Familial pancreatic cancer

Petersen, Gloria M.

doi:10.1053/j.seminoncol.2016.09.002

Cited by 159Pancreatic and Hepatic Oncology ResearchBRCA gene mutations in cancerGenetic factors in colorectal cancer

Familial pancreatic cancer

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Petersen, Gloria M.·2016·Seminars in Oncology

DOI 10.1053/j.seminoncol.2016.09.002PMC PMC5234085

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Abstract

Familial pancreatic cancer (FPC) includes those kindreds that contain at least two first-degree relatives with pancreatic ductal adenocarcinoma. At least 12 known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the foremost being BRCA2 and CDKN2A. Research into the identification of mutations in known cancer predisposition genes and through next-generation sequencing has revealed extensive heterogeneity. The development of genetic panel testing has enabled genetic risk assessment and predisposition testing to be routinely offered. Precision oncology has opened the possibility of "incidental" germline mutations that may have implications for family members. However, in both cases, evidence-based recommendations for managing patients and at-risk family members in light of genetic status remain emergent, with current practice based on expert opinion.

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For most PDAC patients, no single attributable risk factor is identified outside the 10-15% of cases linked to germline mutations or known risk factors.
“outside of the minority (10–15%) of cases ascribed to germline mutations or known risk factors, such as mucinous cystic lesions and chronic pancreatitis, there is no single attributable risk factor for most patients4.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [4]

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Cancer statistics, 2016
Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003 · see citing works
Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
Green, R. C., Berg, J. S., Grody, W. W., Kalia, S. S., Korf, B. R., Martin, C. L., McGuire, A. L., Nussbaum, R. L., O’Daniel, J. M., Ormond, K. E., et al. (2013) · Genetics in Medicine · doi:10.1038/gim.2013.73 · Cited by 2,544 · see citing works
ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662 · see citing works
Patients Tested at a Laboratory for Hereditary Cancer Syndromes Show an Overlap for Multiple Syndromes in Their Personal and Familial Cancer Histories
Saam, J. R., Arnell, C., Theisen, A. P., Moyes, K., Marino, I., Roundy, K. M., & WENSTRUP, R. J. (2015) · Oncology · doi:10.1159/000437307 · Cited by 1,533 · see citing works
Very high risk of cancer in familial Peutz–Jeghers syndrome
Giardiello, F. M., Brensinger, J. D., Tersmette, A. C., Goodman, S. N., Petersen, G. M., Booker, S. V., Cruz–Correa, M., & Offerhaus, G. J. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.20228 · Cited by 1,435 · see citing works
Self-citation
Hereditary Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., DiMagno, E. P., Elitsur, Y., Gates, L. K., Perrault, J., Whitcomb, D. C., & International Hereditary Pancreatitis Study Group (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.6.442 · Cited by 988 · see citing works
Exomic Sequencing Identifies <i>PALB2</i> as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826 · see citing works
International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer
Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J.-W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303108 · Cited by 784 · see citing works
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
Klein, A. P., Brune, K. A., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3823 · Cited by 678 · see citing works
Self-citation
Risk of Pancreatic Cancer in Families With Lynch Syndrome
Kastrinos, F. (2009) · JAMA · doi:10.1001/jama.2009.1529 · Cited by 544 · see citing works
<i>ATM</i> Mutations in Patients with Hereditary Pancreatic Cancer
Roberts, N. J., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0194 · Cited by 491 · see citing works
Self-citation
Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)
Bosetti, C., Lucenteforte, E., Silverman, D. T., Petersen, G. M., Bracci, P. M., Ji, B.-T., Negri, E., Li, D., Risch, H. A., Olson, S. H., et al. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr541 · Cited by 415 · see citing works
Self-citation
Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer
Silverman, D. T., SCHIFFMAN, M. H., Everhart, J., Goldstein, A. M., Lillemoe, K. D., Swanson, G. M., Schwartz, A. G., Brown, L. M., Greenberg, R. S., Schoenberg, J. B., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690607 · Cited by 397 · see citing works
Patient age, histologic features, and length of survival in patients with glioblastoma multiforme
Burger, P. C., & Green, S. B. (1987) · Cancer · doi:10.1002/1097-0142(19870501)59:9 · Cited by 391 · see citing works
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer
Roberts, N. J., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., Kurtz, R. C., Olson, S. H., Rustgi, A. K., Schwartz, A. G., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0402 · Cited by 361 · see citing works
Self-citation
Benefit of surveillance for pancreatic cancer in high-risk individuals: outcome of long-term prospective follow-up studies from three european expert centers
Vasen, H., Ibrahim, I., Ponce, C. G., Slater, E. P., Matthäi, E., Carrato, A., Earl, J., Robbers, K., van Mil, A. M., Potjer, T., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.0730 · Cited by 344 · see citing works
Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA
Schrader, K. A., Cheng, D. T., Vijai, J., Prasad, M., Walsh, M. F., Zehir, A., Ni, A., Thomas, T., Benayed, R., Ashraf, A. M., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.5208 · Cited by 342 · see citing works
Risk Factors for Pancreatic Cancer: Case-Control Study
Hassan, M. M., Bondy, M. L., Wolff, R. A., Abbruzzese, J. L., Vauthey, J., Pisters, P. W. T., Evans, D. B., Khan, R. S., Chou, T.-H., Lenzi, R., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01510.x · Cited by 332 · see citing works
Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer
Grant, R. C., Selander, I., Connor, A. A., Selvarajah, S., Borgida, A., Briollais, L., Petersen, G. M., Lerner-Ellis, J., Holter, S., & Gallinger, S. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.11.042 · Cited by 299 · see citing works
Self-citation
LIFE-STYLE RISK FACTORS FOR PANCREATIC CANCER IN LOUISIANA: A CASE-CONTROL STUDY
Falk, R. T., Pickle, L. W., Fontham, E. T. H., Correa, P., & Fraumeni, J. F. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114972 · Cited by 298 · see citing works
BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study
Zhen, D. B., Rabe, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Goggins, M. G., Hruban, R. H., Cote, M. L., McWilliams, R. R., Roberts, N. J., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2014.153 · Cited by 295 · see citing works
Self-citation
Risk of Pancreatic Adenocarcinoma in Patients With Hereditary Pancreatitis: A National Exhaustive Series
Rebours, V., Boutron‐Ruault, M., Schnee, M., Férec, C., Maire, F., Hammel, P. R., Ruszniewski, P. B., & Lévy, P. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01597.x · Cited by 264 · see citing works
Fanconi anemia gene mutations in young-onset pancreatic cancer.
