Executive function in adolescents with Down Syndrome
Abstract
Background The present work is aimed at analysing executive function (EF) in adolescents with Down Syndrome (DS). So far, EF has been analysed mainly in adults with DS, showing a pattern of impairment. However, less is known about children and adolescents with this syndrome. Studying adolescents with DS might help us better understand whether performances on EF tasks of individuals with DS are determined by age or by Alzheimer disease, as some studies suggest, or whether their performances are directly related to DS cognitive profile. Method A battery of EF tasks assessing set shifting, planning/problem-solving, working memory, inhibition/perseveration and fluency, as well as a tasks assessing sustained attention has been administered to a group of 15 adolescents with DS and 15 typically developing children matched for mental age. All EF tasks were selected from previous studies with individuals with intellectual disabilities or from developmental literature and are thought to be useful for the samples considered. Results The present results revealed that the group of individuals with DS performed at a significantly lower level on tasks assessing set shifting, planning/problem-solving, working memory and inhibition/perseveration, but not on the tasks assessing fluency. In addition, individuals with DS demonstrated a greater number of errors and less strategy use for the sustained attention task. Conclusions The results suggest a broad impairment in EF in adolescents with DS,…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous studies show that DS children manifest learning and memory problems in late infancy which often worsen in adolescence.
“This is in agreement both with previous studies showing that DS children manifest learning and memory problems in late infancy which often worsen in adolescence (Koo et al., 1992; Lanfranchi et al., 2010) and with post-mortem studies that show reduced myelin content (Abraham et al., 2012; Wisniewski, 1990; Wisniewski and Schmidt-Sidor, 1989) and fewer oligodendrocytes in DS striatum (Karlsen and P”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Lanfranchi et al., 2010
The intellectual disability in Down syndrome presents with predominant deficits in executive functioning and memory.
“It presents as a range of impairments including predominant deficits in executive functioning and memory (Vicari et al., 2005, 2000; Lanfranchi et al., 2010; Costanzo et al., 2013; Grieco et al., 2015).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Lanfranchi et al., 2010
Cites
Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000) · Cognitive Psychology · doi:10.1006/cogp.1999.0734 · Cited by 15,798 · see citing works
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · see citing works
From Neuropsychology to Mental Structure
Shallice, T. (1988) · doi:10.1017/cbo9780511526817 · Cited by 4,072 · see citing works
Specific impairments of planning
Shallice, T. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0082 · Cited by 3,741 · see citing works
Executive functions and developmental psychopathology.
Pennington, B. F., & Ozonoff, S. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01380.x · Cited by 3,150 · see citing works
Working memory, short-term memory, and general fluid intelligence: A latent-variable approach.
Engle, R. W., Tuholski, S. W., Laughlin, J. E., & Conway, A. R. A. (1999) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.128.3.309 · Cited by 3,078 · see citing works
Executive function in preschoolers: A review using an integrative framework.
Garon, N., Bryson, S. E., & Smith, I. M. (2008) · Psychological Bulletin · doi:10.1037/0033-2909.134.1.31 · Cited by 2,695 · see citing works
A Modified Card Sorting Test Sensitive to Frontal Lobe Defects
Nelson, H. E. (1976) · Cortex · doi:10.1016/s0010-9452(76)80035-4 · Cited by 2,454 · see citing works
Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262 · see citing works
A simple objective technique for measuring flexibility in thinking
Berg, E. A. (1948) · The Journal of General Psychology · doi:10.1080/00221309.1948.9918159 · Cited by 2,255 · see citing works
Regional Development of the Brain in Early Life
(1968) · Archives of Disease in Childhood · doi:10.1136/adc.43.229.388 · Cited by 2,107 · see citing works
Stuss, D. T., & Benson, D. F. (1986) · Raven Press eBooks · Cited by 2,102 · see citing works
(1967) · Medical Entomology and Zoology · Cited by 1,713 · see citing works
Carpenter, P. A., Just, M. A., & Shell, P. (1990) · Psychological Review · doi:10.1037/0033-295x.97.3.404 · Cited by 1,648 · see citing works
Gerstadt, C. L., Hong, Y. J., & Diamond, A. (1994) · Cognition · doi:10.1016/0010-0277(94)90068-x · Cited by 1,598 · see citing works
Development itself is the key to understanding developmental disorders
Karmiloff-Smith, A. (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01230-3 · Cited by 1,299 · see citing works
Not All Executive Functions Are Related to Intelligence
Friedman, N. P., Miyake, A., Corley, R. P., Young, S. E., DeFries, J. C., & Hewitt, J. K. (2006) · Psychological Science · doi:10.1111/j.1467-9280.2006.01681.x · Cited by 1,293 · see citing works
Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man
Petrides, M., & Milner, B. A. (1982) · Neuropsychologia · doi:10.1016/0028-3932(82)90100-2 · Cited by 1,272 · see citing works
Miyake, A., Friedman, N. P., Rettinger, D. A., Shah, P., & Hegarty, M. (2001) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.130.4.621 · Cited by 1,139 · see citing works
Miyake, A., Friedman, N. P., Rettinger, D. A., Shah, P., & Hegarty, M. (2001) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.130.4.621 · Cited by 1,136 · see citing works
Analysis of the elements of attention: A neuropsychological approach
Mirsky, A. F., Anthony, B. J., Duncan, C. C., Ahearn, M. B., & Kellam, S. G. (1991) · Neuropsychology Review · doi:10.1007/bf01109051 · Cited by 874 · see citing works
Assessing frontal lobe functioning in children: Views from developmental psychology
Welsh, M. C., & Pennington, B. F. (1988) · Developmental Neuropsychology · doi:10.1080/87565648809540405 · Cited by 846 · see citing works
The neuropsychology of down syndrome: evidence for hippocampal dysfunction.
