The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis
Open accessAbstract
Objective To determine whether isoflavones exert estrogen-like effects in men by lowering bioavailable T through evaluation of the effects of soy protein or isoflavone intake on T, sex hormone-binding globulin (SHBG), free T, and free androgen index (FAI) in men.Design PubMed and CAB Abstracts databases were searched through July 1, 2008, with use of controlled vocabulary specific to the databases, such as soy, isoflavones, genistein, phytoestrogens, red clover, androgen, testosterone, and SHBG. Peer-reviewed studies published in English were selected if [1] adult men consumed soy foods, isolated soy protein, or isoflavone extracts (from soy or red clover) and [2] circulating T, SHBG, free T, or calculated FAI was assessed. Data were extracted by two independent reviewers. Isoflavone exposure was abstracted directly from studies.Main outcome measure(s) Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. In addition, 32 reports involving 36 treatment groups were assessed in simpler models to ascertain the results.Result(s) No significant effects of soy protein or isoflavone intake on T, SHBG, free T, or FAI were detected regardless of statistical model.Conclusion(s) The results of this meta-analysis suggest that neither soy foods nor isoflavone supplements alter measures of bioavailable T concentrations in men.
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“A meta-analysis of 15 placebo-controlled studies of men of varying ages have reported that soy protein intake up to 60 g/day has not been associated with significant alterations in testosterone, sex hormone-binding globulin, free testosterone, or free androgen index [136].”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [136]
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Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594
Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature
Messina, M. (2016) · Nutrients · doi:10.3390/nu8120754 · Cited by 537
Self-citationSoy, Soy Foods and Their Role in Vegetarian Diets
Rizzo, G., & Baroni, L. (2018) · Nutrients · doi:10.3390/nu10010043 · Cited by 536
Zaheer, K., & Akhtar, M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.989958 · Cited by 434
Sustaining Protein Nutrition Through Plant-Based Foods
Langyan, S., Yadava, P., Khan, F. N., Dar, Z. A., Singh, R., & Kumar, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.772573 · Cited by 412
Metadata
- Authors
- Hamilton-Reeves, J. M., Vazquez, G., Duval, S. J., Phipps, W. R., Kurzer, M. S., & Messina, M. J.
- Affiliations
- University of Minnesota (US)
- University of Rochester Medicine (US)
- Loma Linda University (US)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 94
- Issue
- 3
- Pages
- 997-1007
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1971875705
- Cited by
- 115
- References
- 74
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 12 · 2015: 3 · 2014: 4 · 2013: 17 · 2012: 5
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- soy protein, isoflavones, phytoestrogens, genistein, red clover, testosterone, sex hormone-binding globulin, free testosterone, free androgen index, bioavailable testosterone, men, reproductive hormones, dietary supplementation
- MeSH terms
- Adult, Algorithms, Clinical Trials as Topic, Humans, Isoflavones, Male, Reproduction, Sex Factors, Treatment Outcome, Soybean Proteins, Gonadal Hormones
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