Cited by 1,826Advanced Radiotherapy TechniquesRadiation Therapy and DosimetryEffects of Radiation Exposure

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Use of Normal Tissue Complication Probability Models in the Clinic

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Marks, Lawrence B., Yorke, Ellen D., Jackson, Andrew, Ten Haken, Randall K., Constine, Louis S., Eisbruch, Avraham, Bentzen, Søren M., Nam, Jiho, Deasy, Joseph O.·2010·International Journal of Radiation Oncology*Biology*Physics

DOI 10.1016/j.ijrobp.2009.07.1754PMC PMC4041542

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Abstract

The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.

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Tolerance of normal tissue to therapeutic irradiation
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Fitting of normal tissue tolerance data to an analytic function
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Clinical dose–volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC)
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Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations
Kutcher, G. J., Burman, C. M., Brewster, L. J., Goitein, M., & Mohan, R. (1991) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(91)90173-2 · Cited by 560
Complication Probability as Assessed from Dose-Volume Histograms
Lyman, J. T. (1985) · Radiation Research Supplement · doi:10.2307/3583506 · Cited by 537
The Linear-Quadratic Model Is Inappropriate to Model High Dose per Fraction Effects in Radiosurgery
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Self-citation
Treatment volume and tissue tolerance
Withers, H. R., Taylor, J. M. G., & Maciejewski, B. (1988) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(88)90098-3 · Cited by 446

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Method
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BackgroundMethod
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Background
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Method
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“A higher dose may be difficult to achieve due to the risk of vision loss with doses greater than 54 Gy to the optic apparatus and greater than 45 Gy to 50 Gy to the retina.(23,24) In this study, most patients had stable or improved vision after a median follow up of 3.”
Background
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Aktuelle Diagnostik und Therapieempfehlungen beim Basalzellkarzinom am Auge
Kakkassery, V., Loeffler, K. U., Sand, M. S., Koch, K. R., Lentzsch, A. M., Nick, A. C., Adamietz, I. U. A., & Heindl, L. M. (2016) · Der Ophthalmologe · doi:10.1007/s00347-016-0370-1 · Cited by 31
Impact of VMAT-IMRT compared to 3D conformal radiotherapy on anal sphincter dose distribution in neoadjuvant chemoradiation of rectal cancer
Dapper, H., Rodríguez, I. A., Münch, S., Peeken, J. C., Borm, K. J., Combs, S. E., & Habermehl, D. (2018) · Radiation Oncology · doi:10.1186/s13014-018-1187-7 · Cited by 31
A Second Course of Radiotherapy in Patients with Recurrent Malignant Gliomas: Clinical Data on Re-irradiation, Prognostic Factors, and Usefulness of Digital Biomarkers
Straube, C., Kessel, K. A., Zimmer, C., Schmidt‐Graf, F., Schlegel, J., Gempt, J., Meyer, B., & Combs, S. E. (2019) · Current Treatment Options in Oncology · doi:10.1007/s11864-019-0673-y · Cited by 31
Precision Radiation Therapy for Metastatic Spinal Cord Compression: Final Results of the PRE-MODE Trial
Rades, D., Cacicedo, J., Conde-Moreno, A. J., Šegedin, B., But-Hadžić, J., Grošelj, B., Kevlishvili, G., Lomidze, D., Ciervide-Jurio, R., Rubio, C., et al. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.11.401 · Cited by 31
Temporally feathered intensity‐modulated radiation therapy: A planning technique to reduce normal tissue toxicity
Alfonso, J. C. L., Parsai, S., Joshi, N. P., Godley, A. R., Shah, C., Koyfman, S. A., Caudell, J. J., Fuller, C. D., Enderling, H., & Scott, J. G. (2018) · Medical Physics · doi:10.1002/mp.12988 · Cited by 31
Trends in Cardiac Mortality in Patients With Locally Advanced Non-Small Cell Lung Cancer
Haque, W. M., Verma, V., Fakhreddine, M., Butler, E. B., Teh, B. S., & Simone, C. B. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.10.031 · Cited by 30
Improved effectiveness of stereotactic radiosurgery in large brain metastases by individualized isotoxic dose prescription: an in silico study
Zindler, J. D., Schiffelers, J., Lambin, P., & Hoffmann, A. L. (2018) · Strahlentherapie und Onkologie · doi:10.1007/s00066-018-1262-x · Cited by 30
“Taking into account that the risk of radionecrosis increases rapidly above 10% as the V12Gy exceeds 10cm3 for single-fraction SRS, it is clinically highly relevant to strive for a smaller GTV-PTV margin and to explore the feasibility of dose delivery with non-coplanar beam arrangements [14].”