Pennington, B. F., Moon, J., Edgin, J., Stedron, J., & Nadel, L. (2003) · Child Development · doi:10.1111/1467-8624.00522 · Cited by 514 · see citing works
Methodology of frontal and executive function
Rieger, M. (1999) · Zeitschrift für Neuropsychologie · doi:10.1024//1016-264x.10.2.123 · Cited by 483 · see citing works
Behavioural assessment of the dysexecutive syndrome (BADS)
Spikman, J. M., & Saan, R. (2012) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 392 · see citing works
Down syndrome: Cognitive phenotype
Silverman, W. (2007) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20156 · Cited by 324 · see citing works
Maturation of the human frontal lobes: Physiological evidence for staging
Thatcher, R. W. (1991) · Developmental Neuropsychology · doi:10.1080/87565649109540500 · Cited by 289 · see citing works
Introduction: Methodologies and Models in the Study of Executive Function
Rabbitt, P. (2004) · Routledge eBooks · doi:10.4324/9780203344187-5 · Cited by 262 · see citing works
Cognitive executive function in Down's syndrome
Rowe, J., Lavender, A., & Turk, V. (2006) · British Journal of Clinical Psychology · doi:10.1348/014466505x29594 · Cited by 254 · see citing works
Relation of task switching to speed, age, and fluid intelligence.
Salthouse, T. A., Fristoe, N. M., McGuthry, K. E., & Hambrick, D. Z. (1998) · Psychology and Aging · doi:10.1037/0882-7974.13.3.445 · Cited by 251 · see citing works
Missile wounds of the brain: a study of psychological deficits
Newcombe, F. (1969) · Max Planck Digital Library · Cited by 212 · see citing works
MISSILE WOUNDS OF THE BRAIN A Study of Psychological Deficits
Hughes, B. (1970) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.33.4.551-b · Cited by 210 · see citing works
Relation of task switching to speed, age, and fluid intelligence.
Salthouse, T. A., Fristoe, N. M., McGuthry, K. E., & Hambrick, D. Z. (1998) · Psychology and Aging · doi:10.1037//0882-7974.13.3.445 · Cited by 207 · see citing works
Ball, S. L., Holland, A. J., Treppner, P., Watson, P., & Huppert, F. A. (2007) · British Journal of Clinical Psychology · doi:10.1348/014466507x230967 · Cited by 194 · see citing works
Genetic Covariance Among Measures of Information Processing Speed, Working Memory, and IQ
Michelle Luciano, A., Wright, M. J., Smith, G. A., Geffen, G. M., Geffen, L. B., & Martin, N. G. (2001) · Behavior Genetics · doi:10.1023/a:1013397428612 · Cited by 154 · see citing works
Working memory and Down syndrome
Baddeley, A., & Jarrold, C. (2007) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2007.00979.x · Cited by 150 · see citing works
Control Functions of the Frontal Lobes. Modularity of the Central-Supervisory System?
