Infusion with the antioxidant N‐acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle

Petersen, A. C.; McKenna, M. J.; Medved, I.; Murphy, K. T.; Brown, M. J.; Della Gatta, P.; Cameron‐Smith, D.

doi:10.1111/j.1748-1716.2011.02344.x

Cited by 99Exercise and Physiological ResponsesCardiovascular and exercise physiologyMuscle Physiology and Disorders

Infusion with the antioxidant N‐acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle

Petersen, A. C., McKenna, M. J., Medved, I., Murphy, K. T., Brown, M. J., Della Gatta, P., Cameron‐Smith, D.·2012·Acta Physiologica

DOI 10.1111/j.1748-1716.2011.02344.x

Open this paper in CoChat — free account

Abstract

AIM: Production of reactive oxygen species (ROS) in skeletal muscle is markedly increased during exercise and may be essential for exercise adaptation. We, therefore, investigated the effects of infusion with the antioxidant N-acetylcysteine (NAC) on exercise-induced activation of signalling pathways and genes involved in exercise adaptation in human skeletal muscle. METHODS: Subjects completed two exercise tests, 7 days apart, with saline (control, CON) or NAC infusion before and during exercise. Exercise tests comprised of cycling at 71% VO(2peak) for 45 min, and then 92% VO(2peak) to fatigue, with vastus lateralis biopsies at pre-infusion, after 45-min cycling and at fatigue. RESULTS: Analysis was conducted on the mitogen-activated protein kinase signalling pathways, demonstrating that NAC infusion blocked the exercise-induced increase in JNK phosphorylation, but not ERK1/2, or p38 MAPK. Nuclear factor-κB p65 phosphorylation was unaffected by exercise; however, it was reduced in NAC at fatigue by 14% (P < 0.05) compared with pre-infusion. Analysis of exercise and/or ROS-sensitive genes demonstrated that exercise-induced mRNA expression is ROS dependent of MnSOD, but not PGC-1α, interleukin-6, monocyte chemotactic protein-1, or heat-shock protein 70. CONCLUSION: These results suggest that inhibition of ROS attenuates some skeletal muscle cell signalling pathways and gene expression involved in adaptations to exercise.

Integrity signals

Registry

Crossref · 10.1111/j.1748-1716.2011.02344.x

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

NAC blunts training adaptations but enhances acute performance.
“For example, NAC blunts training adaptations [160] but enhances acute performance [161,162].”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [160]

