Cited by 115Phytoestrogen effects and researchEstrogen and related hormone effectsHormonal and reproductive studies

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Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis

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Hamilton-Reeves, Jill M., Vazquez, Gabriela, Duval, Sue J., Phipps, William R., Kurzer, Mindy S., Messina, Mark J.·2010·Fertility and Sterility

DOI 10.1016/j.fertnstert.2009.04.038

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Abstract

Objective To determine whether isoflavones exert estrogen-like effects in men by lowering bioavailable T through evaluation of the effects of soy protein or isoflavone intake on T, sex hormone-binding globulin (SHBG), free T, and free androgen index (FAI) in men.Design PubMed and CAB Abstracts databases were searched through July 1, 2008, with use of controlled vocabulary specific to the databases, such as soy, isoflavones, genistein, phytoestrogens, red clover, androgen, testosterone, and SHBG. Peer-reviewed studies published in English were selected if [1] adult men consumed soy foods, isolated soy protein, or isoflavone extracts (from soy or red clover) and [2] circulating T, SHBG, free T, or calculated FAI was assessed. Data were extracted by two independent reviewers. Isoflavone exposure was abstracted directly from studies.Main outcome measure(s) Fifteen placebo-controlled treatment groups with baseline and ending measures were analyzed. In addition, 32 reports involving 36 treatment groups were assessed in simpler models to ascertain the results.Result(s) No significant effects of soy protein or isoflavone intake on T, SHBG, free T, or FAI were detected regardless of statistical model.Conclusion(s) The results of this meta-analysis suggest that neither soy foods nor isoflavone supplements alter measures of bioavailable T concentrations in men.

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Authors: Hamilton-Reeves, J. M., Vazquez, G., Duval, S. J., Phipps, W. R., Kurzer, M. S., & Messina, M. J.
Affiliations: University of Minnesota (US)
University of Rochester Medicine (US)
Loma Linda University (US)
ORCID: Duval, Sue J.
Kurzer, Mindy S.
Messina, Mark J.
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2010-08
Volume: 94
Issue: 3
Pages: 997-1007
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2009.04.038
OpenAlex: W1971875705
Cited by: 115
References: 74
Citations by year: 2026: 1 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 12 · 2015: 3 · 2014: 4 · 2013: 17 · 2012: 5
FWCI: 0.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4317 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: soy protein, isoflavones, phytoestrogens, genistein, red clover, testosterone, sex hormone-binding globulin, free testosterone, free androgen index, bioavailable testosterone, men, reproductive hormones, dietary supplementation
MeSH terms: Adult, Algorithms, Clinical Trials as Topic, Humans, Isoflavones, Male, Reproduction, Sex Factors, Treatment Outcome, Soybean Proteins, Gonadal Hormones

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Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis

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