Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

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Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

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Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

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NK CELL RECEPTORS

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

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Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8 + T cell responses

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Macrophage-Mediated Subversion of Anti-Tumour Immunity

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In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma

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BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen

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Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8+ T-cell exhaustion

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Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections

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PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15

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FOXO1 constrains activation and regulates senescence in CD8 T cells

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Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer

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Impairment of T Cell Function in Parasitic Infections

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Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen–Specific T Cells

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T cell exhaustion and immune-mediated disease — the potential for therapeutic exhaustion

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High DGK-α and Disabled MAPK Pathways Cause Dysfunction of Human Tumor-Infiltrating CD8+ T Cells That Is Reversible by Pharmacologic Intervention

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Alternative Serotype Adenovirus Vaccine Vectors Elicit Memory T Cells with Enhanced Anamnestic Capacity Compared to Ad5 Vectors

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Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells

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Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage

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IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection

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Interactions between NKT cells and Tregs are required for tolerance to combined bone marrow and organ transplants

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Strong homeostatic TCR signals induce formation of self‐tolerant virtual memory CD8 T cells

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Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy

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Level of Herpes Simplex Virus Type 1 Latency Correlates with Severity of Corneal Scarring and Exhaustion of CD8+T Cells in Trigeminal Ganglia of Latently Infected Mice

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miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

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KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection

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Cytokine production and dysregulation in HIV pathogenesis: Lessons for development of therapeutics and vaccines

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Diversity in CD8+ T cell differentiation

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Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection

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Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8+ exhausted-like T cells

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Early CD4+ T Cell Help Prevents Partial CD8+ T Cell Exhaustion and Promotes Maintenance of Herpes Simplex Virus 1 Latency

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HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics

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Mechanisms of HBV immune evasion

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The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells

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Regulators of CD8+ T cell exhaustion

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CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections

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Peginterferon-α does not improve early peripheral blood HBV-specific T-cell responses in HBeAg-negative chronic hepatitis

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Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection

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Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

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Cellular and molecular waypoints along the path of T cell exhaustion

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Single-cell sequencing reveals trajectory of tumor-infiltrating lymphocyte states in pancreatic cancer

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Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection

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Tumour immunotherapy: lessons from predator–prey theory

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The Herpes Simplex Virus 1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8 + T Cells in Latently Infected Trigeminal Ganglia: a Novel Immune Evasion Mechanism

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Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy

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Immune landscape of hepatocellular carcinoma microenvironment: Implications for prognosis and therapeutic applications

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TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection

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Mass‐produced gram‐negative bacterial outer membrane vesicles activate cancer antigen‐specific stem‐like CD8 + T cells which enables an effective combination immunotherapy with anti‐PD‐1

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STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

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Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory

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Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis

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CTLA-4 (CD152): A versatile receptor for immune-based therapy

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CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function

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Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models

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CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition

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Cutting Edge: Persistently Open Chromatin at Effector Gene Loci in Resting Memory CD8+ T Cells Independent of Transcriptional Status

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Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer

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Induction and function of virus-specific CD4+ T cell responses

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CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection

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Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation

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The diversity of CD8+ T cell dysfunction in cancer and viral infection

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OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence

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Cell-Intrinsic IL-27 and gp130 Cytokine Receptor Signaling Regulates Virus-Specific CD4+ T Cell Responses and Viral Control during Chronic Infection

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Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression

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IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection

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Virus‐specific CD8 T cells: activation, differentiation and memory formation

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Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis

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Immunotherapy for advanced thyroid cancers — rationale, current advances and future strategies

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Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis

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CD8+ T cell exhaustion in the tumor microenvironment of breast cancer

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Target-Dependent B7-H1 Regulation Contributes to Clearance of Central Nervous Sysyem Infection and Dampens Morbidity

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TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization

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Galectin-9 Is Rapidly Released During Acute HIV-1 Infection and Remains Sustained at High Levels Despite Viral Suppression Even in Elite Controllers

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