Cited by 431Probiotics and Fermented FoodsProtein Hydrolysis and Bioactive PeptidesMicrobial Metabolites in Food Biotechnology

The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.

Postbiotics and paraprobiotics: From concepts to applications

Cuevas-González, P.F., Liceaga, A.M., Aguilar-Toalá, J.E.·2020·Food Research International

DOI 10.1016/j.foodres.2020.109502

Open this paper in CoChat — free account

Abstract

In recent years, new probiotic-related concepts such as postbiotics and paraprobiotics have been used to describe non-viable microorganisms or bacterial-free extracts that may provide benefits to the host by offering bioactivities additional to probiotics. However, several aspects related to these postbiotics and paraprobiotics bioactivities remain unexplored or are poorly understood. Therefore, the aim of this work is to provide an overview of the general aspects and emerging trends of postbiotics and paraprobiotics, such as conceptualization of terms, production, characterization, bioactivities, health-promoting effects, bioengineering approaches, and applications. In vitro and in vivo studies have demonstrated that some postbiotics and paraprobiotics exhibit bioactivities such as anti-inflammatory, immunomodulatory, anti-proliferative, antioxidant, and antimicrobial. These bioactivities could be involved in health-promoting effects observed in human and clinical trials, but despite the scientific evidence available, the mechanisms of action and the signaling pathways involved have not been fully elucidated. Nevertheless, paraprobiotics and postbiotics possess valuable potential for the development of biotechnological products with functional ingredients for the nutraceutical industry.

Integrity signals

Registry

Crossref · 10.1016/j.foodres.2020.109502

Cites

109 of 109 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592
Probiotics, gut microbiota, and their influence on host health and disease
Sánchez, B., Delgado, S., Blanco‐Míguez, A., Lourenço, A., Gueimonde, M., & Margolles, A. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600240 · Cited by 1,104
Postbiotics: An Evolving Term within the Functional Foods Field
Aguilar-Toalá, J. E., Garcia-Varela, R., Garcia, H. S., Mata-Haro, V., González-Córdova, A. F., Vallejo-Cordoba, B., & Hernández-Mendoza, A. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.03.009 · Cited by 1,078
Self-citation
The Prolongation of Life: Optimistic Studies
Metchnikoff, É. (2003) · Cited by 874
Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities
Amaretti, A., Nunzio, M. D., Pompei, A., Raimondi, S., Rossi, M., & Bordoni, A. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4241-7 · Cited by 532
Paraprobiotics: Evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods
de Almada, C. N., de Almada, C. N., Martinez, R. C. R., & Sant’Ana, A. S. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.09.011 · Cited by 425
Paraprobiotics and postbiotics: Concepts and potential applications in dairy products
Barros, C. P., Guimarães, J. T., Esmerino, E. A., Duarte, M. C. K., Silva, M. C., Silva, R., Ferreira, B. M., Sant’Ana, A. S., Freitas, M. Q., & Cruz, A. G. (2020) · Current Opinion in Food Science · doi:10.1016/j.cofs.2019.12.003 · Cited by 345
Lactobacillus casei Exerts Anti-Proliferative Effects Accompanied by Apoptotic Cell Death and Up-Regulation of TRAIL in Colon Carcinoma Cells
Tiptiri-Kourpeti, A., Spyridopoulou, K., Santarmaki, V., Aindelis, G., Tompoulidou, E., Lamprianidou, E., Saxami, G., Ypsilantis, P., Lampri, E. S., Simopoulos, C. E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147960 · Cited by 327
A Novel Postbiotic From Lactobacillus rhamnosus GG With a Beneficial Effect on Intestinal Barrier Function
Gao, J., Li, Y., Wan, Y., Hu, T., Liu, L., Yang, S., Gong, Z., Zeng, Q., Wei, Y., Yang, W., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00477 · Cited by 311
Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood
Penders, J., Gerhold, K., Stobberingh, E. E., Thijs, C. T., Zimmermann, K., Lau, S., & Hamelmann, E. H. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.05.043 · Cited by 304

Show all 109 references

Research works printed but not linked: 1

Ray, 2010, Cell wall lysed probiotic tincture decreases immune response to pathogenic enteric bacteria and improves symptoms in autistic and immune compromised children, Explore, 19, 1

