CoChat
Sign Up
Cited by 130Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

Serum levels of VEGF and TNF-α and their association with C-reactive protein in patients with endometriosis

Xavier, Pedro, Belo, Luís, Beires, Jorge, Rebelo, Irene, Martinez-de-Oliveira, José, Lunet, Nuno, Barros, Henrique·2006·Archives of Gynecology and Obstetrics
DOI 10.1007/s00404-005-0080-4
Open this paper in CoChat — free account

Abstract

Objective To compare serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) throughout the menstrual cycle in women with and without endometriosis and to quantify the association between these serum markers. Methods Twenty five endometriosis patients (ASRM stage III-IV) and 13 controls were followed through one menstrual cycle. VEGF, TNF-alpha and CRP concentrations were measured with enzyme-linked immunosorbent assay in each of the four cycle phases (early and late proliferative and early and late secretory). Non-parametric methods and Pearson's correlation coefficients were used for statistical analysis. Results Increased serum levels of VEGF in secretory phases and of TNF-alpha in all cycle phases were observed. A positive correlation between CRP and VEGF was found in endometriosis patients but not in controls. Conclusions Our results suggest that excessive systemic angiogenic activity is a feature of patients with endometriosis.

Integrity signals

Registry

Crossref · 10.1007/s00404-005-0080-4

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • CRP may be an inflammatory marker independent from the menstrual cycle, and thus useful in the diagnostics of endometriosis.

    “which indicates that CRP may be an inflammatory marker independent from the menstrual cycle, and thus useful in the diagnostics of endometriosis.”

    From Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis (2021) · cites this paper as [37]

  • Using a hsCRP assay, no differences were found in serum CRP levels between women with and without endometriosis in 2 studies, including a much smaller number of patients (n = 38 and n = 82) than in our study.

    “However, using a hsCRP assay, no differences were found in serum CRP levels between women with and without endometriosis in 2 studies [12,13], including a much smaller number of patients (n = 38 and n = 82, respectively) than in our study.”

    From A high sensitivity assay is more accurate than a classical assay for the measurement of plasma CRP levels in endometriosis (2011) · cites this paper as [12]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Xavier, P., Belo, L., Beires, J., Rebelo, I., Martinez-de-Oliveira, J., Lunet, N., & Barros, H.
Affiliations
Universidade do Porto (PT)
Corresponding author
Xavier, Pedro
ORCID
Venue
Archives of Gynecology and Obstetrics
Publisher
Springer Science and Business Media LLC
Published
2005-10-06
Volume
273
Issue
4
Pages
227-231
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
DOI
10.1007/s00404-005-0080-4
OpenAlex
W2023851164
Cited by
130
References
27
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 4
FWCI
6.97
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometriosis, vascular endothelial growth factor, TNF-α, C-reactive protein, menstrual cycle, luteal phase, angiogenesis, serum biomarkers, inflammatory markers
MeSH terms
Adult, C-Reactive Protein, Endometriosis, Female, Humans, Menstrual Cycle, Tumor Necrosis Factor-alpha, Vascular Endothelial Growth Factor A

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review