The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
Open accessAbstract
Summary Effective clearance of apoptotic cells by macrophages is essential for immune homeostasis. The transcriptional pathways that allow macrophages to sense and respond to apoptotic cells are poorly defined. We demonstrate here that LXR signaling is important for both apoptotic cell clearance and the maintenance of immune tolerance. Apoptotic cell engulfment activates LXR and thereby induces the expression of Mer, a receptor tyrosine kinase critical for phagocytosis. LXR null macrophages exhibit a selective defect in phagocytosis of apoptotic cells and an aberrant pro-inflammatory response to them. As a consequence of these defects, mice lacking LXRs manifest a breakdown in self-tolerance and develop autoantibodies and autoimmune glomerulonephritis. Treatment with an LXR agonist ameliorates disease progression in mouse models of Lupus-like autoimmunity. Thus, activation of LXR by apoptotic cells engages a virtuous cycle that promotes their own clearance and couples engulfment to the suppression of inflammatory pathways.
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“Tolerance is accomplished through several distinct mech- anisms, including suppression of inflammatory cytokine produc- tion and release of anti-inflammatory cytokines such as IL-10 and TGF-b (Fadok et al., 1998b; Li and Flavell, 2008; Voll et al., 1997).”
InfluentialNasir, O. (2013) · Kidney and Blood Pressure Research · doi:10.1159/000350152 · Cited by 2,331
Immunosuppressive effects of apoptotic cells
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A blast from the past: clearance of apoptotic cells regulates immune responses
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Corpse clearance defines the meaning of cell death
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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
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MACROPHAGE RECEPTORS AND IMMUNE RECOGNITION
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Phagocytosis and clearance of apoptotic cells is mediated by MER
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Cited by
Macrophages in the Pathogenesis of Atherosclerosis
Moore, K. J., & Tabas, I. (2011) · Cell · doi:10.1016/j.cell.2011.04.005 · Cited by 2,669
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
Rőszer, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/816460 · Cited by 1,762
Cholesterol, inflammation and innate immunity.
Tall, A. R., & Yvan-Charvet, L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3793 · Cited by 1,479
Apoptotic cell clearance: basic biology and therapeutic potential
Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223
Macrophage death and defective inflammation resolution in atherosclerosis
Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120
Metadata
- Authors
- A-Gonzalez, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J., Ramirez, C., Díaz, M., Gallardo, G., Ruiz de Galarreta, C., Salazar, J., Lopez, F., Edwards, P., Parks, J., Andujar, M., Tontonoz, P., & Castrillo, A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 31
- Issue
- 2
- Pages
- 245-258
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2095474336
- Cited by
- 677
- References
- 66
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- A-Gonzalez, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J., Ramirez, C., Díaz, M., Gallardo, G., Ruiz de Galarreta, C., Salazar, J., Lopez, F., Edwards, P., Parks, J., Andujar, M., Tontonoz, P., & Castrillo, A. (2009). Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR. Immunity. https://doi.org/10.1016/j.immuni.2009.06.018
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