Sorted by citations

Items 201–300 of 429

Exploring the health-promoting potential: Dietary intervention with live or inactivated Lactobacillus gasseri HM1 probiotics in obese mice
Shiu, W.-C., Chen, B.-Y., Ku, Y.-W., & Chen, P. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106129 · Cited by 9
Akkermansia muciniphila postbiotic administration mitigates choline-induced plasma Trimethylamine-N-Oxide production in mice
Xu, H., Bian, X., Wang, H., Huang, L., & Chen, X. (2024) · Applied Biological Chemistry · doi:10.1186/s13765-024-00905-7 · Cited by 9
Pre- to Postbiotics: The Beneficial Roles of Pediatric Dysbiosis Associated with Inflammatory Bowel Diseases
Ottria, R., Xynomilakis, O., Casati, S., & Ciuffreda, P. (2024) · Microorganisms · doi:10.3390/microorganisms12081582 · Cited by 9
Paraprobiotics and postbiotics from the probiotic Streptococcus lutetiensis isolated from Indian fermented food demonstrates immunomodulatory potential
Mehta, J. P., Sahoo, P., Ayakar, S. R., & Singhal, R. S. (2025) · The Microbe · doi:10.1016/j.microb.2025.100304 · Cited by 9
Exploring the potential of lactic acid bacteria to produce postbiotics with antimicrobial and antioxidant properties: focus on the probiotic strain Pediococcus pentosaceus RC007 for industrial-scale production
Cavaglieri, L. A. R., Isgro, M. C., Aminahuel, C. A., Parada, J., Poloni, V. L., Montenegro, M. A., Alonso, V., Falcone, R. D., & Cavaglieri, L. R. (2025) · International Journal of Food Science & Technology · doi:10.1093/ijfood/vvae003 · Cited by 9
Lacticaseibacillus rhamnosus HF01 postbiotics reprogram gut microbial tryptophan metabolism to coordinate enterohepatic barrier-insulin signaling axis
Sun, Y., Liu, X., Zhao, L., Li, D., Guan, K., Ma, Y., Wang, R., & Li, Q. (2025) · Current Research in Food Science · doi:10.1016/j.crfs.2025.101111 · Cited by 13
From Probiotic to Postbiotic: Conversion of Acerola Juice by Thermosonication
do Nascimento, C. S., Santos, B. N., Fonteles, T. V., & Rodrigues, S. (2025) · Processes · doi:10.3390/pr13072122 · Cited by 9
Effects of Postbiotic Administration on Canine Health: A Systematic Review and Meta-Analysis
Bonel-Ayuso, D. P., Pineda‐Pampliega, J., García, P. M., Fernández-Muela, M., la Fuente, J. D., Fernandez, P. M. G., & Redondo, B. I. (2025) · Microorganisms · doi:10.3390/microorganisms13071572 · Cited by 11
Promoting Aquatic Animal Health and Water Quality: A Systematic Review on Probiotics, Prebiotics and Synbiotics in Aquaculture
Wen, Y., Wang, M., Wang, H., Liu, S., Xing, R., Zhang, H., Chen, L., Li, R., & Yu, Z. (2026) · Fishes · doi:10.3390/fishes11030174 · Cited by 12
Lactic acid bacteria fermented foods: Impact on immune system and consequences over type 2 diabetes mellitus
Ahmad, R., Nnamdi, O. A., Etando, A., Sharma, P., Sinha, S., Chowdhury, K., Rowaiye, A. B., Akter, S., Mou, T. J., Dhingra, S., et al. (2023) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2023.142387 · Cited by 12
Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells
Wang, X., Zhang, Y., Wang, D., Su, N., Li, Y., Fu, H., Zhang, J., Li, M., & Wang, C. (2023) · Bioresources and Bioprocessing · doi:10.1186/s40643-023-00678-9 · Cited by 9
A Critical Analysis of Postbiotics: Exploring their Potential Impact on the Health and Food Industries
Babu, A. S., Guruprasath, N., Adeyeye, S. A. O., Sankarganesh, P., Kumar, A. G., & Sivapriya, T. (2023) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.17.4.18 · Cited by 8
A Novel Handrub Tablet Loaded with Pre- and Post-Biotic Solid Lipid Nanoparticles Combining Virucidal Activity and Maintenance of the Skin Barrier and Microbiome
Machado, A. C. H. R., Marinheiro, L. J., Benson, H. A., Grice, J. E., Martins, T. S., Lan, A., Lopes, P. S., Andréo‐Filho, N., & Leite‐Silva, V. R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122793 · Cited by 8
Improvement of the immunological and antioxidant capacity of rainbow trout (Oncorhynchus mykiss) by using the paraprobiotic Bacillus subtilis subsp. spizizenii
Neissi, A., Heidarieh, M., Shahhosseini, G., Majidi-Zahed, H., & Kalantari‐Hesari, A. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102304 · Cited by 8
