The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Use of Normal Tissue Complication Probability Models in the Clinic
Open accessAbstract
The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A seminal paper by Emami et al. ( 6 ) summarized normal-tissue tolerances to external photon irradiation as they were known in 1991, and these data have been gradually updated and expanded through other initiatives such as Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) and Hypofractionated Treatment Effects in the Clinic (HyTEC) ( 25 , 26 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [25]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tolerance of normal tissue to therapeutic irradiation
Emami, B., Lyman, J., Brown, A., Cola, L., Goitein, M., Munzenrider, J. E., Shank, B., Solin, L. J., & Wesson, M. (1991) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(91)90171-y · Cited by 4,488
Trotti, A., Colevas, A. D., Setser, A., Rusch, V. W., Jaques, D. P., Budach, V., Langer, C. J., Murphy, B. A., Cumberlin, R. L., & Coleman, C. N. (2003) · Seminars in Radiation Oncology · doi:10.1016/s1053-4296(03)00031-6 · Cited by 2,569
Fitting of normal tissue tolerance data to an analytic function
Burman, C. M., Kutcher, G. J., Emami, B., & Goitein, M. (1991) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(91)90172-z · Cited by 1,251
Reporting and analyzing dose distributions: A concept of equivalent uniform dose
Niemierko, A. (1997) · Medical Physics · doi:10.1118/1.598063 · Cited by 1,231
Graham, M. V., Purdy, J. A., Emami, B., Harms, W. B., Bosch, W. R., Lockett, M. A., & Perez, C. A. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00183-2 · Cited by 1,221
Complication Probability as Assessed from Dose-Volume Histograms
Lyman, J. T. (1985) · Radiation Research · doi:10.2307/3576626 · Cited by 1,160
Kutcher, G. J., Burman, C. M., Brewster, L. J., Goitein, M., & Mohan, R. (1991) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(91)90173-2 · Cited by 560
Complication Probability as Assessed from Dose-Volume Histograms
Lyman, J. T. (1985) · Radiation Research Supplement · doi:10.2307/3583506 · Cited by 537
The Linear-Quadratic Model Is Inappropriate to Model High Dose per Fraction Effects in Radiosurgery
Kirkpatrick, J. P., Meyer, J. J., & Marks, L. B. (2008) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2008.04.005 · Cited by 519
Self-citationTreatment volume and tissue tolerance
Withers, H. R., Taylor, J. M. G., & Maciejewski, B. (1988) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(88)90098-3 · Cited by 446
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Jolles, 1939, Area factor in skin reaction, Br Emp Cancer Campaign Rep, 16
- Niemierko, 1999, A generalized concept of equivalent uniform dose (EUD), Med Phys, 26, 1100
Cited by
Sorted by citations
Items 801–900 of 1,000
Tsang, S. W. S., Collins, M., Wong, J. T. L., & Chiu, G. (2017) · Journal of Radiotherapy in Practice · doi:10.1017/s1460396917000309 · Cited by 7
Wentzel, A., Mohamed, A., Naser, M. A., van Dijk, L. V., Hutcheson, K. A., Moreno, A. M., Fuller, C. D., Canahuate, G. M., & Marai, G. E. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1210087 · Cited by 7
“02 Other approaches such as Normal Tissue Complication Probability (NTCP) models attempt to account for 3-dimensional dose distributions to organs by considering the contribution for different parts of the dose-volume histogram to output a final risk probability (9).”
BackgroundA narrative review for radiation oncologists to implement preoperative partial breast irradiation
Zerella, M. A., Zaffaroni, M., Ronci, G., Dicuonzo, S., Rojas, D. P., Morra, A., Gerardi, M. A., Fodor, C. I., Rondi, E., Vigorito, S., et al. (2023) · La radiologia medica · doi:10.1007/s11547-023-01706-6 · Cited by 7
“In addition, treatment planning guidelines for external beam RT for stereotactic body radiation therapy [50], a modified version of the QUANTEC recommendations [51] or those published in other SBRT-based clinical trials [52] were used.”
