Evaluation of high-sensitivity C-reactive protein in comparison with C-reactive protein as biochemical serum markers in women with endometriosis
Open accessAbstract
Objective To compare high-sensitivity C-reactive protein (hs-CRP) with CRP as a soluble serum marker for the diagnosis of women with endometriosis. Design Prospective nonrandomized controlled trial (Canadian Task Force classification II-1). Setting University hospital. Patient(s) Eighty-two women were laparoscopically evaluated. No endometriosis was diagnosed in 34 women (the non-E group). Endometriosis was confirmed by histology in 48 women (the E group). Eighty-two women did not undergo laparoscopic evaluation (the unknown-E group). Afterward, the women were staged according to the revised American Society for Reproductive Medicine criteria (r-ASRM). Intervention(s) CRP and hs-CRP were measured initially before laparoscopy. Main outcome measure(s) The hs-CRP and CRP levels and the correlation of those parameters with the stage of the disease. Result(s) There was a trend toward higher CRP levels and higher hs-CRP levels in the E group, while the lowest levels of both markers were found in the non-E group. There was a significantly lower hs-CRP level in the non-E group in comparison with the CRP level in this group. No differences between the different stages of the disease were found with either marker. Conclusion(s) Measurement of the two markers did not appear to be advantageous for the diagnosis of endometriosis independent of the stage of the disease. Nevertheless, a very low hs-CRP level might serve as a marker for an absence of endometriosis.
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As a marker of ongoing inflammation, CRP is tested in almost all diagnostic laboratories.
“As a marker of ongoing inflammation it is tested in almost all diagnostic laboratories [36].”
From Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis (2021) · cites this paper as [36]
The paper describes CRP as widely used to mark ongoing inflammation and measurable in most laboratories (Abstract). That supports the general point, but “almost all diagnostic laboratories” is stronger than the paper’s “most laboratories.” (LLM, conf=0.86)
Experimental — accuracy not yet measuredSerum CRP is a parameter of an acute inflammatory phase, which increases during inflammation.
“Serum CRP is a parameter of an acute inflammatory phase, which increases during inflammation [36].”
From Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis (2021) · cites this paper as [36]
The high correlation between hsCRP and classical CRP assays observed in our study confirms data reported before [13].
“The high correlation between hsCRP and classical CRP assays observed in our study (Table 4) confirms data reported before [13].”
From A high sensitivity assay is more accurate than a classical assay for the measurement of plasma CRP levels in endometriosis (2011) · cites this paper as [13]
Using a hsCRP assay, no differences were found in serum CRP levels between women with and without endometriosis in 2 studies, including a much smaller number of patients (n = 38 and n = 82) than in our study.
“However, using a hsCRP assay, no differences were found in serum CRP levels between women with and without endometriosis in 2 studies [12,13], including a much smaller number of patients (n = 38 and n = 82, respectively) than in our study.”
From A high sensitivity assay is more accurate than a classical assay for the measurement of plasma CRP levels in endometriosis (2011) · cites this paper as [13]
Other studies could not find CRP upregulation.
“However, other studies could not find an upregulation [23, 51].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [51]
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- Authors
- Lermann, J., Mueller, A., Körber, F., Oppelt, P., Beckmann, M. W., Dittrich, R., & Renner, S. P.
- Affiliations
- Universitätsklinikum Erlangen (DE)
- Corresponding author
- Mueller, Andreas
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 93
- Issue
- 7
- Pages
- 2125-2129
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1990643218
- Cited by
- 39
- References
- 27
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 2 · 2014: 8 · 2013: 2 · 2012: 3
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, high-sensitivity C-reactive protein, C-reactive protein, serum biomarkers, endometriosis diagnosis, endometriosis stage, laparoscopic evaluation
- MeSH terms
- Adult, C-Reactive Protein, Diagnostic Techniques, Obstetrical and Gynecological, Endometriosis, Female, Humans, Middle Aged, Laparoscopy, Substrate Specificity, Gynecologic Surgical Procedures, Uterine Diseases, Biomarkers, Disease Progression
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