Bioprotective and Functional Activities of Postbiotics From Lactic Acid Bacteria Derived From Artisanal Dairy Products
Tariq, A., Tahran, M. N., & Ozturkoglu‐Budak, S. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70647 · Cited by 8
Probiotics, Prebiotics and Synbiotics for Combating Antimicrobial Resistance in the Food Chain
Vesković-Moračanin, S. M., Danilović, B., Milijašević, M., Milijašević, J. B., Tambur, Z., & Moračanin, M. (2025) · Processes · doi:10.3390/pr13113483 · Cited by 10
Postbiotics as Emerging Therapeutics for Skin Wound Healing and Dermatological Care: Clinical Trends and Mechanistic Insights
Hashemi, S., Rafati, A., Roohinejad, S., Yaghoobi, F., & Salehi, A. (2025) · International Wound Journal · doi:10.1111/iwj.70799 · Cited by 8
The effect of Bacteroides fragilis and its postbiotics on the expression of genes involved in the endocannabinoid system and intestinal epithelial integrity in Caco-2 cells
Malek, A., Badi, S. A., Karimi, G., Bizouarn, T., Irian, S., & Siadat, S. D. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01264-8 · Cited by 8
Safety considerations in the use of nonviable microbial cells as health-promoting agents in food and dietary supplements
Guglielmetti, S. (2023) · Current Opinion in Food Science · doi:10.1016/j.cofs.2023.101105 · Cited by 8
Role of Nutribiotics in Skin Care
Mourelle, M. L., Gómez, C. P., Legido, J. L., & Pereira, L. (2024) · Applied Sciences · doi:10.3390/app14083505 · Cited by 8
The high-throughput solid-phase extraction of cis-cyclo(L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) from Lactobacillus plantarum demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus
Son, J., Hong, Y., Seong, H., Oh, Y. S., & Kwak, M. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1346598 · Cited by 9
Assessment of the Biological Activity of a Probiotic Fermented Milk Product with the Addition of Lactobacillus helveticus Cell-Free Supernatant
Kishilova, S. A., Рожкова, И. В., Kolokolova, A. Y., Yurova, E., Leonova, V. A., & Mitrova, V. A. (2024) · Fermentation · doi:10.3390/fermentation10100503 · Cited by 8
Probiotics: current regulatory aspects of probiotics for use in different disease conditions
Pogačar, M. Š., Mičetić‐Turk, D., & Fijan, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00021-0 · Cited by 9
Feed Ingredients for Sustainable Aquaculture
McLean, E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823960-5.00085-8 · Cited by 8
Role of Surface Coverage of Sessile Probiotics in Their Interplay with Pathogen Bacteria Investigated by Digital Holographic Microscopy
He, X., Zhang, W., Feng, P., Mai, Z., Gong, X., & Zhang, G. (2023) · Langmuir · doi:10.1021/acs.langmuir.3c02436 · Cited by 8
Co-administration of the prebiotic 1-kestose and the paraprobiotic Lactiplantibacillus plantarum FM8 in magellanic penguins promotes the activity of intestinal Lactobacillaceae and reduces the plc gene levels encoding Clostridium perfringens toxin
Fujii, T., Kezuka, C., KAWAGUCHI, Y., Yamakawa, S., KONDO, N., Funasaka, K., Hirooka, Y., & Tochio, T. (2024) · Journal of Veterinary Medical Science · doi:10.1292/jvms.23-0238 · Cited by 8
Effect of Bacteriocin-Like Inhibitory Substance (BLIS) from Enterococcus faecium DB1 on Cariogenic Streptococcus mutans Biofilm Formation
Kim, N.-N., Kim, B. S., Lee, H. B., An, S., Kim, D.-H., & Kang, S. (2022) · Food Science of Animal Resources · doi:10.5851/kosfa.2022.e49 · Cited by 7
Lactiplantibacillus plantarum 299V fermented in microcapsules shows enhanced stability and could improve the microbial quality and safety of oysters through bioaccumulation
Hua, Q., & Li, D. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17406 · Cited by 7
Functional and Safety Profile of Limosilactobacillus vaginalis and Development of Oral Fast-Disintegrating Tablets for Gut Microbiota Modulation
Giordani, B., Monti, F., Corazza, E., Gasperini, S., Parolin, C., Abruzzo, A., Foschi, C., Marangoni, A., Lenzi, M., Luppi, B., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081011 · Cited by 7
Postbiotics derived from recombinant lactic acid bacteria exhibit high IL6-binding capacity and suppress IL6-induced STAT3 signaling
