Stawicki, S., Chen, Y., Li, J., Zavala-Solorio, J., Phamluong, K., Feng, B., Li, L., Marsters, S., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002669 · Cited by 184 · see citing works
Self-citationDiscrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
Samms, R. J., Smith, D. P., Cheng, C. C., Antonellis, P. P., Perfield, J. W., Kharitonenkov, A., Gimeno, R. E., & Adams, A. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.046 · Cited by 154 · see citing works
FGF21 N‐ and C‐termini play different roles in receptor interaction and activation
Yie, J., Hecht, R., Patel, J., Stevens, J., Wang, W., Hawkins, N., Steavenson, S., Smith, S., Winters, D., Fisher, S., et al. (2009) · FEBS Letters · doi:10.1016/j.febslet.2008.11.023 · Cited by 149 · see citing works
Different roles of N‐ and C‐ termini in the functional activity of FGF21
Micanovic, R., Raches, D. W., Dunbar, J. D., Driver, D. A., Bina, H. A., Dickinson, C. D., & Kharitonenkov, A. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21675 · Cited by 146 · see citing works
Toxicity of Weight Loss Agents
Yen, M., & Ewald, M. B. (2012) · Journal of Medical Toxicology · doi:10.1007/s13181-012-0213-7 · Cited by 132 · see citing works
Osteocyte-Specific Deletion of Fgfr1 Suppresses FGF23
Xiao, Z., Huang, J., Cao, L., Liang, Y., Han, X., & Quarles, L. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104154 · Cited by 113 · see citing works
Yie, J., Wang, W., Deng, L., Tam, L., Stevens, J., Chen, M. M., Li, Y., Xu, J., Lindberg, R., Hecht, R., et al. (2012) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2012.01325.x · Cited by 99 · see citing works
Self-citationSun, H. D., Malabunga, M., Tonra, J. R., DiRenzo, R., Carrick, F. E., Zheng, H., Berthoud, H., McGuinness, O. P., Shen, J., Böhlen, P., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00089.2006 · Cited by 95 · see citing works
Self-citationShatz-Binder, W., Chung, S., Li, B., Marshall, B., Tejada, M. L., Phung, W., Sandoval, W. N., Kelley, R. F., & Scheer, J. M. (2013) · mAbs · doi:10.4161/mabs.26307 · Cited by 88 · see citing works
Pai, R., French, D. M., Ma, N., Hötzel, K., Plise, E. G., Salphati, L., Setchell, K. D. R., Ware, J. A., Lauriault, V., Schutt, L., et al. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs011 · Cited by 76 · see citing works
Yanochko, G. M., Vitsky, A., Heyen, J. R. R., Hirakawa, B. P., Lam, J. L., May, J. R., Nichols, T., Sace, F., Trajkovic, D., & Blasi, E. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft161 · Cited by 75 · see citing works
Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia
Wu, A.-L., Feng, B., Chen, M. Z., Kolumam, G. A., Zavala‐Solorio, J., Wyatt, S. K., Gandham, V. D., Carano, R. A. D., & Sonoda, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057322 · Cited by 67 · see citing works
Self-citationFGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein
Smith, R. J., Duguay, A. N., Bakker, A., Li, P., Weiszmann, J., Thomas, M. R., Alba, B. M., Wu, X., Gupte, J., Li, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061432 · Cited by 59 · see citing works
Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.
