Cited by 115Phytoestrogen effects and researchEstrogen and related hormone effectsHormonal and reproductive studies

The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.

Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis

Open access

Hamilton-Reeves, Jill M., Vazquez, Gabriela, Duval, Sue J., Phipps, William R., Kurzer, Mindy S., Messina, Mark J.·2010·Fertility and Sterility

DOI 10.1016/j.fertnstert.2009.04.038

Open this paper in CoChat — free account

Abstract

Objective To determine whether isoflavones exert estrogen-like effects in men by lowering bioavailable T through evaluation of the effects of soy protein or isoflavone intake on T, sex hormone-binding globulin (SHBG), free T, and free androgen index (FAI) in men.Design PubMed and CAB Abstracts databases were searched through July 1, 2008, with use of controlled vocabulary specific to the databases, such as soy, isoflavones, genistein, phytoestrogens, red clover, androgen, testosterone, and SHBG. Peer-reviewed studies published in English were selected if [1] adult men consumed soy foods, isolated soy protein, or isoflavone extracts (from soy or red clover) and [2] circulating T, SHBG, free T, or calculated FAI was assessed. Data were extracted by two independent reviewers. Isoflavone exposure was abstracted directly from studies.Main outcome measure(s) Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. In addition, 32 reports involving 36 treatment groups were assessed in simpler models to ascertain the results.Result(s) No significant effects of soy protein or isoflavone intake on T, SHBG, free T, or FAI were detected regardless of statistical model.Conclusion(s) The results of this meta-analysis suggest that neither soy foods nor isoflavone supplements alter measures of bioavailable T concentrations in men.

Integrity signals

Registry

Crossref · 10.1016/j.fertnstert.2009.04.038

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
Self-citation
Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β
Kuiper, G. G. J. M., Carlsson, B., Grandien, K., Enmark, E., Häggblad, J., Nilsson, S., & Gustafsson, J.-A. (1997) · Endocrinology · doi:10.1210/endo.138.3.4979 · Cited by 4,442
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203
How should meta‐regression analyses be undertaken and interpreted?
Thompson, S. G., & Higgins, J. P. T. (2002) · Statistics in Medicine · doi:10.1002/sim.1187 · Cited by 3,026
The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones
Setchell, K. D. R., Brown, N. M., & Lydeking-Olsen, E. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.12.3577 · Cited by 1,209
Endogenous Sex Hormones and Prostate Cancer: A Collaborative Analysis of 18 Prospective Studies
Hormones, E. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm323 · Cited by 786
Interindividual Variation in Metabolism of Soy Isoflavones and Lignans: Influence of Habitual Diet on Equol Production by the Gut Microflora
Rowland, I. R., Wiseman, H., Sanders, T. A. B., Adlercreutz, H., & Bowey, E. A. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc3601_5 · Cited by 583
INTENSIVE LIFESTYLE CHANGES MAY AFFECT THE PROGRESSION OF PROSTATE CANCER
Ornish, D. M., Weidner, G., Fair, W. R., Marlin, R. O., Pettengill, E. B., Raisin, C. J., Dunn-Emke, S. R., Crutchfield, L., JACOBS, F. N., Barnard, R. J., et al. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000169487.49018.73 · Cited by 475
Testosterone action on skeletal muscle
Herbst, K. L., & Bhasin, S. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200405000-00006 · Cited by 457

Show all 74 references

Research works printed but not linked: 1

1999, Food labeling: health claims; soy protein and coronary heart disease, Fed Regist, 64, 57699