Zahirović, A., Zupančič, Š., Verdir, A., Nemec, S., Kralj, S., Snoj, L., & Berlec, A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1657810 · Cited by 7
Innovative postbiotic-chia seed mucilage packaging to extend ostrich meat quality and shelf life: development and Support Vector Regression (SVR) modeling of quality parameters
Abadi, B. G. S., Hojjati, M., Jooyandeh, H., Behbahani, B. A., Vasiee, A., & Taki, M. (2026) · Food Production Processing and Nutrition · doi:10.1186/s43014-026-00369-w · Cited by 7
The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics
Monzani, R., Gagliardi, M., Clemente, N., Saverio, V., Pańczyszyn, E., Santoro, C., Yissachar, N., Visciglia, A., Pane, M., Amoruso, A., et al. (2022) · Biology · doi:10.3390/biology11111574 · Cited by 7
A REVIEW OF POSTBIOTICS AS NEW HEALTH PROMOTERS
PRISTAVU, M. C., DIGUTA, C. F., Coulibaly, W. H., FANCHE, S. A. Y., Dopcea, G. N., & MATEI, F. (2022) · AgroLife Scientific Journal · doi:10.17930/agl2022219 · Cited by 8
Microalgal and Cyanobacterial Biomasses Modified the Activity of Extracellular Products from Bacillus pumilus: An In Vitro and In Vivo Assessment
García‐Márquez, J., Galafat, A., Molina-Roque, L., Domínguez‐Maqueda, M., Heras, V. D. L., Simó‐Mirabet, P., Vizcaíno, A. J., Martos-Sitcha, J. A., Alarcón, F. J., Moríñigo, M. Á., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10350-z · Cited by 7
iTRAQ‐based quantitative proteomic analysis of the effect of heat shock on freeze‐drying of Lactobacillus acidophilus ATCC4356
Liu, M., Zeng, X., He, Y., Xia, C., Cheng, L., Wu, Z. F., Lan, H., & Pan, D. (2021) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15101 · Cited by 7
Extractable surface proteins of indigenous probiotic strains confer anti-adhesion knack and protect against methicillin-resistant Staphylococcus aureus induced epithelial hyperpermeability in HT-29 cell line
Nataraj, B. H., Ramesh, C., & Mallappa, R. H. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.104974 · Cited by 7
Antibacterial Effect of Eight Probiotic Strains of Bifidobacterium against Pathogenic Staphylococcus aureus and Pseudomonas aeruginosa
Choi, Y. J., & Shin, H. S. (2021) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2021.51.3.128 · Cited by 7
Bacillus amyloliquefaciens Lysate Ameliorates Photoaging of Human Skin Fibroblasts through NRF2/KEAP1 and TGF-β/SMAD Signaling Pathways
Zhang, Y., Zhao, J., Jiang, Y., Wang, D., Zhao, D., Wang, C., & Li, M. (2022) · Applied Sciences · doi:10.3390/app12189151 · Cited by 7
POSTBIOTICS: A SOLUTION TO PROTECT TROPICAL FRUITS TOWARDS POSTHARVEST ADULTERATION
Tenea, G. N. (2021) · AgroLife Scientific Journal · doi:10.17930/agl2021223 · Cited by 7
Exopolysaccharides from Lactic Acid Bacteria: A Review on Functions, Biosynthesis and Applications in Food Industry
Erdem, T. K., Tatar, H. D., Ayman, S., & Gezginç, Y. (2023) · Turkish Journal of Agriculture - Food Science and Technology · doi:10.24925/turjaf.v11i2.414-423.5213 · Cited by 9
Lactobacillus rhamnosus improves feed intake, condition factors, hepatic and intestinal histomorphometric indexes of dourado Salminus brasiliensis
Oliveira, F. C., de Almeida, P. R., Almeida, R. G. D. S., Owatari, M. S., Pilarski, F., Fernandes, C. E., & de Campos, C. M. (2024) · Aquaculture International · doi:10.1007/s10499-024-01400-y · Cited by 9
Probiotics: Concepts, evolution, and applications
Sampaio, K. B., Fusco, V., Alves, J. L. D. B., & de Souza, E. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89908-6.00019-4 · Cited by 7
In Vitro Analysis of Probiotic Properties Related to the Adaptation of Levilactobacillus brevis to Intestinal Microenvironment and Involvement of S-Layer Proteins
Čuljak, N., Bendelja, K., Pavunc, A. L., Butorac, K., Banić, M., Mlakar, A. S., Cvetić, Ž., Hrsan, J., Novak, J., Šušković, J., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062425 · Cited by 7
Biosynthesis of a novel antimicrobial brevicidine as potential food biopreservative from Brevibacillus laterosporus 811 and its anti-infection effect against Escherichia coli and Salmonella
