Cited by 465Effects and risks of endocrine disrupting chemicalsSexual Differentiation and DisordersReproductive Biology and Fertility

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Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

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Crain, D. Andrew, Janssen, Sarah J., Edwards, Thea M., Heindel, Jerrold, Ho, Shuk-mei, Hunt, Patricia, Iguchi, Taisen, Juul, Anders, McLachlan, John A., Schwartz, Jackie, Skakkebaek, Niels, Soto, Ana M., Swan, Shanna, Walker, Cheryl, Woodruff, Teresa K., Woodruff, Tracey J., Giudice, Linda C., Guillette, Louis J.·2008·Fertility and Sterility

DOI 10.1016/j.fertnstert.2008.08.067PMC PMC4086418

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Abstract

Objective To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health.Design Publications related to the contribution of EDCs to disorders of the ovary (aneuploidy, polycystic ovary syndrome, and altered cyclicity), uterus (endometriosis, uterine fibroids, fetal growth restriction, and pregnancy loss), breast (breast cancer, reduced duration of lactation), and pubertal timing were identified, reviewed, and summarized at a workshop.Conclusion(s) The data reviewed illustrate that EDCs contribute to numerous human female reproductive disorders and emphasize the sensitivity of early life-stage exposures. Many research gaps are identified that limit full understanding of the contribution of EDCs to female reproductive problems. Moreover, there is an urgent need to reduce the incidence of these reproductive disorders, which can be addressed by correlative studies on early life exposure and adult reproductive dysfunction together with tools to assess the specific exposures and methods to block their effects. This review of the EDC literature as it relates to female health provides an important platform on which women's health can be improved.

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Authors: Crain, D. A., Janssen, S. J., Edwards, T. M., Heindel, J., Ho, S.-M., Hunt, P., Iguchi, T., Juul, A., McLachlan, J. A., Schwartz, J., Skakkebaek, N., Soto, A. M., Swan, S., Walker, C., Woodruff, T. K., Woodruff, T. J., Giudice, L. C., & Guillette, L. J.
Affiliations: Maryville College (US)
Natural Resources Defense Council (US)
University of Florida (US)
National Institute of Environmental Health Sciences (US)
University of Cincinnati (US)
Washington State University (US)
National Institute for Basic Biology (JP)
Rigshospitalet (DK)
University of California, San Francisco (US)
Tufts University (US)
University of Rochester Medicine (US)
The University of Texas MD Anderson Cancer Center (US)
Northwestern University (US)
Corresponding author: Guillette, Louis J.
ORCID: Janssen, Sarah J.
Edwards, Thea M.
Heindel, Jerrold
Ho, Shuk-mei
Hunt, Patricia
Iguchi, Taisen
Juul, Anders
McLachlan, John A.
Soto, Ana M.
Swan, Shanna
Woodruff, Teresa K.
Woodruff, Tracey J.
Giudice, Linda C.
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2008-10
Volume: 90
Issue: 4
Pages: 911-940
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2008.08.067
PMC: PMC4086418
OpenAlex: W2154968546
Cited by: 465
References: 315
Citations by year: 2026: 15 · 2025: 17 · 2024: 17 · 2023: 28 · 2022: 31 · 2021: 31 · 2020: 20 · 2019: 28 · 2018: 19 · 2017: 20 · 2016: 38 · 2015: 31 · 2014: 29 · 2013: 35 · 2012: 25
FWCI: 2.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4986 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: National Institute of Environmental Health Sciences (P30ES006096)
National Institute of Dental and Craniofacial Research (UL1DE019587)
National Center for Research Resources (UL1RR024926)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD076188, U54HD041857)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: endocrine disruptors, female reproductive disorders, developmental plasticity, early life exposure, polycystic ovary syndrome, endometriosis, uterine fibroids, fetal growth restriction, miscarriage, breast cancer, lactation length, pubertal timing, reproductive disorders
MeSH terms: Female, Genital Diseases, Female, Humans, Pregnancy, Pregnancy Outcome, Reproduction, Endocrine Disruptors

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Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

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