MethodAyuthaya, I. I. N., Sanghangthum, T., Oonsiri, P., Oonsiri, S., Keawsamur, M., Ruangchan, S., Vannavijit, C., Kanphet, J., Kingkaew, S., Vimolnoch, M., et al. (2023) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.14223 · Cited by 7
Madhavan, S., Gamez, M. E., Garces, Y. I., Lester, S. C., Ma, D. J., Mundy, D. W., Wittich, M. A. N., Qian, J., Routman, D. M., Foote, R. L., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1346797 · Cited by 7
Data Science Opportunities To Improve Radiotherapy Planning and Clinical Decision Making
Deasy, J. O. (2024) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2024.07.012 · Cited by 7
Self-citationLuo, W., & Clair, W. H. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312891 · Cited by 7
Phua, V. C. E., Tan, B. S., Tan, A. L., Eng, K. Y., Ng, B. S., & Ung, N. M. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.4.2243 · Cited by 7
“Dose constraints for the OARs chosen by our institution were based on papers published by Emami in 1991 and the more recent publication in 2010 by the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) initiative (Emami et al., 1991; Marks et al., 2010).”
MethodHerrmann, E., Naehrig, D. N., Sassowsky, M., Bigler, M., Buijsen, J., Ciernik, I. F., Zwahlen, D. R., Franzetti-Pellanda, A., Meister, A., Brauchli, P., et al. (2017) · Radiation Oncology · doi:10.1186/s13014-016-0745-0 · Cited by 7
“V20Gy <20% and Dmean < 12–15Gy), heart (Dmean < 40Gy), spine (D1% <48Gy) and kidneys (Dmean left kidney <12Gy and if V50% of right kidney irradiated >20Gy, Dmean left kidney <5Gy) were provided to facilitate planning [10, 11].”
BackgroundPaleny, R., Bremer, M., Walacides, D., Mainwaring, S., Weber, K., & Henkenberens, C. (2018) · Strahlentherapie und Onkologie · doi:10.1007/s00066-018-1365-4 · Cited by 7
Kairn, T., & Crowe, S. (2019) · Australasian Physical & Engineering Sciences in Medicine · doi:10.1007/s13246-019-00725-w · Cited by 7
Poirier, V. J., Matsuyama, A., Kim, C., Darko, J., & Fleck, A. (2020) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15744 · Cited by 7
Chung, J.-H., Chun, M., Kim, J.-I., Park, J. M., & Shin, K. H. (2020) · British Journal of Radiology · doi:10.1259/bjr.20200047 · Cited by 7
First-passage times and normal tissue complication probabilities in the limit of large populations
Hufton, P. G., Buckingham-Jeffery, E., & Galla, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-64618-9 · Cited by 7
Wang, D., Wang, W., Liu, X., Ren, K., Liang, Y., Zhu, Q., Zhang, F., & Hu, K. (2021) · Cancer Medicine · doi:10.1002/cam4.4418 · Cited by 7
Cheung, E. Y., Ng, S. S. H., Yung, S. H. Y., Cheng, D. Y. T., Chan, F. Y. C., & Cheng, J. K. Y. (2022) · Life · doi:10.3390/life12020195 · Cited by 7
Crouzen, J. A., Petoukhova, A., Wiggenraad, R. G. J., Hutschemaekers, S. A. J., Hooijdonk, C. G. G., van Zyp, N. V. D. V., Mast, M. E., & Zindler, J. D. (2022) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2022.06.004 · Cited by 7
Indrayani, L., Anam, C., Sutanto, H., Subroto, R., & Dougherty, G. (2022) · Polish Journal of Medical Physics And Engineering · doi:10.2478/pjmpe-2022-0012 · Cited by 7
“Dose constraints for several organs based on QUANTEC 16 were: brainstem ( 𝐷 𝑚𝑎𝑥 54 Gy), chiasm ( 𝐷 𝑚𝑎𝑥 55 Gy), spinal cord ( 𝐷 𝑚𝑎𝑥 50 Gy), optic nerve ( 𝐷 𝑚𝑎𝑥 54 Gy), eye ( 𝐷 𝑚𝑎𝑥 54 Gy), and lens ( 𝐷 𝑚𝑎𝑥 7 Gy).”
Held, T., Tessonnier, T., Franke, H., Regnery, S., Bauer, L., Weusthof, K., Harrabi, S., Herfarth, K. K., Mairani, A., Debus, J., et al. (2022) · Radiation Oncology · doi:10.1186/s13014-022-02093-4 · Cited by 7
“Additional 20–30% total cumulative dose to OAR was only allowed after a minimum of two years [17, 18].”
BackgroundThe Mutational Landscape of Cancer's Vulnerability to Ionizing Radiation
Gopal, P., Yard, B. D., Petty, A. P., Lal, J. C., Bera, T. K., Hoang, T. Q., Buhimschi, A. D., & Abazeed, M. E. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1914 · Cited by 10
“Variation implies that generic treatment strategies optimized using decades of population data can lead to significant underor overtreatment of individual patients (3).”