Godefroy, O., Cabaret, M., Petit-Chenal, V., Pruvo, J.-P., & Rousseaux, M. (1999) · Cortex · doi:10.1016/s0010-9452(08)70782-2 · Cited by 141 · see citing works
Hooper, S. R., Hatton, D. D., Sideris, J. H., Sullivan, K. M., Hammer, J., Schaaf, J. M., Mirrett, P., Ornstein, P. A., & Bailey, D. B. (2008) · Neuropsychology · doi:10.1037/0894-4105.22.1.36 · Cited by 117 · see citing works
A specific deficit in visuospatial simultaneous working memory in Down syndrome
Lanfranchi, S., Carretti, B., Spanò, G., & Cornoldi, C. (2009) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2009.01165.x · Cited by 103 · see citing works
Self-citationWorking Memory and Cognitive Skills in Individuals with Down Syndrome
Lanfranchi, S., Jerman, O., & Vianello, R. (2009) · Child Neuropsychology · doi:10.1080/09297040902740652 · Cited by 90 · see citing works
Self-citationExecutive skills in Klinefelter’s syndrome
Temple, C. M., & Sanfilippo, P. M. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00061-7 · Cited by 80 · see citing works
Kogan, C. S., Boutet, I., Cornish, K. M., Graham, G. E., Berry‐Kravis, E., Drouin, A., & Milgram, N. W. (2008) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2008.01135.x · Cited by 79 · see citing works
Frontal lobe function and executive skills in children with turner's syndrome
Temple, C. M., Carney, R., & Mullarkey, S. (1996) · Developmental Neuropsychology · doi:10.1080/87565649609540657 · Cited by 74 · see citing works
Kirk, J. W., Mazzocco, M. M. M., & Kover, S. T. (2005) · Developmental Neuropsychology · doi:10.1207/s15326942dn2803_2 · Cited by 70 · see citing works
Kittler, P. M., Krinsky‐McHale, S. J., & Devenny, D. A. (2008) · American Journal on Mental Retardation · doi:10.1352/0895-8017(2008)113[117:dpaamo]2.0.co;2 · Cited by 68 · see citing works
Down's syndrome : Psychological, psychobiological and socio-educational perspectives
Rondal, J.-A., Perera, J., Nadel, L., & Comblain, A. (1996) · Whurr eBooks · Cited by 62 · see citing works
Cianchetti, C., Corona, S., Foscoliano, M., Contu, D., & Sannio‐Fancello, G. (2006) · The Clinical Neuropsychologist · doi:10.1080/13854040600629766 · Cited by 60 · see citing works
Recent trends in incidence, morbidity and survival in Down's syndrome
McGrother, C. W., & MARSHALL, B. (1990) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1990.tb01514.x · Cited by 59 · see citing works
Cognitive decline due to aging among persons with down syndrome
Das, J. P., Divis, B., Alexander, J., Parrila, R., & Naglieri, J. A. (1995) · Research in Developmental Disabilities · doi:10.1016/0891-4222(95)00030-5 · Cited by 58 · see citing works
Learning and memory as a function of age in Down syndrome: A study using animal-based tasks
Nelson, L. D., Johnson, J. K., Freedman, M., Lott, I. T., Groot, J., Chang, M., Milgram, N. W., & Head, E. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.12.009 · Cited by 56 · see citing works
Verbal intrusions precede memory decline in adults with Down syndrome
Kittler, P. M., Krinsky‐McHale, S. J., & Devenny, D. A. (2005) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2005.00715.x · Cited by 48 · see citing works
Sustained Attention and the Frontal Lobes
Manly, T., & Robertson, I. H. (2004) · Routledge eBooks · doi:10.4324/9780203344187-10 · Cited by 21 · see citing works
Focus on birth defects research
Engels, J. (2006) · Nova Science Publishers eBooks · Cited by 12 · see citing works
Memory profiles in individuals with mental retardation due to genetic causes.
Lanfranchi, S., & Vianello, R. (2006) · Padua Research Archive (University of Padova) · Cited by 4 · see citing works
Self-citationAbbeduto (2004) · doi:10.1352/0895-8017(2004)109
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Cognitive deficits and associated neurological complications in individuals with Down's syndrome
Lott, I. T., & Dierssen, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70112-5 · Cited by 484 · see citing works
Down syndrome: Cognitive and behavioral functioning across the lifespan
Grieco, J. A., Pulsifer, M., Seligsohn, K., Skotko, B. G., & Schwartz, A. (2015) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31439 · Cited by 444 · see citing works
Down syndrome: the brain in trisomic mode
Dierssen, M. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3314 · Cited by 273 · see citing works
Olmos-Serrano, J. L., Kang, H. J., Tyler, W. A., Silbereis, J. C., Cheng, F., Zhu, Y., Pletikos, M., Jankovic-Rapan, L., Cramer, N. P., Galdzicki, Z., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.042 · Cited by 239 · see citing works
“…studies showing that DS children manifest learning and memory problems in late infancy, which often worsen in adolescence (Koo et al., 1992; Lanfranchi et al., 2010), and with postmortem studies that show reduced myelin content (Ábrahám et al., 2012; Wisniewski, 1990; Wisniewski and…”
Costanzo, F., Varuzza, C., Menghini, D., Addona, F., Gianesini, T., & Vicari, S. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2013.01.024 · Cited by 200 · see citing works
Outcome Measures for Clinical Trials in Fragile X Syndrome
Berry‐Kravis, E., Hessl, D. R., Abbeduto, L., Reiss, A. L., Beckel-Mitchener, A. C., & Urv, T. K. (2013) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e31829d1f20 · Cited by 154 · see citing works
Outcome Measures for Clinical Trials in Down Syndrome
Esbensen, A. J., Hooper, S. R., Fidler, D., Hartley, S. L., Edgin, J., d'Ardhuy, X. L., Capone, G., Conners, F. A., Mervis, C. B., Abbeduto, L., et al. (2017) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-122.3.247 · Cited by 153 · see citing works
Hessl, D., Sansone, S. M., Berry-Kravis, E., Riley, K., Widaman, K. F., Abbeduto, L., Schneider, A., Coleman, J., Oaklander, D., Rhodes, K. C., et al. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9167-4 · Cited by 126 · see citing works
Visuo-spatial ability in individuals with Down syndrome: Is it really a strength?