van der Heijden, M. S., Yeo, C. J., Hruban, R. H., & Kern, S. E. (2003) · PubMed · Cited by 262 · see citing works
The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
T. H. B. C. S. G., Iqbal, J., Ragone, A., Lubinski, J., Lynch, H. T., Moller, P., Ghadirian, P., Foulkes, W. D., Armel, S., Eisen, A., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.483 · Cited by 252 · see citing works
Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer
Langer, P., Kann, P. H., Fendrich, V., Habbe, N., Schneider, M., Sina‐Frey, M., Slater, E. P., Heverhagen, J. T., Gress, T. M., Rothmund, Μ., et al. (2009) · Gut · doi:10.1136/gut.2008.171611 · Cited by 249 · see citing works
Genetic susceptibility to pancreatic cancer
Klein, A. P. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20855 · Cited by 235 · see citing works
Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis
Permuth‐Wey, J., & Egan, K. M. (2008) · Familial Cancer · doi:10.1007/s10689-008-9214-8 · Cited by 232 · see citing works
Pancreatic cancer screening in a prospective cohort of high-risk patients: a comprehensive strategy of imaging and genetics
Verna, E. C., Hwang, C., Stevens, P. D., Rotterdam, H., Stavropoulos, S. N., Sy, C. D., Prince, M. A., Chung, W. K., Fine, R. L., Chabot, J. A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3209 · Cited by 201 · see citing works
Family history and the risk of liver, gallbladder, and pancreatic cancer.
Fernández, E., Vecchia, C. L., D’Avanzo, B., Negri, E., & Franceschi, S. (1994) · PubMed · Cited by 200 · see citing works
Correction: Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
(2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1642 · Cited by 160 · see citing works
Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study
Resta, N., Pierannunzio, D., Lenato, G. M., Stella, A., Capocaccia, R., Bagnulo, R., Lastella, P., Susca, F. C., Bozzao, C., Loconte, D. C., et al. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.12.018 · Cited by 157 · see citing works
Familial Risk of Pancreatic Cancer
Schenk, M., Schwartz, A. G., O'Neal, E., Kinnard, M. F., Greenson, J. K., Fryzek, J. P., Ying, G., & Garabrant, D. H. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.8.640 · Cited by 157 · see citing works
Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
Jacobs, E. J., Chanock, S. J., Fuchs, C. S., LaCroix, A., McWilliams, R. R., Steplowski, E., Stolzenberg‐Solomon, R. Z., Arslan, A. A., Bueno‐de‐Mesquita, H. B., Gross, M., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25148 · Cited by 151 · see citing works
Self-citation
Germ Line Fanconi Anemia Complementation Group C Mutations and Pancreatic Cancer
Couch, F. J., Johnson, M. R., Rabe, K. G., Boardman, L., McWilliams, R. R., de Andrade, M., & Petersen, G. M. (2005) · Cancer Research · doi:10.1158/0008-5472.383.65.2 · Cited by 144 · see citing works
Self-citation
Pancreatic Cancer Genetic Epidemiology Consortium
Petersen, G. M., de Andrade, M., Goggins, M., Hruban, R. H., Bondy, M. L., Korczak, J. F., Gallinger, S., Lynch, H. T., Syngal, S., Rabe, K. G., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0734 · Cited by 141 · see citing works
Self-citation
Prevalence of pathogenic mutations in cancer predisposition genes among pancreatic cancer patients
Hu, C., Hart, S. N., Bamlet, W. R., Moore, R. M., Nandakumar, K., Eckloff, B. W., Lee, Y. K., Petersen, G. M., McWilliams, R. R., & Couch, F. J. (2016) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0455 · Cited by 137 · see citing works
Self-citation
Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling
McWilliams, R. R., Wieben, E. D., Rabe, K. G., Pedersen, K. S., Wu, Y., Sicotte, H., & Petersen, G. M. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.198 · Cited by 135 · see citing works
Self-citation
Familial pancreatic cancer
Hruban, R. H., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Falatko, F., Yeo, C. J., & Kern, S. E. (1999) · Annals of Oncology · doi:10.1093/annonc/10.suppl_4.s69 · Cited by 134 · see citing works
Self-citation
Evidence for a major gene influencing risk of pancreatic cancer
Klein, A. P., Beaty, T. H., Wilson, J., Brune, K. A., Hruban, R. H., & Petersen, G. M. (2002) · Genetic Epidemiology · doi:10.1002/gepi.1102 · Cited by 129 · see citing works
Self-citation
Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance
Korsse, S. E., Harinck, F., van Lier, M. G., Biermann, K., Offerhaus, G. J. A., Krak, N. C., Looman, C. W. N., van Veelen, W., Kuipers, E. J., Wagner, A., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101277 · Cited by 118 · see citing works
Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC)
Inoue, M., Tajima, K., Takezaki, T., Hamajima, N., Hirose, K., Ito, H. M., & Tominaga, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg062 · Cited by 115 · see citing works
The impact of age, treatment, and symptoms on the physical and mental health of cancer patients
Given, C. W., Given, B. A., & Stommel, M. (1994) · Cancer · doi:10.1002/1097-0142(19941001)74:7+ · Cited by 112 · see citing works
Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and risk for pancreatic adenocarcinoma
McWilliams, R. R., Petersen, G. M., Rabe, K. G., Holtegaard, L. M., Lynch, P. J., Bishop, M. D., & Highsmith, W. E. (2009) · Cancer · doi:10.1002/cncr.24697 · Cited by 107 · see citing works
Self-citation
Germline Findings in Tumor-Only Sequencing: Points to Consider for Clinicians and Laboratories: Table 1.
