Copeptin is associated with the severity of endometriosis
Abstract
Purpose Endometriosis is defined as the presence of endometrial glands and stroma in ectopic locations and may be associated with local and systemic inflammatory processes. Copeptin is elevated in acute and chronic inflammation conditions. The aim of the present study was to determine whether serum copeptin levels were altered in women with endometriosis and played a role in the pathophysiology of the disease.Methods A total of 86 women were recruited for this case-control study. 50 patients with surgically proven endometriosis were included, while 36 patients without endometriosis comprised the control group. Patients were classified as having minimal, mild, moderate and severe disease in accordance with American Society of Reproductive Medicine revised classification. Two subgroups were formed by combining patients with minimal and mild disease and with moderate and severe disease (Stage 1-2, stage 3-4; respectively). Levels of copeptin, tumor markers (CA-125, CA-19-9, CA-15-3) and C-reactive protein in serum were measured.Results Serum copeptin, CA-125, CA-15-3 and CA-19-9 levels were higher in the endometriosis group (p: 0.002; 0.001; 0.017; 0.015; respectively). Copeptin and CA-19-9 levels were significantly higher in stage 3-4 group as compared to stage 1-2 group (p: 0.004; 0.036 respectively). Serum copeptin levels were positively correlated with stage of the disease and size of endometriomas. ROC analysis revealed that CA-125 had the highest AUC for predicting endometriosis (0.938; 95 % confidence interval 0.882-0.993; p: 0.001).Conclusions Serum copeptin levels were significantly higher in patients with endometriosis as compared to healthy controls. Moreover, severity of the disease was correlated with serum copeptin levels.
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A recent study showed significant increase of CA-125 (P=0.001), CA-19-9 (P=0.015), and CA-15-3 (P=0.017) in endometriosis cases (n=50) versus controls (n=35).
“A recent study showed a significant increase of CA-125 (P = 0.001), CA-19-9 (P = 0.015), and CA-15-3 (P = 0.017) in endometriosis cases (n = 50) versus controls (n = 35) [42].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [42]
ROC curve analysis showed that the area under the curve was highest for CA-125 (0.938).
“ROC curve analysis showed that the area under the curve was the highest for CA-125 (0.938) [42].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [42]
For CA-19-9 a significant positive correlation with disease severity was found.
“For CA-19-9 a significant positive correlation with disease severity was found [42].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [42]
At a cut-off value of 251.18 pg/mL, co-peptin sensitivity to predict endometriosis was 65% and specificity was 58.3%.
“At a cut-off value of 251.18 pg/mL, its sensitivity to predict endometriosis was 65% and the specificity was 58.3% [42].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [42]
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Update on biomarkers for the detection of endometriosis
Fassbender, A., Burney, R. O., F. O, D., D’Hooghe, T., & Giudice, L. (2015) · BioMed Research International · doi:10.1155/2015/130854 · Cited by 195 · see citing works
“002) higher in women with endometriosis (n = 50) than in women without endometriosis (n = 36) and was positively correlated with disease severity [42].”
InfluentialAn integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review
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- Authors
- Tuten, A., Kucur, M., Imamoglu, M., Kaya, B., Acikgoz, A. S., Yilmaz, N., Ozturk, Z., & Oncul, M.
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2014-02-01
- Volume
- 290
- Issue
- 1
- Pages
- 75-82
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2075586126
- Cited by
- 23
- References
- 42
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, copeptin, disease severity, endometriosis stage, CA125, CA19-9, CA15-3, tumor markers, C-reactive protein, endometrioma size, serum biomarkers, inflammation
- MeSH terms
- Adult, C-Reactive Protein, Endometriosis, Endometrium, Female, Glycopeptides, Humans, Middle Aged, ROC Curve, Severity of Illness Index, Biomarkers, Tumor, Case-Control Studies, CA-125 Antigen, CA-19-9 Antigen, Mucin-1
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