Yang, Y., Conners, F. A., & Merrill, E. C. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.04.002 · Cited by 127 · see citing works
Health and disease in adults with Down syndrome
Malt, E. A., Dahl, R. C., Haugsand, T. M., Ulvestad, I. H., Emilsen, N. M., Hansen, B., Cardenas, Y. E. G., Sköld, R. O., Thorsen, A., & Davidsen, E. M. (2013) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.12.0390 · Cited by 115 · see citing works
Hronis, A., Roberts, L., & Kneebone, I. (2017) · British Journal of Clinical Psychology · doi:10.1111/bjc.12133 · Cited by 113 · see citing works
Executive function in Williams and Down syndromes
Carney, D. P. J., Brown, J. H., & Henry, L. A. (2012) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2012.07.013 · Cited by 112 · see citing works
Spaniol, M., & Danielsson, H. (2021) · Journal of Intellectual Disability Research · doi:10.1111/jir.12878 · Cited by 118 · see citing works
Lee, N., Fidler, D. J., Blakeley‐Smith, A., Daunhauer, L. A., Robinson, C. C., & Hepburn, S. (2011) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-116.4.290 · Cited by 106 · see citing works
Relationship Between Brain and Cognitive Processes in Down Syndrome
Menghini, D., Costanzo, F., & Vicari, S. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9448-3 · Cited by 101 · see citing works
Executive function in Down syndrome: A meta-analysis
Tungate, A. S., & Conners, F. A. (2020) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2020.103802 · Cited by 99 · see citing works
Working memory in Down syndrome: is there a dual task deficit?
Lanfranchi, S., Baddeley, A., Gathercole, S. E., & Vianello, R. (2011) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2011.01444.x · Cited by 97 · see citing works
Self-citationRelationship between motor skill competency and executive function in children with D own's syndrome
Schott, N., & Holfelder, B. (2015) · Journal of Intellectual Disability Research · doi:10.1111/jir.12189 · Cited by 97 · see citing works
Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate GeneDyrk1a
Thomazeau, A., Lassalle, O., Iafrati, J., Souchet, B., Guedj, F., Janel, N., Chavis, P., Delabar, J. M., & Manzoni, O. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2852-13.2014 · Cited by 93 · see citing works
D’ardhuy, X. L., Edgin, J. O., Bouis, C., de Sola, S., Goeldner, C., Kishnani, P. S., Noeldeke, J., Rice, S. A., Sacco, S., Squassante, L., et al. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00300 · Cited by 94 · see citing works
Changes in cognitive function after a 12-week exercise intervention in adults with Down syndrome
Ptomey, L. T., Szabo‐Reed, A. N., Willis, E. A., Gorczyca, A. M., Greene, J. L., Danon, J. C., & Donnelly, J. E. (2018) · Disability and health journal · doi:10.1016/j.dhjo.2018.02.003 · Cited by 93 · see citing works
Godfrey, M., & Lee, N. (2018) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9220-y · Cited by 91 · see citing works
Morra, S., Panesi, S., Traverso, L., & Usai, M. C. (2017) · Journal of Experimental Child Psychology · doi:10.1016/j.jecp.2017.11.004 · Cited by 86 · see citing works
Impaired myelination of the human hippocampal formation in Down syndrome
Ábrahám, H., Vincze, A., Veszprémi, B., Kravják, A., Gömöri, É., Kovács, G. G., & Seress, L. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.11.005 · Cited by 85 · see citing works
Cognition in Down syndrome: a developmental cognitive neuroscience perspective
Edgin, J. O. (2013) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1221 · Cited by 82 · see citing works
Memišević, H., & Sinanović, O. (2013) · Journal of Intellectual Disability Research · doi:10.1111/jir.12098 · Cited by 82 · see citing works
Inhibitory mechanisms in Down syndrome: Is there a specific or general deficit?