Sorted by citations

Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594
Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature
Messina, M. (2016) · Nutrients · doi:10.3390/nu8120754 · Cited by 537
Self-citation
Soy, Soy Foods and Their Role in Vegetarian Diets
Rizzo, G., & Baroni, L. (2018) · Nutrients · doi:10.3390/nu10010043 · Cited by 536
An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health
Zaheer, K., & Akhtar, M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.989958 · Cited by 434
Sustaining Protein Nutrition Through Plant-Based Foods
Langyan, S., Yadava, P., Khan, F. N., Dar, Z. A., Singh, R., & Kumar, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.772573 · Cited by 412
Adverse Effects of Nutraceuticals and Dietary Supplements
Ronis, M. J. J., Pedersen, K. B., & Watt, J. D. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052844 · Cited by 393
Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms
Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325
Soy, phytoestrogens and their impact on reproductive health
Cederroth, C. R., Zimmermann, C., & Nef, S. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.049 · Cited by 211
Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review
Domínguez‐López, I., Yago-Aragón, M., Salas‐Huetos, A., Tresserra‐Rimbau, A., & Hurtado‐Barroso, S. (2020) · Nutrients · doi:10.3390/nu12082456 · Cited by 204
Healthy Plant-Based Diets Are Associated with Lower Risk of All-Cause Mortality in US Adults
Kim, H., Caulfield, L. E., & Rebholz, C. M. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy019 · Cited by 196
Efficacy and Safety of Short-Term Genistein Intervention in Patients with Localized Prostate Cancer Prior to Radical Prostatectomy: A Randomized, Placebo-Controlled, Double-Blind Phase 2 Clinical Trial
Lazarevic, B., Boezelijn, G., Diep, L. M., Kvernrød, K., Øgren, O., Ramberg, H., Moen, A. R., Wessel, N., Berg, R. E., Egge-Jacobsen, W. M., et al. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.582221 · Cited by 159
Soy and soy isoflavones in prostate cancer: a systematic review and meta‐analysis of randomized controlled trials
van Die, M. D., Bone, K. M., Williams, S., & Pirotta, M. V. (2013) · British Journal of Urology · doi:10.1111/bju.12435 · Cited by 130
The Role of Soy in Vegetarian Diets
Messina, M. J., & Messina, V. (2010) · Nutrients · doi:10.3390/nu2080855 · Cited by 137
Self-citation
Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism
Martin, L. J., & Touaibia, M. (2020) · Antioxidants · doi:10.3390/antiox9030237 · Cited by 120
The Influence of Metabolic Factors and Diet on Fertility
Łakoma, K., Kukharuk, O., & Śliż, D. (2023) · Nutrients · doi:10.3390/nu15051180 · Cited by 113
Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta‐Analyses of Observational Studies and Randomized Trials in Humans
Li, N., Wu, X., Zhuang, W., Xia, L., Chen, Y., Zhao, R., Yi, M., Wan, Q., Du, L., & Zhou, Y. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900751 · Cited by 86
Soybean isoflavone exposure does not have feminizing effects on men: a critical examination of the clinical evidence
Messina, M. J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.03.002 · Cited by 81
Self-citation
Short-Term Soy Isoflavone Intervention in Patients with Localized Prostate Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Hamilton‐Reeves, J. M., Banerjee, S., Banerjee, S. K., Holzbeierlein, J. M., Thrasher, J. B., Kambhampati, S., Keighley, J., & Veldhuizen, P. J. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068331 · Cited by 76
Self-citation
Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data
Messina, M. J., Mejía, S. B., Cassidy, A., Duncan, A. M., Kurzer, M. S., Nagato, C., Ronis, M. J. J., Rowland, I. R., Sievenpiper, J. L., & Barnes, S. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1895054 · Cited by 79
Self-citation