Background
Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy
Shelley, L. E. A., Sutcliffe, M. P. F., Thomas, S., Noble, D. J., Romanchikova, M., Harrison, K., Bates, A. M., Burnet, N. G., & Jena, R. (2020) · Physics and Imaging in Radiation Oncology · doi:10.1016/j.phro.2020.05.006 · Cited by 30
“Existing toxicity prediction models may no longer be appropriate for the modern high-dose gradient complex treatments currently being delivered, as the historic data used to derive constraints for dose-limiting organs were based on 3D conformal techniques [1,2].”
Background
Incorporating sensitive cardiac substructure sparing into radiation therapy planning
Morris, E. D., Aldridge, K., Ghanem, A. I., Zhu, S., & Glide‐Hurst, C. K. (2020) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.13037 · Cited by 30
“All re‐optimized plans met the original clinical prescription dose to the PTV while doses to the OARs met all objectives based on clinically acceptable guidelines.(27,28) Table 2 outlines the average change in the mean dose and D0.”
Method
Dosimetric predictors of pneumonitis in locally advanced non-small cell lung cancer patients treated with chemoradiation followed by durvalumab
Gao, R. W., Day, C. N., Yu, N. Y., Bush, A. F., Amundson, A. C., Prodduturvar, P., Majeed, U., Butts, E., Oliver, T., Schwecke, A., et al. (2022) · Lung Cancer · doi:10.1016/j.lungcan.2022.06.003 · Cited by 30
Dosimetric validation and clinical implementation of two 3D dose verification systems for quality assurance in volumetric‐modulated arc therapy techniques
Gutiérrez, F. C., & Vara, C. P. (2015) · Journal of Applied Clinical Medical Physics · doi:10.1120/jacmp.v16i2.5190 · Cited by 30
“and recently reviewed dose constraints (QUANTEC)(43) were reported for normal tissue.”
Background
Accumulated dose to the rectum, measured using dose–volume histograms and dose-surface maps, is different from planned dose in all patients treated with radiotherapy for prostate cancer
Scaife, J. E., Thomas, S., Harrison, K., Romanchikova, M., Sutcliffe, M. P. F., Forman, J., Bates, A. M., Jena, R., Parker, M. A., & Burnet, N. G. (2015) · British Journal of Radiology · doi:10.1259/bjr.20150243 · Cited by 30
“In addition, DVHs as produced from the treatment plan are not ideal representations of 3D doses as they discard spatial information.(28)”
Method
Metrics of dose to highly ventilated lung are predictive of radiation-induced pneumonitis in lung cancer patients
Flakus, M. J., Kent, S., Wallat, E. M., Wuschner, A. E., Tennant, E., Yadav, P., Burr, A., Yu, M., Christensen, G. E., Reinhardt, J. M., et al. (2023) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2023.109553 · Cited by 29
Contrasting analytical and data-driven frameworks for radiogenomic modeling of normal tissue toxicities in prostate cancer
Coates, J. T. T., Jeyaseelan, A. K., Ybarra, N., David, M., Faria, S. L., Souhami, L., Cury, F., Duclos, M., & Naqa, I. E. (2015) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2015.03.005 · Cited by 29
“This could be due to the loss of spatial information of the treatment plan when extracting metrics from one-dimensional DVHs but also because dose-volume metrics overlook the important role of which genetics play in radiosensitivity [50].”
BackgroundResult
Does mean heart dose sufficiently reflect coronary artery exposure in left-sided breast cancer radiotherapy?