Ma, Y., Huang, S., Yang, G., Peng, S., Qi, R., Dong, B., Qiao, S., Zeng, X., & Yu, H. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106937 · Cited by 6
Postbiotics of Marine Origin and Their Therapeutic Application
Cerezo, I. M., Pérez‐Gómez, O., Rohra-Benítez, S., Domínguez‐Maqueda, M., García‐Márquez, J., & Arijo, S. (2025) · Marine Drugs · doi:10.3390/md23090335 · Cited by 7
Perspectives on the role of postbiotics in meat and meat products: Current status and future trends
Jin, D., Zou, G.-P., Liu, R., Wu, M., Ge, Q., & Yu, H. (2025) · Meat Science · doi:10.1016/j.meatsci.2025.109978 · Cited by 6
Microalgae and cyanobacteria as microbial substrate and their influence on the potential postbiotic capability of a bacterial probiotic
Domínguez‐Maqueda, M., Pérez‐Gómez, O., García‐Márquez, J., Espinosa‐Ruíz, C., Cuesta, A., Esteban, M. Á., Alarcón, F. J., Cárdenas, C., Tapia-Paniagua, S. T., Balebona, M. C., et al. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.70046 · Cited by 6
Potentially Synbiotic Grape Juice: What is the Impact of The Addition of Lacticaseibacillus casei and Prebiotic Components?
(2020) · Biointerface Research in Applied Chemistry · doi:10.33263/briac113.1070310715 · Cited by 6
Probiotic and paraprobiotic potential of Bacillus coagulans: Impact of processing and storage on viability and resistance in the gastrointestinal tract
Costa, N. D. A., Martins, A. F. L., Guimarães, A. D. B., da Capela, A. P., Magalhães, I. S., Arruda, T. R., Vieira, É. N. R., & Júnior, B. R. D. C. L. (2022) · Research Society and Development · doi:10.33448/rsd-v11i8.31013 · Cited by 6
Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study
Kobatake, E., Iwama, Y., Arai, T., Shioya, N., Kise, M., & Kabuki, T. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1063584 · Cited by 6
Characteristics of Lactococcus petauri GB97 lysate isolated from porcine feces and its in vitro and in vivo effects on inflammation, intestinal barrier function, and gut microbiota composition in mice
Yoon, K., Lee, S. J., Keum, G. B., Song, K.-Y., Park, J., Song, B., Yu, S. Y., Cho, J. H., Kim, E. S., Doo, H., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01334-23 · Cited by 7
Strategies and Trends for Application Exopolysaccharides of Lactic Acid Bacteria in the Food and Biomedical
Hussein, K. A., Niamah, A. K., & Majeed, K. R. (2024) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/1371/6/062017 · Cited by 6
FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER
Gökırmaklı, Ç., Üçgül, B., & Güzel‐Seydim, Z. B. (2021) · GIDA / THE JOURNAL OF FOOD · doi:10.15237/gida.gd21035 · Cited by 8
Properties of postbiotics produced by probiotics: antimicrobial, antioxidant activities and production of vitamins, organic acidsPreprint
Ibrahim, G. A., Mabrouk, A., El-ssayad, M. F., Mehaya, F. M., Sharaf, O. M., & Ibrahim, M. (2024) · Research Square · doi:10.21203/rs.3.rs-4125934/v1 · Cited by 6
Immunoenhancing Effect of Lactobacillus Kefiranofaciens ZW18 Postbiotic On Cyclophosphamide-induced Immunosuppressed Mice
Xu, H., Li, X., Geng, W., Jia, L., Wang, Y., & Wang, J. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10630-2 · Cited by 7
Postbiotics: Modulation of the Gut Microbiota and Potential for Association with Nanotechnology
Cardoso, A. J. R., Carvalho, S. G., Mantovanelli, V. R., Marinho, L. D. F., Silvestre, A. L. P., Forster‐Carneiro, T., Gremião, M. P. D., & Chorilli, M. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10675-3 · Cited by 6
Inactivated Bacillus subtilis R0179 Inhibits Porphyromonas Gingivalis-Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis
Zhao, W., Ji, L., Li, J., Liu, D., Zhang, C., Wang, X., Liu, Y., & Zheng, S. (2025) · Inflammation · doi:10.1007/s10753-025-02348-8 · Cited by 5
Para-probiotics as Novel Anti-Inflammatory Agents: Insight into Health Benefits and Therapeutic Applications
Ashique, S., Debnath, B., Islam, A., Tariq, M., Taj, T., Mantry, S., Sridhar, S. B., Verma, B., Kumar, N., Adhikary, K., et al. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128411949250909113034 · Cited by 7
Fatty acid profile and bio-preservative efficacy of lactic acid bacteria postbiotics for improving microbiological safety in broiler meat