Raymond, V. M., Gray, S. W., Roychowdhury, S., Joffe, S., Chinnaiyan, A. M., Parsons, D. W., & Plon, S. E. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv351 · Cited by 100 · see citing works
Pancreatic Cancer Genetics
Amundadottir, L. T. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.15001 · Cited by 98 · see citing works
Germline Analysis from Tumor–Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings
Seifert, B. A., O’Daniel, J. M., Amin, K. D., Marchuk, D. S., Patel, N. M., Parker, J. S., Hoyle, A. P., Mose, L. E., Marron, A., Hayward, M. C., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0015 · Cited by 95 · see citing works
Ethical, Legal, and Counseling Challenges Surrounding the Return of Genetic Results in Oncology
Lolkema, M. P., Hooijdonk, C. G. G., Bredenoord, A. L., Kapitein, P., Roach, N., Cuppen, E. P. J. G., Knoers, N. V. A. M., & Voest, E. E. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2789 · Cited by 90 · see citing works
Adenocarcinoma of the Pancreas in Four Siblings
MacDermott, R. P., & Kramer, P. A. (1973) · Gastroenterology · doi:10.1016/s0016-5085(19)33156-7 · Cited by 84 · see citing works
The Genetics ofFANCCandFANCGin Familial Pancreatic Cancer
Rogers, C. D., van der Heijden, M. S., Brune, K. A., Yeo, C. J., Hruban, R. H., Kern, S. E., & Goggins, M. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.2.609 · Cited by 82 · see citing works
Risk of malignancy in first‐degree relatives of patients with pancreatic carcinoma
McWilliams, R. R., Rabe, K. G., Olswold, C., de Andrade, M., & Petersen, G. M. (2005) · Cancer · doi:10.1002/cncr.21166 · Cited by 81 · see citing works
Self-citation
Prospective risk of cancer in CDKN2A germline mutation carriers
Goldstein, A. M., Struewing, J. P., Fraser, M. C., Smith, M. W., & Tucker, M. A. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.019349 · Cited by 81 · see citing works
Tumor genome analysis includes germline genome: Are we ready for surprises?
Catenacci, D. V. T., Amico, A. L., Nielsen, S. M., Geynisman, D. M., Rambo, B., Carey, G. B., Gulden, C., Fackenthal, J., Marsh, R. D., Kindler, H. L., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29128 · Cited by 78 · see citing works
Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas
Ghadirian, P., Liu, G., Gallinger, S., Schmocker, B., Paradis, A., Lal, G., Brunet, J., Foulkes, W. D., & Narod, S. A. (2001) · International Journal of Cancer · doi:10.1002/ijc.10123 · Cited by 72 · see citing works
Clinical and pathologic features of familial pancreatic cancer
Humphris, J. L., Johns, A. L., Simpson, S. H., Cowley, M. J., Pajic, M., Chang, D. K.-F., Nagrial, A. M., Chin, V. T., Chantrill, L. A., Pinese, M., et al. (2014) · Cancer · doi:10.1002/cncr.28863 · Cited by 65 · see citing works
Population Attributable Risk for Pancreatic Cancer in Northern Italy
Rosato, V., Polesel, J., Bosetti, C., Serraino, D., Negri, E., & Vecchia, C. L. (2014) · Pancreas · doi:10.1097/mpa.0000000000000251 · Cited by 55 · see citing works
Familial pancreatic adenocarcinoma
Petersen, G. M. (2015) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2015.04.007 · Cited by 53 · see citing works
Self-citation
Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer
Smith, A. L., Alirezaie, N., Connor, A. A., Chan‐Seng‐Yue, M., Grant, R. C., Selander, I., Bascuñana, C., Borgida, A., Hall, A., Whelan, T., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.030 · Cited by 52 · see citing works
Self-citation
Risk Factors for Pancreatic Cancer in China: A Multicenter Case-Control Study
Zheng, Z., Zheng, R., He, Y., Sun, X., Wang, N., Chen, T., & Chen, W. (2015) · Journal of Epidemiology · doi:10.2188/jea.je20140148 · Cited by 47 · see citing works
Prospective risk of cancer and the influence of tobacco use in carriers of the p16-Leiden germline variant
Potjer, T. P., Kranenburg, H. E., Bergman, W., Cappel, W. H. D. V. T. N., van Monsjou, H. S., Barge‐Schaapveld, D. Q. C. M., & Vasen, H. F. A. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.187 · Cited by 33 · see citing works
Screening and Surgical Outcomes of Familial Pancreatic Cancer
Templeton, A. W., & Brentnall, T. A. (2013) · Surgical Clinics of North America · doi:10.1016/j.suc.2013.02.002 · Cited by 31 · see citing works
Genetics of the FANCA gene in familial pancreatic cancer
Rogers, C. D., Couch, F. J., Brune, K., Martin, S. T., Philips, J., Murphy, K. M., Petersen, G., Yeo, C. J., Hruban, R. H., & Goggins, M. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024851 · Cited by 26 · see citing works
Self-citation
Correction
(2013) · Gut · doi:10.1136/gutjnl-2012-303108corr1 · Cited by 25 · see citing works
Familial pancreatic cancer—status quo
Fendrich, V., Langer, P., & Bartsch, D. K. (2013) · International Journal of Colorectal Disease · doi:10.1007/s00384-013-1760-3 · Cited by 24 · see citing works
