CoChat
Sign Up
Cited by 172Exercise and Physiological ResponsesCardiovascular and exercise physiologyRedox biology and oxidative stress

Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training?

Gomez-Cabrera, Mari Carmen, Salvador-Pascual, Andrea, Cabo, Helena, Ferrando, Beatriz, Viña, Jose·2015·Free Radical Biology and Medicine
DOI 10.1016/j.freeradbiomed.2015.04.006
Open this paper in CoChat — free account

Abstract

Physical exercise increases the cellular production of reactive oxygen species (ROS) in muscle, liver, and other organs. This is unlikely due to increased mitochondrial production but rather to extramitochondrial sources such as NADPH oxidase or xanthine oxidase. We have reported a xanthine oxidase-mediated increase in ROS production in many experimental models from isolated cells to humans. Originally, ROS were considered as detrimental and thus as a likely cause of cell damage associated with exhaustion. In the past decade, evidence showing that ROS act as signals has been gathered and thus the idea that antioxidant supplementation in exercise is always recommendable has proved incorrect. In fact, we proposed that exercise itself can be considered as an antioxidant because training increases the expression of classical antioxidant enzymes such as superoxide dismutase and glutathione peroxidase and, in general, lowering the endogenous antioxidant enzymes by administration of antioxidant supplements may not be a good strategy when training. Antioxidant enzymes are not the only ones to be activated by training. Mitochondriogenesis is an important process activated in exercise. Many redox-sensitive enzymes are involved in this process. Important signaling molecules like MAP kinases, NF-κB, PGC-1α, p53, heat shock factor, and others modulate muscle adaptation to exercise. Interventions aimed at modifying the production of ROS in exercise must be performed with care as they may be detrimental in that they may lower useful adaptations to exercise.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2015.04.006

Cites

126 of 126 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several studies suggest that certain supplements, in particular a high intake of antioxidants, could reduce the training adaptation to exercise.

    “It is important to note that several studies have suggested that certain supplements and, in particular, a high intake of antioxidants could actually reduce the training adaptation to exercise [9].”

    From Periodized Nutrition for Athletes (2017) · cites this paper as [9]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Gomez-Cabrera, M. C., Salvador-Pascual, A., Cabo, H., Ferrando, B., & Viña, J.
Affiliations
Universitat de València (ES)
ORCID
Ferrando, Beatriz
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2015-09
Volume
86
Pages
37-46
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/j.freeradbiomed.2015.04.006
OpenAlex
W2084308966
Cited by
172
References
126
Citations by year
2026: 7 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 16 · 2021: 15 · 2020: 31 · 2019: 16 · 2018: 17 · 2017: 19 · 2016: 18 · 2015: 4
FWCI
2.68
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministerio de Educación, Cultura y Deporte (ISCIII2012-RED-43-029, PROMETEO2014/056)
  • Generalitat Valenciana (RS2012-609)
  • European Regional Development Fund
  • INCLIVA Instituto de Investigación Sanitaria
  • European Commission (CM1001)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
mitochondrial biogenesis, exercise training, reactive oxygen species, antioxidant supplementation, xanthine oxidase, NADPH oxidase, redox signaling, superoxide dismutase, glutathione peroxidase, PGC-1α, heat shock transcription factor, p53, NF-κB, mitogen-activated protein kinase, muscle adaptation, exercise fatigue
MeSH terms
Adaptation, Physiological, Animals, Antioxidants, Organelle Biogenesis, Humans, Mitochondria, Muscle, Oxidation-Reduction, Exercise, Oxidative Stress, Muscle, Skeletal, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review