Rahman, M. M., Sazili, A. Q., Ahmad, S. A., Khalil, K. A., Ismail‐Fitry, M. R., Afsana, A. S., & Sarker, M. S. K. (2025) · Food Control · doi:10.1016/j.foodcont.2025.111769 · Cited by 5
Postbiotics in the food industry: applications, delivery systems, and future perspectives
Aydin, E. G. K., Mohammed, S., & Çon, A. H. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04577-9 · Cited by 5
Effect of Postbiotics Derived from Lactobacillus rhamnosus PB01 (DSM 14870) on Sperm Quality: A Prospective In Vitro Study
Liu, S., Alipour, H., Zachar, V., Kesmodel, U. S., & Dardmeh, F. (2024) · Nutrients · doi:10.3390/nu16111781 · Cited by 6
Postbiotic Effect of Escherichia coli CEC15 and Escherichia coli Nissle 1917 on a Murine Model of 5-FU-induced Intestinal Mucositis
Glória, R. D. A., da Silva, T. F., Gomes, T. A. M., Vital, K. D., Fernandes, S. O. A., Cardoso, V. N., Ferreira, E. F., Chatel, J., Langella, P., Cherbuy, C., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10414-0 · Cited by 5
POSTBİYOTİKLER VE GIDA ENDÜSTRİSİNDE KULLANIM ALANLARI
İÇİER, S., GÜZELCAN, C., HIDIR, Ş., & Türköz, B. K. (2022) · GIDA / THE JOURNAL OF FOOD · doi:10.15237/gida.gd21145 · Cited by 6
Tempeh flour as an excellent source of paraprobiotics
Jonesti, W. P., Prihatna, C., Natadiputri, G. H., Suwanto, A., & Meryandini, A. (2023) · Biodiversitas Journal of Biological Diversity · doi:10.13057/biodiv/d240357 · Cited by 5
Efficacy of Lacticaseibacillus paracasei fermented milk on a model of constipation induced by loperamide hydrochloride in BALB/c mice
Xue, C., Li, M., Luo, M., Zhang, B., & Wang, Y. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17338 · Cited by 6
Multi-Omics Approach to Evaluate Effects of Dietary Sodium Butyrate on Antioxidant Capacity, Immune Function and Intestinal Microbiota Composition in Adult Ragdoll Cats
Zhang, A., Li, D., Yu, T., Zhang, M., Cui, Y., Wang, H., Dong, T., & Wu, Y. (2025) · Metabolites · doi:10.3390/metabo15020120 · Cited by 4
Promises and challenges of postbiotics: From bioactive mechanisms to functional food applications
Bodjrenou, D. M., Dhital, S., Li, W., Zeng, H., Huang, Q., Wang, Q., Mackay, C. R., & Zhang, B. (2026) · Food Wellness · doi:10.1016/j.foodw.2026.100041 · Cited by 4
Postbiotics: Production to consumption as natural enhancers and preservatives in the food industry
Akhavan, F., Bari, M. R., Noori, S. M. A., & Amiri, S. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108865 · Cited by 4
Cytotoxic effect of paraprobiotic yogurts on cancer cell lines
Parvarei, M. M., & Mortazavian, A. M. (2022) · Indian Journal of Microbiology Research · doi:10.18231/j.ijmr.2022.019 · Cited by 4
Alcohol-Free Beer Produced Using Maltose-Negative Wine Yeast Saccharomyces cerevisiae with Probiotic Potential
İlpars, E., Titlová, Š., Hanzalíková, K., Křížová, I., & Brányik, T. (2023) · Fermentation · doi:10.3390/fermentation9090805 · Cited by 4
Extracellular vesicles of Lactiplantibacillus plantarum PCM 2675 and Lacticaseibacillus rhamnosus PCM 489: an introductory characteristic
Kowalik, K., Kulig, K., Karnas, E., Woźnicka, O., Zuba‐Surma, E. K., Pyza, E., Rąpała‐Kozik, M., & Karkowska‐Kuleta, J. (2024) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2024.49 · Cited by 4
Relationship Between Antimicrobial Peptides, Probiotics, Postbiotics, and Parabiotics in the Maintenance of a Well-Balanced Gut Ecosystem
Parhi, P. (2024) · Springer eBooks · doi:10.1007/978-3-031-67515-7_8 · Cited by 4
Effects of cell-free supernatants produced by lactic acid bacteria on the safety and quality of poultry meat
Öztürk, B., & Şengün, İ. Y. (2025) · British Poultry Science · doi:10.1080/00071668.2025.2500344 · Cited by 4
Protective effects of metabolites from lactic acid bacteria against infections of mastitis pathogen in bovine cells
Kaewkod, T., Cheepchirasuk, N., Suriyaprom, S., Suriyasathaporn, W., Chitov, T., Panya, A., & Tragoolpua, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-05355-9 · Cited by 3
Precise Nutrition and Metabolic Syndrome, Remodeling the Microbiome with Polyphenols, Probiotics, and Postbiotics
Brizita, D. I., & Ivanović, N. (2022) · Springer eBooks · doi:10.1007/978-3-031-10153-3_6 · Cited by 4
