Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata

Tanaka, Yutaka; Sasaki, Masato; Ito, Fumie; Aoyama, Toshio; Sato-Okamoto, Michiyo; Takahashi-Nakaguchi, Azusa; Chibana, Hiroji; Shibata, Nobuyuki

doi:10.1016/j.funbio.2017.09.007

Cited by 13Fungal and yeast genetics researchEndoplasmic Reticulum Stress and DiseaseAntifungal resistance and susceptibility

Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata

Tanaka, Yutaka, Sasaki, Masato, Ito, Fumie, Aoyama, Toshio, Sato-Okamoto, Michiyo, Takahashi-Nakaguchi, Azusa, Chibana, Hiroji, Shibata, Nobuyuki·2018·Fungal Biology

DOI 10.1016/j.funbio.2017.09.007

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Abstract

Candida glabrata is the second most common source of Candida infections in humans. In this pathogen, the maintenance of cell wall integrity (CWI) frequently precludes effective pharmacological treatment by antifungal agents. In numerous fungi, cell wall modulation is reported to be controlled by endoplasmic reticulum (ER) stress, but how the latter affects CWI maintenance in C. glabrata is not clearly understood. Here, we characterized a C. glabrata strain harboring a mutation in the CNE1 gene, which encodes a molecular chaperone associated with nascent glycoprotein maturation in the ER. Disruption of cne1 induced ER stress and caused changes in the normal cell wall structure, specifically a reduction in the β-1,6-glucan content and accumulation of chitin. Conversely, a treatment with the typical ER stress inducer tunicamycin up-regulated the production of cell wall chitin but did not affect β-1,6-glucan content. Our results also indicated that C. glabrata features a uniquely evolved ER stress-mediated CWI pathway, which differs from that in the closely related species Saccharomyces cerevisiae. Furthermore, we demonstrated that ER stress-mediated CWI pathway in C. glabrata is also induced by the disruption of other genes encoding proteins that function in a correlated manner in the quality control of N-linked glycoproteins in the ER. These results suggest that calcineurin and ER quality control system act as a platform for maintaining CWI in C. glabrata.

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The PKC pathway is also regulated by ER stress.
“Intriguingly, the PKC pathway is also regulated by the ER stress [92].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [92]

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Authors: Tanaka, Y., Sasaki, M., Ito, F., Aoyama, T., Sato-Okamoto, M., Takahashi-Nakaguchi, A., Chibana, H., & Shibata, N.
Affiliations: Tohoku Medical and Pharmaceutical University (JP)
National Institute of Technology, Suzuka College (JP)
Chiba University (JP)
Corresponding author: Shibata, Nobuyuki
ORCID: Tanaka, Yutaka
Chibana, Hiroji
Venue: Fungal Biology
Publisher: Elsevier BV
Published: 2018-01
Volume: 122
Issue: 1
Pages: 19-33
ISSN: 1878-6146 (ISSN-L)
DOI: 10.1016/j.funbio.2017.09.007
OpenAlex: W2763823879
Cited by: 13
References: 54
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1
FWCI: 0.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Fungal Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (15K19090)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: Candida glabrata, endoplasmic reticulum stress, calcineurin signaling, cell wall integrity, molecular chaperones, β-1,6-glucan, tunicamycin, antifungal resistance, fungal pathogens
MeSH terms: Cell Cycle, Cell Wall, Chitin, Fungal Proteins, Glucans, Glycoproteins, Microbial Sensitivity Tests, Mutation, Tunicamycin, Signal Transduction, Gene Expression Regulation, Fungal, Tacrolimus, Calcineurin, Calnexin, Candida glabrata, Unfolded Protein Response, Endoplasmic Reticulum Stress, Calcineurin Inhibitors

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Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata

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