Becker-Schiebe, M., Stockhammer, M., Hoffmann, W., Wetzel, F., & Franz, H. B. G. (2016) · Strahlentherapie und Onkologie · doi:10.1007/s00066-016-1011-y · Cited by 29
Dosimetric predictors for acute esophagitis during radiation therapy for lung cancer: Results of a large statewide observational study
Paximadis, P. A., Schipper, M. J., Matuszak, M. M., Feng, M. U.-S., Jolly, S., Boike, T. P., Grills, I. S., Kestin, L. L., Movsas, B., Griffith, K. A., et al. (2017) · Practical Radiation Oncology · doi:10.1016/j.prro.2017.07.010 · Cited by 29
“studies as outlined in the QUANTEC analysis [3].”
BackgroundMethod
Dosimetric predictors for postoperative pulmonary complications in esophageal cancer following neoadjuvant chemoradiotherapy and surgery
Cho, W. K., Oh, D., Kim, H. K., Ahn, Y. C., Noh, J. M., Shim, Y. M., Zo, J. I., Choi, Y. S., Sun, J., Lee, S., et al. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.01.005 · Cited by 29
The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation
Roeck, L. D., van der Weide, H. L., Eekers, D. B. P., Kramer, M. C. A., Alapetite, C., Blomstrand, M., Burnet, N. G., Calugaru, V., Coremans, I. E. M., Perri, D. D., et al. (2022) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2022.01.018 · Cited by 30
The effect on esophagus after different radiotherapy techniques for early stage Hodgkin's lymphoma
Jørgensen, A. Y. S., Maraldo, M. V., Brodin, N. P., Aznar, M. C., Vogelius, I. R., af Rosenschöld, P. M., Petersen, P. M., & Specht, L. (2013) · Acta Oncologica · doi:10.3109/0284186x.2013.813636 · Cited by 29
“Results from the QUANTEC study [9] show a clear trend demonstrating that volumes receiving 40 – 50 Gy correlate signifi cantly with early esophagitis.”
Background
Evaluation of DVH-based treatment plan verification in addition to gamma passing rates for head and neck IMRT
Visser, R., Wauben, D. J. L., de Groot, M., Steenbakkers, R. J. H. M., Bijl, H. P., Godart, J., Veld, A. A. V., Langendijk, J. A., & Korevaar, E. W. (2014) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2014.08.002 · Cited by 29
“Cutoff values for a 35 fractionation scheme were based on a consensus of our head and neck radiation oncologist group based on their expert opinion combined with QUANTEC data [7].”
Method
Dosiomics Risk Model for Predicting Radiation Induced Temporal Lobe Injury and Guiding Individual Intensity-Modulated Radiation Therapy
Yang, S., OuYang, P., Guo, J., Cai, J., Zhang, J., Peng, Q., He, Y., Zhang, B., Liu, Z.-Q., Hu, X.-F., et al. (2022) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2022.11.036 · Cited by 28
Molecular markers to predict clinical outcome and radiation induced toxicity in lung cancer.
Palmer, J. D., Zaorsky, N. G., Witek, M. E., & Lü, B. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2013.12.04 · Cited by 28
Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer
Fukahori, M., Matsufuji, N., Himukai, T., Kanematsu, N., Mizuno, H., Fukumura, A., Tsuji, H., & Kamada, T. (2015) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2015.11.023 · Cited by 28
Normal tissue considerations and dose–volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer
Fleming, C., Cagney, D. N., O’Keeffe, S., Brennan, S., Armstrong, J. G., & McClean, B. (2016) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2016.03.013 · Cited by 28
“In 2010 the QUANTEC (Quantitative Analysis of Normal Tissue Effects in the Clinic) review of the literature on normal tissue effects was published, summarising tolerance data on an organ-by-organ basis [16].”
BackgroundMethod
Geometric and dosimetric impact of anatomical changes for MR ‐only radiation therapy for the prostate
Nejad‐Davarani, S. P., Sevak, P. R., Moncion, M., Garbarino, K., Weiß, S., Kim, J. P., Schultz, L. R., Elshaikh, M. A., Renisch, S., & Glide‐Hurst, C. K. (2019) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.12551 · Cited by 28
“13 Gy) which is deemed not clinically acceptable.(28) However, the mean dose to the rectum decreased by 11.”
