Cited by 1,259Immune cells in cancerImmune responses and vaccinationsImmune Response and Inflammation

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Macrophage Polarization Comes of Age

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Mantovani,, Alberto, Sica,, Antonio, Locati, Massimo·2005·Immunity

DOI 10.1016/j.immuni.2005.10.001

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Abstract

Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).

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The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Self-citation
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765

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Molecular mechanisms underlying macrophage immunomodulatory activity of Rubus chingii Hu polysaccharides
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Background
Oxysterol mixture and, in particular, 27‐hydroxycholesterol drive M2 polarization of human macrophages
Marengo, B., Bellora, F., Ricciarelli, R., Ciucis, C. D., Furfaro, A. L., Leardi, R., Colla, R., Pacini, D., Traverso, N., Moretta, A., et al. (2015) · BioFactors · doi:10.1002/biof.1243 · Cited by 44
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Background
Adsorbed Fibrinogen Enhances Production of Bone- and Angiogenic-Related Factors by Monocytes/Macrophages
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Altered Polarization, Morphology, and Impaired Innate Immunity Germane to Resident Peritoneal Macrophages in Mice with Long-Term Type 2 Diabetes
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Macrophages and Platelets Are the Major Source of Protease Nexin-1 in Human Atherosclerotic Plaque
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“These polarized macrophages can be broadly categorized into two distinct types: M1 and M2, each assigned speci ﬁ c functions (34).”
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Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases
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The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy
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Effects of Csf1R-Targeted Chimeric Antigen Receptor-Modified Nk92Mi & T Cells on Tumor-Associated Macrophages
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CD14-Dependent Monocyte Isolation Enhances Phagocytosis of Listeria monocytogenes by Proinflammatory, GM-CSF-Derived Macrophages
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“Accordingly, M-MQ have PLOS ONE | www.plosone.org 8 June 2013 | Volume 8 | Issue 6 | e66898 anti-inflammatory capacity similar to M2 or alternatively activated macrophages, which can also be generated ex vivo from monocytes by incubation with IL-4 and/or IL-13 [8,12,34,35], and mimic resident tissue macrophages.”
Background
Macrophage polarization induced by neuropeptide methionine enkephalin (MENK) promotes tumoricidal responses
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“As described previously, macrophages can be functionally polarized into classically activated (M1) macrophages or alternatively activated (M2) macrophages [10, 11].”
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The increased ratio of Mg2+/Ca2+ from degrading magnesium alloys directs macrophage fate for functionalized growth of endothelial cells
Hou, Y., Witte, F., Li, J., & Guan, S. (2022) · Smart Materials in Medicine · doi:10.1016/j.smaim.2022.01.001 · Cited by 43
SS‐31 Protects Liver from Ischemia‐Reperfusion Injury via Modulating Macrophage Polarization
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The roles of extracellular vesicles in the development, microenvironment, anticancer drug resistance, and therapy of head and neck squamous cell carcinoma
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The TLR4–NOS1–AP1 signaling axis regulates macrophage polarization
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Inflammatory Mediators in Vascular Disease: Identifying Promising Targets for Intracranial Aneurysm Research
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Background
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Schultze, J. L., Freeman, T. C., Hume, D. A., & Latz, E. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.02.001 · Cited by 39
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“Although there are many variants of these phenotypes, the simplest concept includes the M1 (proinflammatory) macrophages and the M2 (regulatory, tissue remodeling) phenotypes (46,49,50).”
Background
Macrophages in Renal Development, Injury, and Repair
Williams, T. M., Little, M. H., & Ricardo, S. D. (2010) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2010.03.011 · Cited by 44
Oxidative Stress, Inflammation, and the Corrosion of Metallic Biomaterials
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“This process involves molecular networks, including post-transcriptional regulators, epigenetic mechanisms, transcription factors, and signaling molecules (Mantovani et al. 2005).”
Adipose-derived stem cell-secreted exosomes enhance angiogenesis by promoting macrophage M2 polarization in type 2 diabetic mice with limb ischemia via the JAK/STAT6 pathway
Wang, X., Chen, S., Lu, R., Sun, Y., Song, T., Nie, Z., Yu, C., & Gao, Y. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11495 · Cited by 41
“Macrophages differentiate into M1 phenotype pro-inflammatory cells and M2 phenotype anti-inflammatory cells under different environmental stimuli [28].”
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CCL22-Polarized TAMs to M2a Macrophages in Cervical Cancer In Vitro Model
Wang, Q., Sudan, K., Schmoeckel, E., Kost, B. P., Kühn, C., Vattai, A., Vilsmaier, T., Mahner, S., Jeschke, U., & Heidegger, H. H. (2022) · Cells · doi:10.3390/cells11132027 · Cited by 45
“Conversely, M2 macrophages are stimulated by Th2 factors and promote tumor growth [9].”
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The prognostic significance of carcinoma-associated fibroblasts and tumor-associated macrophages in nasopharyngeal carcinoma
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“Tumor-associated macrophages (TAMs) are also major stromal components within tumors that exist as a heterogeneous population of cells derived from monocytes and are polarized into two functionally distinct forms, M1 and M2, in response to tissue microenvironments and/or inflammatory status.(16) CD68 has been widely us…”
Intravenous Immunoglobulin Promotes Antitumor Responses by Modulating Macrophage Polarization
Domínguez‐Soto, Á., Casas-Engel, M. D. L., Bragado, R., Medina‐Echeverz, J., Aragoneses-Fenoll, L., Martín‐Gayo, E., van Rooijen, N., Berraondo, P., Toribio, M. L., Moro, M. Á., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303375 · Cited by 42
“Microbe- derived factors, or cytokines like IFN-g, GM-CSF, or TNF-a, promote in macrophages the acquisition of proinflammatory, bactericidal, tumor-suppressive, and immunogenic activities, a process commonly referred to as classical or M1 polarization and whose hallmark is the ability to release large amounts of IL-12…”
BackgroundMethodInfluential
Curcumin alleviates immune‐complex‐mediated glomerulonephritis in factor‐H‐deficient mice
Jacob, A., Chaves, L., Eadon, M. T., Chang, A., Quigg, R., & Alexander, J. (2013) · Immunology · doi:10.1111/imm.12079 · Cited by 41
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“The complexity of the inflammatory response was increased by creating two subpopulations of activated macrophages, one with pro-inflammatory (M1 macrophages) and another with antiinflammatory (M2 macrophages) phenotype [28,29].”
BackgroundMethod
Innate Th2-type immune responses and the natural helper cell, a newly identified lymphocyte population
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Authors: Mantovani, Sica, & Locati, M.
Affiliations: University of Milan (IT)
Corresponding author: Mantovani,, Alberto
ORCID: Mantovani,, Alberto
Sica,, Antonio
Locati, Massimo
Venue: Immunity
Publisher: Elsevier BV
Published: 2005-10
Volume: 23
Issue: 4
Pages: 344-346
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2005.10.001
OpenAlex: W1986736465
Cited by: 1,259
References: 0
Citations by year: 2026: 41 · 2025: 60 · 2024: 58 · 2023: 54 · 2022: 70 · 2021: 65 · 2020: 68 · 2019: 58 · 2018: 57 · 2017: 70 · 2016: 67 · 2015: 64 · 2014: 85 · 2013: 89 · 2012: 80
FWCI: 9.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2846 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: Ministero dell’Istruzione, dell’Università e della Ricerca
Associazione Italiana per la Ricerca sul Cancro
European Commission
Ministero della Salute
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: macrophage polarization, M1 macrophages, M2 macrophages, mononuclear phagocytes, macrophage plasticity
MeSH terms: Cell Differentiation, Macrophages

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Macrophage Polarization Comes of Age

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