Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

Restoring function in exhausted CD8 T cells during chronic viral infection

Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680

The B7 family revisited

Greenwald, R. J., Freeman, G. J., & Sharpe, A. H. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115611 · Cited by 2,318

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

Parry, R. V., Chemnitz, J. M., Frauwirth, K. A., Lanfranco, A. R., Braunstein, I., Kobayashi, S. V., Linsley, P. S., Thompson, C. B., & Riley, J. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9543-9553.2005 · Cited by 1,931

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

Wherry, E. J., Blattman, J. N., Murali‐Krishna, K., der Most, R. G. V., & Ahmed, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4911-4927.2003 · Cited by 1,645

NK CELL RECEPTORS

Lanier, L. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.359 · Cited by 1,641

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

Trautmann, L., Janbazian, L., Chomont, N., Said, E. A., Gimmig, S., Bessette, B., Boulassel, M.-R., Delwart, E., Sepulveda, H., Balderas, R. S., et al. (2006) · Nature Medicine · doi:10.1038/nm1482 · Cited by 1,565

CD 8+ T‐cell effector function and transcriptional regulation during HIV pathogenesis

Demers, K., Reuter, M. A., & Betts, M. R. (2013) · Immunological Reviews · doi:10.1111/imr.12069 · Cited by 78

Molecular and genetic inflammation networks in major human diseases

Zhao, Y., Forst, C. V., Sayegh, C. E., Wang, I., Yang, X., & Zhang, B. (2016) · Molecular BioSystems · doi:10.1039/c6mb00240d · Cited by 72

Immune profiling and identification of prognostic immune-related risk factors in human ovarian cancer

Rådestad, E., Klynning, C., Stikvoort, A., Mogensen, O. E., Nava, S., Magalhaes, I., & Uhlin, M. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1535730 · Cited by 71

Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection

Kahan, S. M., Bakshi, R. K., Ingram, J. T., Hendrickson, R. C., Lefkowitz, E. J., Crossman, D. K., Harrington, L. E., Weaver, C. T., & Zajac, A. J. (2022) · Science Immunology · doi:10.1126/sciimmunol.abl6322 · Cited by 67

LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures

Gestermann, N., Saugy, D., Martignier, C., Tillé, L., Fuertes Marraco, S. A., Zettl, M., Tirapu, I., Speiser, D. E., & Verdeil, G. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1736792 · Cited by 69

Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice

Kalia, V., Yuzefpolskiy, Y., Vegaraju, A., Xiao, H., Baumann, F. M., Jatav, S., Church, C. D., Prlic, M., Jha, A., Nghiem, P., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba6006 · Cited by 71

Immune checkpoint receptors in autoimmunity

Burke, K. P., Patterson, D. G., Liang, D., & Sharpe, A. H. (2023) · Current Opinion in Immunology · doi:10.1016/j.coi.2023.102283 · Cited by 70

Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases

Barbarin, A., Cayssials, É., Jacomet, F., Núñez, N. G., Basbous, S., Lefèvre, L., Abdallah, M., Piccirilli, N., Morin, B., Lavoué, V., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00316 · Cited by 69

Interleukin-18 up-regulates amino acid transporters and facilitates amino acid–induced mTORC1 activation in natural killer cells

Almutairi, S. M., Ali, A. K., He, W. R., Yang, D.-S., Ghorbani, P., Wang, L., Fullerton, M. D., & Lee, S.-H. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005892 · Cited by 74

Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy

Zebley, C. C., Gottschalk, S. M., & Youngblood, B. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.06.008 · Cited by 71

Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells.

Youngblood, B., Wherry, E. J., & Ahmed, R. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32834ddcf2 · Cited by 68

4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39 + CD8 T cells from primary and metastatic sites of epithelial ovarian cancers

Leem, G., Park, J., Jeon, M., Kim, E.-S., Kim, S. W., Lee, Y. J., Choi, S. J., Choi, B., Park, S., Jung, I., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001650 · Cited by 68

PDL1‐positive exosomes suppress antitumor immunity by inducing tumor‐specific CD8+ T cell exhaustion during metastasis

Chen, J., Song, Y., Miao, F., Chen, G., Zhu, Y., Wu, N., Pang, L., Chen, Z., & Chen, X. (2021) · Cancer Science · doi:10.1111/cas.15033 · Cited by 70

Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

Prakadan, S. M., Alvarez-Breckenridge, C. A., Markson, S. C., Kim, A. E., Klein, R. H., Nayyar, N., Navia, A. W., Kuter, B. M., Kolb, K. E., Bihun, I. V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25860-5 · Cited by 66

Adenoviral-based vaccine promotes neoantigen-specific CD8 + T cell stemness and tumor rejection

D’Alise, A. M., Brasu, N., Intinis, C. D., Leoni, G., Russo, V., Langone, F., Baev, D. V., Micarelli, E., Petiti, L., Picelli, S., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo7604 · Cited by 69

Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells

He, S., Kato, K., Jiang, J. K., Wahl, D. R., Mineishi, S., Fisher, E. M., Murasko, D. M., Glick, G. D., & Zhang, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020107 · Cited by 71

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection

Moffett, H., Cartwright, A. N., Kim, H.-J., Godec, J., Pyrdol, J. W., Äijö, T., Martinez, G., Rao, A., Lu, J., Golub, T., et al. (2017) · Nature Immunology · doi:10.1038/ni.3755 · Cited by 74

Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models

Lewis, K. E., Selby, M., Masters, G. R., Valle, J., Dito, G., Curtis, W., García, R., Mink, K. A., Waggie, K. S., Holdren, M. S., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1377873 · Cited by 68

Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function

Salerno, F., Turner, M., & Wolkers, M. C. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.01.001 · Cited by 59

T Cell Exhaustion and CAR‐T Immunotherapy in Hematological Malignancies

Tang, L., Zhang, Y., Hu, Y., & Mei, H. (2021) · BioMed Research International · doi:10.1155/2021/6616391 · Cited by 72

Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways

Shao, M., Teng, X., Guo, X., Zhang, H., Huang, Y., Cui, J., Si, X., Ding, L., Wang, X., Li, X., et al. (2022) · Advanced Science · doi:10.1002/advs.202103508 · Cited by 67

BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties

Haymaker, C., Wu, R. C. H., Ritthipichai, K., Bernatchez, C., Forget, M., Chen, J. Q., Liu, H., Wang, E., Marincola, F. M., Hwu, P., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1014246 · Cited by 66

Quantitative and qualitative characterization of expanded CD4+ T cell clones in rheumatoid arthritis patients

Ishigaki, K., Shoda, H., Kochi, Y., Yasui, T., Kadono, Y., Tanaka, S., Fujio, K., & Yamamoto, K. (2015) · Scientific Reports · doi:10.1038/srep12937 · Cited by 68

Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection

Barili, V., Fisicaro, P., Montanini, B., Acerbi, G., Filippi, A., Forleo, G., Romualdi, C., Ferracin, M., Guerrieri, F., Pedrazzi, G., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14137-7 · Cited by 70

Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3–CD8+ T cells

Deng, S., Sun, Z., Qiao, J., Liang, Y., Liu, L., Dong, C., Shen, A., Wang, Y., Tang, H., Fu, Y., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.132000 · Cited by 67

NK cells inhibit humoral immunity by reducing the abundance of CD4+ T follicular helper cells during a chronic virus infection

Cook, K. D., Kline, H. C., & Whitmire, J. K. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4hi1214-594r · Cited by 66

Increased Pretransplant Frequency of CD28+ CD4+ TEM Predicts Belatacept-Resistant Rejection in Human Renal Transplant Recipients

Cerisuelo, M. C., Laurie, S. J., Mathews, D. V., Winterberg, P. D., Larsen, C. P., Adams, A. B., & Ford, M. L. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14350 · Cited by 66

A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivity

Cardone, M., Garcia, K., Tilahun, M. E., Boyd, L. F., Gebreyohannes, S., Yano, M., Roderiquez, G., Akue, A. D., Juengst, L., Mattson, E., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99321 · Cited by 68

Epigenetic Regulation of T Cell Memory: Recalling Therapeutic Implications

Tough, D. F., Rioja, I., Modis, L. K., & Prinjha, R. K. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.11.008 · Cited by 67

The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer

Topchyan, P., Lin, S., & Cui, W. (2023) · Immune Network · doi:10.4110/in.2023.23.e41 · Cited by 73

Decoding and overcoming T cell exhaustion: Epigenetic and transcriptional dynamics in CAR-T cells against solid tumors

Ahn, T., Bae, E., & Seo, H. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.04.004 · Cited by 71

