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Cited by 124Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyDermatology and Skin Diseases

Local IL-23 is required for proliferation and retention of skin-resident memory T H 17 cells

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Whitley, Sarah K., Li, Mushi, Kashem, Sakeen W., Hirai, Toshiro, Igyártó, Botond Z., Knizner, Kelley, Ho, Jonhan, Ferris, Laura K. +4 more·2022·Science Immunology
DOI 10.1126/sciimmunol.abq3254PMC PMC9847353
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Abstract

The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which IL-23 supports tissue-specific immunity remains unclear. In mice, we found that circulating memory T cells were dispensable for anamnestic protection from Candida albicans skin infection, and tissue-resident memory (T RM ) cell–mediated protection from C. albicans reinfection required IL-23. Administration of anti–IL-23 receptor antibody to mice after resolution of primary C. albicans infection resulted in loss of CD69 + CD103 + tissue-resident memory T helper 17 (T RM17 ) cells from skin, and clinical anti–IL-23 therapy depleted T RM17 cells from skin of patients with psoriasis. IL-23 receptor blockade impaired T RM17 cell proliferation but did not affect apoptosis susceptibility or tissue egress. IL-23 produced by CD301b + myeloid cells was required for T RM17 maintenance in skin after C. albicans infection, and CD301b + cells were necessary for T RM17 expansion during the development of imiquimod dermatitis. This study demonstrates that locally produced IL-23 promotes in situ proliferation of cutaneous T RM17 cells to support their longevity and function and provides mechanistic insight into the durable efficacy of IL-23 blockade in the treatment of psoriasis.

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  • Effector T cells play a critical role in the host's defense during reinfection with C. albicans, Staphylococcus aureus, Leishmania major, and HSV.

    “Effector T cells play a critical role in the host’s defense during reinfection with C. albicans, Staphylococcus aureus, Leishmania major, and HSV [28,30–35].”

    From The Emerging Fungal Pathogen Candida auris Induces IFNγ to Colonize the Skin (2025) · cites this paper as [31]

    The Introduction (page not provided) describes skin-resident memory T cells protecting against secondary HSV infection and reinfection with Leishmania major. The Results section on IL-23 blockade (page not provided) demonstrates protection against subsequent C. albicans infection. Our copy does not support the Staphylococcus aureus part of the claim (searched: “Staphylococcus aureus”). (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Th17 cells play a critical role in host defense against C. albicans.

    “Th17 cells play a critical role in host defense against C. albicans [30–33,36], whereas Th1 cells protect the host against reinfection from HSV and L. major [34,35].”

    From The Emerging Fungal Pathogen Candida auris Induces IFNγ to Colonize the Skin (2025) · cites this paper as [31]

  • IL-17-producing TRM cells play a critical role in host defense against C. albicans during reinfection.

    “Previous findings suggest that IL-17-producing TRM cells play a critical role in host defense against C. albicans during reinfection [30–33,36].”

    From The Emerging Fungal Pathogen Candida auris Induces IFNγ to Colonize the Skin (2025) · cites this paper as [31]

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Sorted by citations

Authors
Whitley, S. K., Li, M., Kashem, S. W., Hirai, T., Igyártó, B. Z., Knizner, K., Ho, J., Ferris, L. K., Weaver, C. T., Cua, D. J., McGeachy, M. J., & Kaplan, D. H.
Affiliations
  • University of Pittsburgh (US)
  • Thomas Jefferson University (US)
  • University of Alabama at Birmingham (US)
  • Janssen Research and Development, Spring House, PA, USA.
Corresponding author
  • Whitley, Sarah K.
  • Kaplan, Daniel H.
ORCID
Venue
Science Immunology
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022-11-25
Volume
7
Issue
77
Pages
eabq3254-eabq3254
ISSN
2470-9468 (ISSN-L)
DOI
10.1126/sciimmunol.abq3254
PMC
PMC9847353
OpenAlex
W4308916009
Cited by
124
References
10
Citations by year
2026: 31 · 2025: 44 · 2024: 26 · 2023: 23
FWCI
8.88
Type
journal article
Language
en
Open access
Locations
  • Science Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (T32AI089443)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR077341, T32AR007175, R01AR071720, P30AR069625)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
IL-23, tissue-resident memory T cells, Th17 cells, skin, Candida albicans infection, psoriasis, T cell proliferation, skin immunity, anti-IL-23 therapy
MeSH terms
Animals, Candida albicans, Immunologic Memory, Psoriasis, Interleukin-17, Cell Proliferation, Mice, Interleukin-23

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