Cancer of the pancreas in two brothers and one sister
Ghadirian, P., Simard, A., & Baillargeon, J. (1987) · International Journal of Pancreatology · doi:10.1007/bf02788437 · Cited by 23 · see citing works
A Population-Based Description of Familial Clustering of Pancreatic Cancer
Shirts, B. H., Burt, R. W., Mulvihill, S. J., & Cannon‐Albright, L. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.05.012 · Cited by 22 · see citing works
Family History of Diabetes and Pancreatic Cancer as Risk Factors for Pancreatic Cancer: The PACIFIC Study
Austin, M. A., Kuo, E., Eeden, S. K. V. D., Mandelson, M. T., Brentnall, T. A., Kamineni, A., & Potter, J. D. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0518 · Cited by 20 · see citing works
Progress in the Earlier Detection of Pancreatic Cancer
Brentnall, T. A. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.66.5265 · Cited by 9 · see citing works
Genetic heterogeneity and survival among pancreatic adenocarcinoma (PDAC) patients with positive family history.
Petersen, G. M., Chaffee, K. G., McWilliams, R. R., Majithia, N., Allen, B. A., Kidd, J., Singh, N., Hartman, A., & Oberg, A. L. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.4108 · Cited by 9 · see citing works
Self-citation

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Self-citation
NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020
Daly, M. B., Pilarski, R., Yurgelun, M. B. B., Berry, M. P., Buys, S. S., Dickson, P., Domchek, S. M., Elkhanany, A. M., Friedman, S., Garber, J. E., et al. (2020) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2020.0017 · Cited by 512 · see citing works
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma
Grossberg, A. J., Chu, L. C. H., Deig, C. R., Fishman, E. K., Hwang, W. L., Maitra, A., Marks, D. L., Mehta, A., Nabavizadeh, N., Simeone, D. M., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21626 · Cited by 491 · see citing works
PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications
Zhu, H., Wei, M., Xu, J., Hua, J., Chen, L., Meng, Q., Zhang, Y., Liu, J., Zhang, B., Yu, X., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01167-9 · Cited by 258 · see citing works
Lead-time trajectory of CA19-9 as an anchor marker for pancreatic cancer early detection
Fahrmann, J. F., Schmidt, C. M., Mao, X., Irajizad, E., Loftus, M., Zhang, J., Patel, N., Vykoukal, J., Dennison, J. B., Long, J. P., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.11.052 · Cited by 208 · see citing works
ASGE guideline on screening for pancreatic cancer in individuals with genetic susceptibility: summary and recommendations
Sawhney, M., Calderwood, A. H., Thosani, N. C., Rebbeck, T. R., Wani, S. B., Canto, M. I., Fishman, D. S., Golan, T., Hidalgo, M. M., Kwon, R. S., et al. (2022) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2021.12.001 · Cited by 152 · see citing works
The Role of BRCA Testing in Hereditary Pancreatic and Prostate Cancer Families
Pilarski, R. (2019) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_238977 · Cited by 107 · see citing works
Curation of the Pancreatic Ductal Adenocarcinoma Subset of the Cancer Genome Atlas Is Essential for Accurate Conclusions about Survival-Related Molecular Mechanisms
Peran, I., Madhavan, S., Byers, S. W., & McCoy, M. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0290 · Cited by 96 · see citing works
DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy
de Almeida, L. C., Calil, F. A., Machado‐Neto, J. A., & Costa-Lotufo, L. V. (2020) · Cancer Genetics · doi:10.1016/j.cancergen.2020.12.002 · Cited by 86 · see citing works
A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer
Zhong, J., Jermusyk, A. A., Wu, L., Hoskins, J. W., Collins, I. J., Mocci, E., Zhang, M., Song, L., Chung, C. C., Zhang, T., et al. (2019) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djz246 · Cited by 79 · see citing works
Self-citation
The intricate relationship between diabetes, obesity and pancreatic cancer
Paternoster, S., & Falasca, M. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.188326 · Cited by 79 · see citing works
BRCA mutated pancreatic cancer: A change is coming
Rosen, M. N., Goodwin, R. A., & Vickers, M. M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i17.1943 · Cited by 72 · see citing works
Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
Liu, Y.-H., Hu, C., Hsu, Y.-S., & Lee, W. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05259-w · Cited by 66 · see citing works
From Machine Learning to Patient Outcomes: A Comprehensive Review of AI in Pancreatic Cancer
Tripathi, S., Tabari, A., Mansur, A., Dabbara, H., Bridge, C. P., & Daye, D. (2024) · Diagnostics · doi:10.3390/diagnostics14020174 · Cited by 64 · see citing works
A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants
Earl, J., Galindo-Pumariño, C., Encinas, J., Barreto, E., Castillo, M. E., Pachón, V., Ferreiro, R., Rodríguez-Garrote, M., González-Martínez, S., y Cajal, T. R., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102675 · Cited by 50 · see citing works
Germline Variants and Risk for Pancreatic Cancer
Zhan, W., Shelton, C. A., Greer, P. J., Brand, R. E., & Whitcomb, D. C. (2018) · Pancreas · doi:10.1097/mpa.0000000000001136 · Cited by 48 · see citing works
Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort
Matejcic, M., Lesueur, F., Biessy, C., Renault, A., Mebirouk, N., Yammine, S. G., Keski‐Rahkonen, P., Li, K., Hémon, B., Weiderpass, E., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31797 · Cited by 48 · see citing works
Next-Generation Sequencing in Pancreatic Cancer
Shen, G.-Q., Aleassa, E. M., Walsh, R. M., & Morris‐Stiff, G. J. (2019) · Pancreas · doi:10.1097/mpa.0000000000001324 · Cited by 45 · see citing works
A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk
Liu, D., Zhou, D., Sun, Y., Zhu, J., Ghoneim, D. H., Wu, C., Yao, Q. C., Gamazon, E. R., Cox, N. J., & Wu, L. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1353 · Cited by 44 · see citing works
A blood-based metabolomic signature predictive of risk for pancreatic cancer
Irajizad, E., Kenney, A., Tang, T. M., Vykoukal, J., Wu, R., Murage, E. N., Dennison, J. B., Sans, M., Long, J. P., Loftus, M., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101194 · Cited by 44 · see citing works
Advances in pancreatic cancer early diagnosis, prevention, and treatment: The past, the present, and the future
Mannucci, A., & Goel, A. (2025) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.70035 · Cited by 53 · see citing works
A pancreatic cancer risk prediction model (Prism) developed and validated on large-scale US clinical data
Jia, K., Kundrot, S., Palchuk, M. B., Warnick, J., Haapala, K., Kaplan, I. D., Rinard, M., & Appelbaum, L. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104888 · Cited by 39 · see citing works
Early detection of pancreatic cancer
Garg, S. K., & Chari, S. T. (2020) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000663 · Cited by 39 · see citing works
Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival
Ulanja, M. B., Moody, A. E., Beutler, B. D., Antwi‐Amoabeng, D., Rahman, G. A., & Alese, O. B. (2022) · Oncotarget · doi:10.18632/oncotarget.28242 · Cited by 38 · see citing works
BRCA2 gene mutation in cancer
Xie, C., Luo, J., He, Y., Jiang, L., Zhong, L., & Shi, Y. (2022) · Medicine · doi:10.1097/md.0000000000031705 · Cited by 36 · see citing works
Treatment opportunities and future perspectives for pancreatic cancer patients with germline BRCA1-2 pathogenic variants
Macchini, M., Centonze, F., Peretti, U., Orsi, G., Militello, A. M., Valente, M. M., Cascinu, S., & Reni, M. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102262 · Cited by 33 · see citing works
Epigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance?
Čierniková, S., Earl, J., García‐Bermejo, L., Števurková, V., Carrato, A., & Smolková, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114091 · Cited by 33 · see citing works
Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma
Walker, E. J., Carnevale, J. C., Pedley, C., Blanco, A. M., Chan, S. B., Collisson, E. A., Tempero, M. A., & Ko, A. H. (2018) · Familial Cancer · doi:10.1007/s10689-018-0106-2 · Cited by 30 · see citing works
A systematic review of the prevalence of germline pathogenic variants in patients with pancreatic cancer
Astiazarán-Symonds, E., & Goldstein, A. M. (2021) · Journal of Gastroenterology · doi:10.1007/s00535-021-01806-y · Cited by 30 · see citing works
American Society for Gastrointestinal Endoscopy guideline on screening for pancreatic cancer in individuals with genetic susceptibility: methodology and review of evidence
Calderwood, A. H., Sawhney, M., Thosani, N. C., Rebbeck, T. R., Wani, S. B., Canto, M. I., Fishman, D. S., Golan, T., Hidalgo, M. M., Kwon, R. S., et al. (2022) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2021.12.002 · Cited by 30 · see citing works
Pancreas-targeted lipid nanoparticles for relatively non-invasive interleukin-12 mRNA therapy in orthotopic pancreatic ductal adenocarcinoma
Shen, Q., Liu, J., Zeng, L., Ren, Y., Liao, J., Chen, S., Tang, Y., Zhang, Z., Jiang, M., Liao, H., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113588 · Cited by 30 · see citing works
Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort
Peretti, U., Cavaliere, A., Niger, M., Tortora, G., Marco, M. D., Rodriquenz, M. G., Centonze, F., Rapposelli, I. G., Giordano, G., Vita, F. D., et al. (2021) · ESMO Open · doi:10.1016/j.esmoop.2020.100032 · Cited by 29 · see citing works
Pancreatic Cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation
Vietri, M. T., D’Elia, G., Caliendo, G., Albanese, L., Signoriello, G., Claudio Napoli, A., & Molinari, A. M. (2022) · Genes · doi:10.3390/genes13020321 · Cited by 29 · see citing works