T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract

Lu, B., Chen, L., Liu, L., Zhu, Y., Wu, C., Jiang, J., & Zhang, X. (2011) · Immunologic Research · doi:10.1007/s12026-011-8227-9 · Cited by 67

Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention

Furlan, S. N., Watkins, B. K., Tkachev, V., Flynn, R. P., Cooley, S., Ramakrishnan, S., Singh, K., Giver, C., Hamby, K., Stempora, L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3231 · Cited by 64

Early Effector CD8 T Cells Display Plasticity in Populating the Short-Lived Effector and Memory-Precursor Pools Following Bacterial or Viral Infection

Plumlee, C. R., Obar, J. J., Colpitts, S. L., Jellison, E. R., Haining, W. N., Lefrançois, L., & Khanna, K. M. (2015) · Scientific Reports · doi:10.1038/srep12264 · Cited by 66

T Cell Cosignaling Molecules in Transplantation

Ford, M. L. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.012 · Cited by 67

CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection

Shaabani, N., Duhan, V., Khairnar, V., Gassa, A., Ferrer-Tur, R., Häussinger, D., Recher, M., Zelinskyy, G., Liu, J., Dittmer, U., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.350 · Cited by 64

Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities

Yin, N., Li, X., Zhang, X., Xue, S., Cao, Y., Niedermann, G., Lu, Y., & Xue, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01826-z · Cited by 74

Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells

Shankar, E. M., Che, K. F., Messmer, D., Lifson, J. D., & Larsson, M. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00175 · Cited by 66

Emergence of Distinct Multiarmed Immunoregulatory Antigen-Presenting Cells during Persistent Viral Infection

Wilson, E. B., Kidani, Y., Elsaesser, H. J., Barnard, J., Raff, L., Karp, C. L., Bensinger, S. J., & Brooks, D. G. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.03.009 · Cited by 64

2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses

Liu, D., Krummey, S. M., Badell, I. R., Wagener, M. E., Schneeweis, L. A., Stetsko, D. K., Suchard, S. J., Nadler, S. G., & Ford, M. L. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20130902 · Cited by 64

Probing CD8 T Cell Responses with Listeria monocytogenes Infection

Condotta, S. A., Richer, M. J., Badovinac, V. P., & Harty, J. T. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394590-7.00005-1 · Cited by 64

Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling

Marro, B. S., Ware, B. C., Žák, J., de la Torre, J. C., Rosen, H., & Oldstone, M. B. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700878114 · Cited by 64

The appropriate frequency and function of decidual Tim-3+CTLA-4+CD8+ T cells are important in maintaining normal pregnancy

Wang, S., Sun, F., Li, M., Qian, J., Chen, C., Wang, M., Zang, X., Li, D., Yu, M., & Du, M. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1642-x · Cited by 64

Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: Immunity interruptus

Behar, S. M., Carpenter, S. M., Booty, M. G., Barber, D. L., & Jayaraman, P. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.003 · Cited by 65

Immune Responses to Retroviruses

Sáez‐Cirión, A., & Manel, N. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052155 · Cited by 66

Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor

Mognol, G. P., González‐Avalos, E., Ghosh, S., Spreafico, R., Gudlur, A., Rao, A., Damoiseaux, R. D., & Hogan, P. G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820604116 · Cited by 62

Targeting PD-L1 Initiates Effective Antitumor Immunity in a Murine Model of Cushing Disease

Kemeny, H. R., Elsamadicy, A. A., Farber, S. H., Champion, C. D., Lorrey, S., Chongsathidkiet, P., Woroniecka, K. I., Cui, X., Shen, S. H., Rhodin, K. E., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3486 · Cited by 63

Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML

Nixdorf, D., Sponheimer, M., Berghammer, D., Engert, F., Bader, U., Philipp, N., Pasikhani, M. K., Straub, T., Rohrbacher, L., Wange, L. E., et al. (2023) · Leukemia · doi:10.1038/s41375-023-01905-0 · Cited by 63

Mechanisms of CD8+ T cell exclusion and dysfunction in cancer resistance to anti-PD-(L)1

Mortezaee, K., & Majidpoor, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114824 · Cited by 63

AAV8 Induces Tolerance in Murine Muscle as a Result of Poor APC Transduction, T Cell Exhaustion, and Minimal MHCI Upregulation on Target Cells

