Cited by 1,259Immune cells in cancerImmune responses and vaccinationsImmune Response and Inflammation

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Macrophage Polarization Comes of Age

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Mantovani,, Alberto, Sica,, Antonio, Locati, Massimo·2005·Immunity

DOI 10.1016/j.immuni.2005.10.001

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Abstract

Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).

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The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Self-citation
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765

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“…or in conjunction with cytokines associated with T-helper (Th) 1 response, such as interferon-γ (IFN γ ), M1 macrophage polarization is triggered [23], which activates Th1 immunity and result in substantial production of proinflammatory cytokines to support functions in immune surveillance [24,25].”
Background
A comprehensive review of phytochemicals targeting macrophages for the regulation of colorectal cancer progression
Yang, Y., Zhao, M., Kuang, Q.-X., You, F., & Jiang, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155451 · Cited by 9
CD300a Regulates Mouse Macrophage Functionality in Allergic Inflammation
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“In resolution, M Φ can phagocytize dead inflammatory cells, secrete anti-inflammatory mediators, and switch phenotype from a pro-inflammatory M1 toward a pro-resolutory M2 [9–11].”
Background
CD83 acts as immediate early response gene in activated macrophages and exhibits specific intracellular trafficking properties
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Network Pharmacology and Transcriptomics Reveal the Mechanism of GuaLouQuMaiWan in Treatment of Type 2 Diabetes and Its Active Small Molecular Compound
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“Insulin deficiency is mainly related to glucose toxicity [5] and lipotoxicity [6], which Hindawi Journal of Diabetes Research Volume 2022, Article ID 2736504, 24 pages https://doi.”
Background
Immune System Disequilibrium—Neutrophils, Their Extracellular Traps, and COVID-19-Induced Sepsis
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“Macrophages can be broadly separated into two opposing phenotypes, pro-inflammatory (M1) and antiinflammatory (M2) (8).”
Background
Alterations in macrophage phagocytosis and inflammatory tone following exposure to the organochlorine compounds oxychlordane and trans-nonachlor
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Impact of aging on distribution of IgA + and IgG + cells in aggregated lymphoid nodules area in abomasum of Bactrian camels ( Camelus bactrianus )
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“…including neutrophils (Fulop et al., 2004), monocytes and macrophages (Alvarez and Santa Maria, 1996; Chelvarajan et al., 2006; Kuo et al., 2007; Mantovani et al., 2005; Sebastian et al., 2005), natural kill cells (Borrego et al., 1999; Di Lorenzo et al., 1999; Solana et al., 1999; Solana and…”
Computational modeling of brain pathologies: the case of multiple sclerosis
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Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
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Troglitazone and Δ2Troglitazone Enhance Adiponectin Expression in Monocytes/Macrophages through the AMP-Activated Protein Kinase Pathway
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“Macrophages are heterogenous and plastic population of phagocytic cells, which arise from circulating myeloidderived blood monocytes, enter target tissues, and gain phenotypic and functional attributes partly determined by their tissue of residence [1].”
Background
Whole-cell MALDI-TOF mass spectrometry is an accurate and rapid method to analyze different modes of macrophage activation.
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Stromal Cell Biology - A Way to Understand the Evolution of Cardiovascular Diseases -
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“and arginase that suppress anti-tumor immune responses [22-25].”
Background
Enhancing the Osseointegration of Titanium Implants by Modulating M1/M2 Macrophage Polarization through PI3K-Akt Signal Pathway on a “Cortex-like” Microarc Oxidation Coating
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“12 By effectively and timely converting the M1 phenotype to the M2 phenotype, macrophages facilitate the recruitment and differentiation of osteoblasts on the titanium implant surface by producing cytokines, chemokines, and growth factors, such as bone morphogenetic protein-2 (BMP2), transforming…”
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“Macrophages in different immune microenvironments, key participants in the inflammatory response, can be polarized into two distinct subtypes: M1 (inflammatory) and M2 (anti-inflammatory) [44].”
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“…by producing matrix metalloproteinase-9 (MMP9), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) at primary and metastatic sites (Geh et al. 2022) and angiogenesis in the tumor stroma (Mantovani et al. 2005; Hume 2015; Gordon and Martinez 2010; Pollard 2004).”
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CYP2C19 Contributes to THP-1-Cell-Derived M2 Macrophage Polarization by Producing 11,12- and 14,15-Epoxyeicosatrienoic Acid, Agonists of the PPARγ Receptor
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Background
Time-series biological responses toward decellularized bovine tendon graft and autograft for 52 consecutive weeks after rat anterior cruciate ligament reconstruction
Itoh, M., Imasu, H., Takano, K., Umezu, M., Okazaki, K., & Iwasaki, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-10713-y · Cited by 11
TBK1 participates in glutaminolysis by mediating the phosphorylation of RIPK3 to promote endotoxin tolerance.
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“The TAMs are commonly classified into two functional phenotypes, namely tumour-suppressive M1 and tumour-promoting M2, based on the model proposed by Alberto Mantovani [218, 220].”
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“In vitro Anti-inflammatory Test Since macrophage played a very important role in the inflammatory response via the secretion of a variety of factors (Perry et al., 1993; Mantovani et al., 2005; Cohen and Mosser, 2013), such as nitric oxide (NO) and proinflammatory cytokines (e.”
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Authors: Mantovani, Sica, & Locati, M.
Affiliations: University of Milan (IT)
Corresponding author: Mantovani,, Alberto
ORCID: Mantovani,, Alberto
Sica,, Antonio
Locati, Massimo
Venue: Immunity
Publisher: Elsevier BV
Published: 2005-10
Volume: 23
Issue: 4
Pages: 344-346
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2005.10.001
OpenAlex: W1986736465
Cited by: 1,259
References: 0
Citations by year: 2026: 41 · 2025: 60 · 2024: 58 · 2023: 54 · 2022: 70 · 2021: 65 · 2020: 68 · 2019: 58 · 2018: 57 · 2017: 70 · 2016: 67 · 2015: 64 · 2014: 85 · 2013: 89 · 2012: 80
FWCI: 9.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2846 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: Ministero dell’Istruzione, dell’Università e della Ricerca
Associazione Italiana per la Ricerca sul Cancro
European Commission
Ministero della Salute
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: macrophage polarization, M1 macrophages, M2 macrophages, mononuclear phagocytes, macrophage plasticity
MeSH terms: Cell Differentiation, Macrophages

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Macrophage Polarization Comes of Age

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