Self-associating autotransporters, SAATs: functional and structural similarities

Klemm, Per; Vejborg, Rebecca Munk; Sherlock, Orla

doi:10.1016/j.ijmm.2005.10.002

Cited by 109Escherichia coli research studiesBiochemical and Structural CharacterizationBacterial Genetics and Biotechnology

Self-associating autotransporters, SAATs: functional and structural similarities

Klemm, Per, Vejborg, Rebecca Munk, Sherlock, Orla·2006·International Journal of Medical Microbiology

DOI 10.1016/j.ijmm.2005.10.002

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Abstract

The autotransporter family of translocated proteins in Gram-negative bacteria all contain three structural motifs, a signal sequence, a passenger domain and a translocator domain. The autotransporters constitute a highly versatile group of proteins with respect to function, which accords with the widespread presence of these proteins. The group encompasses many important virulence factors. In Escherichia coli, a subgroup of autotransporter proteins consists of the TibA adhesin/invasin associated with some enterotoxigenic E. coli, the AIDA adhesin from diarrhea-causing E. coli and finally, the Ag43 autoaggregation factor found in the majority of E. coli strains. The three proteins exhibit approximately 25% identity at the sequence level, and are quite different with respect to size, glycosylation and processing. Nevertheless, they share some important properties: all are self-associating proteins that cause bacterial aggregation. They can also interact with each other via heterologous interactions to cause formation of mixed bacterial aggregates. Furthermore, these proteins enhance biofilm formation. Based on these properties we propose to classify them together in a group termed SAATs: self-associating autotransporters.

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Self-associating autotransporters (SAATs) of the Enterobacteriaceae and many type Vc secreted proteins promote strong autoaggregation.
“Among these, particularly the self-associating autotransporters (SAATs) of the Enterobacteriaceae (representing type Va) [69] and many type Vc secreted-proteins, such as the Yersinia adhesin YadA, BadA from Bartonella henselae and AtaA from certain strains of Acinetobacter baumannii [20],[23],[70], promote strong autoaggregation.”
From Bacterial autoaggregation (2018) · cites this paper as [69]

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Fine tuning the mechanism of Antigen 43 self-association to modulate aggregation levels of Escherichia coli pathogensPreprint
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Authors: Klemm, P., Vejborg, R. M., & Sherlock, O.
Affiliations: Technical University of Denmark (DK)
Corresponding author: Klemm, Per
ORCID: Vejborg, Rebecca Munk
Venue: International Journal of Medical Microbiology
Publisher: Elsevier BV
Published: 2006-08
Volume: 296
Issue: 4-5
Pages: 187-195
ISSN: 1438-4221 (ISSN-L)
DOI: 10.1016/j.ijmm.2005.10.002
OpenAlex: W1982077771
Cited by: 109
References: 43
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 12 · 2012: 8
FWCI: 0.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Medical Microbiology (publishedVersion)
PubMed (publishedVersion)
Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Funders: Teknologi og Produktion, Det Frie Forskningsråd
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: autotransporters, Escherichia coli, bacterial adhesins, virulence factors, bacterial aggregation, biofilm formation, enterotoxigenic Escherichia coli, signal peptide, passenger domain, protein glycosylation, protein processing
MeSH terms: Bacterial Adhesion, Bacterial Outer Membrane Proteins, Biological Transport, Carrier Proteins, Escherichia coli, Gram-Negative Bacteria, Hydrogen-Ion Concentration, Fimbriae, Bacterial, Bacterial Capsules, Biofilms, Adhesins, Bacterial, Adhesins, Escherichia coli

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Self-associating autotransporters, SAATs: functional and structural similarities

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