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Epidermal Langerhans Cell-Deficient Mice Develop Enhanced Contact Hypersensitivity
Open accessAbstract
Epidermal Langerhans cells (LCs), a distinct skin-resident dendritic cell population, acquire antigen in the skin and migrate to draining lymph nodes where they are thought to initiate adaptive immune responses. To examine the functional requirement of LCs in skin immunity, we generated BAC transgenic mice in which the regulatory elements from human Langerin were used to drive expression of diphtheria toxin. The resulting mice have a constitutive and durable absence of epidermal LCs but are otherwise intact. Unexpectedly, we found that contact hypersensitivity (CHS) was amplified rather than abrogated in the absence of LCs. Moreover, we showed that LCs act during the priming and not the effector phase. Thus, LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function.
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“However, this premise has been challenged recently by analysis of CHS in mice in which epidermal LC were either conditionally depleted (14, 24) or permanently ablated (13).”
α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin
Ohmatsu, H., Kadono, T., Sugaya, M., Tomita, M., Kai, H., Miyagaki, T., Saeki, H., Tamaki, K., Steeber, D. A., Tedder, T. F., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.048 · Cited by 19
Urocanic Acid: An Endogenous Regulator of Langerhans Cells
Bruhs, A., Eckhart, L., Tschachler, E., Schwarz, T., & Schwarz, A. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.04.016 · Cited by 11
Metadata
- Authors
- Kaplan, D. H., Jenison, M. C., Saeland, S., Shlomchik, W. D., & Shlomchik, M. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 23
- Issue
- 6
- Pages
- 611-620
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2018733478
- Cited by
- 559
- References
- 1
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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