The Microbiome and Pancreatic Cancer
Archibugi, L., Signoretti, M., & Capurso, G. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001092 · Cited by 26 · see citing works
Beyond BRCA: The Emerging Significance of DNA Damage Response and Personalized Treatment in Pancreatic and Prostate Cancer Patients
Dalmasso, B., Puccini, A., Catalano, F., Borea, R., Iaia, M. L., Bruno, W., Fornarini, G., Sciallero, S., Rebuzzi, S. E., & Ghiorzo, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094709 · Cited by 25 · see citing works
The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection
Pflüger, M. J., Griffin, J. F., Hackeng, W. M., Kawamoto, S., Yu, J., Chianchiano, P. E., Shin, E., Lionheart, G., Tsai, H., Wang, H., et al. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004427 · Cited by 25 · see citing works
Hereditary and Sporadic Pancreatic Ductal Adenocarcinoma: Current Update on Genetics and Imaging
Morani, A. C., Hanafy, A. K., Ramani, N. S., Katabathina, V. S., Yedururi, S., Dasyam, A. K., & Prasad, S. R. (2020) · Radiology Imaging Cancer · doi:10.1148/rycan.2020190020 · Cited by 24 · see citing works
BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic
Minucci, A., Scambia, G., Santonocito, C., Concolino, P., & Urbani, A. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05479-3 · Cited by 24 · see citing works
Familial Pancreatic Cancer and Surveillance of High-Risk Individuals
Matsubayashi, H., Takaori, K., Morizane, C., & Kiyozumi, Y. (2019) · Gut and Liver · doi:10.5009/gnl18449 · Cited by 24 · see citing works
Oncology clinic-based germline genetic testing for exocrine pancreatic cancer enables timely return of results and unveils low uptake of cascade testing
Wang, Y., Golesworthy, B., Cuggia, A., Domecq, C., Chaudhury, P. K., Barkun, J. S., Metrakos, P. P., Asselah, J., Bouganim, N., Gao, Z., et al. (2021) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2021-108054 · Cited by 23 · see citing works
Imaging and Screening of Pancreatic Cancer
Burk, K. S., Lo, G. C., Gee, M. S., & Sahani, D. V. (2017) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2017.06.006 · Cited by 23 · see citing works
Germline Aberrations in Pancreatic Cancer: Implications for Clinical Care
Casolino, R., Corbo, V., Beer, P. A., Hwang, C., Paiella, S., Silvestri, V., Ottini, L., & Biankin, A. V. (2022) · Cancers · doi:10.3390/cancers14133239 · Cited by 22 · see citing works
Earlier Diagnosis of Pancreatic Cancer: Is It Possible?
Koltai, T. (2023) · Cancers · doi:10.3390/cancers15184430 · Cited by 22 · see citing works
A Genome-First Approach to Estimate Prevalence of Germline Pathogenic Variants and Risk of Pancreatic Cancer in Select Cancer Susceptibility Genes
Astiazarán-Symonds, E., Kim, J., Haley, J. S., Kim, S. Y., Rao, H. S., Carey, D. J., Stewart, D. R., & Goldstein, A. M. (2022) · Cancers · doi:10.3390/cancers14133257 · Cited by 21 · see citing works
Management of Patients With Pancreatic Cancer Using the “Right Track” Model
Rosenzweig, A., Berlin, J. D., Chari, S. T., Kindler, H. L., Matrisian, L. M., Mayoral, A., Mills, J. B., Nissen, N. N., Picozzi, V. J., Zelada-Arenas, F., et al. (2023) · The Oncologist · doi:10.1093/oncolo/oyad080 · Cited by 21 · see citing works
Clinical interpretation of pathogenic ATM and CHEK2 variants on multigene panel tests: navigating moderate risk
DePersia, A., Blazer, K. R., Stoll, J., Jones, M., Weipert, C. M., Nielsen, S. M., Kupfer, S. S., Weitzel, J. N., & Olopade, O. I. (2018) · Familial Cancer · doi:10.1007/s10689-018-0070-x · Cited by 22 · see citing works
Potential of artificial intelligence in the risk stratification for and early detection of pancreatic cancer
Tovar, D., Rosenthal, M. H., Maitra, A., & Koay, E. J. (2023) · Artificial Intelligence Surgery · doi:10.20517/ais.2022.38 · Cited by 22 · see citing works
Pancreatic Cancer Screening
Das, K. K., & Early, D. S. (2017) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-017-0149-8 · Cited by 19 · see citing works
Genetics, Genomics and Emerging Molecular Therapies of Pancreatic Cancer
Liu, J., Mroczek, M., Mach, A., Stępień, M., Aplas, A., Pronobis‐Szczylik, B., Bukowski, S., Mielczarek, M., Gajewska, E., Topolski, P., et al. (2023) · Cancers · doi:10.3390/cancers15030779 · Cited by 18 · see citing works
Role of bioactive lipofishins in prevention of inflammation and colon cancer
Lombardi, V., Carrera, I., Corzo, L., & Cacabelos, R. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.012 · Cited by 17 · see citing works
A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene
Wong, C., Chen, F., Alirezaie, N., Wang, Y., Cuggia, A., Borgida, A., Holter, S., Lenko, T., Domecq, C., Initiative, A. D. N., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008344 · Cited by 19 · see citing works
Self-citation
Proteostasis Dysregulation in Pancreatic Cancer
