Relationship of epicardial fat thickness and fasting glucose
Abstract
In this study we sought to evaluate whether increase in echocardiographic epicardial fat thickness, index of cardiac and visceral adiposity, is associated with impaired fasting glucose (IFG). Epicardial fat thickness and fasting plasma glucose (FPG) were measured in 115 consecutive non-diabetic Caucasian subjects [65 men, 50 women, median age of 42 years (range 30-64 years), median body mass index (BMI) of 27 kg/m(2) (range 22-33 kg/m(2)), who underwent routine transthoracic echocardiogram. Study subjects were designated as having normal fasting glucose (NFG) with FPG<100 mg/dl; and IFG with FPG (100 and <126 mg/dl). Epicardial fat thickness was significantly higher in IFG than NFG subjects (8+/-3 vs 6+/-2 mm; 7.1+/-4 vs 5.8+/-3 mm, p<0.001 for both and respectively in men and women. Epicardial fat thickness was significantly correlated with FPG (r=0.60, p<0.001). Our data indicate for the first time that higher epicardial fat thickness is associated with IFG in non-diabetic men and women. Echocardiographic epicardial fat measurement may be an additional tool for diabetes-related cardiac risk stratification.
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Diabetic patients often exhibit an abnormally expanded EAT, usually in association with obesity and metabolic syndrome in both T2DM and T1DM.
“On the other hand, diabetic patients often exhibit an abnormally expanded EAT, usually in association with obesity and metabolic syndrome in both T2DM and T1DM [19,20,21,22].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [19]
In non-diabetic people, impaired fasting glucose or obesity-related reduction of insulin sensitivity are associated with increased epicardial fat.
“In non-diabetic people, impaired fasting glucose, or obesity-related reduction of insulin sensitivity, as assessed by euglycemic hyperinsulinemic clamp and other markers of insulin resistance, are associated with increased epicardial fat [19,55].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [19]
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- Authors
- Iacobellis, G., Barbaro, G., & Gerstein, H. C.
- Affiliations
- McMaster University (CA)
- Sapienza University of Rome (IT)
- Corresponding author
- Iacobellis, Gianluca
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 128
- Issue
- 3
- Pages
- 424-426
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2093570996
- Cited by
- 109
- References
- 22
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 12 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 11 · 2014: 6 · 2013: 11 · 2012: 3
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- epicardial fat thickness, impaired fasting glucose, fasting blood glucose, visceral fat, prediabetes, diabetes risk stratification, non-diabetic patients
- MeSH terms
- Adipose Tissue, Adult, Blood Glucose, Cross-Sectional Studies, Fasting, Female, Glucose Tolerance Test, Humans, Male, Middle Aged, Pericardium, Intra-Abdominal Fat
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