Evidence of Arrest of Neurogenesis and Synaptogenesis in Brains of Patients with Down's Syndrome
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The fetal cortex, cerebellum and hippocampus have all been shown to contain fewer neurons in individuals with Down syndrome than in controls, albeit based on small sample sizes.
“The fetal cortex, cerebellum and hippocampus have all been shown to contain fewer neurons in individuals with DS than in controls40–48, albeit based on small sample sizes17.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [48]
Cites
Takashima, S., Becker, L. E., Armstrong, D. L., & Chan, F. (1981) · Brain Research · doi:10.1016/0006-8993(81)90314-0 · Cited by 307 · see citing works
Down's syndrome: Is there a decreased population of neurons?
Ross, M. H., Galaburda, A. M., & Kemper, T. L. (1984) · Neurology · doi:10.1212/wnl.34.7.909 · Cited by 191 · see citing works
Petit, T. L., LeBoutillier, J. C., Alfano, D. P., & Becker, L. E. (1984) · Experimental Neurology · doi:10.1016/0014-4886(84)90041-4 · Cited by 84 · see citing works
Sara, V. R., Hall, K. E., Rodeck, C. H., & Wetterberg, L. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.3175 · Cited by 82 · see citing works
The Structure of the Cerebral Cortex in Down's Syndrome – A quantitative analysis –
Colon, E. J. (1972) · Neuropediatrics · doi:10.1055/s-0028-1091775 · Cited by 56 · see citing works
Trisomy 21: Mechanisms and Models*
Epstein, C. J., Epstein, L. B., Weil, J., & Cox, D. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb26847.x · Cited by 31 · see citing works
40 PATHOLOGIC CHANGES IN ALZHEIMERʼS DISEASE SPECIFICALLY DISRUPT HIPPOCAMPAL CONNECTIONS
Hyman, B. T., Hoesen, G. W. V., & Damasio, A. R. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198405000-00049 · Cited by 5 · see citing works
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Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159 · see citing works
Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome
Belichenko, P. V., Masliah, E., Kleschevnikov, A. M., Villar, A. J., Epstein, C. J., Salehi, A., & Mobley, W. C. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20337 · Cited by 297 · see citing works
MNB/DYRK1A as a multiple regulator of neuronal development
Tejedor, F. J., & Hämmerle, B. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07954.x · Cited by 214 · see citing works
Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice
Roper, R. J., Baxter, L. L., Saran, N. G., Klinedinst, D. K., Beachy, P. A., & Reeves, R. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510750103 · Cited by 205 · see citing works
Deficits in human trisomy 21 iPSCs and neurons
Weick, J. P., Held, D. L., Bonadurer, G. F., Doers, M. E., Liu, Y., Maguire, C., Clark, A., Knackert, J. A., Molinarolo, K., Musser, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216575110 · Cited by 205 · see citing works
Human Models Are Needed for Studying Human Neurodevelopmental Disorders
Zhao, X., & Bhattacharyya, A. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.10.009 · Cited by 192 · see citing works
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer’s disease
Rissman, R. A., & Mobley, W. C. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07237.x · Cited by 172 · see citing works
Human blood-brain barrier insulin-like growth factor receptor
Duffy, K. R., Pardridge, W. M., & Rosenfeld, R. G. (1988) · Metabolism · doi:10.1016/s0026-0495(98)90007-5 · Cited by 158 · see citing works
Nelson, P. G., Kuddo, T., Song, E. Y., Dambrosia, J. M., Kohler, S. J., Satyanarayana, G., VanDunk, C., Grether, J. K., & Nelson, K. B. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.10.003 · Cited by 144 · see citing works
The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome
Contestabile, A., Magara, S., & Cancedda, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00054 · Cited by 141 · see citing works
Hämmerle, B., Ulin, E., Guimera, J., Becker, W., Guillemot, F., & Tejedor, F. J. (2011) · Development · doi:10.1242/dev.066167 · Cited by 137 · see citing works
Communication breaks-Down: From neurodevelopment defects to cognitive disabilities in Down syndrome
Contestabile, A., Benfenati, F., & Gasparini, L. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.01.003 · Cited by 134 · see citing works
Aneuploidy: From a Physiological Mechanism of Variance to Down Syndrome
Dierssen, M., Hérault, Y., & Estivill, X. (2009) · Physiological Reviews · doi:10.1152/physrev.00032.2007 · Cited by 132 · see citing works
Oyama, F., Cairns, N. J., Shimada, H., Oyama, R., Titani, K., & Ihara, Y. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62031062.x · Cited by 129 · see citing works
Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice
Kurt, M. A., Davies, D. C., Kidd, M., Dierssen, M., & Flórez, J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01984-3 · Cited by 127 · see citing works
Ayberk Kurt, M., Ilker Kafa, M., Dierssen, M., & Ceri Davies, D. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.075 · Cited by 126 · see citing works
Aziz, N. M., Guedj, F., Pennings, J. L. A., Olmos-Serrano, J. L., Siegel, A., Haydar, T. F., & Bianchi, D. W. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031013 · Cited by 118 · see citing works
Ishihara, K., Amano, K., Takaki, E., Shimohata, A., Sago, H., Epstein, C. J., & Yamakawa, K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp176 · Cited by 106 · see citing works
SEIZURES IN CHILDREN WITH DOWN SYNDROME: ETIOLOGY, CHARACTERISTICS AND OUTCOME
Stafstrom, C. E., Patxot, O. F., Gilmore, H. E., & Wisniewski, K. E. (1991) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1991.tb05108.x · Cited by 106 · see citing works
Reduced cell number in the neocortical part of the human fetal brain in Down syndrome
Larsen, K. B., Laursen, H., Græm, N., Samuelsen, G. B., Bogdanovic, N., & Pakkenberg, B. (2008) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2008.05.007 · Cited by 87 · see citing works
Traumatic brain injury and hippocampal neurogenesis: functional implications
Redell, J. B., Maynard, M. E., Underwood, E. L., Vita, S. M., Dash, P., & Kobori, N. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113372 · Cited by 62 · see citing works
Impaired myelination of the human hippocampal formation in Down syndrome
Ábrahám, H., Vincze, A., Veszprémi, B., Kravják, A., Gömöri, É., Kovács, G. G., & Seress, L. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.11.005 · Cited by 85 · see citing works
Discrepancy between Alzheimer‐Type Neuropathology and Dementia in Persons with Down's Syndromea
Wı́sniewski, H. M., & Rabe, A. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb40344.x · Cited by 81 · see citing works
Patkee, P. A., Baburamani, A. A., Kyriakopoulou, V., Davidson, A., Avini, E., Dimitrova, R., Allsop, J. M., Hughes, E., Kangas, J., McAlonan, G. M., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102139 · Cited by 73 · see citing works
Altered autonomic cardiac regulation in individuals with Down syndrome
Iellamo, F., Galante, A., Legramante, J. M., Lippi, M. E., Condoluci, C., Albertini, G., & Volterrani, M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00560.2005 · Cited by 69 · see citing works
Low Blood Pressure in Down's Syndrome
Rd, M., McGrath, A., Davidson, G., Brown, J. J., Murray, G. D., & Lever, A. F. (1996) · Hypertension · doi:10.1161/01.hyp.28.4.569 · Cited by 68 · see citing works
Consequences of Trisomy 16 for Mouse Brain Development: Corticogenesis in a Model of Down Syndrome
