p53 at the crossroads between cancer and neurodegeneration

p53, the cellular gatekeeper for growth and division

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Surfing the p53 network

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The Epigenomics of Cancer

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Epigenetics in Cancer

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Reactive oxygen species in cancer

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Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

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Hypomethylation distinguishes genes of some human cancers from their normal counterparts

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

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p53 mutant mice that display early ageing-associated phenotypes

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When mutants gain new powers: News from the mutant p53 field

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

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Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

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Hydrogen peroxide as second messenger in lymphocyte activation

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Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

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Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

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The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

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Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

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Involvement of oxidative stress in Alzheimer disease

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DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease

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Modulation of mammalian life span by the short isoform of p53

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Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

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Redox Control of Cell Death

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Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

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Initiating Cellular Stress Responses

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Delayed ageing through damage protection by the Arf/p53 pathway

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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Alzheimer's disease: the two-hit hypothesis.

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Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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Redox-Dependent Transcriptional Regulation

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A complex barcode underlies the heterogeneous response of p53 to stress

Murray-Zmijewski, F., Slee, E. A., & Lu, X. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2451 · Cited by 420 · see citing works

DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons

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Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

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Two faces of p53: aging and tumor suppression

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p53 in neuronal apoptosis

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Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

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Bax Involvement in p53-Mediated Neuronal Cell Death

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Relevance of DNA methylation in the management of cancer

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β‐Site APP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways

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A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide

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Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

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Role of Cysteine Residues in Regulation of p53 Function

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Transient Adaptation to Oxidative Stress in Mammalian Cells

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Cancer linked to Alzheimer disease but not vascular dementia

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Reply to: 'Clearance of amyloid β-peptide from brain: transport or metabolism?'

Iwata, N., Tsubuki, S., Hama, E., Takaki, Y., Shirotani, K., & Saido, T. C. (2000) · Nature Medicine · doi:10.1038/77399 · Cited by 285 · see citing works

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate

Knights, C. D., Catania, J., Giovanni, S. D., Muratoglu, S. C., Perez, R. E., Swartzbeck, A., Quong, A. A., Zhang, X., Beerman, T. A., Pestell, R. G., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512059 · Cited by 284 · see citing works

Mutant p53: an oncogenic transcription factor

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The critical role of methionine 35 in Alzheimer's amyloid β-peptide (1–42)-induced oxidative stress and neurotoxicity

Butterfield, D. A., & Debra Boyd-kimball, A. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.10.014 · Cited by 267 · see citing works

Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations

Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708043104 · Cited by 264 · see citing works

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 241 · see citing works

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

Gualberto, A., Aldape, K., Kozakiewicz, K., & Tlsty, T. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5166 · Cited by 237 · see citing works

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

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The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration

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Alzheimer disease and cancer

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Hot-spot mutants of p53 core domain evince characteristic local structural changes

Wong, K., DeDecker, B. S., Freund, S. M. V., Proctor, M. R., Bycroft, M., & Fersht, A. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8438 · Cited by 219 · see citing works

Hypomethylation of the amyloid precursor protein gene in the brain of an alzheimer’s disease patient

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Variation in the human TP53 gene affects old age survival and cancer mortality

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Neuronal life and death: an essential role for the p53 family

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Complete sequencing of TP53 predicts poor response to systemic therapy of advanced breast cancer.

Berns, E., Foekens, J. A., van Vossen, R., et al. (2000) · PubMed · Cited by 196 · see citing works

Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.

Calmels, S., Hainaut, P. L., & Ohshima, H. (1997) · PubMed · Cited by 188 · see citing works

Changes of p53 in the Brains of Patients with Alzheimer's Disease

Kitamura, Y., Shimohama, S., Kamoshima, W., Matsuoka, Y., Nomura, Y., & Taniguchi, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6301 · Cited by 185 · see citing works

Role of p53 in Sensing Oxidative DNA Damage in Response to Reactive Oxygen Species-Generating Agents

Achanta, G., & Huang, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0494 · Cited by 184 · see citing works

Zinc Binding and Redox Control of p53 Structure and Function

Hainaut, P. L., & Mann, K. (2001) · Antioxidants and Redox Signaling · doi:10.1089/15230860152542961 · Cited by 183 · see citing works

Reduction with age in methylcytosine in the promoter region −224∼−101 of the amyloid precursor protein gene in autopsy human cortex

Tohgi, H., Utsugisawa, K., Nagane, Y., Yoshimura, M., Genda, Y., & Ukitsu, M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00163-1 · Cited by 181 · see citing works

p53: A Guide to Apoptosis

Meulmeester, E., & Jochemsen, A. G. (2008) · Current Cancer Drug Targets · doi:10.2174/156800908783769337 · Cited by 179 · see citing works

Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

Seluanov, A., Gorbunova, V., Falcovitz, A., Sigal, A., Milyavsky, M., Zurer, I., Shohat, G., Goldfinger, N., & Rotter, V. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1552-1564.2001 · Cited by 178 · see citing works

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

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Amyloid β-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists

Butterfield, D. A., Griffin, S. T., Münch, G. W., & Pasinetti, G. M. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4309 · Cited by 174 · see citing works

Redox signalling and transition metals in the control of the p53 pathway

Méplan, C., Richard, M., & Hainaut, P. L. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00297-x · Cited by 163 · see citing works

The non‐apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon

Tedeschi, A., & Giovanni, S. D. (2009) · EMBO Reports · doi:10.1038/embor.2009.89 · Cited by 159 · see citing works

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

Salminen, A., Ojala, J., & Kaarniranta, K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0597-y · Cited by 158 · see citing works

Telomerase, senescence and ageing

Shawi, M., & Autexier, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.007 · Cited by 156 · see citing works

Does p53 affect organismal aging?

Donehower, L. A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10104 · Cited by 155 · see citing works

TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer.

Geisler, S. B., Børresen‐Dale, A., Johnsen, H., et al. (2003) · PubMed · Cited by 155 · see citing works

Reciprocal Inhibition of p53 and Nuclear Factor-κB Transcriptional Activities Determines Cell Survival or Death in Neurons

Culmsee, C., Siewe, J., Junker, V., Retiounskaia, M., Schwarz, S., Camandola, S., El-Metainy, S., Behnke, H., Mattson, M. P., & Krieglstein, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08586.2003 · Cited by 146 · see citing works

The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells.

Chen, K.-L., Wang, S. S., Yang, Y.-Y., Yuan, R.-Y., Chen, R.-M., & Hu, C.-J. (2009) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2008.10.173 · Cited by 144 · see citing works

Mutant p53 protein expression interferes with p53-independent apoptotic pathways

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A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration

Tedeschi, A., Nguyen, T. N., Puttagunta, R., Gaub, P., & Giovanni, S. D. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.175 · Cited by 139 · see citing works

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

Zalcenstein, A., Stambolsky, P., Weisz, L., Müller, M., Wallach, D., Goncharov, T. M., Krammer, P. H., Rotter, V., & Oren, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206724 · Cited by 123 · see citing works

Multiple signaling events in amyloid β-induced, oxidative stress-dependent neuronal apoptosis

Tamagno, E. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00244-2 · Cited by 122 · see citing works

Cancer as a Risk Factor for Long-Term Cognitive Deficits and Dementia

Heflin, L., Meyerowitz, B. E., Hall, P. N., Lichtenstein, P., Johansson, B. E. A., Pedersen, N. L., & Gatz, M. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji137 · Cited by 120 · see citing works

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

Buzek, J. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2340 · Cited by 117 · see citing works

Modulation of Gene Expression by Tumor-Derived p53 Mutants

Scian, M. J., Stagliano, K. E., Ellis, M. A., Hassan, S., Bowman, M., Miles, M. F., Deb, S. P., & Deb, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1568 · Cited by 117 · see citing works

Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging

Salminen, A., & Kaarniranta, K. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.012 · Cited by 111 · see citing works

Redox regulation of the transcriptional repressor Bach1

Ishikawa, M., Numazawa, S., & Yoshida, T. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.021 · Cited by 109 · see citing works

Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA Breaks In vivo

Rashid, S. T. A., Dellaire, G., Cuddihy, A. R., Jalali, F., Vaid, M., Coackley, C. L., Folkard, M., Xu, Y., Chen, B. P. C., Chen, D. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0729 · Cited by 107 · see citing works

Induction of tumour‐suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids

Uberti, D. L., Belloni, M., Grilli, M., Spano, P., & Memo, M. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00042.x · Cited by 106 · see citing works

Novel p53 Inactivators with Neuroprotective Action: Syntheses and Pharmacological Evaluation of 2-Imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-Imino-2,3,4,5,6,7-hexahydrobenzoxazole Derivatives

Zhu, X., Yu, Q.-S., Cutler, R. G., Culmsee, C., Holloway, H. W., Lahiri, D. K., Mattson, M. P., & Greig, N. H. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020044d · Cited by 105 · see citing works

Transcriptional activities of mutant p53: When mutations are more than a loss

Kim, E. L., & Deppert, W. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20271 · Cited by 102 · see citing works

Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA

Parks, D. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1289 · Cited by 99 · see citing works

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest

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Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53

Salvioli, S., Capri, M., Bucci, L., Lanni, C., Racchi, M., Uberti, D. L., Memo, M., Mari, D., Govoni, S. M., & Franceschi, C. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0639-6 · Cited by 84 · see citing works

Conformationally altered p53: a novel Alzheimer's disease marker?

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Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

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