1 retracted

Effects of Eccentric Exercise on NF-κB Activation in Blood Mononuclear Cells
López, D. G., Cuevas, M. J., Almar, M., Lima‐Cabello, E., Fernández, J. A. D. P., & González‐Gallego, J. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04f6 · Cited by 59 · see citing works
Retracted
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,634 · see citing works
The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
Aruoma, O. I., Halliwell, B. B., Hoey, B. M., & Butler, J. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90066-x · Cited by 1,774 · see citing works
Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739 · see citing works
Antioxidants prevent health-promoting effects of physical exercise in humans
Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582 · see citing works
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works
Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
Gomez-Cabrera, M.-C., Domenech, E., Romagnoli, M., Arduini, A., Borras, C., Pallardo, F. V., Sastre, J., & Viña, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.142 · Cited by 844 · see citing works
Oxidants and antioxidants in exercise
Sen, C. K. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.3.675 · Cited by 628 · see citing works
Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1
Manna, S. K., Zhang, H. J., Yan, T., Oberley, L. W., & Aggarwal, B. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13245 · Cited by 563 · see citing works
MAP kinase pathways
Qi, M., & Elion, E. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02470 · Cited by 524 · see citing works
Decreasing xanthine oxidase‐mediated oxidative stress prevents useful cellular adaptations to exercise in rats
Gómez‐Cabrera, M. C., Borrás, C., Pallardó, F. V., Sastre, J., Ji, L. L., & Viña, J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080564 · Cited by 477 · see citing works
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
Karin, M., & Gallagher, E. D. (2005) · IUBMB Life · doi:10.1080/15216540500097111 · Cited by 414 · see citing works
Exercise, MAPK, and NF-κB signaling in skeletal muscle
Kramer, H. F., & Goodyear, L. J. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00085.2007 · Cited by 375 · see citing works
Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells
Irrcher, I., Ljubicic, V., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2007 · Cited by 356 · see citing works
Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
Coffey, V. G., Zhong, Z., Shield, A., Canny, B. J., Chibalin, A. V., Zierath, J. R., & Hawley, J. A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4809fje · Cited by 336 · see citing works
Vitamins E and C are safe across a broad range of intakes1,2
Hathcock, J. N., Azzi, A., Blumberg, J. B., Bray, T. Μ., Dickinson, A., Frei, B. B., Jialal, I., Johnston, C. S., Kelly, F. J., Kraemer, K., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.4.736 · Cited by 307 · see citing works
Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit
Vermeulen, L., Wilde, G. D., Notebaert, S., Berghe, W. V., & Haegeman, G. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01161-9 · Cited by 304 · see citing works
Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle
Fischer, C. P., Hiscock, N. J., Penkowa, M., Basu, S., Vessby, B., Kallner, A., Sjöberg, L., & Pedersen, B. K. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.066779 · Cited by 293 · see citing works
Acute exercise activates nuclear factor (NF)‐ΚB signaling pathway in rat skeletal muscle
Ji, L. L., Gómez‐Cabrera, M. C., Steinhafel, N. W., & Viña, J. (2004) · The FASEB Journal · doi:10.1096/fj.04-1846com · Cited by 279 · see citing works
Effect of Vitamin C Supplements on Antioxidant Defence and Stress Proteins in Human Lymphocytes and Skeletal Muscle
Khassaf, M. B., McArdle, A., Esanu, C., Vasilaki, A., McArdle, F., Griffiths, R. D., Brodie, D. A., & Jackson, M. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040303 · Cited by 273 · see citing works
Involvement of the Transcription Factor NF-κB in Tubular Morphogenesis of Human Microvascular Endothelial Cells by Oxidative Stress
Shono, T., Ono, M., Izumi, H., Jimi, S., Matsushima, K., Okamoto, T., Kohno, K., & Kuwano, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4231 · Cited by 272 · see citing works
N ‐acetylcysteine attenuates the decline in muscle Na + ,K + ‐pump activity and delays fatigue during prolonged exercise in humans
McKenna, M. J., Medved, I., Goodman, C. A., Brown, M. J., Bjorksten, A. R., Murphy, K. T., Petersen, A. C., Sostaric, S. M., & Gong, X. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.115352 · Cited by 265 · see citing works
ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts
Kefaloyianni, E., Gaitanaki, C., & Beis, I. D. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.05.004 · Cited by 256 · see citing works
Activation of Transcription Factor NF-κB and p38 Mitogen-activated Protein Kinase Is Mediated by Distinct and Separate Stress Effector Pathways
Wesselborg, S., Bauer, M. K. A., Vogt, M., Schmitz, M. L., & Schulze‐Osthoff, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12422 · Cited by 237 · see citing works
N -acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals
Medved, I., Brown, M. J., Bjorksten, A. R., Murphy, K. T., Petersen, A. C., Sostaric, S. M., Gong, X., & McKenna, M. J. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00371.2004 · Cited by 232 · see citing works
Superoxide dismutase gene expression is activated by a single bout of exercise in rat skeletal muscle
Hollander, J. M., Fiebig, R., Gore, M. T., Ookawara, T., Ohno, H., & Ji, L. (2001) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240100539 · Cited by 231 · see citing works
Oxidative stress and delayed-onset muscle damage after exercise
Aoi, W., Naito, Y., Takanami, Y., Kawai, Y., Sakuma, K., Ichikawa, H., Yoshida, N., & Yoshikawa, T. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.008 · Cited by 230 · see citing works
Hepatitis B virus transactivator MHBst: activation of NF‐kappa B, selective inhibition by antioxidants and integral membrane localization.
Meyer, M., Caselmann, W. H., Schlüter, V., Schreck, R., HOFSCHNEIDER, P. H., & Baeuerle, P. A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05369.x · Cited by 203 · see citing works
Antioxidant Supplementation Does Not Alter Endurance Training Adaptation
Yfanti, C., Akerstrom, T. C. A., Nielsen, S. J., Nielsen, A. R., Mounier, R., Mortensen, O. H., Lykkesfeldt, J., Rose, A. J., Fischer, C. P., & Pedersen, B. K. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181cd76be · Cited by 182 · see citing works
The influence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise
Peake, J. M., Suzuki, K., & Coombes, J. S. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.10.005 · Cited by 176 · see citing works
Regulation of metabolic transcriptional co‐activators and transcription factors with acute exercise
Russell, A. P., Hesselink, M. K. C., Lo, S. K., & Schrauwen, P. (2005) · The FASEB Journal · doi:10.1096/fj.04-3168fje · Cited by 173 · see citing works
Hsp70 expression in human skeletal muscle after exercise
Puntschart, A., Vogt, M., Widmer, H. R., Hoppeler, H. H., & Billeter, R. (1996) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1996.512270000.x · Cited by 159 · see citing works
Singlet oxygen induces collagenase expression in human skin fibroblasts
Scharffetter‐Kochanek, K., Wlaschek, M., Briviba, K., & Sies, H. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80357-z · Cited by 155 · see citing works
Differential Stimulation of ERK and JNK Activities by Ultraviolet B Irradiation and Epidermal Growth Factor in Human Keratinocytes
Assefa, Z., Garmyn, M., Bouillon, R., Merlevede, W. J., Vandenheede, J. R., & Agostinis, P. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12292595 · Cited by 146 · see citing works
Interleukin-6 production by contracting human skeletal muscle: autocrine regulation by IL-6
Keller, P., Keller, C., Carey, A. L., Jauffred, S., Fischer, C. P., Steensberg, A., & Pedersen, B. K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.048 · Cited by 135 · see citing works
The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-γ coactivator 1α (PGC-1α), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is dependent on reactive oxygen species
Silveira, L. R., Pilegaard, H., Kusuhara, K., Curi, R., & Hellsten, Y. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.06.010 · Cited by 127 · see citing works
Regulation of IκB kinase and NF-κB in contracting adult rat skeletal muscle
Ho, R. C., Hirshman, M. F., Li, Y., Cai, D., Farmer, J. R., Aschenbach, W. G., Witczak, C. A., Shoelson, S. E., & Goodyear, L. J. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00632.2004 · Cited by 121 · see citing works
Interleukin-1β Induction of Mitogen-activated Protein Kinases in Human Mesangial Cells
Wilmer, W. A., Tan, L. C., Dickerson, J. A., Danne, M. M., & Rovin, B. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10877 · Cited by 114 · see citing works
N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans
Medved, I., Brown, M. J., Bjorksten, A. R., Leppik, J. A., Sostaric, S. M., & McKenna, M. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00884.2002 · Cited by 114 · see citing works
Inflammatory gene changes associated with the repeated-bout effect
Hubal, M. J., Chen, T. C., Thompson, P. D., & Clarkson, P. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00853.2007 · Cited by 113 · see citing works
Marathon running transiently increases c‐Jun NH2‐terminal kinase and p38γ activities in human skeletal muscle
Boppart, M. D., Asp, S., Wojtaszewski, J. F. P., Fielding, R. A., Mohr, T. T., & Goodyear, L. J. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00663.x · Cited by 105 · see citing works
Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise
Medved, I., Brown, M. J., Bjorksten, A. R., & McKenna, M. J. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00458.2003 · Cited by 102 · see citing works
Eccentric exercise markedly increases c-Jun NH 2 -terminal kinase activity in human skeletal muscle
Boppart, M. D., Aronson, D., Gibson, L., Roubenoff, R., Abad, L. W., Bean, J. F., Goodyear, L. J., & Fielding, R. A. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.5.1668 · Cited by 93 · see citing works
Vitamin E isoform-specific inhibition of the exercise-induced heat shock protein 72 expression in humans
Fischer, C. P., Hiscock, N. J., Basu, S., Vessby, B. O., Kallner, A., Sjöberg, L., Febbraio, M. A., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00421.2005 · Cited by 92 · see citing works
Exercise Stimulates c-Jun NH2Kinase Activity and c-Jun Transcriptional Activity in Human Skeletal Muscle
Aronson, D., Boppart, M. D., Dufresne, S. D., Fielding, R. A., & Goodyear, L. J. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9435 · Cited by 89 · see citing works
Nitric oxide production is a proximal signaling event controlling exercise‐induced mRNA expression in human skeletal muscle
Steensberg, A., Keller, C., Hillig, T., Frøsig, C., Wojtaszewski, J. F. P., Pedersen, B. K., Pilegaard, H., & Sander, M. (2007) · The FASEB Journal · doi:10.1096/fj.06-7477com · Cited by 87 · see citing works
Free radicals in skin and muscle: damaging agents or signals for adaptation?
Jackson, M. J. (1999) · Proceedings of The Nutrition Society · doi:10.1017/s0029665199000877 · Cited by 86 · see citing works
Modification of the xanthine-converting enzyme of perfused rat heart during ischemia and oxidative stress
Bindoli, A., Cavallini, L., Rigobello, M. P., Coassin, M., & Lisa, F. D. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90024-x · Cited by 71 · see citing works
Fatiguing exercise reduces DNA binding activity of NF-κB in skeletal muscle nuclei
Durham, W. J., Li, Y.-P., Gerken, E., Farid-Moayer, M., Arbogast, S., Wolfe, R. R., & Reid, M. B. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00088.2004 · Cited by 69 · see citing works
Eccentric training impairs NF-κB activation and over-expression of inflammation-related genes induced by acute eccentric exercise in the elderly
Jiménez-Jiménez, R., Cuevas, M. J., Almar, M., Lima‐Cabello, E., López, D. G., Fernández, J. A. D. P., & González‐Gallego, J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.007 · Cited by 65 · see citing works
Supplemental Vitamin C Appears to Slow Racing Greyhounds
Marshall, R. J., Scott, K. C., Hill, R. C., Lewis, D. D., Sundstrom, D. A., Jones, G. L., & Harper, J. R. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1616s · Cited by 64 · see citing works
Physical Exercise Induces Activation of NF- κ B in Human Peripheral Blood Lymphocytes
Vider, J., Laaksonen, D. E., Kilk, A., Atalay, M., Lehtmaa, J., Zilmer, M., & Sen, C. K. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203639 · Cited by 53 · see citing works
Pharmacokinetics of intravenous N-acetylcysteine in men at rest and during exercise
Brown, M. J., Bjorksten, A. R., Medved, I., & McKenna, M. J. (2004) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-004-0862-9 · Cited by 45 · see citing works
Hypoxia stimulates via separate pathways ERK phosphorylation and NF-κB activation in skeletal muscle cells in primary culture
Osorio‐Fuentealba, C., Valdés, J. A., Riquelme, D., Hidalgo, J., Hidalgo, C., & Carrasco, M. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91224.2008 · Cited by 22 · see citing works