Isoflavones derived from plant raw materials: bioavailability, anti-cancer, anti-aging potentials, and microbiome modulation
Aboushanab, S. A., Khedr, S. M., Гетте, И. Ф., Danilova, I. G., Кольберг, Н. А., Ravishankar, G. A., Rao, A. R., & Kovaleva, E. G. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1946006 · Cited by 76
Biochemical investigation and gene analysis of equol: A plant and soy‐derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications
Gopaul, R., Knaggs, H. E., & Lephart, E. D. (2012) · BioFactors · doi:10.1002/biof.191 · Cited by 72
Health impact of childhood and adolescent soy consumption
Messina, M. J., Rogero, M. M., Fisberg, M., & Waitzberg, D. L. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux016 · Cited by 73
Self-citation
Effects of soy containing diet and isoflavones on cytochrome P450 enzyme expression and activity
Ronis, M. J. J. (2016) · Drug Metabolism Reviews · doi:10.1080/03602532.2016.1206562 · Cited by 71
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies
Reed, K. E., Camargo, J. T., Hamilton‐Reeves, J. M., Kurzer, M. S., & Messina, M. J. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.12.019 · Cited by 71
Self-citation
Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial
Reidy, P. T., Borack, M. S., Markofski, M. M., Dickinson, J. M., Deer, R. R., Husaini, S. H., Walker, D. K., Igbinigie, S., Robertson, S. M., Cope, M. B., et al. (2016) · The Journal of Nutrition · doi:10.3945/jn.116.231803 · Cited by 67
Dietary Soy Intake Is Not Associated with Risk of Cardiovascular Disease Mortality in Singapore Chinese Adults
Talaei, M., Koh, W., van Dam, R. M., Yuan, J., & Pan, A. (2014) · Journal of Nutrition · doi:10.3945/jn.114.190454 · Cited by 58
Effect of Soy in Men With Type 2 Diabetes Mellitus and Subclinical Hypogonadism – A Randomized Controlled Study
Sathyapalan, T., Rigby, A. S., Bhasin, S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2875 · Cited by 56
Does equol production determine soy endocrine effects?
Shor, D., Sathyapalan, T., Atkin, S. L., & Thatcher, N. J. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0331-7 · Cited by 56
The Potential Toxic Side Effects of Flavonoids
Tang, Z., & Zhang, Q. (2021) · Biocell · doi:10.32604/biocell.2022.015958 · Cited by 54
Systematic review and meta-analysis of soy products consumption in patients with type 2 diabetes mellitus.
Yang, B., Chen, Y., Xu, T., Yu, Y., Huang, T., Hu, X., & Li, D. (2011) · PubMed · Cited by 55
Isoflavones and Prostate Cancer
Zhang, H., Cui, J., Zhang, Y., Wang, Z., Chong, T., & Wang, Z. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.174488 · Cited by 54
Phytoestrogens (Resveratrol and Equol) for Estrogen-Deficient Skin—Controversies/Misinformation versus Anti-Aging In Vitro and Clinical Evidence via Nutraceutical-Cosmetics
Lephart, E. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011218 · Cited by 55
Soy Isoflavones Genistein and Daidzein Exert Anti-Apoptotic Actions via a Selective ER-mediated Mechanism in Neurons following HIV-1 Tat1–86 Exposure
Adams, S. M., Aksenova, M. V., Aksenov, M. Y., Mactutus, C. F., & Booze, R. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037540 · Cited by 52
Development of genomic resources for the narrow-leafed lupin (Lupinus angustifolius): construction of a bacterial artificial chromosome (BAC) library and BAC-end sequencing
Gao, L., Hane, J. K., Kamphuis, L. G., Foley, R. C., Shi, B.-J., Atkins, C. A., & Singh, K. B. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-521 · Cited by 52
The essential role of genetic resources in narrow-leafed lupin improvement
Berger, J. D., Clements, J. C., Nelson, M. N., Kamphuis, L. G., Singh, K. B., & Buirchell, B. J. (2013) · Australian Journal of Agricultural Research · doi:10.1071/cp13092 · Cited by 50
Androgen receptor and soy isoflavones in prostate cancer (Review)
Sivoňov�, M., Kapl�n, P., Tatarkov�, Z., Lichardusov�, L., Dusenka, R., & Jurečekov�, J. (2018) · Molecular and Clinical Oncology · doi:10.3892/mco.2018.1792 · Cited by 49
