Cited by 86Cardiovascular Disease and AdiposityAdipokines, Inflammation, and Metabolic DiseasesCardiac Fibrosis and Remodeling

Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity

Malavazos, Alexis E., Ermetici, Federica, Coman, Calin, Corsi, Massimiliano M., Morricone, Lelio, Ambrosi, Bruno·2007·International Journal of Cardiology

Abstract

Adipocytokine levels and visceral adipose tissue (VAT) seem to be associated with some cardiac abnormalities and a role of visceral fat in predisposing to cardiac dysfunction, possibly through a low-grade state of inflammation, has been demonstrated. In this study we firstly show that elevated levels of both monocyte chemoattractant protein 1 (MCP-1) and soluble IL-6 receptor/interleukin-6 (sIL-6R/IL-6) complex are closely correlated with epicardial fat thickness.

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Crossref · 10.1016/j.ijcard.2006.08.061

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  • There is growing appreciation for the potential importance of autocrine and paracrine effects mediated by adipokines derived from myocardium itself or the larger pericardial fat mass in obese subjects.

    “Importantly, there is also a growing appreciation for the potential importance of autocrine and paracrine effects mediated by adipokines derived from myocardium itself or the larger pericardial fat mass in obese subjects (153, 220, 281, 285, 293).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [220]

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Authors
Malavazos, A. E., Ermetici, F., Coman, C., Corsi, M. M., Morricone, L., & Ambrosi, B.
Affiliations
  • University of Milan (IT)
  • IRCCS Policlinico San Donato (IT)
Corresponding author
Ambrosi, Bruno
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2007-09
Volume
121
Issue
1
Pages
132-134
ISSN
0167-5273 (ISSN-L)
OpenAlex
W2073586541
Cited by
86
References
18
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 2 · 2015: 2 · 2014: 7 · 2013: 6 · 2012: 5
FWCI
5.21
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
epicardial adipose tissue, visceral obesity, adipokines, MCP-1, epicardial fat thickness, cardiac dysfunction, low-grade inflammation, obesity cardiomyopathy
MeSH terms
Adipose Tissue, Adult, Female, Heart Septum, Heart Ventricles, Humans, Obesity, Pericardium, Regression Analysis, Ultrasonography, Interleukin-6, Case-Control Studies, Chemokine CCL2, Receptors, Interleukin-6

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