Flagged first, then by citations

Sorted by citations

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084 · see citing works
Skeletal muscle energy metabolism during exercise
Hargreaves, M., & Spriet, L. L. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0251-4 · Cited by 1,258 · see citing works
Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling
Radak, Z. O., Zhao, Z., Koltai, E., Ohno, H., & Atalay, M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4498 · Cited by 616 · see citing works
Exercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413 · see citing works
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress
Raghu, G., Berk, M., Campochiaro, P. A., Jaeschke, H., Marenzi, G., Richeldi, L., Wen, F., Nicoletti, F., & CALVERLEY, P. M. A. (2020) · Current Neuropharmacology · doi:10.2174/1570159x19666201230144109 · Cited by 299 · see citing works
Molecular Responses to Acute Exercise and Their Relevance for Adaptations in Skeletal Muscle to Exercise Training
Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278 · see citing works
New strategies in sport nutrition to increase exercise performance
Close, G. L., Hamilton, D. L., Philp, A., Burke, L. M., & Morton, J. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.016 · Cited by 221 · see citing works
Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights
Mason, S. A., Trewin, A. J., Parker, L., & Wadley, G. D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101471 · Cited by 226 · see citing works
Type 2 diabetes as a redox disease
Watson, J. D. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62365-x · Cited by 203 · see citing works
Exercise-induced hormesis and skeletal muscle health
Ji, L. L., Kang, C., & Zhang, Y. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.025 · Cited by 176 · see citing works
Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training?
Gomez-Cabrera, M. C., Salvador-Pascual, A., Cabo, H., Ferrando, B., & Viña, J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.006 · Cited by 172 · see citing works
Exercise-Induced Oxidative Stress and Dietary Antoxidative
Yavari, A., Javadi, M., Mirmiran, P., & Bahadoran, Z. (2015) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.24898 · Cited by 156 · see citing works
Redox basis of exercise physiology
Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Kyparos, A., & Nikolaidis, M. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101499 · Cited by 129 · see citing works
MicroRNAs in skeletal muscle biology and exercise adaptation
Kirby, T. J., & McCarthy, J. J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.004 · Cited by 123 · see citing works
Monitoring Exercise-Induced Muscle Fatigue and Adaptations: Making Sense of Popular or Emerging Indices and Biomarkers
Theofilidis, G., Bogdanis, G. C., Koutedakis, Y., & Karatzaferi, C. (2018) · Sports · doi:10.3390/sports6040153 · Cited by 120 · see citing works
Resistance training to improve type 2 diabetes: working toward a prescription for the future
Pesta, D. H., Goncalves, R. L. S., Madiraju, A. K., Strasser, B., & Sparks, L. M. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0173-7 · Cited by 120 · see citing works
Does Vitamin C and E Supplementation Impair the Favorable Adaptations of Regular Exercise?
Nikolaidis, M. G., Kerksick, C. M., Lamprecht, M., & McAnulty, S. R. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/707941 · Cited by 116 · see citing works
Molecular bases of the crosstalk between bone and muscle
Karsenty, G., & Mera, P. (2017) · Bone · doi:10.1016/j.bone.2017.04.006 · Cited by 116 · see citing works
Electrical pulse stimulation of cultured skeletal muscle cells as a model for in vitro exercise – possibilities and limitations
Nikolić, N., Görgens, S. W., Thoresen, G. H., Aas, V., Eckel, J., & Eckardt, K. (2016) · Acta Physiologica · doi:10.1111/apha.12830 · Cited by 110 · see citing works
Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1
Whitham, M., Chan, M. H. S., Pal, M., Matthews, V. B., Prelovsek, O., Lunke, S., El-Osta, A., Broenneke, H., Alber, J., Brüning, J. C., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310581 · Cited by 107 · see citing works
Muscle redox signalling pathways in exercise. Role of antioxidants
Mason, S. A., Morrison, D., McConell, G. K., & Wadley, G. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.022 · Cited by 103 · see citing works
The Role of Oxidative, Inflammatory and Neuroendocrinological Systems During Exercise Stress in Athletes: Implications of Antioxidant Supplementation on Physiological Adaptation During Intensified Physical Training
Slattery, K., Bentley, D. J., & Coutts, A. J. (2014) · Sports Medicine · doi:10.1007/s40279-014-0282-7 · Cited by 107 · see citing works
Exercise-induced ROS in heat shock proteins response
Dimauro, I., Mercatelli, N., & Caporossi, D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.028 · Cited by 95 · see citing works
A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development
Lasram, M. M., Dhouib, I. B., Annabi, A. B., Fazâa, S. E., & Gharbi, N. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.04.017 · Cited by 93 · see citing works
Modulating exercise-induced hormesis: Does less equal more?
Peake, J. M., Markworth, J. F., Nosaka, K., Raastad, T., Wadley, G. D., & Coffey, V. G. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01055.2014 · Cited by 96 · see citing works
Redox interventions to increase exercise performance
Reid, M. B. (2015) · The Journal of Physiology · doi:10.1113/jp270653 · Cited by 85 · see citing works
Antioxidants in Personalized Nutrition and Exercise
Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Kyparos, A., & Nikolaidis, M. G. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy052 · Cited by 84 · see citing works
Reactive Oxygen Species as Agents of Fatigue
Reid, M. B. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001006 · Cited by 80 · see citing works