Metabolic profiling of probiotic strain Lactobacillus delbrueckii subsp. bulgaricus L14 cultivated in presence of prebiotic oligosaccharides and polysaccharides in simulating in vitro gastrointestinal tract system
Dimov, I., Mollova, D., Vasileva, T. A., Bivolarski, V., Nikolova, M., Bivolarska, A. V., & Iliev, I. N. (2023) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2023.2178825 · Cited by 6
Improving Antimicrobial Stewardship in Human Health Using Probiotics and Their Derivatives
Nyathi, N., Ndhlovu, D., Rabvukwa, E., & Ndudzo, A. (2024) · Pharmaceutical science. · doi:10.5772/intechopen.112497 · Cited by 4
Small-Molecule Peptides from Lactiplantibacillus plantarum SCS2 Attenuate H2O2-Induced Oxidative Damage in INS-1 Cells via Regulating the Keap1-Nrf2 Signaling Pathway
Huang, X., Jiang, L.-S., Zhang, Y., Lin, J., Meng, X., & Liu, S. (2024) · Journal of Food Biochemistry · doi:10.1155/2024/8847548 · Cited by 4
The immunomodulatory effects of paraprobiotic mixtures derived from novel probiotic isolates in dextran sodium sulfate-induced colitis in mice via MAPK pathway
Rezaie, N., Ashrafian, F., Davijani, Z. M., Aghamohammad, S., & Rohani, M. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101247 · Cited by 4
Mechanisms of Gut Microbiota Modulation by Food, Probiotics, Prebiotics and More
Molinero, N., Sabater, C., Calvete‐Torre, I., Delgado, S., Ruas‐Madiedo, P., Ruíz, L., & Margollés, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00095-4 · Cited by 4
Complete genome sequence of Clostridium perfringens B20, a bacteriocin-producing pathogen
Elnar, A. G., & Kim, G. (2021) · Journal of Animal Science and Technology · doi:10.5187/jast.2021.e113 · Cited by 4
Role of Microbes in Sustainable Food Preservation
Öztürk, H. İ., & Ozturkoglu‐Budak, S. (2023) · Springer eBooks · doi:10.1007/978-981-99-4784-3_3 · Cited by 4
Postbiotics- Functional Food MaterialsPreprint
Gurunathan, S., Thangaraj, P., & Kim, J. (2023) · Preprints.org · doi:10.20944/preprints202309.2069.v1 · Cited by 4
New Insights into a Conceptual Bionic Colonic Bioreactor: A Model, ‘Probiotics in Human Colon’, Showing How Probiotics Alleviate Constipation from a Bioprocess Engineering Perspective
Wang, N., Wu, P., & Chen, X. D. (2025) · Foods · doi:10.3390/foods14081335 · Cited by 4
The overlooked hazard: Clostridioides difficile in preterm infants and immature immune systems—harnessing postbiotics for safer therapeutic strategies
Soleimani, R. A., Milani, P. G., Khani, N., & Rad, A. H. (2025) · Letters in Applied Microbiology · doi:10.1093/lambio/ovaf083 · Cited by 3
Submerged fermentation with autochthonous Pediococcus pentosaceus enhances physicochemical properties, enriches bioactive compounds, and boosts the antioxidant and antibacterial activities of mandacaru (Cereus jamacaru DC.) fruit
Medeiros, G. K. V. D. V., Martins, A. C. S., Vasconcelos, M. G., Garcia, E. F., Rodrigues, N. P. A., Lima, M. D. S., do Nascimento, Y. M., da Silva, E. F., Tavares, J. F., da Silva, M. S., et al. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145947 · Cited by 3
Understanding the ambiguity behind Enterococcus as a probiotic ally or a pathogenic adversary
Elnar, A. G., & Kim, G. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2562926 · Cited by 3
Efficacy of Gut Microbiome-Targeted Interventions on Mental Health Symptoms in Women Across Key Hormonal Life Stages: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Dubois, N., Vincent, C., & Giroux, I. (2025) · Healthcare · doi:10.3390/healthcare13222851 · Cited by 4
Organic Acids: Key Products of Fermented Foods and Sources of Anti-Inflammatory Potential
Li, W., Ghamry, M., Xu, X., Zhang, L., & Li, J. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2529546 · Cited by 3
The evolution of probiotic foods in human health over the past 25 years: a clear history of the term “probiotics,” world market, main products, trends and updates on the effects on human health
de Souza, H. F., Filho, J. G. A. C., Teixeira, R. D., Silva, F. V., Teixeira, F. D., Bell, J. M. L. N. D. M., Rocha, R. S., da Cruz, A. G., Brandi, I. V., & Kamimura, E. S. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118767 · Cited by 3
