From Saccharomyces cerevisiae to Candida glabrata in a few easy steps: important adaptations for an opportunistic pathogen: Candida glabrata stress response

Roetzer, Andreas; Gabaldón, Toni; Schüller, Christoph

doi:10.1111/j.1574-6968.2010.02102.x

Cited by 154Fungal and yeast genetics researchAntifungal resistance and susceptibilityYeasts and Rust Fungi Studies

From Saccharomyces cerevisiae to Candida glabrata in a few easy steps: important adaptations for an opportunistic pathogen: Candida glabrata stress response

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Roetzer, Andreas, Gabaldón, Toni, Schüller, Christoph·2011·FEMS Microbiology Letters

DOI 10.1111/j.1574-6968.2010.02102.xPMC PMC3015064

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Abstract

The opportunistic human fungal pathogen Candida glabrata is closely related to Saccharomyces cerevisiae, yet it has evolved to survive within mammalian hosts. Which traits help C. glabrata to adapt to this different environment? Which specific responses are crucial for its survival in the host? The main differences seem to include an extended repertoire of adhesin genes, high drug resistance, an enhanced ability to sustain prolonged starvation and adaptations of the transcriptional wiring of key stress response genes. Here, we discuss the properties of C. glabrata with a focus on the differences to related fungi.

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The C. glabrata genome harbors several members of a specific gene family encoding epithelial adhesin proteins (EPA genes), which are considered a key factor in its ability to infect humans.
“The C. glabrata genome harbors several members of a specific gene family encoding epithelial adhesin proteins (EPA genes), which are considered a key factor in its ability to infect humans (Cormack and Falkow, 1999; Roetzer et al., 2011; Gabaldón et al., 2013; Vale-Silva et al., 2017).”
From Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations (2019) · cites this paper as Roetzer et al., 2011
The number of generations that occurred within the time-lapse of DSY562 and DSY565 isolation may correspond to at least 250-500 generations, taking into account 5-10 generations/d according to published data.
“The number of generations that occurred within the time-lapse of DSY562 and DSY565 isolation may correspond to at least 250–500 generations, when taking into account 5–10 generations/d according to published data (Forche et al. 2009; Roetzer et al. 2011).”
From Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates (2017) · cites this paper as Roetzer et al. 2011

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Authors: Roetzer, A., Gabaldón, T., & Schüller, C.
Affiliations: University of Vienna (AT)
Centre for Genomic Regulation (ES)
Corresponding author: Schüller, Christoph
ORCID: Gabaldón, Toni
Schüller, Christoph
Venue: FEMS Microbiology Letters
Publisher: Oxford University Press (OUP)
Published: 2010-09-16
Volume: 314
Issue: 1
Pages: 1-9
ISSN: 0378-1097 (ISSN-L)
DOI: 10.1111/j.1574-6968.2010.02102.x
PMC: PMC3015064
OpenAlex: W1941779326
Cited by: 154
References: 82
Citations by year: 2026: 11 · 2025: 8 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 11 · 2017: 4 · 2016: 16 · 2015: 14 · 2014: 13 · 2013: 11 · 2012: 9
FWCI: 2.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: FEMS Microbiology Letters (publishedVersion)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Austrian Science Fund
Universität Wien (I031-B)
Ministerio de Ciencia e Innovación
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: Candida glabrata, Saccharomyces cerevisiae, opportunistic fungal pathogens, host adaptation, adhesin genes, antifungal resistance, starvation resistance, fungal evolution
MeSH terms: Adaptation, Physiological, Animals, Candidiasis, Fungal Proteins, Humans, Phylogeny, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Candida glabrata

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From Saccharomyces cerevisiae to Candida glabrata in a few easy steps: important adaptations for an opportunistic pathogen: Candida glabrata stress response

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