Arpalahti, L., Haglund, C., & Holmberg, C. I. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-38266-7_4 · Cited by 17 · see citing works
Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer
Figueroa‐González, G., Carrillo, J. F., Perez-Rodriguez, I., de León, D. F. C., Campos-Parra, A. D., Martínez-Gutiérrez, A. D., Coronel-Hernández, J., García-Castillo, V., López‐Camarillo, C., Peralta-Zaragoza, Ó., et al. (2020) · Genes · doi:10.3390/genes11091058 · Cited by 16 · see citing works
Attitudes Toward Return of Genetic Research Results to Relatives, Including After Death: Comparison of Cancer Probands, Blood Relatives, and Spouse/Partners
Breitkopf, C. R., Wolf, S. M., Rabe, K. G., Robinson, M., Lindor, N. M., Gordon, D. R., Koenig, B. A., & Petersen, G. M. (2018) · Journal of Empirical Research on Human Research Ethics · doi:10.1177/1556264618769165 · Cited by 15 · see citing works
Self-citation
Building towards Precision Oncology for Pancreatic Cancer: Real-World Challenges and Opportunities
Wang, Y., Lakoma, A., & Zogopoulos, G. (2020) · Genes · doi:10.3390/genes11091098 · Cited by 14 · see citing works
Genetic Signature of Human Pancreatic Cancer and Personalized Targeting
Reshkin, S. J., Cardone, R. A., & Koltai, T. (2024) · Cells · doi:10.3390/cells13070602 · Cited by 14 · see citing works
A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition
Horn, I. P., Marks, D., Koenig, A. N., Hogenson, T. L., Almada, L. L., Goldstein, L., Duran, P. A. R., Vera, R. E., Vrabel, A., Cui, G., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100634 · Cited by 9 · see citing works
Self-citation
CDKN2A founder mutation in pancreatic ductal adenocarcinoma patients without cutaneous features of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome
Cremin, C., Howard, S. V., Le, L., Karsan, A., Schaeffer, D. F., Renouf, D. J., & Schrader, K. A. (2018) · Hereditary Cancer in Clinical Practice · doi:10.1186/s13053-018-0088-y · Cited by 13 · see citing works
Recommendations, evidence and sustainability of screening for pancreatic cancer in high-risk individuals
Bogdanski, A. M., Acedo, P., Wallace, M. B., van Leerdam, M. E., & Klatte, D. C. F. (2025) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2025.101974 · Cited by 12 · see citing works
Risk of Syndrome-Associated Cancers Among First-Degree Relatives of Patients With Pancreatic Ductal Adenocarcinoma With Pathogenic or Likely Pathogenic Germline Variants
Chen, X., Meyer, M. A., Kemppainen, J. L., Horibe, M., Chandra, S., Majumder, S., Petersen, G. M., & Rabe, K. G. (2023) · JAMA Oncology · doi:10.1001/jamaoncol.2023.0806 · Cited by 12 · see citing works
Self-citation
Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential
Alors‐Pérez, E., Pedraza‐Arévalo, S., Blázquez‐Encinas, R., Moreno-Montilla, M. T., García‐Vioque, V., Berbel, I., Luque, R. M., Sáinz, B., Ibáñez‐Costa, A., & Castano, J. P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02858-z · Cited by 11 · see citing works
Genetic and other risk factors for pancreatic ductal adenocarcinoma (PDAC)
Jacobs, M. F., & Stoffel, E. M. (2024) · Familial Cancer · doi:10.1007/s10689-024-00372-5 · Cited by 12 · see citing works
From classical approaches to artificial intelligence, old and new tools for PDAC risk stratification and prediction
Farinella, R., Felici, A., Peduzzi, G., Testoni, S. G. G., Costello, E., Aretini, P., Blázquez‐Encinas, R., Oz, E., Pastore, A., Tacelli, M., et al. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.03.004 · Cited by 13 · see citing works
Surveillance of Individuals with a Family History of Pancreatic Cancer and Inherited Cancer Syndromes: A Strategy for Detecting Early Pancreatic Cancers
Matsubayashi, H., Kiyozumi, Y., Ishiwatari, H., Uesaka, K., Kikuyama, M., & Ono, H. (2019) · Diagnostics · doi:10.3390/diagnostics9040169 · Cited by 12 · see citing works
Duktales Adenokarzinom des Pankreas
Gallmeier, E., & Gress, T. M. (2018) · Der Internist · doi:10.1007/s00108-018-0460-z · Cited by 12 · see citing works
Small non-coding RNAs and pancreatic ductal adenocarcinoma: Linking diagnosis, pathogenesis, drug resistance, and therapeutic potential
Fuller, R. N., Morcos, A., Bustillos, J. G., Molina, D. C., & Wall, N. R. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189153 · Cited by 11 · see citing works
Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains
Park, D., Shakya, R., Koivisto, C. S., Pitarresi, J. R., Szabolcs, M. J., Kladney, R. D., Hadjis, A. D., Mace, T. A., & Ludwig, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226714 · Cited by 10 · see citing works
McCune Albright syndrome is a genetic predisposition to intraductal papillary and mucinous neoplasms of the pancreas associated pancreatic cancer in relation with GNAS somatic mutation – a case report
Gaujoux, S., Pasmant, É., Silve, C., Mehsen-Cêtre, N., Coriat, R., Rouquette, A., Douset, B., Prat, F., & Leroy, K. (2019) · Medicine · doi:10.1097/md.0000000000018102 · Cited by 10 · see citing works
Design of nano-delivery systems for pancreatic cancer immunotherapy
Fu, S., Gao, C., Yu, Q., Gong, R., Yang, Z., Zang, X., Shan, S., Mombrú, D., Romero, M., Mombrú, Á. W., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218098 · Cited by 11 · see citing works
Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival
Earl, J., Barreto, E., Castillo, M., Fuentes, R., Rodríguez-Garrote, M., Ferreiro, R., Reguera, P., Muñoz, G., García‐Seisdedos, D., López, J., et al. (2021) · Cancers · doi:10.3390/cancers13071612 · Cited by 9 · see citing works
Implementation of BRCA mutations testing in formalin-fixed paraffin-embedded (FFPE) samples of different cancer types
Zannini, G., Facchini, G., SIO, M. D., Vita, F. D., Ronchi, A., Orditura, M., Vietri, M. T., Ciardiello, F., Franco, R., Accardo, M., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154336 · Cited by 9 · see citing works
Prognostic significance of BRCA1 and BRCA2 methylation status in circulating cell-free DNA of Pancreatic Cancer patients
Koukaki, T., Balgkouranidou, I., Biziota, E., Karayiannakis, A. J., Bolanaki, H., Karamitrousis, E., Zarogoulidis, P., Deftereos, S. P., Charalampidis, C., Ioannidis, A., et al. (2024) · Journal of Cancer · doi:10.7150/jca.93184 · Cited by 9 · see citing works
Genetic landscape of pancreatic cancer: a narrative review
Yakar, D. O., Bozkirli, B. O., & Ceyhan, G. O. (2022) · Chinese Clinical Oncology · doi:10.21037/cco-22-4 · Cited by 9 · see citing works
Is Biannual Surveillance for Pancreatic Cancer Sufficient in Individuals With Genetic Syndromes or Familial Pancreatic Cancer?
Wang, Y., Cuggia, A., Chen, Y., Parent, J., Stanek, A., Denroche, R. E., Zhang, A. X. W., Grant, R. C., Domecq, C., Golesworthy, B., et al. (2022) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2021.7107 · Cited by 9 · see citing works
Life's Essential 8, genetic susceptibility, and risk of incident pancreatic cancer: A prospective cohort study
Wu, Z., Zeng, L., Fang, Z., Yuan, Y., Zhou, Y., & Chen, R. (2024) · International Journal of Cancer · doi:10.1002/ijc.35184 · Cited by 8 · see citing works
Significant detection of new germline pathogenic variants in Australian Pancreatic Cancer Screening Program participants
Murali, K., Dwarte, T. M., Nikfarjam, M., Tucker, K., Vaughan, R., Efthymiou, M., Collins, A., Spigelman, A. D., Salmon, L., Johns, A. L., et al. (2021) · Hereditary Cancer in Clinical Practice · doi:10.1186/s13053-021-00190-1 · Cited by 8 · see citing works
Risk of pancreatic ductal adenocarcinoma associated with carriage of BRCA1 and/or BRCA2 mutation: A systematic review and meta‐analysis
McGarry, J., Creavin, B., Kelly, M. E., & Gallagher, T. K. (2022) · Journal of Surgical Oncology · doi:10.1002/jso.26994 · Cited by 8 · see citing works
The implication of liquid biopsies to predict chemoresistance in pancreatic cancer
Pietri, E., Balsano, R., Corianò, M., Gelsomino, F., Leonardi, F., Bui, S., Gnetti, L., Valle, R. D., & Garajová, I. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2021.01 · Cited by 8 · see citing works
Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts
Erreni, M., Fumagalli, M. R., D’Anna, R., Sollai, M., Bozzarelli, S., Nappo, G., Zanini, D., Parente, R., Garlanda, C., Rimassa, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1472433 · Cited by 7 · see citing works
Hydrogel models of pancreatic adenocarcinoma to study cell mechanosensing
Walker, M., & Morton, J. (2024) · Biophysical Reviews · doi:10.1007/s12551-024-01265-8 · Cited by 7 · see citing works
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Authors: Petersen, G. M.
Affiliations: Mayo Clinic (US)
Corresponding author: Petersen, Gloria M.
ORCID: Petersen, Gloria M.
Venue: Seminars in Oncology
Publisher: Elsevier BV
Published: 2016-10
Volume: 43
Issue: 5
Pages: 548-553
ISSN: 0093-7754 (ISSN-L)
DOI: 10.1053/j.seminoncol.2016.09.002
PMC: PMC5234085
OpenAlex: W2522369252
Cited by: 157
References: 69
Citations by year: 2026: 10 · 2025: 16 · 2024: 21 · 2023: 16 · 2022: 19 · 2021: 21 · 2020: 22 · 2019: 15 · 2018: 12 · 2017: 5
FWCI: 1.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Oncology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P50CA102701, R01CA097075)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: familial pancreatic cancer, pancreatic ductal adenocarcinoma, hereditary cancer, BRCA2, CDKN2A, germline mutations, genetic panel testing, precision oncology, genetic risk prediction
MeSH terms: Fanconi Anemia Complementation Group N Protein, Humans, Nuclear Proteins, Pancreatic Neoplasms, Cyclin-Dependent Kinase Inhibitor p16, Genetic Predisposition to Disease, Genes, BRCA2, Tumor Suppressor Proteins, Cyclin-Dependent Kinase Inhibitor p18, Fanconi Anemia Complementation Group C Protein

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