Cited by 128Exercise and Physiological ResponsesCardiovascular and exercise physiologyMuscle Physiology and Disorders

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Exercise-induced skeletal muscle signaling pathways and human athletic performance

Camera, Donny M., Smiles, William J., Hawley, John A.·2016·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2016.02.007

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Abstract

Skeletal muscle is a highly malleable tissue capable of altering its phenotype in response to external stimuli including exercise. This response is determined by the mode, (endurance- versus resistance-based), volume, intensity and frequency of exercise performed with the magnitude of this response-adaptation the basis for enhanced physical work capacity. However, training-induced adaptations in skeletal muscle are variable and unpredictable between individuals. With the recent application of molecular techniques to exercise biology, there has been a greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses. This review summarizes the molecular and cellular events mediating adaptation processes in skeletal muscle in response to exercise. We discuss established and novel cell signaling proteins mediating key physiological responses associated with enhanced exercise performance and the capacity for reactive oxygen and nitrogen species to modulate training adaptation responses. We also examine the molecular bases underpinning heterogeneous responses to resistance and endurance exercise and the dissociation between molecular 'markers' of training adaptation and subsequent exercise performance.

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Authors: Camera, D. M., Smiles, W. J., & Hawley, J. A.
Affiliations: Australian Catholic University (AU)
Liverpool John Moores University (GB)
Corresponding author: Hawley, John A.
ORCID: Camera, Donny M.
Smiles, William J.
Hawley, John A.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2016-09
Volume: 98
Pages: 131-143
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2016.02.007
OpenAlex: W2291295533
Cited by: 128
References: 185
Citations by year: 2026: 8 · 2025: 7 · 2024: 7 · 2023: 19 · 2022: 8 · 2021: 20 · 2020: 23 · 2019: 8 · 2018: 13 · 2017: 10 · 2016: 5
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Research Bank (Australian Catholic University) (submittedVersion)
Funders: ACURF Grant (36331)
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: skeletal muscle, exercise adaptation, signal transduction, athletic performance, endurance exercise, resistance training, reactive oxygen species, reactive nitrogen species, training effects, interindividual variability
MeSH terms: Adaptation, Physiological, Humans, Physical Endurance, Signal Transduction, Exercise, Muscle, Skeletal, Athletic Performance, Resistance Training

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Exercise-induced skeletal muscle signaling pathways and human athletic performance

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