Soy Bioactive Components in Functional Perspective: A Review
Garg, S., Lule, V. K., Malik, R. K., & Tomar, S. K. (2016) · International Journal of Food Properties · doi:10.1080/10942912.2015.1136936 · Cited by 48
The Role of Nutraceuticals in Male Fertility
Ko, E., & Sabanegh, E. S. (2013) · Urologic Clinics of North America · doi:10.1016/j.ucl.2013.08.003 · Cited by 43
Dietary Soy Intake Is Inversely Associated with Risk of Type 2 Diabetes in Japanese Women but Not in Men
Konishi, K., Wada, K., Yamakawa, M., Goto, Y., Mizuta, F., Koda, S., Uji, T., Tsuji, M., & Nagata, C. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz047 · Cited by 35
The role of soy and soy isoflavones on women’s fertility and related outcomes: An update
Rizzo, G., Feraco, A., Storz, M. A., & Lombardo, M. (2022) · Journal of Nutritional Science · doi:10.1017/jns.2022.15 · Cited by 34
The Soy Isoflavone Genistein Blunts Nuclear Factor Kappa-B, MAPKs and TNF-α Activation and Ameliorates Muscle Function and Morphology in Mdx Mice
Messina, S., Bitto, A., Aguennouz, M., Vita, G. L., Polito, F., Irrera, N., Altavilla, D., Marini, H., Migliorato, A., Squadrito, F., et al. (2011) · Neuromuscular Disorders · doi:10.1016/j.nmd.2011.04.014 · Cited by 33
How Food Choices Impact on Male Fertility
Pecora, G., Sciarra, F., Gangitano, E., & Venneri, M. A. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00503-x · Cited by 33
Phytoestrogens in Human Pregnancy
Jarrell, J. F., Foster, W. G., & Kinniburgh, D. W. (2012) · Obstetrics and Gynecology International · doi:10.1155/2012/850313 · Cited by 33
The relationship between diet, energy balance and fertility in men
Suliga, E., & Głuszek, S. (2019) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000577 · Cited by 32
Sex-specific associations of habitual intake of soy protein and isoflavones with risk of type 2 diabetes
Woo, H. W., Kim, M. K., Lee, Y. H., Shin, D. H., Shin, M., & Choi, B. Y. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.04.035 · Cited by 32
Phenolics in Human Nutrition: Importance of the Intestinal Microbiome for Isoflavone and Lignan Bioavailability
Clavel, T., & Mapesa, J. O. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_94 · Cited by 30
Role of soybean-derived bioactive compounds in inflammatory bowel disease
Juritsch, A. F., & Moreau, R. F. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy021 · Cited by 31
Flavonoids and Related Members of the Aromatic Polyketide Group in Human Health and Disease: Do They Really Work?
Tauchen, J., Huml, L., Rimpelová, S., & Jurášek, M. (2020) · Molecules · doi:10.3390/molecules25173846 · Cited by 30
Human-relevant potency threshold (HRPT) for ERα agonism
Borgert, C. J., Matthews, J. C., & Baker, S. P. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2186-z · Cited by 26
Application of the BRAFO-tiered approach for benefit-risk assessment to case studies on natural foods
Watzl, B., Gelencsér, É., Hoekstra, J., Kulling, S. E., Lydeking-Olsen, E., Rowland, I. R., Schilter, B., van Klaveren, J., & Chiodini, A. M. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.02.010 · Cited by 27
Manipulation of Dietary Intake on Changes in Circulating Testosterone Concentrations
Zamir, A., Ben‐Zeev, T., & Hoffman, J. R. (2021) · Nutrients · doi:10.3390/nu13103375 · Cited by 24
Review: Anti-Oxidant and Anti-Aging Properties of Equol in Prostate Health (BPH)
Lephart, E. D. (2014) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2014.41001 · Cited by 22
Impact of soy consumption on human health: integrative review
Nogueira‐de‐Almeida, C. A., Ferraz, I. S., Ued, F. D. V., Almeida, A. C. F., & Ciampo, L. A. D. (2020) · Brazilian journal of food technology/Brazilian Journal of Food Technology · doi:10.1590/1981-6723.12919 · Cited by 29
Principles of herbal pharmacology
(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00002-5 · Cited by 27