Gavrilova, O., Marcus‐Samuels, B., & Reitman, M. L. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1910 · Cited by 59 · see citing works
Adiponectin and its receptors: implications for obesity-associated diseases and longevity
Kadowaki, T., Yamauchi, T., Okada‐Iwabu, M., & Iwabu, M. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70120-7 · Cited by 46 · see citing works
ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data
Friedman, B. A., & Maniatis, T. (2011) · Genome biology · doi:10.1186/gb-2011-12-7-r69 · Cited by 45 · see citing works
Søndergaard, E., Gormsen, L. C., Christensen, M. H., Pedersen, S. B., Christiansen, P., Nielsen, S., Poulsen, P. L., & Jessen, N. (2014) · Diabetic Medicine · doi:10.1111/dme.12595 · Cited by 43 · see citing works
Dikeman, M. E. (2013) · Cited by 8 · see citing works
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Labrijn, A. F., Janmaat, M. L., Reichert, J. M., & Parren, P. W. H. I. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0028-1 · Cited by 1,303 · see citing works
Next generation antibody drugs: pursuit of the 'high-hanging fruit'
Carter, P. J., & Lazar, G. A. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.227 · Cited by 760 · see citing works
Targeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Geng, L., Lam, K. S. L., & Xu, A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0386-0 · Cited by 607 · see citing works
Cheng, L., Wang, J., Dai, H., Duan, Y., An, Y., Shi, L., Lv, Y., Li, H., Wang, C., Ma, Q., et al. (2021) · Adipocyte · doi:10.1080/21623945.2020.1870060 · Cited by 377 · see citing works
Flippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311 · see citing works
Bispecific Antibodies: From Research to Clinical Application
Ma, J., Mo, Y., Tang, M., Shen, J., Qi, Y., Zhao, W., Huang, Y., Xu, Y., & Qian, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626616 · Cited by 310 · see citing works
A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21
Kliewer, S. A., & Mangelsdorf, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.004 · Cited by 273 · see citing works
Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A., & Mangelsdorf, D. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.005 · Cited by 261 · see citing works
Self-citationStructures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
Lee, S., Choi, J., Mohanty, J., Sousa, L. P., Tome, F., Pardon, E., Steyaert, J., Lemmon, M. A., Lax, I., & Schlessinger, J. (2018) · Nature · doi:10.1038/nature25010 · Cited by 236 · see citing works
Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222 · see citing works
Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works
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Cuevas-Ramos, D., Mehta, R., & Aguilar-Salinas, C. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00037 · Cited by 149 · see citing works
New developments in the biology of fibroblast growth factors
Ornitz, D. M., & Itoh, N. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1549 · Cited by 143 · see citing works
Fibroblast Growth Factor Signaling in Metabolic Regulation
Nies, V. J. M., Sancar, G., Liu, W., van Zutphen, T., Struik, D., Yu, R. T., Atkins, A. R., Evans, R. M., Jonker, J. W., & Downes, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00193 · Cited by 135 · see citing works
The role of adipokines in skeletal muscle inflammation and insulin sensitivity
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Minard, A. Y., Tan, S., Yang, P., Fazakerley, D. J., Domanova, W., Parker, B. L., Humphrey, S. J., Jothi, R., Stöckli, J., & James, D. E. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.086 · Cited by 118 · see citing works
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Baruch, A., Wong, C., Chinn, L. W., Vaze, A., Sonoda, J., Gelzleichter, T., Chen, S., Lewin-Koh, N., Morrow, L., Dheerendra, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012073117 · Cited by 95 · see citing works
Self-citationBiology drives the discovery of bispecific antibodies as innovative therapeutics
Nie, S., Wang, Z., Moscoso‐Castro, M., D'Souza, P., Lei, C., Xu, J., & Gu, J. (2020) · Antibody Therapeutics · doi:10.1093/abt/tbaa003 · Cited by 95 · see citing works
Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle
Vandanmagsar, B., Warfel, J. D., Wicks, S. E., Ghosh, S., Salbaum, J. M., Burk, D., Dubuisson, O. S., Mendoza, T. M., Zhang, J., Noland, R. C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.057 · Cited by 92 · see citing works
FGF21 in obesity and cancer: New insights
Lu, W., Li, X., & Luo, Y. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.026 · Cited by 92 · see citing works
Jin, L., Yang, R., Geng, L., & Xu, A. (2023) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-032322-093904 · Cited by 71 · see citing works
Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders
Zhang, J., & Li, Y. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00168 · Cited by 70 · see citing works
Current status and future perspectives of FGF21 analogues in clinical trials
Chui, Z. S. W., Shen, Q., & Xu, A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.02.001 · Cited by 68 · see citing works
Hultman, K., Scarlett, J. M., Baquero, A. F., Cornea, A. M., Zhang, Y., Salinas, C. B. G., Brown, J. M., Morton, G. J., Whalen, E. J., Grove, K. L., et al. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24668 · Cited by 65 · see citing works
Self-citationSchumacher, J. D., & Guo, G. L. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_228 · Cited by 64 · see citing works
Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho
Aaldijk, A. S., Verzijl, C. R. C., Jonker, J. W., & Struik, D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150222 · Cited by 63 · see citing works
Chen, M. Z., Chang, J. C., Zavala-Solorio, J., Kates, L., Thai, M., Ogasawara, A., Bai, X., Flanagan, S., Nunez, V., Phamluong, K., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.09.003 · Cited by 58 · see citing works
Self-citationThe renaissance of chemically generated bispecific antibodies
Szijj, P. A., & Chudasama, V. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-020-00241-6 · Cited by 54 · see citing works
The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases
Yan, J., Nie, Y., Cao, J., Luo, M., Yan, M., Chen, Z., & He, B. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.655575 · Cited by 53 · see citing works
Adipokines as Clinically Relevant Therapeutic Targets in Obesity
Würfel, M., Blüher, M., Stümvoll, M., Ebert, T., Kovacs, P. L., Tönjes, A., & Breitfeld, J. (2023) · Biomedicines · doi:10.3390/biomedicines11051427 · Cited by 54 · see citing works
Peng, X., Gennemark, P., O’Mahony, G., & Bartesaghi, S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00174 · Cited by 49 · see citing works
FGF-based drug discovery: advances and challenges
Chen, G., Chen, L., Li, X., & Mohammadi, M. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01125-w · Cited by 51 · see citing works
Hepatic hormone FGF21 and its analogues in clinical trials
Shao, W., & Jin, T. (2021) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2021.08.005 · Cited by 46 · see citing works
Bartesaghi, S., Wallenius, K., Hovdal, D., Liljeblad, M., Wallin, S., Dekker, N., Barlind, L., Davies, N. M., Seeliger, F., Winzell, M. S., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.04.010 · Cited by 40 · see citing works
Beta-klotho in type 2 diabetes mellitus: From pathophysiology to therapeutic strategies
Hua, S., Liu, Q., Li, J., Fan, M., Yan, K., & Ye, D. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09661-1 · Cited by 39 · see citing works
Wong, C., Dash, A., Fredrickson, J. O., Lewin‐Koh, N., Chen, S., Yoshida, K. J., Liu, Y., Gutierrez, J., & Kunder, R. S. (2022) · Hepatology · doi:10.1002/hep.32742 · Cited by 35 · see citing works
Self-citationHu, X., Jogasuria, A. P., Wang, J., Kim, C., Han, Y., Shen, H., Wu, J., & You, M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.737015 · Cited by 34 · see citing works
Weng, Y., Ishino, T., Sievers, A., Talukdar, S., Chabot, J., Tam, A. S. P., Duan, W., Kerns, K. M., Sousa, E. A., He, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22456-w · Cited by 33 · see citing works
A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity
Shi, S. Y., Lu, Y., Liu, Z., Stevens, J. L., Murawsky, C. M., Wilson, V., Hu, Z., Richards, W. G., Michaels, M. L., Zhang, J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.001752 · Cited by 32 · see citing works
A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling
Shi, S. Y., Lu, Y., Richardson, J., Min, X., Weiszmann, J., Richards, W. G., Wang, Z., Zhang, Z., Zhang, J., & Li, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-29396-5 · Cited by 30 · see citing works
Bioassay Development for Bispecific Antibodies—Challenges and Opportunities
Register, A. C., Tarighat, S. S., & Lee, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105350 · Cited by 32 · see citing works
Woolsey, S., Beaton, M. D., Mansell, S. E., Leon‐Ponte, M., Yu, J., Pin, C. L., Adams, P. C., Kim, R. B., & Tirona, R. G. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.104687 · Cited by 32 · see citing works
Ji, F., Liu, Y., Hao, J., Wang, L., Dai, M.-J., Shen, G.-F., & Yan, X. (2019) · Aging · doi:10.18632/aging.102293 · Cited by 31 · see citing works
Agonist antibody discovery: Experimental, computational, and rational engineering approaches
Schardt, J. S., Jhajj, H. S., O’Meara, R. L., Lwo, T. S., Smith, M. D., & Tessier, P. M. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.09.008 · Cited by 29 · see citing works
Min, B.-K., Oh, C. J., Park, S., Lee, J.-M., Go, Y., Park, B.-Y., Kang, H., Kim, D. W., Kim, J., Yoo, E. K., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0315-2 · Cited by 28 · see citing works
Self-citationUnliganded Fibroblast Growth Factor Receptor 1 Forms Density-independent Dimers
Comps‐Agrar, L., Dunshee, D. R., Eaton, D., & Sonoda, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.681395 · Cited by 27 · see citing works
Self-citationAn efficient route to bispecific antibody production using single-reactor mammalian co-culture
Shatz-Binder, W., Ng, D., Dutina, G., Wong, A. W., Dunshee, D. R., Sonoda, J., Shen, A. Y., & Scheer, J. M. (2016) · mAbs · doi:10.1080/19420862.2016.1234569 · Cited by 26 · see citing works
Self-citationEffect of vitamin K supplementation on insulin sensitivity: a meta-analysis
Suksomboon, N., Poolsup, N., & Ko, H. D. K. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s137571 · Cited by 25 · see citing works
Chang, J. C., Durinck, S., Chen, M. Z., Martinez-Martín, N., Zhang, J. A., Lehoux, I. E., Li, H., Lin, M. H., Wu, J., Bainbridge, T. W., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45354-1 · Cited by 24 · see citing works
Self-citationNutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine
Fang, H., Stone, K. P., Forney, L. A., Wanders, D., & Gettys, T. W. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.773975 · Cited by 24 · see citing works
Use of FGF21 analogs for the treatment of metabolic disorders: a systematic review and meta-analysis
Carbonetti, M. P., Almeida‐Oliveira, F., & Majerowicz, D. (2023) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2022-0493 · Cited by 24 · see citing works
Autocrine FGF1 signaling promotes glucose uptake in adipocytes
Nies, V. J. M., Struik, D., Liu, S., Liu, W., Kruit, J. K., Downes, M., van Zutphen, T., Verkade, H. J., Evans, R. M., & Jonker, J. W. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2122382119 · Cited by 23 · see citing works
Fibroblast growth factor 21: A “rheostat” for metabolic regulation?
She, Q.-Y., Bao, J., Wang, H.-Z., Liang, H., Huang, W., Wu, J., Zhong, Y.-W., Ling, H., Li, A., & Qin, S.-L. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155166 · Cited by 22 · see citing works
The role of FGF19 in metabolic regulation: insights from preclinical models to clinical trials
de Carvalho, M. B., Jorge, G. M. C. P., Zanardo, L. W., Hamada, L. M., Izabel, L. D. S., Santoro, S., & Magdalon, J. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00156.2024 · Cited by 21 · see citing works
Induced proximity at the cell surface
Till, N. A., Ramanathan, M., & Bertozzi, C. R. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02592-1 · Cited by 21 · see citing works
Chu, Y., Yang, S., & Chen, X. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108844 · Cited by 21 · see citing works
Raji, A., Gantz, I., Crutchlow, M. F., Flynn, H., Xu, L., Rodgers, A. J., Krishnan, R., Rizk, M. L., Hu, S., Kaufman, K. D., et al. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70038 · Cited by 17 · see citing works
Identification and characterization of adipose surface epitopes
Onogi, Y., Khalil, A., & Ussar, S. (2020) · Biochemical Journal · doi:10.1042/bcj20190462 · Cited by 15 · see citing works
Beall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160045 · Cited by 16 · see citing works
Sakamoto, K., Kawata, Y., Masuda, Y., Umemoto, T., Ito, T., Asami, T., Takekawa, S., Ohtaki, T., & Inooka, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.009 · Cited by 15 · see citing works
Beneficial Gut Microbiome Remodeled During Intermittent Fasting in Humans
Larrick, J. W., Mendelsohn, A. R., & Larrick, J. W. (2021) · Rejuvenation Research · doi:10.1089/rej.2021.0025 · Cited by 15 · see citing works
Amatya, R., Lee, D.-H., Min, K. A., & Shin, M. C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071963 · Cited by 13 · see citing works
Fine-tuning bispecific therapeutics
Lim, S. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107582 · Cited by 14 · see citing works
Ellerman, D. A. (2024) · BioDrugs · doi:10.1007/s40259-024-00691-0 · Cited by 13 · see citing works
Meroni, M., Dongiovanni, P., Tiano, F., Piciotti, R., Alisi, A., & Panera, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117608 · Cited by 13 · see citing works
Saber-Ayad, M. M., Hammoudeh, S. M., Radwan, H. M., Manzoor, S., Jabbar, H. A., Wardeh, R., Ashraf, A., Habib, P. T., Alsamman, A. M., & Hamoudi, R. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.05.020 · Cited by 11 · see citing works
Peng, H., Yu, Y., Wang, P., Yao, Y., Wu, X., Zheng, Q., Wang, J., Tian, B., Wang, Y., Ke, T., et al. (2022) · Obesity · doi:10.1002/oby.23580 · Cited by 11 · see citing works
Ghanem, M., Archer, G., Crestani, B., & Mailleux, A. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108669 · Cited by 11 · see citing works
Wang, X., Lu, L.-J., Li, Y., & Xu, C. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120925 · Cited by 11 · see citing works
Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening
Kim, H. S., Dunshee, D. R., Yee, A., Tong, R. K., Kim, I., Farahi, F., Hongo, J.-A., Ernst, J. A., Sonoda, J., & Spiess, C. (2017) · Protein Engineering Design and Selection · doi:10.1093/protein/gzx034 · Cited by 11 · see citing works
Self-citationLv, Y., Zhao, C., Jiang, Q., Rong, Y., Ma, M., Liang, L., Li, W., Zhang, J., Xu, N., & Wu, H. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09540-3 · Cited by 10 · see citing works
Sepa-Kishi, D. M., & Ceddia, R. B. (2018) · Adipocyte · doi:10.1080/21623945.2018.1504591 · Cited by 10 · see citing works
Xie, Z., & Protzer, U. (2024) · Antiviral Research · doi:10.1016/j.antiviral.2024.105972 · Cited by 7 · see citing works
Double promoter and tandem gene strategy for efficiently expressing recombinant FGF21
Liu, L., Ning, N., Xu, S., Chen, D., Zhou, L., Guo, Z., Liang, X., & Ye, X. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02447-5 · Cited by 6 · see citing works
Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr−/−.Leiden mice
Inia, J. A., Attema, J., de Ruiter, C., Menke, A. L., Caspers, M. P. M., Verschuren, L., Wilson, M. E., Arlantico, A., Brightbill, H. D., Jukema, J. W., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202401397r · Cited by 5 · see citing works
Self-citationWhat’s So Special about FGF19—Unique Effects Reported on Skeletal Muscle Mass and Function
Glass, D. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.017 · Cited by 6 · see citing works
Yoshida, K. J., Poon, V., Dash, A., Kunder, R. S., Chinn, L. W., & Kågedal, M. (2024) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.13111 · Cited by 6 · see citing works
Hitting Ebola, to the power of two
Labrijn, A. F., & Parren, P. W. H. I. (2016) · Science · doi:10.1126/science.aaj2036 · Cited by 6 · see citing works
Rajan, S., Mandikian, D., Baruch, A., Gelzleichter, T. R., Stevens, D. W., Sonoda, J., Cowan, K. J., Boswell, C. A., & Stefanich, E. G. (2017) · mAbs · doi:10.1080/19420862.2017.1373923 · Cited by 6 · see citing works
Self-citationWozniak‐Knopp, G. (2020) · Learning materials in biosciences · doi:10.1007/978-3-030-54630-4_7 · Cited by 6 · see citing works
Korkmaz, D., Konya, P. Ş., & Demirtürk, N. (2022) · Turkish Journal of Parasitology · doi:10.4274/tpd.galenos.2022.14633 · Cited by 5 · see citing works
Treating metabolic dysfunction‐associated steatohepatitis: The fat‐trimming FGF21 approach
Li, X., Rao, Z., Hu, W., Lu, W., & Luo, Y. (2024) · Obesity Reviews · doi:10.1111/obr.13861 · Cited by 6 · see citing works
Animal Models for Manipulation of Thermogenesis
Fuller‐Jackson, J., Clarke, I. J., & Henry, B. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00012-7 · Cited by 4 · see citing works
Bibliometric analysis of fibroblast growth factor 21 research over the period 2000 to 2021
She, Q.-Y., Li, L., Liu, M.-H., Tan, R.-Y., Zhong, Y.-W., Bao, J., & Xie, J.-D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1011008 · Cited by 9 · see citing works
The role of FGF19–FGFR4 signaling pathway in liver health and disease: Guardian or destroyer
Wu, Z., Wang, Y., Zhang, J., Li, S., Wen, J., Hu, D., Jiang, J., Zhang, Z., Luo, X., & Xia, L. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101989 · Cited by 3 · see citing works
Buss, N. A. P. S., Lapointe, J., de Haan, L., Price, S. R., Ahnmark, A., Irving, L. M., Buchanan, A. G., Keyes, F., Davidsson, P., Dixit, R., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.06.033 · Cited by 3 · see citing works
Process Design for Bispecific Antibodies
Williams, A. J., Giese, G. S., Schaubmar, A. R., & von Hirschheydt, T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-100623-8.00042-6 · Cited by 2 · see citing works
Chan, J., Chan, J., Shao, L., Stawicki, S., Pham, V. C., Akita, R., Hafner, M., Crocker, L. M., Yu, K., Koerber, J. T., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102729 · Cited by 2 · see citing works
Self-citationTissot, A. C., & Brinkmann, U. (2017) · Springer eBooks · doi:10.1007/978-3-319-42252-7_5 · Cited by 2 · see citing works
Lin, J., Liu, K., Joycelyn, Ge, S., Dawa, Y., He, J., Yan, N., Zheng, R., Xie, Z., & Li, H. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101691 · Cited by 1 · see citing works
Su, C., Cheng, Q., & Wang, L. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s298897 · Cited by 1 · see citing works
Effects of Deep Sea Water on Anti-Obesity Properties in Induction of Beige Adipocytes
Nani, S. Z. M., Jaafar, A. B., Majid, F. A. A., Mahdzir, A. M., & Musa, M. N. (2018) · Current Chemical Biology · doi:10.2174/2212796812666180705143429 · Cited by 1 · see citing works
Analytical Characterization of Bispecific Antibodies and Bispecific Molecules
Dillon, M. A., Lombana, T. N., & Spiess, C. (2025) · doi:10.1002/9781394236145.ch2 · Cited by 1 · see citing works
Self-citation
- Authors
- Kolumam, G., Chen, M. Z., Tong, R., Zavala-Solorio, J., Kates, L., van Bruggen, N., Ross, J., Wyatt, S. K., Gandham, V. D., Carano, R. A. D., Dunshee, D. R., Wu, A.-L., Haley, B., Anderson, K., Warming, S., Rairdan, X. Y., Lewin-Koh, N., Zhang, Y., Gutierrez, J., Baruch, A., Gelzleichter, T. R., Stevens, D., Rajan, S., Bainbridge, T. W., Vernes, J.-M., Meng, Y. G., Ziai, J., Soriano, R. H., Brauer, M. J., Chen, Y., Stawicki, S., Kim, H. S., Comps-Agrar, L., Luis, E., Spiess, C., Wu, Y., Ernst, J. A., McGuinness, O. P., Peterson, A. S., & Sonoda, J.
- Affiliations
- Genentech (US)
- Vanderbilt University (US)
- Corresponding author
- Sonoda, Junichiro
- ORCID
- Kolumam, Ganesh
- Tong, Raymond
- Gandham, Vineela D.
- Carano, Richard A.D.
- Dunshee, Diana Ronai
- Haley, Benjamin
- Anderson, Keith
- Warming, Søren
- Zhang, Yingnan
- Baruch, Amos
- Bainbridge, Travis W.
- Meng, Y. Gloria
- Ziai, James
- Brauer, Matthew J.
- Chen, Yongmei
- Kim, Hok Seon
- Spiess, Christoph
- Wu, Yan
- McGuinness, Owen P.
- Peterson, Andrew S.
- Venue
- EBioMedicine
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 2
- Issue
- 7
- Pages
- 730-743
- ISSN
- 2352-3964 (ISSN-L)
- PMC
- PMC4534681
- OpenAlex
- W2156319327
- Cited by
- 108
- References
- 58
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 12 · 2023: 5 · 2022: 13 · 2021: 12 · 2020: 9 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 10 · 2015: 4
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- EBioMedicine (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Genentech
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipose tissue, humanized monoclonal antibody, FGF21, FGF19, energy expenditure, white adipose tissue browning, weight loss, insulin sensitization, high molecular weight adiponectin, obesity, type 2 diabetes, hepatic steatosis, dyslipidemia, hyperglycemia
- MeSH terms
- Klotho Proteins, Animals, Adipose Tissue, Brown, Cell Line, Energy Metabolism, Fibroblast Growth Factors, Humans, Insulin, Macaca fascicularis, Male, Membrane Proteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Obese, Protein Binding, Weight Loss, Antibodies, Bispecific, Thermogenesis, Receptor, Fibroblast Growth Factor, Type 1, Adiponectin, HEK293 Cells
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