Background
Cardiac toxicity of lung cancer radiotherapy
Vojtíšek, ̈. (2019) · Reports of Practical Oncology & Radiotherapy · doi:10.1016/j.rpor.2019.10.007 · Cited by 28
Evaluation of bolus electron conformal therapy compared with conventional techniques for the treatment of left chest wall postmastectomy in patients with breast cancer
Opp, D., Forster, K. M., Li, W., Zhang, G. G., & Harris, E. E. R. (2013) · Medical dosimetry · doi:10.1016/j.meddos.2013.08.002 · Cited by 28
Stereotactic Body Radiotherapy as Primary Therapy for Head and Neck Cancer in the Elderly or Patients with Poor Performance
Amini, A., McDermott, J. D., Gan, G. N., Bhatia, S., Sumner, W., Fisher, C. M., Jimeno, A., Bowles, D. W., Raben, D., & Karam, S. D. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00274 · Cited by 28
“5 Gy in a single fraction is predicted to be associated with <5% risk for cranial neuropathy or necrosis (37).”
Background
Up-front neck dissection followed by definitive (chemo)-radiotherapy in head and neck squamous cell carcinoma: Rationale, complications, toxicity rates, and oncological outcomes – A systematic review
Eliçin, O., Nisa, L., Pra, A. D., Bojaxhiu, B., Caversaccio, M. D., Schmücking, M., Aebersold, D. M., & Giger, R. (2016) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2016.03.003 · Cited by 28
“Progress in the RT techniques and better understanding of dosimetric parameters of the organs at risk may positively affect toxicity related outcomes and decrease the post-(C)RT related toxicity in patients both with and without UFND [75].”
Isotoxic radiosurgery planning for brain metastases
Bohoudi, O., Bruynzeel, A. M. E., Lagerwaard, F. J., Cuijpers, J. P., Slotman, B. J., & Palacios, M. A. (2016) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2016.05.001 · Cited by 28
Dose–volume toxicity modeling for de-intensified chemo-radiation therapy for HPV-positive oropharynx cancer
Mavroidis, P., Price, A. T., Fried, D., Kostich, M., Amdur, R. J., Mendenhall, W. M., Liu, C., Das, S. K., Marks, L. B., & Chera, B. S. (2017) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2017.06.020 · Cited by 27
Self-citation
Multiparametric MRI-guided dose boost to dominant intraprostatic lesions in CT-based High-dose-rate prostate brachytherapy
Wang, T., Press, R. H., Giles, M., Jani, A. B., Rossi, P. J., Lei, Y., Curran, W. J., Patel, P. R., Liu, T., & Yang, X. (2019) · British Journal of Radiology · doi:10.1259/bjr.20190089 · Cited by 27
Dose-volume effects of breast cancer radiation therapy on the risk of second oesophageal cancer
Journy, N., Schonfeld, S. J., Hauptmann, M., Roberti, S., Howell, R. M., Smith, S. A., Vaalavirta, L., Stovall, M., van Leeuwen, F. E., Weathers, R. E., et al. (2020) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2020.07.022 · Cited by 27
Initial experience of ArcCHECK and 3DVH software for RapidArc treatment plan verification
Infusino, E., Mameli, A., Conti, R., Gaudino, D., Stimato, G., Bellesi, L., D’Angelillo, R. M., Ramella, S., Benassi, M., & Trodella, L. (2014) · Medical dosimetry · doi:10.1016/j.meddos.2014.04.004 · Cited by 27
A two-variable linear program solves the standard linear–quadratic formulation of the fractionation problem in cancer radiotherapy
Saberian, F., Ghate, A., & Kim, M. (2015) · Operations Research Letters · doi:10.1016/j.orl.2015.02.005 · Cited by 27
“∗Corresponding author: Fatemeh Saberian, Industrial and Systems Engineering, University of Washington, Box 352650, Seattle, WA 98195, USA; saberian@uw.edu †Industrial and Systems Engineering, University of Washington, Seattle, USA ‡Radiation Oncology, University of Washington, Seattle, USA”