Soy isoflavone consumption and age at pubarche in adolescent males
Segovia‐Siapco, G., Pribis, P., Oda, K., & Sabaté, J. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1504-1 · Cited by 21
Phytoestrogen biomonitoring: an extractionless LC-MS/MS method for measuring urinary isoflavones and lignans by use of atmospheric pressure photoionization (APPI)
Parker, D. L., Rybak, M. E., & Pfeiffer, C. M. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5550-x · Cited by 20
The Effect of Soy Isoflavones on Steroid Metabolism
Swart, A. C., Johannes, I. D., Sathyapalan, T., & Atkin, S. L. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00229 · Cited by 18
Effective Anti-aging Strategies in an Era of Super-aging
Park, S., Yang, M.-J., Ha, S.-N., & Lee, J. (2014) · Journal of Menopausal Medicine · doi:10.6118/jmm.2014.20.3.85 · Cited by 18
The chronic alcohol consumption influences the gonadal axis in men: Results from a meta‐analysis
Santi, D., Cignarelli, A., Baldi, M., Sansone, A., Spaggiari, G., Simoni, M., & Corona, G. (2024) · Andrology · doi:10.1111/andr.13526 · Cited by 17
Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants
Martin, L. J., & Touaibia, M. (2024) · Nutrients · doi:10.3390/nu16121815 · Cited by 16
Regulation of the neuroendocrine axis in male rats by soy-based diets is independent of age and due specifically to isoflavone action†
Jeminiwa, B. O., Knight, R. M., Braden, T. D., Cruz‐Espindola, C., Boothe, D. M., & Akingbemi, B. T. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa101 · Cited by 18
Phytoestrogens as Pharma Foods
Gupta, C., Prakash, D., & Gupta, S. L. (2016) · Advanced in Food Technology and Nutritional Sciences - Open Journal · doi:10.17140/aftnsoj-2-127 · Cited by 16
The effects of tamoxifen and soy on dark neuron production in hippocampal formation after pentylenetetrazole-induced repeated seizures in rats
Ebrahimzadeh‐Bideskan, A., Ataei, M. L., Mansouri, S., & Hosseini, M. (2015) · Pathophysiology · doi:10.1016/j.pathophys.2015.04.001 · Cited by 15
Secondary Hypogonadism due to Excessive Ingestion of Isoflavone in a Man
Imai, H., Nishikawa, H., Suzuki, A., Kodama, E., Iida, T., Mikura, K., Hashizume, M., Kigawa, Y., Tadokoro, R., Sugisawa, C., et al. (2022) · Internal Medicine · doi:10.2169/internalmedicine.8578-21 · Cited by 15
The relationship between plant and animal based protein with semen parameters: A cross-sectional study in infertile men
Abdollahi, N., Nouri, M., Leilami, K., Mustafa, Y. F., & Shirani, M. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.03.019 · Cited by 13
Sociodemographic and Lifestyle Variables Are Compound- and Class-Specific Correlates of Urine Phytoestrogen Concentrations in the U.S. Population
Rybak, M. E., Sternberg, M., & Pfeiffer, C. M. (2013) · Journal of Nutrition · doi:10.3945/jn.112.172981 · Cited by 12
Impact of 18-Month Soy Protein Supplementation on Steroid Hormones and Serum Biomarkers of Angiogenesis, Apoptosis, and the Growth Hormone/IGF-1 Axis: Results of a Randomized, Placebo-Controlled Trial in Males Following Prostatectomy
Bosland, M. C., Huang, J. H., Schlicht, M. J., Enk, E., Xie, H. W., & Kato, I. (2021) · Nutrition and Cancer · doi:10.1080/01635581.2020.1870706 · Cited by 12
Exploring the Soyfood Controversy
Messina, M. J., & Messina, V. (2013) · Nutrition Today · doi:10.1097/nt.0b013e31828fff54 · Cited by 11
Self-citation
Does soy protein affect circulating levels of unbound IGF-1?
Messina, M. J., & Magee, P. J. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1459-2 · Cited by 11
Self-citation
Gender Differences in Protein Consumption and Body Composition: The Influence of Socioeconomic Status on Dietary Choices
Lombardo, M. (2025) · Foods · doi:10.3390/foods14050887 · Cited by 11
How Food Intakes Modify Testosterone Level
Terrier, J., & Isidori, A. M. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.07.001 · Cited by 10
