Interaction of dietary resveratrol with animal-associated bacteria
Abstract
Resveratrol (3,5,4'-trihydroxy-trans-stilbene), an antifungal phytoalexin produced by grapes, peanuts, and Japanese knotweeds, is thought to be a beneficial dietary phytochemical in red wine and grape juice. Information on its antibacterial properties and biotransformation, however, is limited. We surveyed the interactions of resveratrol with 43 strains of bacterial species that are often animal- or human-associated. Resveratrol at 50 mg L(-1) reduced the growth rates of most of the bacteria tested, but did not totally prevent growth even at much higher levels. Eleven of the 43 bacteria were capable of transforming at least 20% of the resveratrol. Three major metabolites were identified as resveratroloside, piceid, and dihydroresveratrol, and three other metabolites were partially characterized.
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Resveratrol consumption can significantly modulate the growth of certain gut microbiota in vivo, including increasing the Bacteroidetes-to-Firmicutes ratio and the growth of Bacteroides, Lactobacillus, and Bifidobacterium.
“Moreover, it has been found that RSV consumption can significantly modulate the growth of certain gut microbiota in vivo, including increasing the Bacteroidetes-to-Firmicutes ratios, and the growth of Bacteroides, Lactobacillus, and Bifidobacterium (18–22).”
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- Authors
- Jung, C. M., Heinze, T. M., Schnackenberg, L. K., Mullis, L. B., Elkins, S. A., Elkins, C. A., Steele, R. S., & Sutherland, J. B.
- Affiliations
- United States Army (US)
- National Center for Toxicological Research (US)
- Center for Food Safety and Applied Nutrition (US)
- Corresponding author
- Sutherland, John B.
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08
- Volume
- 297
- Issue
- 2
- Pages
- 266-273
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W2069391842
- Cited by
- 86
- References
- 38
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 14 · 2020: 8 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 2 · 2012: 3
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEMS Microbiology Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- Oak Ridge Institute for Science and Education
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- resveratrol, antibacterial activity, bacterial biotransformation, resveratrol metabolites, piceid, phytochemicals, animal-associated bacteria
- MeSH terms
- Resveratrol, Animals, Bacteria, Biotransformation, Humans, Stilbenes
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