“Nutraceuticals” in relation to human skeletal muscle and exercise
Deane, C. S., Wilkinson, D. J., Phillips, B. E., Smith, K., Etheridge, T., & Atherton, P. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2016 · Cited by 73 · see citing works
Dietary thiols in exercise: oxidative stress defence, exercise performance, and adaptation
McLeay, Y., Stannard, S. R., Houltham, S., & Starck, C. S. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0168-9 · Cited by 73 · see citing works
The Emerging Roles of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 in Skeletal Muscle Redox Signaling and Metabolism
Henríquez‐Olguín, C., Boronat, S., Cabello‐Verrugio, C., Jaimovich, E., Hidalgo, E., & Jensen, T. E. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7678 · Cited by 71 · see citing works
Role of exercise-induced reactive oxygen species in the modulation of heat shock protein response
Fittipaldi, S., Dimauro, I., Mercatelli, N., & Caporossi, D. (2013) · Free Radical Research · doi:10.3109/10715762.2013.835047 · Cited by 70 · see citing works
The Ability of Exercise-Associated Oxidative Stress to Trigger Redox-Sensitive Signalling Responses
Webb, R., Hughes, M. G., Thomas, A. J., & Morris, K. (2017) · Antioxidants · doi:10.3390/antiox6030063 · Cited by 66 · see citing works
Effect of N-acetylcysteine on Cycling Performance after Intensified Training
Slattery, K., Dascombe, B. J., Wallace, L., Bentley, D. J., & Coutts, A. J. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000222 · Cited by 63 · see citing works
NOX2 Inhibition Impairs Early Muscle Gene Expression Induced by a Single Exercise Bout
Henríquez‐Olguín, C., Díaz‐Vegas, A., Utreras‐Mendoza, Y., Campos, C., Arias‐Calderón, M., Llanos, P., Contreras‐Ferrat, A. E., Espinosa, A., Altamirano, F. J., Jaimovich, E., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00282 · Cited by 62 · see citing works
Redox homeostasis in sport: do athletes really need antioxidant support?
Antonioni, A., Fantini, C., Dimauro, I., & Caporossi, D. (2018) · Research in Sports Medicine · doi:10.1080/15438627.2018.1563899 · Cited by 60 · see citing works
Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling
Parker, L., Shaw, C. S., Stepto, N. K., & Levinger, I. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00087 · Cited by 55 · see citing works
Reactive oxygen species in exercise and insulin resistance: Working towards personalized antioxidant treatment
McKeegan, K., Mason, S. A., Trewin, A. J., Keske, M. A., Wadley, G. D., Gatta, P. A. D., Nikolaidis, M. G., & Parker, L. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102005 · Cited by 55 · see citing works
Acute and Chronic Effects of Antioxidant Supplementation on Exercise Performance
Bentley, D. J., Ackerman, J., Clifford, T., & Slattery, K. S. (2014) · CRC Press eBooks · doi:10.1201/b17442-9 · Cited by 45 · see citing works
MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men
Broome, S. C., Pham, T., Braakhuis, A. J., Narang, R. K., Wang, H. W., Hickey, A. J., Mitchell, C. J., & Merry, T. L. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102341 · Cited by 47 · see citing works
Effect of N-acetylcysteine infusion on exercise-induced modulation of insulin sensitivity and signaling pathways in human skeletal muscle
Trewin, A. J., Lundell, L. S., Perry, B. D., Patil, K. V., Chibalin, A., Levinger, I., McQuade, L. R., & Stepto, N. K. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00605.2014 · Cited by 40 · see citing works
Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation
Gallego-Selles, Á., Galván-Álvarez, V., Martinez‐Canton, M., García-Gonzalez, E., Morales‐Álamo, D., Santana, A., González, J. J., Dorado, C., Calbet, J. A. L., & Martín-Rincón, M. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102398 · Cited by 38 · see citing works
Ergogenic Aids and Supplements
Porrini, M., & Bo’, C. D. (2016) · Frontiers of hormone research · doi:10.1159/000445176 · Cited by 36 · see citing works
The effect of exercise-intensity on skeletal muscle stress kinase and insulin protein signaling
Parker, L., Trewin, A. J., Levinger, I., Shaw, C. S., & Stepto, N. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171613 · Cited by 36 · see citing works
Reductive stress: The key pathway in metabolic disorders induced by overnutrition
Zhang, S., Wang, N., Gao, Z., Gao, Z., Wang, X., Xie, H., Wang, C.-Y., & Zhang, S. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.012 · Cited by 34 · see citing works
Effects of ginger (Zingiber officinale Roscoe) supplementation and resistance training on some blood oxidative stress markers in obese men
Atashak, S., Peeri, M., Azarbayjani, M. A., & Stannard, S. R. (2014) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2014.01.002 · Cited by 34 · see citing works
Antioxidant Supplementation and Adaptive Response to Training: A Systematic Review
Pastor, R., & Tur, J. A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190701164923 · Cited by 33 · see citing works
Antioxidants and Skeletal Muscle Performance: “Common Knowledge” vs. Experimental Evidence
Hernández, A., Cheng, A. J., & Westerblad, H. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00046 · Cited by 33 · see citing works
Molecular stressors underlying exercise training‐induced improvements in K+ regulation during exercise and Na+,K+‐ATPase adaptation in human skeletal muscle
Christiansen, D. (2018) · Acta Physiologica · doi:10.1111/apha.13196 · Cited by 32 · see citing works
MicroRNAs and Physical Activity
Altana, V., Geretto, M., & Pulliero, A. (2015) · MicroRNA · doi:10.2174/2211536604666150813152450 · Cited by 33 · see citing works
Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy
Argaev-Frenkel, L., & Rosenzweig, T. (2023) · Antioxidants · doi:10.3390/antiox12050994 · Cited by 32 · see citing works
Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans
Romero, S. A., Ely, M. R., Sieck, D. C., Luttrell, M. J., Buck, T. M., Kono, J. M., Branscum, A. J., & Halliwill, J. R. (2015) · Experimental Physiology · doi:10.1113/ep085030 · Cited by 30 · see citing works
Evidence of a Redox-Dependent Regulation of Immune Responses to Exercise-Induced Inflammation
Sakelliou, A., Fatouros, I., Athanailidis, I., Tsoukas, D., Chatzinikolaou, A., Draganidis, D., Jamurtas, A., Liacos, C., Papassotiriou, I., Mandalidis, D., et al. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2840643 · Cited by 30 · see citing works
Influence of N-Acetylcysteine Supplementation on Physical Performance and Laboratory Biomarkers in Adult Males: A Systematic Review of Controlled Trials
Fernández‐Lázaro, D., Domínguez-Ortega, C., Busto, N., Santamaría‐Peláez, M., Roche, E., Gutiérrez‐Abejón, E., & Mielgo‐Ayuso, J. (2023) · Nutrients · doi:10.3390/nu15112463 · Cited by 27 · see citing works
Total Dietary Antioxidant Intake Including Polyphenol Content: Is It Capable to Fight against Increased Oxidants within the Body of Ultra-Endurance Athletes?
Devrim-Lanpir, A., Bilgiç, P., Kocahan, T., Deliceoğlu, G., Rosemann, T. J., & Knechtle, B. (2020) · Nutrients · doi:10.3390/nu12061877 · Cited by 27 · see citing works
Demystifying Oxidative Stress
Ghezzi, P., & Mooradian, A. D. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_379 · Cited by 23 · see citing works
Effects of oral N-acetylcysteine on walking capacity, leg reactive hyperemia, and inflammatory and angiogenic mediators in patients with intermittent claudication
da Silva, N. D., Roseguini, B. T., Chehuen, M. D. R., Fernandes, T. M., da Mota, G. D. F. A., Martin, P. K. M., Han, S. W., Forjaz, C. L. M., Wolosker, N., & de Oliveira, E. M. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00158.2015 · Cited by 23 · see citing works
Physiological regulation of cardiac contractility by endogenous reactive oxygen species
Perjés, Á., Kubin, A., Kónyi, A., Szabados, S., Cziráki, A., Skoumal, R., Ruskoaho, H. J., & Szokodi, I. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02391.x · Cited by 23 · see citing works
Redox Aspects of Chaperones in Cardiac Function
Penna, C. R. R., Sorge, M., Femminò, S., Pagliaro, P., & Brancaccio, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00216 · Cited by 21 · see citing works
Nrf2 in Type 2 diabetes and diabetic complications: Yin and Yang
Fu, J., Hou, Y., Xue, P., Wang, H., Xu, Y., Qu, W., Zhang, Q., & Pi, J. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.08.001 · Cited by 20 · see citing works
ROS and RNS Signaling in Skeletal Muscle: Critical Signals and Therapeutic Targets
Michaelson, L. P., Iler, C., & Ward, C. W. (2013) · Annual Review of Nursing Research · doi:10.1891/0739-6686.31.367 · Cited by 20 · see citing works
Altering the redox state of skeletal muscle by glutathione depletion increases the exercise-activation of PGC-1α
Strobel, N., Matsumoto, A., Peake, J. M., Marsh, S. A., Peternelj, T. T., Briskey, D. R., Fassett, R. G., Coombes, J. S., & Wadley, G. D. (2014) · Physiological Reports · doi:10.14814/phy2.12224 · Cited by 19 · see citing works
How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective
Devrim-Lanpir, A., Hill, L., & Knechtle, B. (2021) · Antioxidants · doi:10.3390/antiox10020153 · Cited by 19 · see citing works
8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists
Martínez-Noguera, F. J., Marín‐Pagán, C., Carlos‐Vivas, J., & Alcaráz, P. E. (2021) · Antioxidants · doi:10.3390/antiox10030432 · Cited by 19 · see citing works
Physiological regulation of cardiac contractility by endogenous reactive oxygen species
Perjés, Á., Kubin, A., Kónyi, A., Szabados, S., Cziráki, A., Skoumal, R., Ruskoaho, H. J., & Szokodi, I. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02391.x · Cited by 19 · see citing works
The contributions of oxidative stress, oxidised lipoproteins and AMPK towards exercise-associated PPARγ signalling within human monocytic cells
Davies, N. A., Watkeys, L. J., Butcher, L., Potter, S., Hughes, M. G., Moir, H. J., Morris, K., Thomas, A. W., & Webb, R. (2014) · Free Radical Research · doi:10.3109/10715762.2014.978311 · Cited by 18 · see citing works
N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner
Jiang, Y., Rumble, J., Gleixner, A. M., Unnithan, A. S., Pulugulla, S. H., Posimo, J. M., Choi, H. J. H., Crum, T. S., Pant, D. B., & Leak, R. K. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.049 · Cited by 16 · see citing works
Multi-Day Prolonged Low- to Moderate-Intensity Endurance Exercise Mimics Training Improvements in Metabolic and Oxidative Profiles Without Concurrent Chromosomal Changes in Healthy Adults
Gagnon, D. D., Dorman, S. C., Ritchie, S. D., Mutt, S. J., Stenbäck, V., Walkowiak, J., & Herzig, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01123 · Cited by 14 · see citing works
Effects of losartan and exercise on muscle mass and exercise endurance of old mice
Lin, C.-H., Chang, P., Chu, P., Chuang, Y., Huang, R., & Chen, C. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111869 · Cited by 13 · see citing works
Age your garlic for longevity!
Persson, P. B., & Persson, A. B. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02424.x · Cited by 12 · see citing works
Trade-Offs Between Anti-Aging Dietary Supplementation and Exercise
Mendelsohn, A. R., & Larrick, J. W. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1484 · Cited by 11 · see citing works
Redox Biology of Exercise
Nikolaidis, M. G., Kerksick, C. M., Lamprecht, M., & McAnulty, S. R. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/407978 · Cited by 11 · see citing works
Exercise-modulated IL-6 in cancer cachexia: molecular mechanisms and therapeutic potential
Wei, S., Lv, X., Xu, Y., & Ding, S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07690-5 · Cited by 11 · see citing works
Effect of 8-week of dietary micronutrient supplementation on gene expression in elite handball athletes
Molina‐López, J., Quispe-Ricalde, M. A., Hernández, B. V., Planells, A., Otero, R., & Planells, E. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232237 · Cited by 10 · see citing works
Preliminary evidence of reductive stress in human cytotoxic T cells following exercise
Wadley, A. J., Holliday, A., Morgan, R. G., Heesom, K. J., Aldred, S., Peters, D. M., Bueno, A. A., & Coles, S. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01137.2017 · Cited by 10 · see citing works
Protective effect of N‐acetylcysteine against ischemia/reperfusion injury in rat urinary bladders
Shin, J., Kim, G., Song, K.-H., Na, Y. G., Sul, C.-K., & Lim, J. (2013) · Cell Biochemistry and Function · doi:10.1002/cbf.2967 · Cited by 9 · see citing works
The impact of cysteine on lifespan in three model organisms: A systematic review and meta‐analysis
Ma, Y., Chen, M., Huang, K., & Chang, W. (2024) · Aging Cell · doi:10.1111/acel.14392 · Cited by 7 · see citing works
Effects of N-acetylcysteine on isolated skeletal muscle contractile properties after an acute bout of aerobic exercise
Jannig, P. R., Alves, C. R. R., Voltarelli, V. A., Bozi, L. H. M., Vieira, J. S., Brum, P. C., & Bechara, L. R. G. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.10.012 · Cited by 7 · see citing works
The impact of N‐acetylcysteine on lactate, biomarkers of oxidative stress, immune response, and muscle damage: A systematic review and meta‐analysis
Sadowski, M., Zawieja, E. E., & Chmurzyńska, A. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70198 · Cited by 6 · see citing works
Reactive oxygen species in exercise biology: from adaptive stress response to cell signaling and beyond
Sireno, L., Dimauro, I., & Caporossi, D. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.12.044 · Cited by 6 · see citing works
Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers
Stary, C. M., & Hogan, M. C. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01060.2015 · Cited by 6 · see citing works
Acute mitochondrial reactive oxygen species emissions drive mitochondrial dysfunction after traumatic muscle injury in male mice
Heo, J., Miller, D. L., Hoffman, J. R., Oberholtzer, E., Castelli, K. M., Sparagna, G. C., Fisher‐Wellman, K. H., Greising, S. M., & Call, J. A. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00407.2025 · Cited by 5 · see citing works
Mangiferin Alleviates Exercise-Induced Fatigue through Inhibition of NFκB-Mediated Inflammation and Oxidative Stress Based on Network Pharmacology
Li, C.-J., Li, M.-T., Zhang, Y., Xu, S.-F., Li, H.-X., Chen, W.-Q., Cheng, J., Gu, D., Geng, X., Si, Y.-C., et al. (2024) · Journal of Food Biochemistry · doi:10.1155/2024/6662942 · Cited by 3 · see citing works
Blood parameters as a measure for controlling physical performance of young Algerian cyclists (U23 category)
Abdelhamid, A. K., Khelifa, S. A., Mohamed, A., Abderrezzak, B., & Sahraoui, S. M. H. (2021) · Pedagogy of Physical Culture and Sports · doi:10.15561/26649837.2021.0202 · Cited by 3 · see citing works
Evidence of a redox-dependent control of vascular function following muscle-damaging exercise in young adults: A randomized placebo-controlled trial.
Mavraganis, G., Sakelliou, A., Georgiopoulos, G., Delialis, D., Papaioannou, M., Maneta, E., Angelidakis, L., Zervas, G., Poulios, A., Papanikolaou, K., et al. (2025) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2025.07.007 · Cited by 2 · see citing works
Protein Kinases in the Pathogenesis of Muscle Wasting
Penna, F., Costamagna, D., Camperi, A., Muscaritoli, M., Baccino, F., & Costelli, P. (2012) · InTech eBooks · doi:10.5772/38476 · Cited by 1 · see citing works
An optimal exercise protocol for improving endurance performance and health
Tanaka, H., Morimura, K., & Shiose, K. (2012) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.1.595 · Cited by 1 · see citing works
Sustained Post-exercise Vasodilation: Histaminergic Mechanisms and Adaptations
Romero, S. A. (2015) · Scholars' Bank (University of Oregon) · Cited by 1 · see citing works
Exploring changes in markers of oxidative stress and inflammation in response to exercise
Wadley, A. J. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Dealing with radicals
Persson, A. B., & Persson, P. B. (2013) · Acta Physiologica · doi:10.1111/apha.12193
Heat shock proteins and endogenous antioxidants in skeletal muscle: acute responses to exercise and adaptations to training
Cumming, K. T. (2014) · BIBSYS Brage (BIBSYS (Norway))
Perfil de expressão de microRNAs circulantes após uma sessão aguda de exercício em indivíduos com doença arterial periférica: papel da N-acetilcisteína
Júnior, N. D. D. S. (2016) · doi:10.11606/t.5.2016.tde-06092016-151124
Effect Of Quercetin And Epigallocatechin-3-Gallate On Anti-inflammatory Activity In Vitro And In Vivo
Kennerly, K. (2017) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) · doi:10.71889/5fylantbak.29861930
The Physiological Effects of N-Acetylcysteine in Clinical Studies
Frye, R. E. (2018) · Springer eBooks · doi:10.1007/978-981-10-5311-5_19
Extreme environments
Persson, A. B., & Persson, P. B. (2014) · Acta Physiologica · doi:10.1111/apha.12347
The role N-acetylcysteine (nac) in the therapy of diseases characterized by oxidative stress (literature review)
Зыблева, С. В., Rozhko, Y. I., Zharikova, A. V., Kabeshev, B. O., & Зыблев, С. Л. (2023) · Medical and Biological Problems of Life Activity · doi:10.58708/2074-2088.2023-2(30)-6-16
Skeletal muscle toxicity and statins : role of mitochondrial adaptations
Singh, F. (2016) · theses.fr (ABES) · doi:10.70675/362675f3z0a19z46f5z977az009dcec8ed40
The role of antioxidants in mitigating muscle damage from physical training: a molecular and clinical review
Shi, Z., Xu, H., Ren, J., & Tang, T. (2026) · Sport Sciences for Health · doi:10.1007/s11332-025-01629-x · Cited by 1 · see citing works
Glutathione and N-acetylcysteine in athletes: redox regulation and performance
Diler, B., Arslan, S., & Göbel, P. (2026) · Academia Nutrition and Dietetics · doi:10.20935/acadnutr8568

Effect of N-acetylcysteine infusion on exercise-induced modulation of insulin sensitivity and signaling pathways in human skeletal muscle
Trewin, A. J., Lundell, L. S., Perry, B. D., Patil, K. V., Chibalin, A., Levinger, I., McQuade, L. R., & Stepto, N. K. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00605.2014 · Cited by 40 · see citing works
Muscle redox signalling pathways in exercise. Role of antioxidants
(12502222), S. M., (7779026), D. M., (14472168), G. M., & Wadley, G. D. (2024) · Figshare
N‐Acetylcysteine infusion does not affect glucose disposal during prolonged moderate‐intensity exercise in humans
Merry, T. L., Wadley, G. D., Stathis, C. G., GARNHAM, A. P., Rattigan, S., Hargreaves, M., & McConell, G. K. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.184333 · Cited by 43 · see citing works
Effect of N‐acetylcysteine on markers of skeletal muscle injury after fatiguing contractile activity
Pinheiro, C. H., Vitzel, K. F., & Curi, R. (2010) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2010.01143.x · Cited by 29 · see citing works
N ‐acetylcysteine attenuates the decline in muscle Na + ,K + ‐pump activity and delays fatigue during prolonged exercise in humans
McKenna, M. J., Medved, I., Goodman, C. A., Brown, M. J., Bjorksten, A. R., Murphy, K. T., Petersen, A. C., Sostaric, S. M., & Gong, X. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.115352 · Cited by 265 · see citing works