Borella, E., Carretti, B., & Lanfranchi, S. (2012) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2012.07.017 · Cited by 80 · see citing works
Self-citationDesigner Receptors Enhance Memory in a Mouse Model of Down Syndrome
Fortress, A. M., Hamlett, E. D., Vazey, E. M., Aston‐Jones, G., Cass, W. A., Boger, H. A., & Granholm, A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2658-14.2015 · Cited by 74 · see citing works
A cross‐sectional analysis of executive function in Down syndrome from 2 to 35 years
Loveall, S. J., Conners, F. A., Tungate, A. S., Hahn, L. J., & Osso, T. D. (2017) · Journal of Intellectual Disability Research · doi:10.1111/jir.12396 · Cited by 77 · see citing works
A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
de Sola, S., The TESDAD Study Group, de la Torre, R., Sánchez‐Benavides, G., Benejam, B., Cuenca‐Royo, A., Soriano, L. D. H., RodrÃguez, J., Catuara‐Solarz, S., Sánchez-Gutiérrez, J., et al. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00708 · Cited by 70 · see citing works
Executive function and academic achievement in primary – grade students with Down syndrome
Will, E., Fidler, D. J., Daunhauer, L. A., & Gerlach-McDonald, B. (2016) · Journal of Intellectual Disability Research · doi:10.1111/jir.12313 · Cited by 64 · see citing works
The LonDownS adult cognitive assessment to study cognitive abilities and decline in Down syndrome
Startin, C. M., Hamburg, S., Hithersay, R., Davies, A., Rodger, E., Aggarwal, N., Al‐Janabi, T., & Strydom, A. (2016) · Wellcome Open Research · doi:10.12688/wellcomeopenres.9961.1 · Cited by 67 · see citing works
A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease
Maciejewska, K., Czarnecka, K., & Szymański, P. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00293-5 · Cited by 64 · see citing works
Age-Related Neurodegeneration and Memory Loss in Down Syndrome
Lockrow, J. P., Fortress, A. M., & Granholm, A. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/463909 · Cited by 64 · see citing works
Castillo, S. E., Bueno, A. D., Ribas‐Vidal, N., Alsina, M. V., Alsina, R. N., & Alba, J. G. (2013) · Revista de Neurología · doi:10.33588/rn.5708.2013259 · Cited by 62 · see citing works
Improving Executive Functions at School in Children With Special Needs by Educational Robotics
Lieto, M., Castro, E., Pecini, C., Inguaggiato, E., Cecchi, F., Dario, P., Cioni, G., & Sgandurra, G. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02813 · Cited by 60 · see citing works
Lee, N., Anand, P., Will, E., Adeyemi, E. I., CLASEN, L. S., Blumenthal, J. D., Giedd, J. N., Daunhauer, L. A., Fidler, D. J., & Edgin, J. O. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00264 · Cited by 59 · see citing works
Sung, M., Ku, B., Leung, W. C. W., & MacDonald, M. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05009-5 · Cited by 59 · see citing works
Cognitive Functioning in Children with Down Syndrome: Current Knowledge and Future Directions
Lukowski, A. F., Milojevich, H. M., & Eales, L. (2019) · Advances in child development and behavior · doi:10.1016/bs.acdb.2019.01.002 · Cited by 56 · see citing works
Daunhauer, L. A., Tomaszewski, B. R., Will, E., & Fidler, D. J. (2017) · Developmental Neuropsychology · doi:10.1080/87565641.2017.1360303 · Cited by 53 · see citing works
Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome
Hamlett, E. D., Boger, H. A., Ledreux, A., Kelley, C. M., Mufson, E. J., Falangola, M. F., Guilfoyle, D. N., Nixon, R. A., Patterson, D., Duval, N., et al. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150921095505 · Cited by 51 · see citing works
Rafii, M. S., Kleschevnikov, A. M., Sawa, M., & Mobley, W. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00017-0 · Cited by 52 · see citing works
Ringenbach, S. D. R., Holzapfel, S. D., Mulvey, G. M., Jimenez, A., Benson, A. M., & Richter, M. (2016) · Journal of Intellectual Disability Research · doi:10.1111/jir.12275 · Cited by 48 · see citing works
Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome
Chang, P., Bush, D., Schorge, S., Good, M., Canonica, T., Shing, N., Noy, S., Wiseman, F. K., Burgess, N., Tybulewicz, V. L. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.065 · Cited by 47 · see citing works
Neurodevelopment in Down syndrome: Concordance in humans and models
Klein, J. A., & Haydar, T. F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.941855 · Cited by 47 · see citing works
“The impairments in executive functioning include deficits in attention, inhibition, planning and organization, setshifting, and self-monitoring, all of which are critical categories of intellectual function needed for independent living (Cornish et al., 2007; Abbeduto et al., 2008; Trezise et al., 2008; Lanfranchi et…”
BackgroundThe effect of configuration on VSWM performance of Down syndrome individuals
Carretti, B., & Lanfranchi, S. (2010) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2010.01334.x · Cited by 47 · see citing works
Self-citationWilkinson, K. M., O’Neill, T., & McIlvane, W. J. (2013) · Journal of Speech Language and Hearing Research · doi:10.1044/2013_jslhr-l-12-0159 · Cited by 46 · see citing works
The profile of social functioning in children with Down syndrome
Næss, K.-A. B., Nygaard, E., Ostad, J., Dolva, A., & Lyster, S. H. (2016) · Disability and Rehabilitation · doi:10.1080/09638288.2016.1194901 · Cited by 45 · see citing works
Anderson-Mooney, A. J., Schmitt, F. A., Head, E., Lott, I. T., & Heilman, K. M. (2016) · Brain and Cognition · doi:10.1016/j.bandc.2016.02.007 · Cited by 44 · see citing works
Traverso, L., Fontana, M., Usai, M. C., & Passolunghi, M. C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00660 · Cited by 44 · see citing works
Chen, C., Ringenbach, S. D. R., Crews, D. J., Kulinna, P. H., & Amazeen, E. L. (2014) · Journal of Intellectual Disability Research · doi:10.1111/jir.12163 · Cited by 43 · see citing works
Building an adaptive brain across development: targets for neurorehabilitation must begin in infancy
Edgin, J. O., Clark, C. A. C., Massand, E., & Karmiloff‐Smith, A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00232 · Cited by 40 · see citing works
Cognitive control of movement in down syndrome
Brunamonti, E., Pani, P., Papazachariadis, O., Onorati, P., Albertini, G., & Ferraina, S. (2011) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2011.03.008 · Cited by 40 · see citing works
Plasma metabolome and cognitive skills in Down syndrome
Antonaros, F., Ghini, V., Pulina, F., Ramacieri, G., Cicchini, E., Mannini, E., Martelli, A., Feliciello, A., Lanfranchi, S., Onnivello, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67195-z · Cited by 40 · see citing works
Self-citationHolzapfel, S. D., Ringenbach, S. D. R., Mulvey, G. M., Sandoval-Menendez, A. M., Cook, M., Ganger, R., & Bennett, K. (2015) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2015.08.003 · Cited by 40 · see citing works
Executive functions among youth with Down Syndrome and co‐existing neurobehavioural disorders
Pritchard, A. E., Kalback, S., McCurdy, M., & Capone, G. T. (2015) · Journal of Intellectual Disability Research · doi:10.1111/jir.12217 · Cited by 39 · see citing works
Executive functions in intellectual disability syndromes
Janke, K. M., & Klein-Tasman, B. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511977954.010 · Cited by 38 · see citing works
Startin, C. M., Rodger, E., Fodor-Wynne, L., Hamburg, S., & Strydom, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154596 · Cited by 38 · see citing works
Ringenbach, S. D. R., Albert, A. R., Chen, C., & Alberts, J. L. (2014) · Intellectual and developmental disabilities · doi:10.1352/1934-9556-52.2.124 · Cited by 37 · see citing works
Reliability of Informant-Report Measures of Executive Functioning in Children With Down Syndrome
Esbensen, A. J., Hoffman, E. K., Shaffer, R. C., Chen, E., Patel, L., & Jacola, L. M. (2019) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-124.3.220 · Cited by 37 · see citing works
Roberts, L., & Richmond, J. L. (2014) · Developmental Science · doi:10.1111/desc.12225 · Cited by 37 · see citing works
A Multi-Method Investigation of Pragmatic Development in Individuals With Down Syndrome
Lee, M., Bush, L. C., Martin, G. E., Barstein, J., Maltman, N., Klusek, J., & Losh, M. C. (2017) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-122.4.289 · Cited by 36 · see citing works
Executive Function and Ambiguous Sentence Comprehension
Key-DeLyria, S., & Altmann, L. J. P. (2016) · American Journal of Speech-Language Pathology · doi:10.1044/2015_ajslp-14-0111 · Cited by 36 · see citing works
Impact of sleep on executive functioning in school‐age children with Down syndrome
Esbensen, A. J., & Hoffman, E. K. (2018) · Journal of Intellectual Disability Research · doi:10.1111/jir.12496 · Cited by 35 · see citing works
