Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects
Abstract
Obesity is associated with atrial dilation and diastolic dysfunction although the causative mechanisms are not completely understood. In this study we showed for the first time that increase in epicardial fat thickness is significantly correlated with atria enlargement and impairment in diastolic filling in morbidly obese subjects.
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There is growing appreciation for the potential importance of autocrine and paracrine effects mediated by adipokines derived from myocardium itself or the larger pericardial fat mass in obese subjects.
“Importantly, there is also a growing appreciation for the potential importance of autocrine and paracrine effects mediated by adipokines derived from myocardium itself or the larger pericardial fat mass in obese subjects (153, 220, 281, 285, 293).”
From Cardiac remodeling in obesity (2008) · cites this paper as [153]
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Functions and origins of cardiac fat
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Lipids and diastolic dysfunction: Recent evidence and findings
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RETRACTED: Epicardial adipose tissue and cardiac lipotoxicity: A review
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Threshold Values of High-risk Echocardiographic Epicardial Fat Thickness
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Plasma sMer, sAxl and GAS6 levels correlate with disease activity and severity in lupus nephritis
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- Authors
- Iacobellis, G., Leonetti, F., Singh, N., & M Sharma, A.
- Affiliations
- Sapienza University of Rome (IT)
- Corresponding author
- Iacobellis, Gianluca
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 115
- Issue
- 2
- Pages
- 272-273
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2054391979
- Cited by
- 224
- References
- 13
- Citations by year
- 2025: 7 · 2024: 11 · 2023: 13 · 2022: 13 · 2021: 12 · 2020: 21 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 18 · 2013: 9 · 2012: 12
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- epicardial adipose tissue, epicardial fat thickness, atrial dilatation, atrial dimensions, diastolic dysfunction, diastolic filling, morbid obesity, obesity cardiomyopathy
- MeSH terms
- Adipose Tissue, Adult, Diastole, Female, Heart Atria, Humans, Male, Obesity, Morbid, Pericardium, Ultrasonography
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