BackgroundMethodLiu, H., Sintay, B., & Wiant, D. (2023) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.13939 · Cited by 7
Vargas, C. S., Andersson, M., Bouvier‐Capely, C., Li, W. B., Madas, B. G., Covens, P., Struelens, L., & Strigari, L. (2023) · Zeitschrift für Medizinische Physik · doi:10.1016/j.zemedi.2023.02.006 · Cited by 7
Locally advanced non-small cell lung cancer: current issues and recent trends
Alaswad, M. (2023) · Reports of Practical Oncology & Radiotherapy · doi:10.5603/rpor.a2023.0019 · Cited by 7
“Dose limits for OARs QUANTEC [64] 3D-CRT (RTOG 0617) [65] SABR (RTOG 0618, 18 Gy delivered in 3 fractions) [66]”
MethodAmoush, A., Murray, E. J., Yu, J. S., & Xia, P. (2015) · Journal of Applied Clinical Medical Physics · doi:10.1120/jacmp.v16i4.5188 · Cited by 7
“01), but both techniques still satisfy the normal tissue constraint guidelines as recommended by the quantitative analysis of normal tissue effects in the clinic (QUANTEC).(18) The percentage volume of the contralateral breast receiving a dose of 1 Gy was less than 2.”
BackgroundReducing Heart dose during Left Breast Cancer Radiotherapy: Comparison among 3 Radiation Techniques
D’Agostino, G. R., Diletto, B., Mantini, G., Nardone, L., Mattiucci, G. C., Catucci, F., Canna, R., Martino, A., Azario, L., & Valentini, V. (2015) · Tumori Journal · doi:10.5301/tj.5000414 · Cited by 7
“The IMRT optimization was made following the Quantitative Analyses of Normal Tissue Effects in the Clinic recommended constraints and plans were normalized at the target mean (21).”
MethodFocus on treatment complications and optimal management: radiation oncology.
Billiet, C., Peeters, S., & Ruysscher, D. D. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2014.06.08 · Cited by 7
“The QUANTEC review summarized 11 studies that used 3D treatment planning (14).”
BackgroundMethodHoover, D. A., MacFarlane, M. J., Wong, E., Battista, J. J., & Chen, J. Z. (2015) · Medical Physics · doi:10.1118/1.4905373 · Cited by 7
Ashamalla, H. L., Tejwani, A., Parameritis, I., Swamy, U., Luo, P. C., Guirguis, A., & Lavaf, A. (2013) · Radiation Oncology Journal · doi:10.3857/roj.2013.31.2.104 · Cited by 7
“All plans were optimized using a standard planning constraint set based on the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) [4] and Radiation Therapy Oncology Group (RTOG) protocols [5], dose objectives and priorities.”
MethodInoue, T., Masai, N., Oh, R., Shiomi, H., & Hashida, N. (2014) · Journal of Radiation Research · doi:10.1093/jrr/rru023 · Cited by 7
“At the last reduction, the monitor unit of each beam was changed in order to avoid late injury to the optic nerve [8, 9].”
BackgroundInoue, T., Masai, N., Shiomi, H., Oh, R., Uemoto, K., & Hashida, N. (2016) · Journal of Radiation Research · doi:10.1093/jrr/rrw104 · Cited by 7
“Since the classic tolerance dose proposed for the retina in conventional fractionated radiotherapy does not apply to the modern IMRT technology and fractionation for choroidal melanoma [34, 35], up-to-date information is necessary for determining the relevant tolerance dose for future IMRT strategies involving the F-M…”
BackgroundGómez, L., Andrés, C., & Ruiz, A. (2017) · Reports of Practical Oncology & Radiotherapy · doi:10.1016/j.rpor.2017.02.005 · Cited by 7
Cozzolino, M., Oliviero, C., D’Andrea, B., Guglielmi, G., Califano, G., Caivano, R., Bianculli, A., & Fusco, V. (2018) · Case Reports in Medicine · doi:10.1155/2018/4137943 · Cited by 7
“For the left lung, the conventional objectives were considered as acceptable, that is, the mean lung dose< 15Gy and the volume receiving 20Gy< 20–30% [24].”
BackgroundThe Aperture Shape Optimization Based on Fuzzy Enhancement
Zhang, P., Zhang, L., Yang, J., & Gui, Z. (2018) · IEEE Access · doi:10.1109/access.2018.2849208 · Cited by 7
“The results (Figure 4 and 5) proved that the proposedmethodwas capable of generating clinically acceptable plans which meet the practical clinical guidelines [25].”
BackgroundPötter, R., Balosso, J., Baumann, M. A., Bert, C., Davies, J., Enghardt, W., Fossati, P., Harris, S., Jones, B., Krämer, M., et al. (2018) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2018.04.027 · Cited by 7
Tasaki, M., Kasahara, T., Kaidu, M., Kawaguchi, G., Hara, N., Yamana, K., Maruyama, R., Takizawa, I., Ishizaki, F., Saito, K., et al. (2019) · Transplantation Proceedings · doi:10.1016/j.transproceed.2018.10.027 · Cited by 7
Draghini, L., Costantini, S., Vicenzi, L., Italiani, M., Loreti, F., Trippa, F., Arcidiacono, F., Casale, M., Mantello, G., & Maranzano, E. (2019) · La radiologia medica · doi:10.1007/s11547-019-01023-x · Cited by 7
“The HDR-BT was administered 3 times a week, fractionation schemes were selected taking into account equivalent dose, Quantec organs at risk (OAR) constrains, patient compliance and previous IMRT dose [15, 16].”
BackgroundMethodInfluentialTreatment of radiation-induced myelopathy with bevacizumab
Canedo, G. D. O., Muñiz, I. S., Segundo, C. G. S., Madero, L., & Lassaletta, Á. (2019) · Clinical & Translational Oncology · doi:10.1007/s12094-019-02209-5 · Cited by 7
Reiner, B. S., Bownes, P. J., Buckley, D. L., & Thwaites, D. (2017) · Europe PMC (PubMed Central) · Cited by 7
Ghate, A. (2020) · Physics in Medicine and Biology · doi:10.1088/1361-6560/abb935 · Cited by 7
“The treatment length and total tolerance doses are from standard treatment guidelines such as Bekelman and Lee (2017), Emami et al (1991), Marks et al (2010), Olsson et al (2018).”
BackgroundDeCesaris, C. M., Pollock, A., Zhang, B., Poirier, Y. P., Kowalski, E. S., Paulosky, K. E., Mishra, M. V., & Nichols, E. M. (2020) · Practical Radiation Oncology · doi:10.1016/j.prro.2020.09.003 · Cited by 7
Evaluation of HIF-1α and VEGF-A expression in radiation-induced cystitis: A case-control study
de Mattos, R. C., Guimarães, I. D. S., Thiago, L. S., & de Melo, A. C. (2021) · International braz j urol · doi:10.1590/s1677-5538.ibju.2020.0054 · Cited by 7
“The external radiotherapy dose that reached the bladder, calculated when the three-dimensional conformational technique was used, did not reach the maximum restrictive value of 6500cGy for all cases (10).”
MethodDuffy, S. R., Zheng, Y., Muenkel, J., Ellis, R. J., Baig, T. N., Krancevic, B., Langmack, C. B., Kelley, K. D., & Choi, S. (2020) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.13102 · Cited by 7
“1].(19) All overlapping OAR segments were entered into AP as a way of informing the planning system of the previously delivered dose and the strict constraints that would be necessary to accomplish the desired re‐irradiation.”
MethodHarnessing benefit of highly conformal RT techniques for lymphoma patients
Petersen, R. H., Mikhaeel, N. G., Ricardi, U., & Brady, J. L. (2021) · British Journal of Radiology · doi:10.1259/bjr.20210469 · Cited by 7
Chen, H., Huang, Y., Wang, H., Shao, Y., Yue, N. J., Gu, H., Duan, Y., Feng, A., & Xu, Z. (2021) · Radiation Oncology · doi:10.1186/s13014-021-01882-7 · Cited by 7
Salem, A., Mohamad, I., Dayyat, A., Kana’an, H., Sarhan, N., Roujob, I., Salem, A.-F., Afifi, S., Jaradat, I., Mubiden, R., et al. (2015) · Medical dosimetry · doi:10.1016/j.meddos.2014.12.001 · Cited by 7
Radojčić, Đ. S., Kolacio, M. Š., Radojčić, M., Rajlić, D., Casar, B., Faj, D., & Jurković, S. (2018) · Medical dosimetry · doi:10.1016/j.meddos.2017.11.008 · Cited by 7
Adaptive treatment-length optimization in spatiobiologically integrated radiotherapy
Ajdari, A., Ghate, A., & Kim, M. (2018) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aab4b6 · Cited by 7
Henry, T., & Ödén, J. (2018) · Physica Medica · doi:10.1016/j.ejmp.2018.10.025 · Cited by 7
Tumors of the Central Nervous System
Gray, P. J., Loeffler, J. S., & Shih, H. A. (2017) · Wiley eBooks · doi:10.1002/9781119341154.ch39 · Cited by 7
Lester-Coll, N. H., & Margalit, D. N. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.03.040 · Cited by 7
Morphis, M., van Staden, J. A., du Raan, H., Ljungberg, M. H., & Gleisner, K. S. (2024) · EJNMMI Physics · doi:10.1186/s40658-024-00657-9 · Cited by 6
“A wide range of I-131-mIBG liver absorbed dose values have been reported in literature, with values ranging from 0.3 to 1.1 mGy/MBq [1, 9, 38–40] and others ranging from 2.0 to 5.5 mGy/MBq [19, 32, 41, 42].”
BackgroundInfluentialUncertainties in outcome modelling in radiation oncology
Dünger, L., Mäusel, E., Zwanenburg, A., & Löck, S. (2025) · Physics and Imaging in Radiation Oncology · doi:10.1016/j.phro.2025.100774 · Cited by 7
“…models for predicting normal tissue complication probability (NTCP) that are in actual clinical use, e.g. as summarised in the QUANTEC articles [2], to complex artificial-intelligence-(AI) based, multi-modal approaches for treatment personalisation that have gained considerable importance…”
Giannini, N., Gonnelli, A., Gadducci, G., Puccini, P., Cavalieri, A., Masturzo, L., Pensavalle, J. H., Celentano, M., Martino, F. D., Cocco, F., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c19638 · Cited by 6
Akçay, M., Etiz, D., Çelik, Ö., & Özen, A. (2021) · Indian Journal of Cancer · doi:10.4103/ijc.ijc_666_19 · Cited by 6
Türkkan, G., Bilici, N., Sertel, H., Keskus, Y., Alkaya, S., Tavli, B., Ozkirim, M., & Fayda, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.909402 · Cited by 6
“10) treatment planning system in accordance with previous recommendations (6).”
Analysis of correlative risk factors for radiation-induced hypothyroidism in head and neck tumors
Wang, C., Hou, Y., Wang, L., Yang, Y., & Li, X. (2024) · BMC Cancer · doi:10.1186/s12885-023-11749-7 · Cited by 6
“The 2010 quantitative analysis report of clinical normal tissue effects did not mention the limiting dose of the thyroid gland [9]; thus, many studies are currently devoted to exploring the risk factors for hypothyroidism after radiotherapy for HNC and establishing normal tissue complication…”
BackgroundZha, Y., Zhang, J., Yan, X., Chen, Y., Wen, L., & Li, M.-Y. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-02899-w · Cited by 6
“The lung V20 is a classic and frequently described dosimetry parameter, and limiting lung V20 can significantly reduce the incidence of RP [30].”
BackgroundLow rate of severe-end-stage kidney disease after SABR for localised primary kidney cancer
Ali, M., Koo, K., Chang, D., Chan, P., Oon, S. F., MOON, D. A., Murphy, D. G., Eapen, R. S., Goad, J. R., Lawrentschuk, N., et al. (2024) · Radiation Oncology · doi:10.1186/s13014-024-02413-w · Cited by 6
“There should in theory be no effect on nephrons not receiving a significant radiation dose and the severity of radiation nephropathy therefore depends on the total dose and the kidney volume being irradiated [27, 28].”
BackgroundBin-Alamer, O., Abou‐Al‐Shaar, H., Singh, R. B., Bowden, G. N., Mathieu, D., Perlow, H. K., Palmer, J. D., Elhamdani, S., Shepard, M. J., Liang, Y., et al. (2024) · Journal of neurosurgery · doi:10.3171/2024.7.jns24920 · Cited by 6
Warren, S., Partridge, M., Fokas, E., Eccles, C. L., & Brunner, T. B. (2013) · Acta Oncologica · doi:10.3109/0284186x.2013.813072 · Cited by 6
Hamatani, N., Sumida, I., Takahashi, Y., Oda, M., Seo, Y., Isohashi, F., Tamari, K., & Ogawa, K. (2017) · Journal of Radiation Research · doi:10.1093/jrr/rrx017 · Cited by 6
“These constraints were determined based on the literature [11].”
MethodInfluentialCollery, A., & Forde, E. (2017) · Journal of medical imaging and radiation sciences · doi:10.1016/j.jmir.2017.04.003 · Cited by 6
Jazirehi, A. R. (2017) · Cancer therapy & Oncology International Journal · doi:10.19080/ctoij.2017.06.555682 · Cited by 6
Evolving Role of Novel Quantitative PET Techniques to Detect Radiation-Induced Complications
Dreyfuss, A. D., Jahangiri, P., Simone, C. B., & Alavi, A. A. (2019) · PET Clinics · doi:10.1016/j.cpet.2019.08.003 · Cited by 6
Is Locally Advanced Head-Neck Cancer One More Candidate for Accelerated Hypofractionation?
Koukourakis, I. M., Zygogianni, A. G., Kouloulias, V., Kyrgias, G., Panteliadou, M., Nanos, C., Abatzoglou, I. M., & Koukourakis, M. I. (2021) · Anticancer Research · doi:10.21873/anticanres.14797 · Cited by 6
Early Toxicities After High Dose Rate Proton Therapy in Cancer Treatments
Doyen, J., Sunyach, M., Almairac, F., Bourg, V., Naghavi, A. O., de Bénazé, G. D., Claren, A., Padovani, L., Bénézery, K., Noël, G., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.613089 · Cited by 6
Dell’Oro, M., Short, M., Wilson, P., & Bezak, E. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103415 · Cited by 6
Ray, X. J., Sumner, W., Sutton, L., Sanghvi, P. R., Deichaite, I., & Moiseenko, V. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03047-2 · Cited by 6
“Mean dose was used for both the pharynx and sub-pharyngeal muscles as it has been linked to dysphagia in the QUANTEC reviews [16, 17].”
MethodLui, J. C. F., Tang, A. M., Law, C. C., Lee, J. C. Y., Lee, F. K. H., Chiu, J., & Wong, K.-H. (2021) · Physica Medica · doi:10.1016/j.ejmp.2021.10.008 · Cited by 6
Albarakati, H., Jackson, P. A., Gulal, O., Ramachandran, P., Osbourne, G., Liu, M., Kron, T., & Geso, M. (2022) · Physical and Engineering Sciences in Medicine · doi:10.1007/s13246-022-01105-7 · Cited by 6
“Dose constraints for plans were taken from QUANTEC guidelines suggesting V20 (percentage of total lung volume receiving more than 20 Gy) of less than 30% total lung volume, heart mean dose less than 26 Gy and max dose 45 Gy for spinal cord [17].”
MethodPulmonary toxicity of craniospinal irradiation using helical tomotherapy
Lee, J., Kim, E., Kim, N., Suh, C., Chung, Y., & Yoon, H. I. (2022) · Scientific Reports · doi:10.1038/s41598-022-07224-1 · Cited by 6
The Impact of Optic Nerve Movement on Intracranial Radiation Treatment
Qing, K., Nie, K., Liu, B., Feng, X., Stone, J. R., Cui, T., Zhang⋆, Y., Zhu, J., Chen, Q., Wang, X., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.803329 · Cited by 6
Haematotoxicity in IMRT/VMAT curatively treated anal cancer
Lohynská, R., Nýdlová, A., Drbohlavová, T., Mazaná, E., Jirkovská, M., Veselský, T., Malinová, B., & Stankušová, H. (2020) · Klinicka onkologie · doi:10.14735/amko2020288 · Cited by 6
Acquah, G. F., Hasford, F., Tagoe, S. N. A., Kyere, A. K., Owusu-Kyere, R., Kyeremeh, P. O., Aznar, M. C., & Osei, E. K. (2022) · Scientific African · doi:10.1016/j.sciaf.2022.e01316 · Cited by 6
Prayongrat, A., Srimaneekarn, N., Thonglert, K., Khorprasert, C., Amornwichet, N., Alisanant, P., Shirato, H., Kobashi, K., & Sriswasdi, S. (2022) · Radiation Oncology · doi:10.1186/s13014-022-02138-8 · Cited by 6
“To simplify the entire DVH into a single measurement and simultaneously account for organ architecture, the generalized equivalent uniform dose (gEUD) was calculated from the differential DVH pairs (vi and Di represent the volume and dose in the i dose bin) using the following formula [26, 27] :”
MethodRadiotherapy-associated Sensorineural Hearing Loss in Pediatric Oncology Patients
Aslam, M. A., Ahmad, H., Malik, H. S., Uinarni, H., Karim, Y. S., Akhmedov, Y. M., Abdelbasset, W. K., Awadh, S. A., Abid, M. K., Mustafa, Y. F., et al. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230515112245 · Cited by 8
Vishwanath, L., Mandal, S. K., Sunil, R., Latha, D. A., Bhaskar, N., Palled, S. R., Naveen, T., Pasha, C. V. T., Joseph, B., & Krishna, U. (2023) · Cancer Research Statistics and Treatment · doi:10.4103/crst.crst_304_22 · Cited by 6
He, R., Duggar, W. N., Yang, C. C., & Vijayakumar, S. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02667-2 · Cited by 6
Baudou, É., Péran, P., Tensaouti, F., Arribarat, G., Pariente, J., Courbieres, N., Pollidoro, L., Bertozzi, A., Gambart, M., Sévely, A., et al. (2023) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2023.110073 · Cited by 6
Application of Dempster–Shafer theory in dose response outcome analysis
Chen, W., Cui, Y., He, Y., Yu, Y., Galvin, J. M., Hussaini, Y., & Xiao, Y. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/17/5575 · Cited by 6
“Finally, the parameters obtained from the LKB model curve fitting are compared with those from Emami and Burman’s papers (Emami et al 1991, Burman et al 1991), those from QUANTEC review (Marks et al 2010a), and those from Semenenko and Li (2008) which used the maximum likelihood method.”
BackgroundMethodResultInfluentialvan Dijk, I. W. E. M., van Os, R., van de Kamer, J. B., Franken, N. A. P., van der Pal, H. J. H., Koning, C. C. E., Caron, H. N., Ronckers, C. M., & Kremer, L. C. M. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-014-0373-3 · Cited by 6
“, normal tissue complications in the radiation oncology literature) for which fractionation effects are probably most relevant [31].”
BackgroundKazda, T., Pospíšil, P., Vrzal, M., Ševela, O., Procházka, T., Jančálek, R., Šlampa, P., & Laack, N. N. I. (2015) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2014.11.013 · Cited by 6
Duman, E., İnal, A., Şengül, A., Koca, T., Çeçen, Y., & Yavuz, M. (2016) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.179189 · Cited by 6
Unwrapping 3D complex hollow organs for spatial dose surface analysis
Witztum, A., George, B., Warren, S., Partridge, M., & Hawkins, M. (2016) · Medical Physics · doi:10.1118/1.4964790 · Cited by 6
Huang, P., Yu, G., Chen, J., Ma, C., Qin, S., Yin, Y., Liang, Y., Li, H., & Li, D. (2016) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.12008 · Cited by 6
Tavakkoli, M. B., Abedi, I., Jabbari, K., Amouheidari, A., & Yadegarfard, G. (2017) · Journal of Medical Signals & Sensors · doi:10.4103/2228-7477.205504 · Cited by 6
“[1] One of the strategies to improve the efficiency of radiotherapy is increasing the prescribed dose.”
BackgroundZielvolumenkonzepte in der Strahlentherapie und ihre Bedeutung für die Bildgebung
Burnet, N. G., Noble, D., Paul, A., Whitfield, G. A., & Delorme, S. (2018) · Der Radiologe · doi:10.1007/s00117-018-0420-6 · Cited by 6
Maemoto, H., Ariga, T., Nakachi, S., Toita, T., Hashimoto, S., Heianna, J., Shiina, H., Kusada, T., Makino, W., Kakinohana, Y., et al. (2018) · Journal of Radiation Research · doi:10.1093/jrr/rry068 · Cited by 6
“Excessive radiation doses should not be used because the frequency and severity of radiation-related adverse events depend on the radiation dose [18].”
BackgroundPartial Bladder Boost Using Lipiodol Marking During Image-guided Radiotherapy for Bladder Cancer
Nakamura, R., KAKUHARA, H., Kikuchi, K., Segawa, T., Oikawa, H., IWASAKI, K., Obara, W., & Ariga, H. (2018) · Anticancer Research · doi:10.21873/anticanres.12793 · Cited by 6
A Column Generation Approach Based on Region Growth
Zhang, L., Gui, Z., Yang, J., & Zhang, P. (2019) · IEEE Access · doi:10.1109/access.2019.2896175 · Cited by 6
“Further, according to the guidelines for clinical practice [38], for head and neck cancer cases, the dose distributions of the spinal cord and brain stem were restricted by the maximum dose subobjective function, which required that the maximum doses for the spinal cord and brain stem should not exceed 50 and 54 Gy (t…”
BackgroundMethodInfluentialConical beam geometry intensity-modulated radiation therapy
Schüler, E., Wang, L., Loo, B. W., & Maxim, P. G. (2019) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ab246f · Cited by 6
Siker, M., Bovi, J. A., & Alexander, B. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-24098-7.00030-7 · Cited by 6
Outaggarts, Z., Wegener, D., Berger, B., Zips, D., Paulsen, F., Bleif, M., Thorwarth, D., Alber, M. L., Dohm, O. S., & Müller, A. (2020) · Acta Oncologica · doi:10.1080/0284186x.2020.1760349 · Cited by 6
“Yet, all of Quantec’s constraints were met by both plans (16).”
BackgroundRadiation dose homogeneity and critical organs in radiotherapy treatment of prostate cancer
Khairi, Y., Omer, H. B., Sulieman, A., Deiab, N. A., Mokhtar, M. H., Abolaban, F. A., Alkhorayef, M. A., & Bradley, D. A. (2020) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2020.109000 · Cited by 6
Sakanaka, K., Ishida, Y., Fujii, K., Ishihara, Y., Nakamura, M., Hiraoka, M., & Mizowaki, T. (2020) · Clinical Oncology · doi:10.1016/j.clon.2020.07.012 · Cited by 6
Stefanowicz, S., Wlodarczyk, W., Frosch, S., Zschaeck, S., & Troost, E. G. C. (2020) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2020.12.001 · Cited by 6
“The treatment goals for the OARs (with their priority) were chosen taking into account the institutional guidelines and QUANTEC dose constraints [25]: The maximum dose to the spinal cord (Dmax) was set to be 45 Gy (priority 1) and the volume of the liver receiving 30 Gy (V30Gy) 100ccm (priority 5).”
BackgroundMethodAchard, V., Ris, F., Rouzaud, M., Puppa, G., Buchs, N. C., de Perrot, T., Koessler, T., Picardi, C., & Zilli, T. (2021) · British Journal of Radiology · doi:10.1259/bjr.20200931 · Cited by 6
Innocente, R., Navarria, F., Petri, R., Palazzari, E., Vecchiato, M., Polesel, J., Ziccarelli, A., Martino, A., Ubiali, P., Tonin, D. M., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626275 · Cited by 6
“Radiation dose was prescribed to the PTVs according to the International Commission on Radiation Units & Measurements (ICRU) criteria (12) and normal tissue dose constraints were defined according to European Organisation for Research and Treatment of Cancer- Radiation Oncology Group (EORTC-ROG) (11) and NCCN (13) gui…”
MethodHou, Z., Li, S., Jiang, Y., Sun, F., Liu, J., Gao, S., Chen, W., & Yan, J. (2021) · Translational Cancer Research · doi:10.21037/tcr-21-1324 · Cited by 6
“Radiobiological model, which uses the dose-volume histogram (DVH), allows for quantification of normal tissue complication probability (NTCP) (12-15) and is widely used in clinical decision making (16), treatment technique selection (17), and planning optimization (18).”
MethodHanke, L., Tang, H., Schröder, C., Windisch, P. Y., Kudura, K., Shelan, M., Buchali, A., Bodis, S. B., Forster, R. E., & Zwahlen, D. R. (2023) · Cancers · doi:10.3390/cancers15133454 · Cited by 6
Metadata
- Authors
- Marks, L. B., Yorke, E. D., Jackson, A., Ten Haken, R. K., Constine, L. S., Eisbruch, A., Bentzen, S. M., Nam, J., & Deasy, J. O.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Rochester Medicine (US)
- University of Michigan (US)
- University of Wisconsin–Madison (US)
- Washington University in St. Louis (US)
- Corresponding author
- Marks, Lawrence B.
- ORCID
- Venue
- International Journal of Radiation Oncology*Biology*Physics
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 76
- Issue
- 3
- Pages
- S10-S19
- ISSN
- 0360-3016 (ISSN-L)
- PMC
- PMC4041542
- OpenAlex
- W2046701188
- Cited by
- 1,826
- References
- 30
- Citations by year
- 2026: 92 · 2025: 110 · 2024: 125 · 2023: 132 · 2022: 130 · 2021: 160 · 2020: 138 · 2019: 146 · 2018: 164 · 2017: 122 · 2016: 108 · 2015: 102 · 2014: 112 · 2013: 87 · 2012: 55
- FWCI
- 56.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Lance Armstrong Foundation
- Armstrong Foundation
- National Institutes of Health
- National Cancer Institute (CA69579, R29CA069579, R29CA085181, R01CA069579, R01CA129182, R01CA085181, CA85181)
- Topics
- Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- normal tissue complication probability, QUANTEC, normal tissue tolerance, NTCP models
- MeSH terms
- Adult, Child, Dose-Response Relationship, Radiation, Humans, Models, Biological, Organ Specificity, Radiation Injuries, Radiation Tolerance, Models, Statistical, Practice Guidelines as Topic, Radiation Oncology, Dose Fractionation, Radiation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
