Cited by 102Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsParkinson's Disease Mechanisms and Treatments

Nanoparticle technology for treatment of Parkinson’s disease: The role of surface phenomena in reaching the brain

Leyva-Gómez, Gerardo, Cortés, Hernán, Magaña, Jonathan J., Leyva-García, Norberto, Quintanar-Guerrero, David, Florán, Benjamín·2015·Drug Discovery Today

Abstract

The absence of a definitive treatment for Parkinson's disease has driven the emerging investigation in the search for novel therapeutic alternatives. At present, the formulation of different drugs on nanoparticles has represented several advantages over conventional treatments. This type of multifunctional carrier, owing to its size and composition, has different interactions in biological systems that can lead to a decrease in ability to cross the blood-brain barrier. Therefore, this review focuses on the latest advances in obtaining nanoparticles for Parkinson's disease and provides an overview of technical aspects in the design of brain drug delivery of nanoparticles and an analysis of surface phenomena, a key aspect in the development of functional nanoparticles for Parkinson's disease.

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Crossref · 10.1016/j.drudis.2015.02.009

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Authors
Leyva-Gómez, G., Cortés, H., Magaña, J. J., Leyva-García, N., Quintanar-Guerrero, D., & Florán, B.
Affiliations
Instituto Nacional de Rehabilitación (MX)
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2015-07
Volume
20
Issue
7
Pages
824-837
ISSN
1359-6446 (ISSN-L)
OpenAlex
W2005325784
Cited by
102
References
136
Citations by year
2026: 4 · 2025: 7 · 2024: 12 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 20 · 2019: 6 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 5
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Discovery Today (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • PAPIIT
  • CONACyT
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
Parkinson's disease, nanoparticles, brain drug delivery, blood-brain barrier, surface phenomena, nanoparticle design, drug carriers, neurodegenerative disease treatment
MeSH terms
Animals, Antiparkinson Agents, Blood-Brain Barrier, Chemistry, Pharmaceutical, Drug Carriers, Humans, Parkinson Disease, Permeability, Polymers, Solubility, Technology, Pharmaceutical, Nanomedicine, Nanoparticles

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