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Cited by 120Endometriosis Research and TreatmentReproductive System and PregnancyEctopic Pregnancy Diagnosis and Management

Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach

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Tariverdian, Nadja, Theoharides, Theoharis C., Siedentopf, Friederike, Gutiérrez, Gabriela, Jeschke, Udo, Rabinovich, Gabriel A., Blois, Sandra M., Arck, Petra C.·2007·Seminars in Immunopathology
DOI 10.1007/s00281-007-0077-0PMC PMC2668599
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Abstract

Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endometriosis is still largely elusive. Inadequate immune and neuroendocrine responses are significantly involved in the pathophysiology of endometriosis, and key findings are summarized in the present review. We discuss here the role of different immune mechanisms particularly adhesion molecules, proteinglycan interactions, and pro-angiogenic mediators in the development and progression of the disease. Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis.

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  • Women with endometriosis are more likely to be diagnosed with inflammatory bowel diseases, allergic manifestations, and autoimmune diseases.

    “An increased risk of inflammatory bowel diseases (Chron’s disease, ulcerative colitis) [146] allergic manifestations [sinus allergic rhinitis, and food allergy) [147], autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, Sjogren’s syndrome, multiple sclerosis, fibromyalgia) are more likely to be diagnosed in women with endometriosis”

    From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [152]

    The ‘Stress perception, endometriosis, and sickness response’ section says perceived stress may aggravate inflammatory bowel disease; it does not say women with endometriosis are more likely to receive that diagnosis. The ‘Role of adaptive immune responses in endometriosis’ section reports autoantibodies, not increased diagnoses of autoimmune disease. Searches for allergic manifestations and the named conditions found no passage establishing the claimed diagnostic risks; the indexed passages provide no page numbers. (LLM, conf=0.75)

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Research works printed but not linked: 2

  1. [4]Bruckner C Steck T Felberbaum R Küpker W Bruckner C Finas D Symptoms and diagnosis Endometriosis. Development, diagnosis, progression, therapy 2004 New York Springer 81 101 Bruckner C (2004) Symptoms and diagnosis. In: Steck T, Felberbaum R, Küpker W, Bruckner C, Finas D (eds) Endometriosis. Development, diagnosis, progression, therapy. Springer, New York, pp 81–101
  2. [5]Steck T Steck T Felberbaum R Küpker W Bruckner C Finas D Manifestations and progression Endometriosis. Development, diagnosis, progression, therapy 2004 Berlin Heidelberg New York Springer 37 79 Steck T (2004) Manifestations and progression. In: Steck T, Felberbaum R, Küpker W, Bruckner C, Finas D (eds) Endometriosis. Development, diagnosis, progression, therapy. Springer, Berlin Heidelberg New York, pp 37–79

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Authors
Tariverdian, N., Theoharides, T. C., Siedentopf, F., Gutiérrez, G., Jeschke, U., Rabinovich, G. A., Blois, S. M., & Arck, P. C.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • Tufts University (US)
  • DRK Kliniken Berlin (DE)
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
  • Ludwig-Maximilians-Universität München (DE)
  • Stiftung Charité (DE)
Corresponding author
Arck, Petra C.
ORCID
Venue
Seminars in Immunopathology
Publisher
Springer Science and Business Media LLC
Published
2007-05-15
Volume
29
Issue
2
Pages
193-210
ISSN
  • 1863-2297 (ISSN-L)
  • 1863-2300
DOI
10.1007/s00281-007-0077-0
PMC
PMC2668599
OpenAlex
W1979443587
Cited by
120
References
198
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 12 · 2013: 13 · 2012: 7
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Seminars in Immunopathology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • John Simon Guggenheim Memorial Foundation
  • European Commission
  • Deutsche Forschungsgemeinschaft
  • Consejo Nacional de Investigaciones Científicas y Técnicas
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, immune mechanisms, adhesion molecules, perceived stress, chronic pelvic pain, infertility, endometriosis pathophysiology
MeSH terms
Endometriosis, Endometrium, Female, Humans, Immunity, Cellular, Immunity, Innate, Lymphokines, Neurosecretory Systems, Stress, Physiological, Cell Adhesion Molecules, Angiogenesis Modulating Agents

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