Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular Disease
Open accessAbstract
Background The National Heart Foundation of Australia (NHFA) 2008 review on omega-3 long-chain polyunsaturated fatty acids (LCPUFA) made recommendations with respect to supplementation for primary and secondary prevention of cardiovascular disease. Since then, new findings have been published regarding the relationship between omega-3 polyunsaturated fatty acids, including supplementation, and cardiovascular health.Methods A literature search was undertaken in PubMed and Medline, for literature published between January 1, 2007 and August 31, 2013.Results and conclusions A total of eight research questions were developed and, using the National Health and Medical Research Council's evidence assessment framework, conclusions were made in relation to dietary intake of fish and omega-3 LCPUFA for cardiovascular health. In the evidence published since 2007, this summary of evidence concludes that dietary intake of fish was found to be mostly consistent with respect to protection from heart disease and stroke. Higher fish intake was associated with lower incident rates of heart failure in addition to lower sudden cardiac death, stroke and myocardial infarction. In relation to omega-3 LCPUFA supplementation, neither a beneficial nor adverse effect was demonstrated in primary or secondary prevention of coronary heart disease (CHD). Although the evidence continues to be positive for the role of omega-3 LCPUFA in the treatment of hypertriglyceridaemia and a modest positive benefit in heart failure. No further evidence was found to support the consumption of 2g alpha-linolenic acid (ALA)/day over the current Australian guidelines for 1 g/day.
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Not all reviews support the presence of a beneficial role of n-3 LCPUFA in cardiovascular health.
“Despite these recommendations, not all reviews support the presence of a beneficial role of n-3 LCPUFA in cardiovascular health [495051].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [51]
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Flagged first, then by citations
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National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2
Jacobson, T. A., Maki, K. C., Orringer, C. E., Jones, P. H., Kris-Etherton, P., Sikand, G., La Forge, R., Daniels, S. R., Wilson, D. P., Morris, P. B., et al. (2015) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2015.09.002 · Cited by 784 · see citing works
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Challenges in Functional Food Products with the Incorporation of Some Microalgae
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- Authors
- Nestel, P., Clifton, P., Colquhoun, D., Noakes, M., Mori, T. A., Sullivan, D., & Thomas, B.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- University of South Australia (AU)
- The University of Queensland (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- The University of Western Australia (AU)
- The University of Sydney (AU)
- National Heart Foundation of Australia (AU)
- Corresponding author
- Nestel, Paul
- Venue
- Heart, Lung and Circulation
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 24
- Issue
- 8
- Pages
- 769-779
- ISSN
- 1443-9506 (ISSN-L)
- OpenAlex
- W2094823376
- Cited by
- 160
- References
- 99
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 9 · 2020: 11 · 2019: 18 · 2018: 22 · 2017: 26 · 2016: 22 · 2015: 13
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart Lung and Circulation (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- National Heart Foundation of Australia
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- n-3 long-chain polyunsaturated fatty acids, fish consumption, omega-3 supplementation, cardiovascular disease prevention, coronary artery disease, heart failure, sudden cardiac death, stroke, myocardial infarction, hypertriglyceridemia, alpha-linolenic acid, dietary recommendations
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Fatty Acids, Omega-3, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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