Cited by 720Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

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Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

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Yan, Michael H., Wang, Xinglong, Zhu, Xiongwei·2013·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2012.11.014PMC PMC3744189

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Abstract

Alzheimer disease (AD) and Parkinson disease (PD) are the two most common age-related neurodegenerative diseases characterized by prominent neurodegeneration in selective neural systems. Although a small fraction of AD and PD cases exhibit evidence of heritability, among which many genes have been identified, the majority are sporadic without known causes. Molecular mechanisms underlying neurodegeneration and pathogenesis of these diseases remain elusive. Convincing evidence demonstrates oxidative stress as a prominent feature in AD and PD and links oxidative stress to the development of neuronal death and neural dysfunction, which suggests a key pathogenic role for oxidative stress in both AD and PD. Notably, mitochondrial dysfunction is also a prominent feature in these diseases, which is likely to be of critical importance in the genesis and amplification of reactive oxygen species and the pathophysiology of these diseases. In this review, we focus on changes in mitochondrial DNA and mitochondrial dynamics, two aspects critical to the maintenance of mitochondrial homeostasis and function, in relationship with oxidative stress in the pathogenesis of AD and PD.

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Authors: Yan, M. H., Wang, X., & Zhu, X.
Affiliations: Case Western Reserve University (US)
Corresponding author: Wang, Xinglong
Zhu, Xiongwei
ORCID: Wang, Xinglong
Zhu, Xiongwei
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2013-09
Volume: 62
Pages: 90-101
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2012.11.014
PMC: PMC3744189
OpenAlex: W2027783468
Cited by: 718
References: 209
Citations by year: 2026: 14 · 2025: 34 · 2024: 73 · 2023: 56 · 2022: 69 · 2021: 67 · 2020: 53 · 2019: 47 · 2018: 53 · 2017: 71 · 2016: 54 · 2015: 49 · 2014: 48 · 2013: 30
FWCI: 16.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: the National Institutes of Health (AG031852, NS071184)
Alzheimer's Association (IIRG-10–173358)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, Parkinson's disease, mitochondrial dysfunction, oxidative stress, mitochondrial DNA, mitochondrial dynamics, reactive oxygen species, neurodegeneration, mitochondrial homeostasis
MeSH terms: Alzheimer Disease, Humans, Mitochondria, Nerve Degeneration, Neurons, Parkinson Disease, Amyloid beta-Peptides, Cell Death, Reactive Oxygen Species, Oxidative Stress

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Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

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