Substantial changes in epicardial fat thickness after weight loss in severely obese subjects
Open accessAbstract
We sought to evaluate the effect of weight loss on echocardiographic epicardial fat thickness, as index of visceral adiposity, and whether epicardial fat change after the weight loss can be proportionally different from overall body weight changes and related to cardiac parameters changes in severely obese subjects. This was an interventional study in 20 severely obese subjects (12 women, 8 men, BMI 45+/-5 kg/m(2), 35+/-10 years) who underwent 6-month very low calorie diet weight loss program. Baseline and after 6-month weight loss anthropometrics, echocardiographic epicardial fat thickness, left ventricular mass (LVM), and diastolic function parameters were assessed. Subjects lost 20% of original body weight, BMI reduced by 19% of original BMI, waist circumference decreased by 23% of initial waist circumference. Epicardial fat thickness decreased from 12.3+/-1.8 to 8.3+/-1 mm P<0.001 after the 6-month very low calorie diet, as -32% of baseline epicardial fat thickness. LVM and diastolic function changes were better correlated with epicardial fat changes. We showed that significant weight loss can be associated with significant reduction in the epicardial fat thickness, marker of visceral adiposity in severely obese subjects. Epicardial fat decrease, therefore visceral fat decrease, can be proportionally higher than overall adiposity decrease. Epicardial fat changes are significantly associated with obesity-related cardiac morphological and functional changes during weight loss. Measurement of echocardiographic epicardial fat thickness may provide an additional tool in understanding the metabolic risk associated with variation in fat distribution.
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The change in EAT thickness with very low-calorie diet is greater and faster than that of BMI and waist circumference.
“Interestingly, the change of EAT thickness was greater and faster than that of BMI and waist circumference [139].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [139]
A very low-calorie diet in severely obese subjects is associated with a higher EAT shrink than overall adiposity.
“Instead, a very low-calorie diet in severely obese subjects was associated with a higher EAT shrink than overall adiposity, and a better correlation with cardiac morphological and functional changes such as LV mass reduction and diastolic function amelioration, indicating a cardio-protective effect.”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [139]
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- Authors
- Iacobellis, G., Singh, N., Wharton, S., & Sharma, A. M.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Iacobellis, Gianluca
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2008-07
- Volume
- 16
- Issue
- 7
- Pages
- 1693-1697
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2062571251
- Cited by
- 238
- References
- 26
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 12 · 2022: 15 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 6 · 2017: 19 · 2016: 13 · 2015: 20 · 2014: 16 · 2013: 19 · 2012: 16
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- epicardial fat thickness, weight loss, morbid obesity, visceral fat, very low calorie diet, left ventricular mass, diastolic function, cardiac remodeling, body fat distribution, echocardiography
- MeSH terms
- Adult, Female, Heart Ventricles, Humans, Male, Obesity, Pericardium, Severity of Illness Index, Time Factors, Ultrasonography, Weight Loss, Body Mass Index, Ventricular Function, Left, Treatment Outcome, Caloric Restriction, Body Size, Intra-Abdominal Fat, Adiposity
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