Cited by 47Sirtuins and Resveratrol in MedicineGut microbiota and healthPhytochemicals and Antioxidant Activities

Distinctive anti-inflammatory effects of resveratrol, dihydroresveratrol, and 3-(4-hydroxyphenyl)-propionic acid on DSS-induced colitis in pseudo-germ-free mice

Zhang, Bowei, Zhang, Yunhui, Liu, Xiaoxia, Zhao, Congying, Yin, Jia, Li, Xiang, Zhang, Xuejiao, Wang, Jin +1 more·2023·Food Chemistry

Abstract

Resveratrol is a dietary polyphenol that interacts with gut microbiota to possess various biological activities. To identify the microbial metabolites of resveratrol, fresh feces from 12 volunteers were cultured in vitro. Their urine samples were collected after taking a commercial capsule containing 600 mg of resveratrol. Metabolites were characterized and quantified by UPLC-Q-Exactive plus orbitrap MS/MS. The results showed that dihydroresveratrol, 3-(4-hydroxyphenyl)-propionic acid, and lunularin were the major microbial metabolites of RSV with interindividual differences. 3-(4-Hydroxyphenyl)-propionic acid significantly attenuated the inflammatory response of LPS-treated RAW264.7 cells and DSS-induced colitis in antibiotics-treated pseudo-germ-free mice by regulating MAPK and NF-κB pathways. In contrast, dihydroresveratrol did not exhibit significant anti-inflammatory effects, and lunularin exhibited pro-inflammatory effects in cells. This study may help to better understand the health effects of resveratrol and its microbial metabolites.

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Crossref · 10.1016/j.foodchem.2022.133904

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Authors
Zhang, B., Zhang, Y., Liu, X., Zhao, C., Yin, J., Li, X., Zhang, X., Wang, J., & Wang, S.
Affiliations
Nankai University (CN)
Corresponding author
  • Wang, Jin
  • Wang, Shuo
Venue
Food Chemistry
Publisher
Elsevier BV
Published
2023-01
Volume
400
Pages
133904
ISSN
0308-8146 (ISSN-L)
OpenAlex
W4293860862
Cited by
47
References
55
Citations by year
2026: 9 · 2025: 15 · 2024: 14 · 2023: 7 · 2022: 2
FWCI
5.26
Type
journal article
Language
en
Open access
closed
Locations
  • Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (32101962)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
resveratrol, 3-(4-hydroxyphenyl)propionic acid, gut microbiota, microbial metabolites, DSS-induced colitis, anti-inflammatory activity, NF-κB signaling, MAPK signaling, RAW 264.7 macrophages, lipopolysaccharide-induced inflammation, interindividual variability
MeSH terms
Resveratrol, Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Bibenzyls, Colitis, Lipopolysaccharides, Mice, Inbred C57BL, Phenols, Phenylpropionates, Propionates, Stilbenes, Dextran Sulfate, NF-kappa B, Mice, Tandem Mass Spectrometry, Polyphenols

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