Background
Contour scanning for penumbra improvement in pencil beam scanned proton therapy
Meier, G., Leiser, D., Besson, R., Mayor, A., Safai, S., Weber, D. C., & Lomax, A. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa5dde · Cited by 27
Real-time dose-rate monitoring with gynecologic brachytherapy: Results of an initial clinical trial
Belley, M. D., Craciunescu, O. I., Chang, Z., Langloss, B. W., Stanton, I. N., Yoshizumi, T. T., Therien, M. J., & Chino, J. (2018) · Brachytherapy · doi:10.1016/j.brachy.2018.07.014 · Cited by 27
Single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging for radiotherapy planning in patients with lung cancer: a meta-analysis
Lee, S. J., & Park, H. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-71445-5 · Cited by 27
“Siva24 2016 Article Prospective 14 65 (median, range 47–90) NSCLC I (5), II (1), III (7), IV (1)”
Background
Rethinking Dosimetry: A European Perspective
Tran‐Gia, J., Cicone, F., Koole, M. J. B., Giammarile, F., Gear, J. I., Deshayes, E., Gabiña, P. M., Cremonesi, M., Wadsley, J., Bernhardt, P., et al. (2025) · Journal of Nuclear Medicine · doi:10.2967/jnumed.124.269378 · Cited by 26
“Valuable insights can be drawn from EBRT, for which absorbed dose constraints for organs at risk have been consistently re ﬁ ned in response to evolving clinical evidence ( 32 , 91 ).”
Volumetric Modulated Arc Therapy Planning for Primary Prostate Cancer With Selective Intraprostatic Boost Determined by 18F-Choline PET/CT
Kuang, Y., Wu, L., Hirata, E. Y., Miyazaki, K., Sato, M. M., & Kwee, S. A. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2014.12.052 · Cited by 26
“Adherence to these constraints should result in 15% late grade 2 rectal complications (35).”
BackgroundMethod
Establishment of practice standards in nomenclature and prescription to enable construction of software and databases for knowledge-based practice review
Mayo, C. S., Pisansky, T. M., Petersen, I. A., Yan, E., Davis, B. J., Stafford, S. L., Garces, Y. I., Miller, R. C., Martenson, J. A., Mutter, R. W., et al. (2016) · Practical Radiation Oncology · doi:10.1016/j.prro.2015.11.001 · Cited by 26
Dosimetric Impact of Interfractional Variations in Prostate Cancer Radiotherapy—Implications for Imaging Frequency and Treatment Adaptation
Bostel, T., Sachpazidis, I., Splinter, M., Bougatf, N., Fechter, T., Zamboglou, C., Jäkel, O., Huber, P., Baltas, D., Debus, J., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00940 · Cited by 26
An N-Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy
Cheal, S. M., Patel, M., Yang, G., Veach, D. R., Xu, H. W., Guo, H.-F., ZANZONICO, P. B., Axworthy, D. B., Cheung, N. V., Ouerfelli, O., et al. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00736 · Cited by 26
A prospective, comparative analysis of acute toxicity profile between three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) in locally advanced head and neck cancer patients
Kucha, N., Soni, T. P., Jakhotia, N., Patni, N., Singh, D. K., Gupta, A. K., Sharma, L. M., & Goyal, J. (2020) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2020.100223 · Cited by 26
Machine learning and statistical prediction of patient quality-of-life after prostate radiation therapy
Yang, Z., Olszewski, D., He, C., Pintea, G. I., Lian, J., Chou, T., Chen, R. C., & Shtylla, B. (2020) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2020.104127 · Cited by 27
“However their analysis focused only on urinary symptoms during post-prostatectomy radiotherapy and NTCP models rely on already reduced DVH information.”
Influential
Very high-energy electron therapy as light-particle alternative to transmission proton FLASH therapy – An evaluation of dosimetric performances
Böhlen, T. T., Germond, J., Desorgher, L., Veres, I., Bratel, A., Landström, E., Engwall, E., Herrera, F. G., Özşahin, M., Bourhis, J., et al. (2024) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2024.110177 · Cited by 26
“TP plan optimization and evaluation was conducted following institutional prescriptions and using clinical goals based on RTOG and QUANTEC [45].”
Retrospective evaluation of dosimetric quality for prostate carcinomas treated with 3D conformal, intensity modulated and volumetric modulated arc radiotherapy
Crowe, S., Kairn, T., Middlebrook, N., Hill, B., Christie, D., Knight, R. T., Kenny, J., Langton, C. M., & Trapp, J. (2013) · Journal of Medical Radiation Sciences · doi:10.1002/jmrs.24 · Cited by 26
“Two OAR guidelines were adopted from objectives presented by Marks et al.20 and Michalski et al.21 as part of the QUANTEC analysis (Quantitative Analyses of Normal Tissue Effects in the Clinic) of normal tissue effects: that no more than 35% of the rectum should receive 60 Gy (V60Gy ≤ 35”
Method
Doses in organs at risk during head and neck radiotherapy using IMRT and 3D-CRT
Peszyńska-Piorun, M., Malicki, J., & Golusiński, W. (2012) · Radiology and Oncology · doi:10.2478/v10019-012-0050-y · Cited by 26
Factors Associated with Occurrence of Radiation-induced Optic Neuropathy at “Safe” Radiation Dosage
Doroslovački, P., Tamhankar, M. A., Liu, G. T., Shindler, K. S., Ying, G., & Alonso‐Basanta, M. (2017) · Seminars in Ophthalmology · doi:10.1080/08820538.2017.1346133 · Cited by 26
“581 Due to the poor visual prognosis and lack of effective treatments for RION, much research effort has been dedicated to identifying a safe radiation dose for the optic nerves and to create safe delivery parameters for radiation therapy in order to prevent RION.”
BackgroundInfluential

Authors: Marks, L. B., Yorke, E. D., Jackson, A., Ten Haken, R. K., Constine, L. S., Eisbruch, A., Bentzen, S. M., Nam, J., & Deasy, J. O.
Affiliations: University of North Carolina at Chapel Hill (US)
Memorial Sloan Kettering Cancer Center (US)
University of Rochester Medicine (US)
University of Michigan (US)
University of Wisconsin–Madison (US)
Washington University in St. Louis (US)
Corresponding author: Marks, Lawrence B.
ORCID: Marks, Lawrence B.
Yorke, Ellen D.
Jackson, Andrew
Constine, Louis S.
Eisbruch, Avraham
Bentzen, Søren M.
Nam, Jiho
Deasy, Joseph O.
Venue: International Journal of Radiation Oncology*Biology*Physics
Publisher: Elsevier BV
Published: 2010-03
Volume: 76
Issue: 3
Pages: S10-S19
ISSN: 0360-3016 (ISSN-L)
DOI: 10.1016/j.ijrobp.2009.07.1754
PMC: PMC4041542
OpenAlex: W2046701188
Cited by: 1,826
References: 30
Citations by year: 2026: 92 · 2025: 110 · 2024: 125 · 2023: 132 · 2022: 130 · 2021: 160 · 2020: 138 · 2019: 146 · 2018: 164 · 2017: 122 · 2016: 108 · 2015: 102 · 2014: 112 · 2013: 87 · 2012: 55
FWCI: 56.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Lance Armstrong Foundation
Armstrong Foundation
National Institutes of Health
National Cancer Institute (CA69579, R29CA069579, R29CA085181, R01CA069579, R01CA129182, R01CA085181, CA85181)
Topics: Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: normal tissue complication probability, QUANTEC, normal tissue tolerance, NTCP models
MeSH terms: Adult, Child, Dose-Response Relationship, Radiation, Humans, Models, Biological, Organ Specificity, Radiation Injuries, Radiation Tolerance, Models, Statistical, Practice Guidelines as Topic, Radiation Oncology, Dose Fractionation, Radiation

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Use of Normal Tissue Complication Probability Models in the Clinic

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