Postbiotics in Food Systems: Components, Production Methods, Food Applications, Functional Properties, and Technological Challenges
Taşpınar, T., & Güzeler, N. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72173 · Cited by 3
Preparation of Postbiotics from Bacillus
Beulah, B. F. P., & Rajasekar, T. (2023) · Methods and protocols in food science · doi:10.1007/978-1-0716-3421-9_11 · Cited by 4
Pediococcus pentosaceus CCFM1402 could repair skin barrier via AHR-OVOL1 pathway and OX40 receptor modulation
Ren, B., Mao, B., Tang, X., Zhang, Q., Zhao, J., Chen, W., & Cui, S. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.105852 · Cited by 3
Immunomodulatory and growth-enhancing postbiotic effects in poultry
Karuvelan, M., Sumukhi, S. S., Rajakannu, S., Chelliah, R., Barathikannan, K., Vijayalakshmi, S., Rubab, M., & Oh, D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22188-0.00033-4 · Cited by 3
Symbiotic honey beverages: A matrix which tells a story of survival and protection of human health from a gastronomic and industrial perspective
Neto, W. D. P. P., de Lucena, T. M. C., da Paixão, G. A., Shinohara, N. K. S., Pinheiro, A. C., Vicente, A. A., de Souza, R. B., & de Morais, M. A. (2025) · International Journal of Gastronomy and Food Science · doi:10.1016/j.ijgfs.2025.101183 · Cited by 6
Paraprobiotics Mitigate Inflammation and Anxiety-Like Behavior in a Lipopolysaccharide-Induced Mouse Model
Michels, M., Jesus, G. F. A., Córneo, E. D. S., Rocha, L. B., Dias, R., Voytena, A. P. L., Rossetto, M. P., Ramlov, F., Dal‐Pizzol, F., & Pesarico, A. P. (2025) · Current Microbiology · doi:10.1007/s00284-025-04386-9 · Cited by 3
Effects of Levilactobacillus brevis GKEX supplementation on exercise performance and fatigue resistance in mice
Lin, T.-C., Chen, C., Tsai, Y., Lin, S., Huang, C., & Hsu, Y.-J. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1625645 · Cited by 3
Postbiotics: perspectives on innovative applications
Castro-López, C., Romero‐Luna, H. E., Garcia, H. S., Vallejo‐Córdoba, B., González-Córdova, A. F., & Hernández‐Mendoza, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15346-4.00009-4 · Cited by 3
Improvement in growth, enzyme activity, and gene expression against Edwardsiellosis in African catfish (Clarias sp.) with dietary supplementation of euryhaline probiotic and paraprobiotic Bacillus cereus BR2
Yuhana, M., Asvia, S., Widanarni, W., & Afiff, U. (2024) · Aquaculture International · doi:10.1007/s10499-024-01617-x · Cited by 3
Postbiotics from Bacillus amyloliquefaciens J and Lactiplantibacillus plantarum SN4 (PWE) alleviates E. coli-induced enteritis via gut barrier enhancement, microbiota modulation, and liver protection
Tong, Y., Abbas, Z., Wu, S. L., Zhang, J., Mo, P., Wang, J., Li, Z., Zhang, H., Hu, X., Yao, M., et al. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106732 · Cited by 3

Authors: Cuevas-González, P. F., Liceaga, A. M., & Aguilar-Toalá, J. E.
Affiliations: Universidad Tecnologica de Tijuana (MX)
Purdue University West Lafayette (US)
Corresponding author: Liceaga, A.M.
Aguilar-Toalá, J.E.
ORCID: Cuevas-González, P.F.
Liceaga, A.M.
Aguilar-Toalá, J.E.
Venue: Food Research International
Publisher: Elsevier BV
Published: 2020-10
Volume: 136
Pages: 109502
ISSN: 0963-9969 (ISSN-L)
DOI: 10.1016/j.foodres.2020.109502
OpenAlex: W3038698648
Cited by: 431
References: 109
Citations by year: 2026: 70 · 2025: 90 · 2024: 84 · 2023: 73 · 2022: 54 · 2021: 53 · 2020: 6
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Food Research International (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: postbiotics, paraprobiotics, bacterial extracts, bioactive compounds, anti-inflammatory activity, immunomodulation, antioxidant activity, antimicrobial activity, health-promoting properties, nutraceuticals, functional food ingredients
MeSH terms: Anti-Bacterial Agents, Bacteria, Humans, Dietary Supplements, Probiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Postbiotics and paraprobiotics: From concepts to applications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks