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Cited by 24Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolSchizophrenia research and treatment

Short post-weaning social isolation induces long-term changes in the dopaminergic system and increases susceptibility to psychostimulants in female rats

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Lampert, Carine, Arcego, Danusa Mar, de Sá Couto‐Pereira, Natividade, dos Santos Vieira, Aline, Toniazzo, Ana Paula, Krolow, Rachel, Garcia, Emily, Vendite, Deusa Aparecida +2 more·2017·International Journal of Developmental Neuroscience
DOI 10.1016/j.ijdevneu.2017.05.003
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Abstract

Childhood and adolescence are sensitive periods of development, marked by high brain maturation and plasticity. Exposure to early life stress, such as social isolation, is able to prompt changes in sensitive brain circuitries, essentially in the mesolimbic dopaminergic system and increase the risk for addictive behaviors later in life. Post-weaning social isolation can stimulate the consumption of rewarding substances, like drugs of abuse and palatable foods. However, most studies analyze long periods of social isolation and very little is known about the effects of a brief social isolation in a sensitive period of development and its association with palatable food on the reward system sensitization. Furthermore, females are more susceptible to the reinforcing effect of drugs than males. Therefore, the aim of this study was to analyze the effects of a short post-weaning social isolation combined with a free access to a chronic high sugar diet (HSD) on the dopaminergic system, oxidative status and behavioral response to an amphetamine-like drug in adulthood. We used female Wistar rats that were socially isolated from post-natal days (PD) 21 to 35 and received free access to a HSD until PD 60. On PD 65, animals were submitted to a challenge with diethylpropion (DEP), an amphetamine-like drug and different responses were analyzed: locomotor activity, immmunocontent of dopamine related proteins, and the oxidative status in the striatum, before and after the DEP challenge. We showed that a short post-weaning social isolation (SI) increased the locomotor response to DEP, when compared with previous saline administration. Social isolation also increased dopamine transporter, tyrosine hydroxylase, and decreased dopamine D2 receptor immunocontent. Additionally, SI increased the overall oxidative status parameters after the challenge with DEP. Interestingly, the exposure to a HSD prevented the SI effects on locomotor response, but did not interfere in the dopaminergic parameters evaluated, despite having modified some oxidative parameters. This study showed for the first time that a short post-weaning social isolation was able to induce long-term changes in the striatal dopaminergic system and increased the response to psychostimulants. These results emphasize the importance of stressful experiences during a short period of development on programming susceptibility to psychostimulants later in life.

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  • Acute social isolation in rodents is sufficient to cause behavioral abnormalities, including increased vulnerability to drug addiction and depressive-like behavior, later in life.

    “During adolescence, social and cognitive skills depend on peer-to-peer interactions (Vanderschuren et al., 1997; Baarendse et al., 2013), and acute social isolation in rodents is sufficient to cause behavioral abnormalities, including increased vulnerability to drug addiction and depressive-like behavior, later in life (Lampert et al., 2017; Takatsu-Coleman et al., 2013; Whitaker et al., 2013).”

    From Oxytocin neurons mediate the effect of social isolation via the VTA circuits (2022) · cites this paper as Lampert et al., 2017

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Authors
Lampert, C., Arcego, D. M., de Sá Couto‐Pereira, N., dos Santos Vieira, A., Toniazzo, A. P., Krolow, R., Garcia, E., Vendite, D. A., Calcagnotto, M. E., & Dalmaz, C.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • Programa de Pós‐Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre RS Brazil
Corresponding author
Lampert, Carine
ORCID
Venue
International Journal of Developmental Neuroscience
Publisher
Wiley
Published
2017-05-27
Volume
61
Issue
1
Pages
21-30
ISSN
  • 0736-5748 (ISSN-L)
  • 1873-474X
DOI
10.1016/j.ijdevneu.2017.05.003
OpenAlex
W2618368954
Cited by
24
References
103
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2
FWCI
0.67
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)/Brazil
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
post-weaning social isolation, early life stress, mesolimbic dopamine system, diethylpropion, high-sugar diet, dopamine transporter, tyrosine hydroxylase, dopamine D2 receptor, striatum, oxidative stress, locomotor activity, female rats
MeSH terms
Amphetamine, Central Nervous System Stimulants, Animals, Animals, Newborn, Catalase, Corpus Striatum, Dopamine, Female, Fluoresceins, Food Preferences, Glutathione Peroxidase, Locomotion, Receptors, Dopamine, Social Isolation, Superoxide Dismutase, Rats, Wistar, Oxidative Stress, Substance-Related Disorders, Dopamine Plasma Membrane Transport Proteins, Rats

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