Authors: Petersen, A. C., McKenna, M. J., Medved, I., Murphy, K. T., Brown, M. J., Della Gatta, P., & Cameron‐Smith, D.
Affiliations: Deakin University (AU)
Victoria University (AU)
Corresponding author: Petersen, A. C.
ORCID: Petersen, A. C.
McKenna, M. J.
Murphy, K. T.
Cameron‐Smith, D.
Venue: Acta Physiologica
Publisher: Wiley
Published: 2011-09-29
Volume: 204
Issue: 3
Pages: 382-392
ISSN: 1748-1708 (ISSN-L)
1748-1716
DOI: 10.1111/j.1748-1716.2011.02344.x
OpenAlex: W2167217629
Cited by: 99
References: 54
Citations by year: 2026: 4 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 9
FWCI: 9.40
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Physiologica (publishedVersion)
PubMed (publishedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: N-acetylcysteine, antioxidant supplementation, reactive oxygen species, exercise adaptation, skeletal muscle, mitogen-activated protein kinase, JNK phosphorylation, NF-κB p65, manganese superoxide dismutase, PGC-1α, interleukin-6, MCP-1, HSP70, exercise fatigue, vastus lateralis
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, NF-KappaB Inhibitor alpha, Acetylcysteine, Adaptation, Physiological, Adult, Analysis of Variance, Antioxidants, Bicycling, Biopsy, Double-Blind Method, Gene Expression Regulation, Heat-Shock Proteins, Humans, Infusions, Intravenous, Male, Muscle Contraction, Oxygen Consumption, Phosphorylation, RNA, Messenger, Superoxide Dismutase, Time Factors, Transcription Factors, Victoria, Signal Transduction, Exercise, Interleukin-6, NF-kappa B, Reactive Oxygen Species, Oxidative Stress, Cross-Over Studies, Muscle Fatigue, HSP70 Heat-Shock Proteins, Chemokine CCL2, I-kappa B Proteins, JNK Mitogen-Activated Protein Kinases, Quadriceps Muscle, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Infusion with the antioxidant N‐acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks