Cited by 1,259Immune cells in cancerImmune responses and vaccinationsImmune Response and Inflammation

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Macrophage Polarization Comes of Age

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Mantovani,, Alberto, Sica,, Antonio, Locati, Massimo·2005·Immunity

DOI 10.1016/j.immuni.2005.10.001

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Abstract

Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).

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The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Self-citation
Alternative activation of macrophages
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Fibrotic disease and the TH1/TH2 paradigm
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Authors: Mantovani, Sica, & Locati, M.
Affiliations: University of Milan (IT)
Corresponding author: Mantovani,, Alberto
ORCID: Mantovani,, Alberto
Sica,, Antonio
Locati, Massimo
Venue: Immunity
Publisher: Elsevier BV
Published: 2005-10
Volume: 23
Issue: 4
Pages: 344-346
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2005.10.001
OpenAlex: W1986736465
Cited by: 1,259
References: 0
Citations by year: 2026: 41 · 2025: 60 · 2024: 58 · 2023: 54 · 2022: 70 · 2021: 65 · 2020: 68 · 2019: 58 · 2018: 57 · 2017: 70 · 2016: 67 · 2015: 64 · 2014: 85 · 2013: 89 · 2012: 80
FWCI: 9.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2846 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: Ministero dell’Istruzione, dell’Università e della Ricerca
Associazione Italiana per la Ricerca sul Cancro
European Commission
Ministero della Salute
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: macrophage polarization, M1 macrophages, M2 macrophages, mononuclear phagocytes, macrophage plasticity
MeSH terms: Cell Differentiation, Macrophages

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Macrophage Polarization Comes of Age

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