Mays, L. E., Wang, L., Lin, J., Bell, P. L., Crawford, A., Wherry, E. J., & Wilson, J. M. (2013) · Molecular Therapy · doi:10.1038/mt.2013.134 · Cited by 69

Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice

Yoon, S. K., Seo, Y. B., Im, S. J., Bae, S. H., Song, D. S., You, C. R., Jang, J., Yang, S. H., Suh, Y. S., Song, J. S., et al. (2014) · Liver International · doi:10.1111/liv.12530 · Cited by 62

Blockade of Programmed Death-1 Pathway Rescues the Effector Function of Tumor-Infiltrating T Cells and Enhances the Antitumor Efficacy of Lentivector Immunization

Zhou, Q., Xiao, H., Liu, Y., Peng, Y., Yuan, H., Yagita∥, H., Chandler, P., Munn, D. H., Mellor, A. L., Fu, N., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001821 · Cited by 62

TIMs: central regulators of immune responses

Hafler, D. A., & Kuchroo, V. K. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20082429 · Cited by 62

MHC–peptide tetramers for the analysis of antigen-specific T cells

Sims, S., Willberg, C. B., & Klenerman, P. (2010) · Expert Review of Vaccines · doi:10.1586/erv.10.66 · Cited by 62

CD103+ CD8 T Cells in the Toxoplasma-Infected Brain Exhibit a Tissue-Resident Memory Transcriptional Profile

Landrith, T. A., Sureshchandra, S., Rivera, A., Jang, J. C., Rais, M., Nair, M. G., Messaoudi, I., & Wilson, E. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00335 · Cited by 64

Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma

Schadendorf, D., Nghiem, P., Bhatia, S., Hauschild, A., Saïag, P., Mahnke, L. A., Hariharan, S., & Kaufman, H. L. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1338237 · Cited by 66

Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor

Slutsky, R., Romero, R. J., Xu, Y., Galaz, J., Miller, D., Done, B., Tarca, A. L., Gregor, S., Hassan, S. S., Leng, Y., et al. (2019) · Journal of Immunology Research · doi:10.1155/2019/3128010 · Cited by 62

CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer

Lee, Y. J., Kim, J. Y., Jeon, S. H., Nam, H., Jung, J. H., Jeon, M., Kim, E.-S., Bae, S. J., Ahn, J., Yoo, T.-K., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abn8390 · Cited by 56

Exhaustion and over-activation of immune cells in COVID-19: Challenges and therapeutic opportunities

Alahdal, M., & Elkord, E. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109177 · Cited by 60

TIM-3 + CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies

Minnie, S. A., Waltner, O. G., Zhang, P., Takahashi, S., Nemychenkov, N. S., Ensbey, K. S., Schmidt, C. R., Legg, S. R. W., Comstock, M., Boiko, J. R., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adg1094 · Cited by 58

Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model

Zehn, D., & Wherry, E. J. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-15774-0_10 · Cited by 60

Mechanism of T cell exhaustion in a chronic environment

Jin, H.-T., Jeong, Y. H., Park, H.-J., & Ha, S. (2011) · BMB Reports · doi:10.5483/bmbrep.2011.44.4.217 · Cited by 62

Active Evasion of CTL Mediated Killing and Low Quality Responding CD8+ T Cells Contribute to Persistence of Brucellosis

Durward, M., Radhakrishnan, G., Harms, J. S., Bareiss, C., Magnani, D. M., & Splitter, G. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034925 · Cited by 60

Epstein–Barr virus and multiple sclerosis. From evidence to therapeutic strategies

Menéndez, S. F., Fernández-Morán, M., Fernández‐Vega, I., Pérez-Álvarez, Á. I., & Villafani, J. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.01.013 · Cited by 68

Prostaglandin E2 and PD-1 mediated inhibition of antitumor CTL responses in the human tumor microenvironment

Miao, J., Xu, L., Hu, Y., Piao, C., Wu, X., Liu, X., Huang, C., Wang, Y., Li, D., & Liu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.21155 · Cited by 66

CD4 + T help promotes influenza virus-specific CD8 + T cell memory by limiting metabolic dysfunction

Cullen, J. G., McQuilten, H. A., Quinn, K. M., Olshansky, M., Russ, B. E., Morey, A., Wei, S., Prier, J. E., Gruta, N. L. L., Doherty, P. C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808849116 · Cited by 65

IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation

Liu, X., Li, F., Niu, H., Ma, L., Chen, J., Zhang, Y., Peng, L., Gan, C., Ma, X., & Zhu, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02350 · Cited by 61

ADAP and SKAP55 deficiency suppresses PD‐1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti‐tumor immunotherapy

Li, C., Li, W., Xiao, J., Jiao, S., Teng, F., Xue, S., Zhang, C., Sheng, C., Leng, Q., Rudd, C. E., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404578 · Cited by 60

Layilin augments integrin activation to promote antitumor immunity

Mahuron, K. M., Moreau, J. M., Glasgow, J. E., Boda, D. P., Pauli, M. L., Gouirand, V., Panjabi, L., Grewal, R., Luber, J. M., Mathur, A. N., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192080 · Cited by 60

Progress of immune checkpoint LAG‑3 in immunotherapy (Review)

Shan, C., Li, X., & Zhang, J. (2020) · Oncology Letters · doi:10.3892/ol.2020.12070 · Cited by 60

EOMES is essential for antitumor activity of CD8+ T cells in chronic lymphocytic leukemia

Cid, L. L., Roessner, P. M., Chapaprieta, V., Öztürk, S., Roider, T., Bordas, M., Ízcue, A., Colomer, D., Dietrich, S., Stilgenbauer, S., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01198-1 · Cited by 64

Emerging Roles for the FCRL Family Members in Lymphocyte Biology and Disease

Li, F. J., Won, W.-J., Becker, E., Easlick, J. L., Tabengwa, E. M., Li, R., Shakhmatov, M. A., Honjo, K., Burrows, P. D., & Davis, R. S. (2014) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-07911-0_2 · Cited by 60

Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity

Dougan, S. K., Dougan, M. L., Kim, J., Turner, J., Ogata, S., Cho, H.-I., Jaenisch, R., Celis, E., & Ploegh, H. L. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0047 · Cited by 60

Reduced Functional Avidity Promotes Central and Effector Memory CD4 T Cell Responses to Tumor-Associated Antigens

Caserta, S., Kleczkowska, J., Mondino, A., & Zamoyska, R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001867 · Cited by 64

EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

Istaces, N., Splittgerber, M., Silva, V. L., Nguyen, M., Thomas, S., Le, A., Achouri, Y., Calonne, E., Defrance, M., Fuks, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11233-6 · Cited by 65

Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection

Sandu, I., Cerletti, D., Claassen, M., & Oxenius, A. (2020) · Nature Communications · doi:10.1038/s41467-020-18256-4 · Cited by 60

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

Wagle, M. V., Vervoort, S. J., Kelly, M. J., Byl, W. V. D., Peters, T. J., Martin, B. P., Martelotto, L. G., Nüssing, S., Ramsbottom, K. M., Torpy, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23044-9 · Cited by 62

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Ta, T. M., Malik, S., Anderson, E. M., Jones, A. D., Perchik, J., Freylikh, M., Sardo, L., Klase, Z. A., & Izumi, T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.862270 · Cited by 61

An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

Jaiswal, A., Verma, A., Dannenfelser, R., Melssen, M. M., Tirosh, I., Izar, B., Kim, T., Nirschl, C. J., Devi, K. S. P., Olson, W. C., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.04.005 · Cited by 61

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Chi, X., Luo, S., Ye, P., Hwang, W., Cha, J., Yan, X., & Yang, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1104771 · Cited by 62

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Zhou, Z., Wang, J., Wang, J., Yang, S., Wang, R., Zhang, G., Li, Z., Shi, R., Wang, Z., & Lu, Q. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02047-2 · Cited by 66

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Rodrigue‐Gervais, I. G., Rigsby, H., Jouan, L., Sauvé, D., Sékaly, R., Willems, B. E., & Lamarre, D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902522 · Cited by 58

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Vieyra, M. B., Leisman, S. A., Raedler, H., Kwan, W.-H., Yang, M., Strainic, M. G., Medof, M. E., & Heeger, P. S. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.04.038 · Cited by 59

Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis

Guo, X.-Z. J., Dash, P., Calverley, M., Tomchuck, S. L., Dallas, M. H., & Thomas, P. G. (2016) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2015.54 · Cited by 59

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Nice, T. J., Osborne, L. C., Tomov, V. T., Artis, D., Wherry, E. J., & Virgin, H. W. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005684 · Cited by 61

Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non–Small Cell Lung Cancer

Tassi, E., Grazia, G., Vegetti, C., Bersani, I., Bertolini, G., Molla, A., Baldassari, P., Andriani, F., Roz, L., Sozzi, G., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1387 · Cited by 57

Molecular Dissection of CD8 + T-Cell Dysfunction

Wang, C., Singer, M., & Anderson, A. C. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.05.008 · Cited by 60

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Gefen, T., Castro, I., Muharemagic, D., Puplampu-Dove, Y., Patel, S., & Gilboa, E. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.06.023 · Cited by 61

Dendritic Cell Regulation of Graft-Vs.-Host Disease: Immunostimulation and Tolerance

Yu, H., Tian, Y., Wang, Y., Mineishi, S., & Zhang, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00093 · Cited by 59

Transcription and DNA Methylation Patterns of Blood-Derived CD8+ T Cells Are Associated With Age and Inflammatory Bowel Disease But Do Not Predict Prognosis

Gasparetto, M., Payne, F., Nayak, K., Kraiczy, J., Glemas, C., Philip-McKenzie, Y., Ross, A., Edgar, R. D., Zerbino, D. R., Salvestrini, C., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.08.017 · Cited by 60

Persistent Simian Immunodeficiency Virus Infection Drives Differentiation, Aberrant Accumulation, and Latent Infection of Germinal Center Follicular T Helper Cells

Xu, H., Wang, X., Malam, N., Aye, P. P., Alvarez, X. A., Lackner, A. A., & Veazey, R. S. (2015) · Journal of Virology · doi:10.1128/jvi.02471-15 · Cited by 58

Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy

Bachireddy, P., Azizi, E., Burdziak, C., Nguyen, V. N., Ennis, C. S., Maurer, K., Park, C. Y., Choo, Z.-N., Li, S., Gohil, S. H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109992 · Cited by 55

Emerging CAR T Cell Strategies for the Treatment of AML

Vishwasrao, P., Li, G., Boucher, J. C., Smith, D. L., & Hui, S. K. (2022) · Cancers · doi:10.3390/cancers14051241 · Cited by 61

Immunological mechanisms of tolerance: Central, peripheral and the role of T and B cells

Meng, X., Layhadi, J. A., Keane, S. T., Cartwright, N., Durham, S. R., & Shamji, M. H. (2023) · Asia Pacific Allergy · doi:10.5415/apallergy.0000000000000128 · Cited by 70

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Fankhauser, S. C., & Starnbach, M. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301657 · Cited by 56

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Charlton, J., Chatzidakis, I., Tsoukatou, D., Boumpas, D., Garinis, G. A., & Mamalaki, C. (2013) · Journal of Immunology · doi:10.4049/jimmunol.1201617 · Cited by 63

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Vandeven, N. A., & Nghiem, P. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0179 · Cited by 58

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Waugh, K. A., Leach, S. M., Moore, B. L., Bruno, T. C., Buhrman, J. D., & Slansky, J. E. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600589 · Cited by 59

CAR T cells and checkpoint inhibition for the treatment of glioblastoma

Shen, S. H., Woroniecka, K. I., Barbour, A. B., Fecci, P. E., Sanchez-Perez, L. A., & Sampson, J. H. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1727436 · Cited by 62

Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

McPherson, R. C., Konkel, J. E., Prendergast, C. T., Thomson, J. P., Ottaviano, R., Leech, M. D., Kay, O., Zandee, S., Sweenie, C. H., Wraith, D. C., et al. (2014) · eLife · doi:10.7554/elife.03416 · Cited by 61

Raising Lazarus: Exhaustion, death and resurrection of CD8+ T cell responses during chronic viral infection

Blackburn, S. D. (2008) · Scholarly Commons (University of Pennsylvania)

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Sandu, I., Cerletti, D., Oetiker, N., Borsa, M., Wagen, F., Spadafora, I., Welten, S. P. M., Stolz, U., Oxenius, A., & Claassen, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108078 · Cited by 78

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Ali, R. (2017)

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Crawford, A., Angelosanto, J., Kao, C., Doering, T. A., Odorizzi, P. M., Barnett, B. E., & Wherry, E. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.005 · Cited by 513

Use of genome wide expression profiles in analysis of T cell dysfunction in Hepatitis C virus infection

Gupta, P. (2014) · Oxford University Research Archive (ORA) (University of Oxford) · doi:10.5287/ora-0odnyd1r7