Haydar, T. F., Blue, M. E., Molliver, M. E., Krueger, B. K., & Yarowsky, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06175.1996 · Cited by 66 · see citing works
New approaches to studying early brain development in Down syndrome
Baburamani, A. A., Patkee, P. A., Arichi, T., & Rutherford, M. A. (2019) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14260 · Cited by 74 · see citing works
Normal Neurogenesis but Abnormal Gene Expression in Human Fragile X Cortical Progenitor Cells
Bhattacharyya, A., McMillan, E., Wallace, K., Tubon, T. C., Capowski, E. E., & Svendsen, C. N. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0073 · Cited by 61 · see citing works
Chromosomal disorders associated with epilepsy
Battaglia, A., & Guerrini, R. (2005) · Epileptic Disorders · doi:10.1684/j.1950-6945.2005.tb00120.x · Cited by 60 · see citing works
Kaur, G., Sharma, A., Xu, W., Gerum, S., Alldred, M. J., Subbanna, S., Basavarajappa, B. S., Pawlik, M., Ohno, M., Ginsberg, S. D., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5338-13.2014 · Cited by 58 · see citing works
Park, J., Yang, E. J., Yoon, J. H., & Chung, K. C. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.07.007 · Cited by 61 · see citing works
Developmental Defects in Trisomy 21 and Mouse Models
Delabar, J. M., Aflalo-Rattenbac, R., & Créau, N. (2006) · The Scientific World JOURNAL · doi:10.1100/tsw.2006.322 · Cited by 47 · see citing works
Recent Advances in the Genetics of Epilepsy: Insights from Human and Animal Studies
Prasad, A. N., Prasad, C., & Stafstrom, C. E. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb02004.x · Cited by 47 · see citing works
Shaw, P. R., Klein, J. A., Aziz, N. M., & Haydar, T. F. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.046243 · Cited by 45 · see citing works
Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP
Park, J., Sung, J. Y., Park, J., Song, W., Chang, S., & Chung, K. C. (2012) · Journal of Cell Science · doi:10.1242/jcs.086124 · Cited by 44 · see citing works
Fetal Cerebellum: US Appearance with Advancing Gestational Age
Hashimoto, K., Shimizu, T., Shimoya, K., Kanzaki, T., Clapp, J. F., & Murata, Y. (2001) · Radiology · doi:10.1148/radiol.2211001583 · Cited by 43 · see citing works
Moldrich, R. X., Dauphinot, L., Laffaire, J., Vitalis, T., Hérault, Y., Beart, P., Rossier, J., Vivien, D., Gehrig, C., Antonarakis, S., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22131 · Cited by 48 · see citing works
Abnormal Expression of Synaptic Proteins and Neurotrophin-3 in the Down Syndrome Mouse Model Ts65Dn
Pollonini, G., Gao, V., Rabe, A., Palminiello, S., Albertini, G., & Alberini, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.025 · Cited by 42 · see citing works
Prehension in young children with Down syndrome
Kearney, K., & Gentile, A. M. (2002) · Acta Psychologica · doi:10.1016/s0001-6918(02)00083-5 · Cited by 40 · see citing works
Chapter 4 Age-related changes in Down syndrome brain and the cellular pathology of Alzheimer disease
Williams, R. S., & Matthysse, S. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)64297-1 · Cited by 39 · see citing works
Altered patterning of trisomy 21 interneuron progenitors
Giffin-Rao, Y., Sheng, J., Strand, B., Xu, K., Huang, L., Medo, M., Risgaard, K. A., Dantinne, S., Mohan, S., Keshan, A., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.05.001 · Cited by 38 · see citing works
Astrocytes in Down Syndrome Across the Lifespan
Ponroy Bally, B., & Murai, K. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.702685 · Cited by 35 · see citing works
Schaer, M., & D, S. E. M. (2007) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.02.002 · Cited by 33 · see citing works
Kleschevnikov, A. M., Belichenko, P. V., Salehi, A., & Wu, C. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00010-8 · Cited by 29 · see citing works
Consequences of trisomy 21 for brain development in Down syndrome
Russo, M. L., Sousa, A. M. M., & Bhattacharyya, A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-024-00866-2 · Cited by 28 · see citing works
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Bhattacharyya, A., & Svendsen, C. N. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00025.x · Cited by 27 · see citing works
Comprehensive volumetric phenotyping of the neonatal brain in Down syndrome
Fukami-Gartner, A., Baburamani, A. A., Dimitrova, R., Patkee, P. A., Ojinaga-Alfageme, O., Bonthrone, A. F., Cromb, D., Uus, A. U., Counsell, S. J., Hajnal, J. V., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad171 · Cited by 24 · see citing works
Genetic and Epigenetic Mechanisms in Down Syndrome Brain
Lu, J., & Shee, V. (2013) · InTech eBooks · doi:10.5772/52807 · Cited by 23 · see citing works
Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome
Bambrick, L. L., Yarowsky, P., & Krueger, B. K. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10630 · Cited by 23 · see citing works
Senile myoclonic epilepsy in Down syndrome: a video and EEG presentation of two cases
Simone, R. D., Daquin, G., & Genton, P. (2006) · Epileptic Disorders · doi:10.1684/j.1950-6945.2006.tb00191.x · Cited by 22 · see citing works
Hypothalamic versus pituitary dysfunction in Down's syndrome as cause of growth retardation
Castells, S., Beaulieu, I., Torrado, C., Wisniewski, K. E., Zarny, S., & Gelato, M. C. (1996) · Journal of Intellectual Disability Research · doi:10.1046/j.1365-2788.1996.802802.x · Cited by 21 · see citing works
Growth hormone deficiency in Down's syndrome children
Castells, S., Torrado, C., Bastian, W., & Wisniewski, K. E. (1992) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1992.tb00469.x · Cited by 20 · see citing works
Carcinogenesis in Down syndrome: What can be learned from trisomy 21?
Satgé, D., & Bénard, J. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.020 · Cited by 19 · see citing works
Kaur, G., Gauthier, S. A., Pérez‐González, R., Pawlik, M., Singh, A. B., Cosby, B., Mohan, P. S., Smiley, J. F., & Levy, E. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.08.025 · Cited by 17 · see citing works
Regular trisomy 21 not accompanied by increased copper‐zinc superoxide dismutase (SOD1) activity
Jeziorowska, A., Jakubowski, L., Lach, J., & Kałużewski, B. (1988) · Clinical Genetics · doi:10.1111/j.1399-0004.1988.tb04259.x · Cited by 17 · see citing works
Transcriptional consequences of trisomy 21 on neural induction
Martinez, J. L., Piciw, J. G., Crockett, M., Sorci, I. A., Makwana, N., Sirois, C. L., Giffin-Rao, Y., & Bhattacharyya, A. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1341141 · Cited by 15 · see citing works
Plioplys, A. V. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90263-2 · Cited by 13 · see citing works
Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome
Kurabayashi, N., Fujii, K., Otobe, Y., Hiroki, S., Hiratsuka, M., Yoshitane, H., Kazuki, Y., & Takao, K. (2023) · iScience · doi:10.1016/j.isci.2023.108379 · Cited by 13 · see citing works
Age‐Related Changes in Occipital Alpha Rhythm of Adults with Down Syndrome
Ono, Y., Yoshida, H., Momotani, Y., YOSHIMASU, F., & Higashi, Y. (1992) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1992.tb00540.x · Cited by 11 · see citing works
Campbell, N. B., Patel, Y., Moore, T. L., Medalla, M., & Zeldich, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043477 · Cited by 8 · see citing works
Markers of neural degeneration and regeneration in Down syndrome patients
Abdel-Meguid, I. E., Abdel-Salam, E., Latif, D. M. A., Korraa, S., & Ismaiel, A. (2012) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2012.08.008 · Cited by 8 · see citing works
Yao, F. S., Caserta, M. T., & Wyrwicz, A. M. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00043-5 · Cited by 8 · see citing works
The role of Down syndrome cell adhesion molecule in Down syndrome
Hergenreder, T., Yang, T., & Ye, B. (2024) · Medical Review · doi:10.1515/mr-2023-0056 · Cited by 7 · see citing works
A yeast model of Down syndrome
Moldrich, R. X. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.10.001 · Cited by 7 · see citing works
Murine trisomy 16 model of Down's syndrome: Central nervous system electron microscopic observations
Plioplys, A. V., & Bedford, H. M. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90048-8 · Cited by 7 · see citing works
Lee, S. E., Baxter, L. L., Duran, M. I., Morris, S. D., Mosley, I. A., Fuentes, K. A., Pennings, J., Guedj, F., & Bianchi, D. W. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae160 · Cited by 3 · see citing works
McClure‐Begley, T. D., Ebmeier, C. C., Ball, K. A., Jacobsen, J. R., Kogut, I., Bilousova, G., Klymkowsky, M. W., & Old, W. M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/315317 · Cited by 6 · see citing works
Combinatorial Gene Effects on the Neural Progenitor Pool in Down Syndrome
Lu, J., & Sheen, V. (2011) · InTech eBooks · doi:10.5772/20888 · Cited by 1 · see citing works
Deficiency of Adult Neurogenesis in the Ts65Dn Mouse Model of Down Syndrome
Pavel, V., & Alexander, M. (2011) · InTech eBooks · doi:10.5772/24585 · Cited by 4 · see citing works
All-Optical Wavelength-Selective Switch by Intensity Control in Cascaded Interferometers
Kishikawa, H., Goto, N., & Kimiy, K. (2010) · InTech eBooks · doi:10.5772/39555 · Cited by 3 · see citing works
Child Epilepsy: West Syndrome Associated with Chromosome Abnormalities: Clinicoelectrical Study
Mizukawa, M., Ohtsuka, Y., Murashima, I., Ohtahara, S., & Narahara, K. (1992) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1992.tb00893.x · Cited by 3 · see citing works
Development of Molecular Neuropathology in Down Syndrome across the Lifespan
Bhattacharyya, A., de la Torre-Ubieta, L., Zhu, Y., Head, E., Swarup, V., & Sousa, A. M. M. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1365-25.2025 · Cited by 3 · see citing works
Genetic Mechanisms of Memory Disorders (Excluding Alzheimer's Disease)
Kaas, G. A., Hawkins, K. E., & Sweatt, J. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21125-5 · Cited by 2 · see citing works
Cerebral Palsy: What Is Known Regarding Cause?
Nelson, K. B. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb40317.x · Cited by 2 · see citing works
Brown, S. (2002) · Wiley eBooks · doi:10.1002/9780470776216.ch7 · Cited by 2 · see citing works
Bowman, A. B., Ess, K. C., Kumar, K. K., & Summar, K. L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397267-5.00130-8 · Cited by 1 · see citing works
Kempermann, G. (2010) · Oxford University Press eBooks · doi:10.1093/med/9780199729692.003.0012 · Cited by 1 · see citing works
Chapter 6 Progress in Understanding the Genetics of Epilepsy
Stafstrom, C. E., Prasad, A. N., Prasad, C., & Slevin, J. T. (1999) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60026-7
Sato, T., Baxter, L. L., Adams, A., Bishop, L. A., Guedj, F., & Bianchi, D. W. (2025) · Biology Open · doi:10.1242/bio.062296
The Role of the Immunoglobulin Superfamily of Cell Adhesion Molecules in Intellectual Disability
Zaman, N., Bui, K., & Sytnyk, V. (2026) · Cells · doi:10.3390/cells15191801
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-11
- Volume
- 311
- Issue
- 18
- Pages
- 1187-1188
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4240806457
- Cited by
- 82
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Down syndrome, neurogenesis, synaptogenesis, brain development
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