The impact of cognitive functions and intellectual impairment on pacing and performance in sports
Sakalidis, K. E., Burns, J., Biesen, D. V., Dreegia, W., & Hettinga, F. J. (2020) · Psychology of sport and exercise · doi:10.1016/j.psychsport.2020.101840 · Cited by 35 · see citing works
Trends in Toilet Training and Voiding Habits among Children with Down Syndrome
Powers, M. K., Brown, E. T., Hogan, R. M., Martin, A. D., Ortenberg, J., & Roth, C. C. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.03.114 · Cited by 34 · see citing works
Nouns and predicates comprehension and production in children with Down syndrome
Bello, A., Onofrio, D., & Caselli, M. C. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.01.023 · Cited by 34 · see citing works
Sabat, C., Arango, P. S., Tassé, M. J., & Tenorio, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-58409-5 · Cited by 34 · see citing works
Executive functions and adaptive behaviour in individuals with Down syndrome
Onnivello, S., Colaianni, S., Pulina, F., Locatelli, C., Marcolin, C., Ramacieri, G., Antonaros, F., Vione, B., Piovesan, A., & Lanfranchi, S. (2021) · Journal of Intellectual Disability Research · doi:10.1111/jir.12897 · Cited by 34 · see citing works
Self-citationPulina, F., Carretti, B., Lanfranchi, S., & Mammarella, I. C. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01265 · Cited by 31 · see citing works
Self-citationExecutive Functions in Children and Adolescents With Autism Spectrum Disorder
Czermainski, F. R., Riesgo, R. D. S., Guimarães, L. S. P., de Salles, J. F., & Bosa, C. A. (2014) · Paidéia (Ribeirão Preto) · doi:10.1590/1982-43272457201411 · Cited by 31 · see citing works
Approximate additions and working memory in individuals with Down syndrome
Belacchi, C., Passolunghi, M. C., Brentan, E., Dante, A., Persi, L., & Cornoldi, C. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.01.036 · Cited by 31 · see citing works
Soriano, L. D. H., Xicota, L., Sánchez‐Benavides, G., Cuenca‐Royo, A., de Sola, S., Langohr, K., Fagundo, A. B., Farré, M., Dierssen, M., & de la Torre, R. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00301 · Cited by 31 · see citing works
Human and mouse model cognitive phenotypes in Down syndrome
Edgin, J. O., Mason, G. M., Spanò, G., Fernández, A., & Nadel, L. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00007-8 · Cited by 31 · see citing works
Zagaria, T., Antonucci, G., Buono, S., Recupero, M., & Zoccolotti, P. (2021) · Brain Sciences · doi:10.3390/brainsci11010042 · Cited by 29 · see citing works
Lee, N., Nayak, A., Irfanoglu, M. O., Sadeghi, N., Stoodley, C. J., Adeyemi, E. I., CLASEN, L. S., & Pierpaoli, C. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-61799-1 · Cited by 29 · see citing works
Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis?
Reiche, L., Küry, P., & Göttle, P. (2019) · Cells · doi:10.3390/cells8121591 · Cited by 28 · see citing works
Down syndrome and DYRK1A overexpression: relationships and future therapeutic directions
Murphy, A. J., Wilton, S. D., Aung-Htut, M. T., & McIntosh, C. S. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1391564 · Cited by 27 · see citing works
Vimercati, S. L., Galli, M., Stella, G. C., Caiazzo, G., Ancillao, A., & Albertini, G. (2014) · Journal of Intellectual Disability Research · doi:10.1111/jir.12132 · Cited by 27 · see citing works
Barisnikov, K., & Lejeune, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200932 · Cited by 27 · see citing works
Startin, C. M., Lowe, B., Hamburg, S., Hithersay, R., & Strydom, A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00158 · Cited by 27 · see citing works
Hocking, D. R., Menant, J. C., Kirk, H., Lord, S. R., & Porter, M. A. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2013.10.005 · Cited by 28 · see citing works
Evaluating working memory outcome measures for children with Down syndrome
Schworer, E. K., Esbensen, A. J., Fidler, D. J., Beebe, D. W., Carle, A., & Wiley, S. (2022) · Journal of Intellectual Disability Research · doi:10.1111/jir.12833 · Cited by 26 · see citing works
Memory and Learning in Intellectual Disability
Vicari, S., Costanzo, F., & Menghini, D. (2016) · International review of research in developmental disabilities · doi:10.1016/bs.irrdd.2016.05.003 · Cited by 26 · see citing works
Roubertoux, P. L., Baril, N., Cau, P., Scajola, C., Ghata, A. S., Bartoli, C., Bourgeois, P., di Christofaro, J., Tordjman, S., & Carlier, M. (2017) · Behavior Genetics · doi:10.1007/s10519-017-9835-5 · Cited by 26 · see citing works