Determination of S- and/or R-equol in plant-based food products and efficacy of topical or oral 4′,7-isoflavandiol (R/S equol) to improve skin health in adult men, a Placebo-controlled pilot study
Lephart, E. D. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104563 · Cited by 10
Combined effects of urinary phytoestrogens metabolites and polymorphisms in metabolic enzyme gene on idiopathic male infertility
Qin, Y., Du, G., Chen, M., Hu, W., Lu, C., Wu, W., Hang, B., Zhou, Z., Wang, X., & Xia, Y. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1205-y · Cited by 10
Isoflavones: toxicological aspects and efficacy
Esch, H. L., & Lehmann, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00045-8 · Cited by 9
Potential Intervention Targets in Utero and Early Life for Prevention of Hormone Related Cancers
Schooling, C. M., Houghton, L. C., & Terry, M. B. (2016) · PEDIATRICS · doi:10.1542/peds.2015-4268e · Cited by 9
Long time exposure to soy/isoflavone-rich diet enhances testicular and prostate health in Long-Evans rats
Blake, C., Hansen, T., Simmons, T. C., & Lephart, E. D. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.04.009 · Cited by 8
Soy Protein Isolate Suppresses Bone Resorption and Improves Trabecular Microarchitecture in Spontaneously Hyperphagic, Rapidly Growing Male OLETF Rats
Dirkes, R. K., Richard, M. W., Meers, G. M.-E., Butteiger, D. N., Krul, E. S., Thyfault, J. P., Rector, R. S., & Hinton, P. S. (2018) · Current Developments in Nutrition · doi:10.1093/cdn/nzy010 · Cited by 8
Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé
Chevalier, D., Debeuf, C., Joubrel, G., Kocken, M., & Planchenault, N. (2016) · OCL · doi:10.1051/ocl/2016025 · Cited by 6
Environment-wide association study to comprehensively test and validate associations between nutrition and lifestyle factors and testosterone deficiency: NHANES 1988–1994 and 1999–2004
López, D. S., Wulaningsih, W., Tsilidis, K. K., Baillargeon, J., Williams, S., Urban, R. J., & Rohrmann, S. (2020) · HORMONES · doi:10.1007/s42000-020-00179-w · Cited by 7
Isoflavones
Esch, H. L., Kleider, C., Scheffler, A., & Lehmann, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00034-6 · Cited by 6
Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis
Ronis, M. J. J., Gómez-Acevedo, H., Shankar, K., Sharma, N., Blackburn, M. L., Singhal, R., Mercer, K. E., & Badger, T. M. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218771333 · Cited by 5
If we eat soy, do we keep the beneficial effects of the Mediterranean diet?
Aulisa, G., Binda, C., Padua, E., Pratesi, A., Bellia, A., Bellia, C., & Lombardo, M. (2020) · Nutrition & Food Science · doi:10.1108/nfs-10-2019-0322 · Cited by 5
Antioxidant Treatment and Prevention of Human Sperm DNA Fragmentation: Role in Health and Fertility
Abad, C., Frau, J. G., Hannaoui, N., & García-Peiró, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800872-0.00035-4 · Cited by 5
Potential beneficial effects of oral administration of isoflavones in patients with chronic mountain sickness
Cui, J., GAO, L., Hai-jun, Y., Wang, F., Jiang, C., & Gao, Y. (2013) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2013.1388 · Cited by 4
The association between soy consumption and metabolic syndrome in Chinese adults: a cross-sectional study
Hidayat, K., Huang, Y., Qian, X., Chen, X., Yu, L., Zhou, H., & Qin, L. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1637413 · Cited by 4
Symposium on Plant Polyphenols: Nutrition, Health and Innovations, June 2009
Chang, A. S., Yeong, B.-Y., & Koh, W. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00283.x · Cited by 4
Consumption of soy isoflavones during the prepubertal phase delays puberty and causes hypergonadotropic hypogonadism with disruption of hypothalamic-pituitary gonadotropins regulation in male rats
Oliveira, J. M., de Oliveira, I. M., Sleiman, H. K., Forno, G. O. D., Romano, M. A., & Romano, R. M. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.08.004 · Cited by 3
