Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis
Open accessAbstract
Objective To determine matrix metalloproteinase 2 (MMP-2) levels in sera and peritoneal fluids of women with or without endometriosis-associated infertility and to determine whether MMP-2 had correlation with 17beta-E(2) and P in the sera and peritoneal fluids of the patients with endometriosis.Design A case-control study.Setting A women's hospital in China.Patient(s) Forty patients with endometriosis-associated infertility undergoing laparoscopy and 18 women undergoing tubal ligation.Intervention(s) Sera and peritoneal fluids were collected from women with or without endometriosis.Main outcome measure(s) Matrix metalloproteinase 2, 17beta-E(2), and P concentration.Result(s) Compared with the control women, the patients with endometriosis had higher MMP-2 levels in their sera and peritoneal fluids. Serum and peritoneal fluid MMP-2 levels were higher in the proliferative phase than in the secretory phase. The level of MMP-2 in the patients was correlated positively with 17beta-E(2) in serum and peritoneal fluid and negatively with P.Conclusion(s) The results demonstrated a correlation between MMP-2 concentrations and steroid hormones in sera and peritoneal fluids of the patients with endometriosis-associated infertility. Estradiol might up-regulate MMP-2, resulting in the formation of endometriosis. Progesterone might down-regulate MMP-2 to inhibit the formation and development of endometriosis.
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MMP-2 and MMP-9 have been found to be significantly increased in endometriosis patients versus controls.
“MMP-2 [63] and MMP-9 [64] have been found to be significantly increased in endometriosis patients versus controls.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [63]
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- Authors
- Huang, H.-F., Hong, L.-H., Tan, Y., & Sheng, J.-Z.
- Affiliations
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- University of Calgary (CA)
- Corresponding author
- Huang, He-Feng
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 81
- Issue
- 5
- Pages
- 1235-1239
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2058602477
- Cited by
- 90
- References
- 28
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 5
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- MMP-2, endometriosis, endometriosis-associated infertility, serum biomarkers, peritoneal fluid, estradiol, progesterone, menstrual cycle phases
- MeSH terms
- Adult, Ascitic Fluid, Endometriosis, Estradiol, Female, Humans, Menstrual Cycle, Progesterone, Follicular Fluid, Case-Control Studies, Matrix Metalloproteinase 2
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