Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones

THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY

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Microencapsulation : methods and industrial applications

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Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.

Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., & Alyautdin, R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031877 · Cited by 801 · see citing works

Araldite as an Embedding Medium for Electron Microscopy

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Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)

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Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles

Kreuter, J., Ramge, P., Petrov, V. E., Hamm, S., Gelperina, S. E., Engelhardt, B., Alyautdin, R. N., von Briesen, H., & Begley, D. J. (2003) · Pharmaceutical Research · doi:10.1023/a:1022604120952 · Cited by 469 · see citing works

Long-circulating pegylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery.

Calvo, P., Gouritin, B., Chacun, H., Desmaële, D., D'Angelo, J., Noel, J.-P., Georgin, D., Fattal, E., Andreux, J. P., & Couvreur, P. (2001) · Pharmaceutical Research · doi:10.1023/a:1010931127745 · Cited by 443 · see citing works

Chemotherapy of glioblastoma in rats using doxorubicin‐loaded nanoparticles

Steiniger, S. C. J., Kreuter, J., Khalansky, A. S., Skidan, I. N., Bobruskin, A. I., Smirnova, Z. S., Severin, E. S., Uhl, R., Kock, M., Geiger, K. D., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20048 · Cited by 434 · see citing works

Covalent Linkage of Apolipoprotein E to Albumin Nanoparticles Strongly Enhances Drug Transport into the Brain

Michaelis, K., Hoffmann, M. M., Dreis, S., Herbert, E., Alyautdin, R. N., Michaelis, M., Kreuter, J., & Langer, K. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.097139 · Cited by 346 · see citing works

Implications of the Blood-Brain Barrier and Its Manipulation

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Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: Revisiting the role of surfactants

Petri, B., Bootz, A., Khalansky, A. S., Hekmatara, T., Müller, R. H., Uhl, R., Kreuter, J., & Gelperina, S. E. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.10.015 · Cited by 299 · see citing works

The Blood-brain Barrier: Principles for Targeting Peptides and Drugs to the Central Nervous System

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Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain

Kreuter, J., Hekmatara, T., Dreis, S., Vogel, T., Gelperina, S. E., & Langer, K. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.012 · Cited by 263 · see citing works

Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity

Olivier, J.-C., Fenart, L., Chauvet, R., Pariat, C., Cecchelli, R., & Couet, W. (1999) · Pharmaceutical Research · doi:10.1023/a:1018947208597 · Cited by 213 · see citing works

Human serum albumin–polyethylenimine nanoparticles for gene delivery

Rhaese, S., von Briesen, H., Rübsamen‐Waigmann, H., Kreuter, J., & Langer, K. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00302-x · Cited by 180 · see citing works

Interaction of Poly(butylcyanoacrylate) Nanoparticles with the Blood-Brain Barrierin vivoandin vitro

Alyaudtin, R. N., Reichel, A., Löbenberg, R., Ramge, P., Kreuter, J., & Begley, D. J. (2001) · Journal of drug targeting · doi:10.3109/10611860108997929 · Cited by 166 · see citing works

Desolvation process and surface characteristics of HSA-nanoparticles

Weber, C., Kreuter, J., & Langer, K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00420-2 · Cited by 158 · see citing works

Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles

Alyautdin, R. N., Gothier, D., Петров, Kharkevich, D. A., & Kreuter, J. (1995) · European Journal of Pharmaceutics and Biopharmaceutics · Cited by 148 · see citing works

Lysosomal Storage Diseases and the Blood-Brain Barrier

Begley, D. J., Pontikis, C., & Scarpa, M. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784705504 · Cited by 145 · see citing works

Targeted delivery across the blood–brain barrier

Gaillard, P. J., Visser, C. C., & de Boer, A. G. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2.2.299 · Cited by 130 · see citing works

Functional Protein Delivery into Neurons Using Polymeric Nanoparticles

Hasadsri, L., Kreuter, J., Hattori, H., Iwasaki, T., & George, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805956200 · Cited by 127 · see citing works

Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model

Ambruosi, A., Gelperina, S. E., Khalansky, A. S., Tanski, S., Theisen, A., & Kreuter, J. (2006) · Journal of Microencapsulation · doi:10.1080/02652040600788080 · Cited by 100 · see citing works

Delivery of nanoparticles to the brain detected by fluorescence microscopy

Reimold, I., Domke, D., Bender, J., Seyfried, C. A., Radunz, H.-E., & Fricker, G. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.05.007 · Cited by 89 · see citing works

Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat

Wolburg, H., Wolburg‐Buchholz, K., Sam, H., Horvát, S., Deli, M. A., & Mack, A. F. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0410-2 · Cited by 85 · see citing works

Absence of albumin receptor on brain capillaries in vivo or in vitro

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Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: Focus on cardio- and testicular toxicity

Переверзева, Э. Р., Трещалин, И. Д., Бодягин, Д. А., Максименко, О. О., Langer, K., Dreis, S., Asmussen, B., Kreuter, J., & Gelperina, S. E. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.01.031 · Cited by 76 · see citing works

Coaxing the LDL Receptor Family into the Fold

Herz, J., & Marschang, P. (2003) · Cell · doi:10.1016/s0092-8674(03)00073-4 · Cited by 73 · see citing works

Intravenous tolerance of a nanoparticle-based formulation of doxorubicin in healthy rats

Переверзева, Э. Р., Трещалин, И. Д., Бодягин, Д. А., Максименко, О. О., Kreuter, J., & Gelperina, S. E. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.01.020 · Cited by 47 · see citing works

Blood-Brain Barrier Disruption in the Treatment of Brain Tumors

Neuwelt, E. A., & Barnett, P. A. (1989) · Springer eBooks · doi:10.1007/978-1-4615-7255-8_4 · Cited by 44 · see citing works

7 Nanoparticles as drug carriers

Tadros Tharwat, F. (2018) · Spark · doi:10.1515/spark.43.8 · Cited by 20 · see citing works

Nanoparticulate Carriers for Drug Delivery to the Brain

Kreuter, J. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860949074_0024 · Cited by 11 · see citing works

Nanoparticles as Drug Delivery Systems for the Brain

Kreuter, J. (2006) · ChemInform · doi:10.1002/chin.200640275 · Cited by 7 · see citing works

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609 · see citing works

Transport of drugs across the blood–brain barrier by nanoparticles.

Wohlfart, S., Gelperina, S., & Kreuter, J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.017 · Cited by 715 · see citing works

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

Kreuter, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.008 · Cited by 554 · see citing works

Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

Lajoie, J. M., & Shusta, E. V. (2015) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124852 · Cited by 399 · see citing works

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

S. Hersh, D., S. Wadajkar, A., B. Roberts, N., G. Perez, J., P. Connolly, N., Frenkel, V., A. Winkles, J., F. Woodworth, G., & J. Kim, A. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151221150733 · Cited by 387 · see citing works

Brain-targeted drug delivery by manipulating protein corona functions

Zhang, Z., Guan, J., Jiang, Z., Yang, Y., Liu, J., Hua, W., Mao, Y., Li, C., Lu, W., Qian, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11593-z · Cited by 334 · see citing works

Breaking Down the Barriers to Precision Cancer Nanomedicine

von Roemeling, C., Jiang, W., Chan, C. K., Weissman, I. L., & Kim, B. Y. S. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.07.006 · Cited by 330 · see citing works

Neurotherapeutic applications of nanoparticles in Alzheimer’s disease

Sahni, J. K., Doggui, S., Ali, J., Baboota, S., Dao, L., & Ramassamy, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.033 · Cited by 219 · see citing works

Smuggling drugs into the brain: an overview of ligands targeting transcytosis for drug delivery across the blood–brain barrier.

Georgieva, J., Hoekstra, D., & Zuhorn, I. (2014) · Pharmaceutics · doi:10.3390/pharmaceutics6040557 · Cited by 211 · see citing works

Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (bbb).

Kreuter, J. (2013) · Journal of Microencapsulation · doi:10.3109/02652048.2012.692491 · Cited by 172 · see citing works

Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules

Frozza, R. L., Bernardi, A., Hoppe, J. B., Meneghetti, A. B., Matté, A., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., & Salbego, C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8401-2 · Cited by 165 · see citing works

The potential of protein–nanomaterial interaction for advanced drug delivery

Peng, Q., & Mu, H. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.041 · Cited by 134 · see citing works

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line.

Markoutsa, E., Pampalakis, G., Niarakis, A., Romero, I. A., Weksler, B., Couraud, P.-O., & Antimisiaris, S. G. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.11.015 · Cited by 122 · see citing works

Optimization of brain targeted chitosan nanoparticles of Rivastigmine for improved efficacy and safety

Nagpal, K., Singh, S. K., & Mishra, D. N. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.04.024 · Cited by 116 · see citing works

Influence of protein corona and caveolae-mediated endocytosis on nanoparticle uptake and transcytosis

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Therapeutics, imaging and toxicity of nanomaterials in the central nervous system.

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Human 3D Cultures as Models for Evaluating Magnetic Nanoparticle CNS Cytotoxicity after Short- and Repeated Long-Term Exposure

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Peptide transport across the blood-brain barrier

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Exploring the Blood Brain Barrier: Structure, Function, and Medical Implications

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Transcytosis at the blood–brain barrier

Ayloo, S., & Gu, C. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.12.014 · Cited by 297 · see citing works

Caveolae-Mediated Endothelial Transcytosis across the Blood-Brain Barrier in Acute Ischemic Stroke

Zhou, M., Shi, S. X.-Y., Liu, N., Jiang, Y., Karim, M. S., Vodovoz, S. J., Wang, X., Zhang, B., & Dumont, A. S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173795 · Cited by 46 · see citing works

Vectorization of proteins across the blood–brain barrier: high transcytosis of melanotransferrin (P97)

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