Urinary equol is associated with bioavailable testosterone but not total testosterone in women
Dong, H., Xiong, F., Zhong, Q.-W., Li, Y.-H., Liu, M., Ling, W., Tang, X., & Chen, Y. (2019) · Endocrine Journal · doi:10.1507/endocrj.ej19-0319 · Cited by 3
Evidence does not support the conclusion that soy is an endocrine disruptor
Messina, M. J. (2011) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2011.271 · Cited by 3
Self-citation
The Impact of Soy Products and Isoflavones on Male Reproductive Hormones: A Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials
Rajaie, S. H., Mohseni‐Takalloo, S., Sadeghi, O., & Hashempur, M. H. (2025) · Food Frontiers · doi:10.1002/fft2.70090 · Cited by 2
Modification of milk protein concentrate and applicability in high-protein nutrition bars
Banach, J. C. (2012) · doi:10.31274/etd-180810-1397 · Cited by 2
Sex-specific associations between dietary legume subtypes and type 2 diabetes in a prospective cohort study
Woo, H. W., Hong, S., Shin, M., Koh, S. B., Kim, H. C., Kim, Y., & Kim, M. K. (2024) · Epidemiology and Health · doi:10.4178/epih.e2024083 · Cited by 1
Associations of dietary patterns and lower urinary tract symptoms (LUTS) in Korean adults
Lim, J.-S., Hwang, W., Kim, J. K., Kim, M., Kwon, O., Han, S., Oh, B., & Kim, J. S. (2025) · Nutrition Research and Practice · doi:10.4162/nrp.2025.19.2.318 · Cited by 1
Nutritional Value of Grain Legumes in Relation for Global Food Security
Січкар, В. І. (2025) · Acta fytotechnica et zootechnica/Acta fytotechnica et zootechnica · doi:10.15414/afz.2025.28.01.40-51 · Cited by 1
Soybean Phytoestrogens – Friends or Foes?
Šošić‐Jurjević, B., Filipovi, B., & SEKULI, M. I. (2011) · InTech eBooks · doi:10.5772/19078 · Cited by 1
Queer, Toxic Soybeans and Estrogen Panic: Gendered Food Fearmongering
Vaughn, R. (2022) · Media+Environment · doi:10.1525/001c.37271 · Cited by 1
Impact of Soybean Phytoestrogen-Rich Extract on Hormonal Imbalance and Ovarian Function in Menopausal Rat Induced with 4-Vinylcyclohexene Diepoxide: A Neglected Naturaceutical
Olaniyan, S. O., Abiodun, E. M., Oyakhire, F. O., Olaniyan, O., Juliana, E., Uwumarongie, O. H., Ugege, C. O., Kelly, E. I., & Efenarhua, S. (2024) · Scholars Journal of Applied Medical Sciences · doi:10.36347/sjams.2024.v12i04.013 · Cited by 1
Prostate cancer chemoprevention in men of African descent: current state of the art and opportunities for future research
Chornokur, G., & Kumar, N. B. (2013) · Cancer Causes & Control · doi:10.1007/s10552-013-0241-x · Cited by 1
Isoflavones
Frankenfeld, C. L. (2020) · doi:10.1002/9781119563754.ch6 · Cited by 1
Letters to the Editor
Messina, M. J., Melby, M. K., Kronenberg, F., Kurzer, M. S., & Taku, K. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318284e64a · Cited by 1
Self-citation

Authors: Hamilton-Reeves, J. M., Vazquez, G., Duval, S. J., Phipps, W. R., Kurzer, M. S., & Messina, M. J.
Affiliations: University of Minnesota (US)
University of Rochester Medicine (US)
Loma Linda University (US)
ORCID: Duval, Sue J.
Kurzer, Mindy S.
Messina, Mark J.
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2010-08
Volume: 94
Issue: 3
Pages: 997-1007
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2009.04.038
OpenAlex: W1971875705
Cited by: 115
References: 74
Citations by year: 2026: 1 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 12 · 2015: 3 · 2014: 4 · 2013: 17 · 2012: 5
FWCI: 0.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4317 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: soy protein, isoflavones, phytoestrogens, genistein, red clover, testosterone, sex hormone-binding globulin, free testosterone, free androgen index, bioavailable testosterone, men, reproductive hormones, dietary supplementation
MeSH terms: Adult, Algorithms, Clinical Trials as Topic, Humans, Isoflavones, Male, Reproduction, Sex Factors, Treatment Outcome, Soybean Proteins, Gonadal Hormones

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks