Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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Restoring function in exhausted CD8 T cells during chronic viral infection

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

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The B7 family revisited

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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

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Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

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Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

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NK CELL RECEPTORS

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

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HIV-Mediated Phosphatidylinositol 3-Kinase/Serine–Threonine Kinase Activation in APCs Leads to Programmed Death-1 Ligand Upregulation and Suppression of HIV-Specific CD8 T Cells

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The Interplay between T Cells and Cancer: The Basis of Immunotherapy

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Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation

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CTL Induction of Tumoricidal Nitric Oxide Production by Intratumoral Macrophages Is Critical for Tumor Elimination

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Therapeutic vaccination and novel strategies to treat chronic HBV infection

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Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer

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Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells

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Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease

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Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation

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Roles, function and relevance of LAG3 in HIV infection

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Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

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Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma

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PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis

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Phagocytosis, a Potential Mechanism for Myeloid-Derived Suppressor Cell Regulation of CD8+ T Cell Function Mediated through Programmed Cell Death-1 and Programmed Cell Death-1 Ligand Interaction

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T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases

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Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T cells

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Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex

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A Ceramide Analogue Stimulates Dendritic Cells To Promote T Cell Responses upon Virus Infections

Pritzl, C. J., Seo, Y., Xia, C., Vijayan, M., Stokes, Z. D., & Hahm, B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402672 · Cited by 38

Enhanced Antiviral T Cell Function in the Absence of B7-H1 Is Insufficient To Prevent Persistence but Exacerbates Axonal Bystander Damage during Viral Encephalomyelitis

Phares, T. W., Stohlman, S. A., Hinton, D. R., Atkinson, R., & Bergmann, C. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001984 · Cited by 38

Exogenous OX40 Stimulation during Lymphocytic Choriomeningitis Virus Infection Impairs Follicular Th Cell Differentiation and Diverts CD4 T Cells into the Effector Lineage by Upregulating Blimp-1

Boettler, T., Choi, Y. S., Salek‐Ardakani, S., Cheng, Y., Moeckel, F., Croft, M., Crotty, S., & von Herrath, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300013 · Cited by 38

Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine

Boldajipour, B. A., Nelson, A., & Krummel, M. F. (2016) · JCI Insight · doi:10.1172/jci.insight.89289 · Cited by 37

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

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Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis

Liu, J., Cho, Y. B., Hong, H. K., Wu, S., Ebert, P. J., Bray, S. M., Wong, S. S., Ting, J. C., Calley, J. N., Whittington, C. F., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67842-5 · Cited by 38

Transcriptional and epigenetic regulation of PD-1 expression

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T-cell Exhaustion in Organ Transplantation

Angeletti, A., Cantarelli, C., Riella, L. V., Fribourg, M., & Cravedi, P. (2021) · Transplantation · doi:10.1097/tp.0000000000003851 · Cited by 39

Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’

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Metabolic Implications of Immune Checkpoint Proteins in Cancer

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Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance?

Jonjić, S., Polić, B., & Krmpotić, A. (2008) · European Journal of Immunology · doi:10.1002/eji.200838823 · Cited by 38

Ligand-Independent Exhaustion of Killer Immunoglobulin-Like Receptor-Positive CD8 + T Cells in Human Immunodeficiency Virus Type 1 Infection

Alter, G., Rihn, S. J., Streeck, H., Teigen, N. C., Trocha, A. K., Moss, K., Cohen, K. W., Meier, A., Pereyra, F., Walker, B. D., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00341-08 · Cited by 38

T-cell senescence: A crucial player in autoimmune diseases

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The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

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Prospects and feasibility of synergistic therapy with radiotherapy, immunotherapy, and DNA methyltransferase inhibitors in non-small cell lung cancer

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Advances in LAG3 cancer immunotherapeutics

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Attrition of T-Cell Functions and Simultaneous Upregulation of Inhibitory Markers Correspond with the Waning of BCG-Induced Protection against Tuberculosis in Mice

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Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes

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Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques

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Targeting the programmed cell death-1 pathway in rheumatoid arthritis

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T lymphocytes against solid malignancies: winning ways to defeat tumours

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Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells

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Interrogating Adaptive Immunity Using LCMV

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Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency

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CD38 in Advanced Prostate Cancers

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Harnessing the IL-21-BATF Pathway in the CD8+ T Cell Anti-Tumor Response

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Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing

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Cellular Senescence in Immunity against Infections

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Signature Channels of Excitability no More: L-Type Channels in Immune Cells

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Molecular Analysis of Tumor-Promoting CD8+ T Cells in Two-Stage Cutaneous Chemical Carcinogenesis

Kwong, B. Y., Roberts, S. J., Silberzahn, T., Filler, R. B., Neustadter, J. H., Galan, A., Reddy, S., Lin, W. M., Ellis, P. D., Langford, C. F., et al. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.362 · Cited by 37

T Cell Memory in the Context of Persistent Herpes Viral Infections

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Toripalimab, a therapeutic monoclonal anti-PD-1 antibody with high binding affinity to PD-1 and enhanced potency to activate human T cells

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HIV-associated memory B cell perturbations

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Targeting lymphocyte co-stimulation: From bench to bedside

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PD-L1/B7-H1 Regulates the Survival but Not the Function of CD8+ T Cells in Herpes Simplex Virus Type 1 Latently Infected Trigeminal Ganglia

Jeon, S., Leger, A. J. S., Cherpes, T. L., Sheridan, B. S., & Hendricks, R. L. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300582 · Cited by 36

TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections

Lewis, G. M., Wehrens, E. J., Labarta-Bajo, L., Streeck, H., & Zúñiga, E. I. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87041 · Cited by 38

Impaired activation of lesional CD8+ T-cells is associated with enhanced expression of Programmed Death-1 in Indian Post Kala-azar Dermal Leishmaniasis

Mukherjee, S., Sengupta, R., Mukhopadhyay, D., Braun, C., Mitra, S., Roy, S., Das, N. K., Chatterjee, U., von Stebut, E., & Chatterjee, M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37144-y · Cited by 36

Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient survival

Cho, E. J., Kim, M., Jo, D., Kim, J., Oh, J., Chung, H. C., Lee, S.-H., Kim, D., Chun, S., Kim, J., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02034-1 · Cited by 36

The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer

Beumer‐Chuwonpad, A., Taggenbrock, R. L. R. E., Ngo, T. A., & van Gisbergen, K. P. J. M. (2021) · Cells · doi:10.3390/cells10092234 · Cited by 40

COVID and Lung Cancer

Calabrò, L., Rossi, G., Covre, A., Morra, A., & Maio, M. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01125-8 · Cited by 33

Interactions Between Anti-Angiogenic Therapy and Immunotherapy in Glioblastoma

Jain, S., Chalif, E. J., & Aghi, M. K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.812916 · Cited by 36

Regulatory effects of IRF4 on immune cells in the tumor microenvironment

Lu, J., Liang, T., Li, P., & Yin, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1086803 · Cited by 36

CD8 T Cells andToxoplasma gondii: A New Paradigm

Gigley, J. P., Bhadra, R., & Khan, I. A. (2011) · Journal of Parasitology Research · doi:10.1155/2011/243796 · Cited by 36

Recognition of self and altered self by T cells in autoimmunity and allergy

Yin, L., Dai, S., Clayton, G. M., Gao, W., Wang, Y., Kappler, J. W., & Marrack, P. (2013) · Protein & Cell · doi:10.1007/s13238-012-2077-7 · Cited by 36

Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia

Mohan, S. R., Clemente, M. J., Afable, M. G., Cazzolli, H., Bejanyan, N., Włodarski, M. W., Lichtin, A. E., & Maciejewski, J. (2009) · Haematologica · doi:10.3324/haematol.2009.009191 · Cited by 36

Generating long‐lived CD8+ T‐cell memory: Insights from epigenetic programs

Dogra, P., Ghoneim, H. E., Abdelsamed, H. A., & Youngblood, B. (2016) · European Journal of Immunology · doi:10.1002/eji.201545550 · Cited by 38

Immune Checkpoint Inhibitors for Cancer Therapy in the COVID-19 Era

Maio, M., Hamid, O., Larkin, J., Covre, A., Altomonte, M., Calabrò, L., Vardhana, S. A., Robert, C., Ibrahim, R. A., Anichini, A., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1657 · Cited by 35

Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation

Edwards, K. J., Chang, B. H., Babazada, H., Lohith, K., Park, D. H., Farwell, M. D., & Sellmyer, M. A. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0874 · Cited by 35

Characteristics of immunological events in Epstein-Barr virus infection in children with infectious mononucleosis

Zhang, Y., Huang, C.-R., Zhang, H., Duan, Z., Liu, Q., Li, J.-F., Zong, Q., Wei, Y., Liu, F., Duan, W., et al. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1060053 · Cited by 30

The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer

Zhang, J., Lei, F., & Tan, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1166128 · Cited by 39

ETV7 limits the antiviral and antitumor efficacy of CD8+ T cells by diverting their fate toward exhaustion

Cheng, J., Xiao, Y., Peng, T., Zhang, Z., Qin, Y., Wang, Y., Shi, J., Yan, J., Zhao, Z., He, Z., et al. (2025) · Nature Cancer · doi:10.1038/s43018-024-00892-0 · Cited by 37

Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer

Rivadeneira, D. B., Thosar, S. A., Quann, K., Gunn, W. G., Dean, V. G., Xie, B., Parise, A. M., McGovern, A. C., Spahr, K., Lontos, K., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.08.008 · Cited by 37

Contracting the ‘mus cells’– does down‐sizing suit us for diving into the memory pool?

Kurtuluş, S., Tripathi, P., Opferman, J. T., & Hildeman, D. A. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00920.x · Cited by 35

Buffered memory: a hypothesis for the maintenance of functional, virus-specific CD8+ T cells during cytomegalovirus infection

Snyder, C. M. (2011) · Immunologic Research · doi:10.1007/s12026-011-8251-9 · Cited by 35

CD4 T Cell Responses in Latent and Chronic Viral Infections

Walton, S. M., Mandarić, S., & Oxenius, A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00105 · Cited by 35

Nano-Pulse Stimulation Ablates Orthotopic Rat Hepatocellular Carcinoma and Induces Innate and Adaptive Memory Immune Mechanisms that Prevent Recurrence

Lassiter, B. P., Guo, S., & Beebe, S. J. (2018) · Cancers · doi:10.3390/cancers10030069 · Cited by 36

Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease

Roy, S., Coulon, P.-G. A., Srivastava, R., Vahed, H., Kim, G. J., Walia, S. S., Yamada, T., Fouladi, M. A., Ly, V. T., & BenMohamed, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02922 · Cited by 35

T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy

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CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model

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