The DOI matches its Crossref record; 184 of the 185 references it cites were found in a registry or an index.
Exercise-induced skeletal muscle signaling pathways and human athletic performance
Abstract
Skeletal muscle is a highly malleable tissue capable of altering its phenotype in response to external stimuli including exercise. This response is determined by the mode, (endurance- versus resistance-based), volume, intensity and frequency of exercise performed with the magnitude of this response-adaptation the basis for enhanced physical work capacity. However, training-induced adaptations in skeletal muscle are variable and unpredictable between individuals. With the recent application of molecular techniques to exercise biology, there has been a greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses. This review summarizes the molecular and cellular events mediating adaptation processes in skeletal muscle in response to exercise. We discuss established and novel cell signaling proteins mediating key physiological responses associated with enhanced exercise performance and the capacity for reactive oxygen and nitrogen species to modulate training adaptation responses. We also examine the molecular bases underpinning heterogeneous responses to resistance and endurance exercise and the dissociation between molecular 'markers' of training adaptation and subsequent exercise performance.
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“mTORC1 also activates p70S6K1, which in turn phosphorylates upstream binding factor (UBF), a protein required for recruitment of RNA polymerase I to rDNA promoters”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [24]
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“Long-term growth is not a simple mathematical summation of acute fluctuations in enzymatic efficiency”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [24]
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Metadata
- Authors
- Camera, D. M., Smiles, W. J., & Hawley, J. A.
- Affiliations
- Australian Catholic University (AU)
- Liverpool John Moores University (GB)
- Corresponding author
- Hawley, John A.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 98
- Pages
- 131-143
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2291295533
- Cited by
- 128
- References
- 185
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 7 · 2023: 19 · 2022: 8 · 2021: 20 · 2020: 23 · 2019: 8 · 2018: 13 · 2017: 10 · 2016: 5
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Funders
- ACURF Grant (36331)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- skeletal muscle, exercise adaptation, signal transduction, athletic performance, endurance exercise, resistance training, reactive oxygen species, reactive nitrogen species, training effects, interindividual variability
- MeSH terms
- Adaptation, Physiological, Humans, Physical Endurance, Signal Transduction, Exercise, Muscle, Skeletal, Athletic Performance, Resistance Training
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