Neuroanatomical alterations in higher-order thalamic nuclei of fetuses with Down syndrome
Stagni, F., Giacomini, A., Emili, M., Uguagliati, B., Bonasoni, M. P., Bartesaghi, R., & Guidi, S. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.105870 · Cited by 26 · see citing works
Executive functioning in individuals with intellectual disabilities and autism spectrum disorders
Roelofs, R. L., Visser, E., Berger, H. J. C., Prins, J. B., Valk, H. M. J. V. S. L., & Teunisse, J. (2013) · Journal of Intellectual Disability Research · doi:10.1111/jir.12085 · Cited by 26 · see citing works
Will, E., Schworer, E. K., & Esbensen, A. J. (2021) · Child Neuropsychology · doi:10.1080/09297049.2021.1917531 · Cited by 25 · see citing works
Numerical estimation in individuals with Down syndrome
Lanfranchi, S., Berteletti, I., Torrisi, E., Vianello, R., & Zorzi, M. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.10.010 · Cited by 25 · see citing works
Self-citationCasarin, F. S., Wong, C. E. I., Parente, M. A. D. M. P., de Salles, J. F., & Fonseca, R. P. (2012) · The Spanish Journal of Psychology · doi:10.5209/rev_sjop.2012.v15.n3.39386 · Cited by 25 · see citing works
Demily, C., Rigard, C., Peyroux, É., Chesnoy-Servanin, G., Morel, A., & Nicolas Franck, B. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00010 · Cited by 25 · see citing works
Visual Acuity Deficits in Children With Nystagmus and Down Syndrome
Felius, J., Beauchamp, C. L., & Stager, D. R. (2013) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2013.09.023 · Cited by 24 · see citing works
Milojevich, H. M., & Lukowski, A. F. (2015) · Journal of Intellectual Disability Research · doi:10.1111/jir.12242 · Cited by 24 · see citing works
Executive functioning in Cornelia de Lange syndrome: domain asynchrony and age-related performance
Reid, D., Moss, J. F., Nelson, L., Groves, L., & Oliver, C. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9208-7 · Cited by 24 · see citing works
Esbensen, A. J., Hoffman, E. K., Shaffer, R. C., Patel, L., & Jacola, L. M. (2021) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-126.4.307 · Cited by 23 · see citing works
Jojoa, M., Signo, S., García-Zapirain, B., Gimeno-Santos, M., Zorrilla, A. M., Vaidya, C. J., Molins-Sauri, M., Guerra-Balic, M., & Bruna-Rabassa, O. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182010785 · Cited by 23 · see citing works
Stavroussi, P., Ανδρέου, Γ., & Karagiannopoulou, D. (2015) · International Journal of Disability Development and Education · doi:10.1080/1034912x.2015.1111307 · Cited by 23 · see citing works
Basten, I. A., Boada, R., Taylor, H., Koenig, K., Barrionuevo, V. L., Brandão, A., & Costa, A. C. S. (2018) · Brain Science · doi:10.3390/brainsci8120205 · Cited by 22 · see citing works
Auditory and visual sustained attention in Down syndrome
Faught, G. G., Conners, F. A., & Himmelberger, Z. M. (2016) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2016.01.021 · Cited by 22 · see citing works
Learning potential and cognitive abilities in preschool boys with fragile X and Down syndrome
Naranjo, N. V., & Bello, M. A. R. (2016) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2016.12.001 · Cited by 22 · see citing works
- Authors
- Lanfranchi, S., Jerman, O., Dal Pont, E., Alberti, A., & Vianello, R.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Lanfranchi, S.
- Venue
- Journal of Intellectual Disability Research
- Publisher
- Wiley
- Published
- 2010-03-20
- Volume
- 54
- Issue
- 4
- Pages
- 308-319
- ISSN
- 0964-2633 (ISSN-L)
- 1365-2788
- OpenAlex
- W2132167906
- Cited by
- 308
- References
- 54
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 17 · 2023: 20 · 2022: 23 · 2021: 32 · 2020: 29 · 2019: 13 · 2018: 22 · 2017: 21 · 2016: 27 · 2015: 22 · 2014: 20 · 2013: 18 · 2012: 14
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Intellectual Disability Research (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- executive function, Down syndrome, adolescents, set-shifting, planning and problem solving, working memory, inhibition, perseveration, fluency, sustained attention, intellectual disability, cognitive profile
- MeSH terms
- Adolescent, Child, Child, Preschool, Cognition Disorders, Down Syndrome, Female, Humans, Male, Neuropsychological Tests, Severity of Illness Index, Executive Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
